2024
Trends in the Use of Medications for Secondary Ischemic Stroke Prevention in Denmark, 2005-2021.
Skajaa N, Laugesen K, Lauffenburger J, Schwamm L, Sørensen H, Patorno E. Trends in the Use of Medications for Secondary Ischemic Stroke Prevention in Denmark, 2005-2021. Neurology 2024, 102: e209309. PMID: 38648572, PMCID: PMC11226314, DOI: 10.1212/wnl.0000000000209309.Peer-Reviewed Original ResearchConceptsMedication useOral anticoagulant medicationsGlucose-lowering medication useFactors associated with medication useLipid-lowering medication useSevere strokeIschemic stroke hospitalizationsAntihypertensive medication useAnticoagulant medicationOlder patientsCare of patientsSodium-glucose cotransporter-2 inhibitorsGlucagon-like peptide-1 receptor agonistsStroke preventionAnticoagulant medication useLipid-loweringPeptide-1 receptor agonistsGlucose-loweringReduced life expectancyIschemic strokeCotransporter-2 inhibitorsStroke careCohort of patientsStroke hospitalizationsSecondary ischemic stroke prevention
2022
Evaluation of Evidence-Based Dual Antiplatelet Therapy for Secondary Prevention in US Patients With Acute Ischemic Stroke
Xian Y, Xu H, Smith E, Fonarow G, Bhatt D, Schwamm L, Peterson E. Evaluation of Evidence-Based Dual Antiplatelet Therapy for Secondary Prevention in US Patients With Acute Ischemic Stroke. JAMA Internal Medicine 2022, 182: 559-564. PMID: 35344009, PMCID: PMC8961397, DOI: 10.1001/jamainternmed.2022.0323.Peer-Reviewed Original ResearchMeSH KeywordsAspirinClopidogrelDrug Therapy, CombinationHumansIschemic Attack, TransientIschemic StrokePlatelet Aggregation InhibitorsSecondary PreventionStroke
2021
Antithrombotic Therapy for Stroke Prevention in Patients With Ischemic Stroke With Aspirin Treatment Failure
Lusk J, Xu H, Peterson E, Bhatt D, Fonarow G, Smith E, Matsouaka R, Schwamm L, Xian Y. Antithrombotic Therapy for Stroke Prevention in Patients With Ischemic Stroke With Aspirin Treatment Failure. Stroke 2021, 52: e777-e781. PMID: 34702067, PMCID: PMC8608737, DOI: 10.1161/strokeaha.121.034622.Peer-Reviewed Original ResearchMeSH KeywordsAgedAspirinDual Anti-Platelet TherapyFemaleFibrinolytic AgentsHumansIschemic StrokeMaleSecondary PreventionTreatment FailureConceptsAspirin treatment failureDual antiplatelet therapyIschemic strokeAspirin monotherapyClopidogrel monotherapyAntiplatelet therapyAntithrombotic therapyTreatment failureAntithrombotic treatment patternsAspirin/dipyridamoleGuidelines-Stroke registryIschemic stroke survivorsAcute ischemic strokeHalf of patientsAmerican Heart AssociationComplex clinical scenariosNonvitamin KOral anticoagulantsStroke preventionStroke RegistryOlder patientsPreventive therapyTreatment patternsHeart AssociationStroke survivorsAnticonvulsant Primary and Secondary Prophylaxis for Acute Ischemic Stroke Patients
Jones F, Sanches P, Smith J, Zafar S, Hernandez-Diaz S, Blacker D, Hsu J, Schwamm L, Westover M, Moura L. Anticonvulsant Primary and Secondary Prophylaxis for Acute Ischemic Stroke Patients. Stroke 2021, 52: 2782-2791. PMID: 34126758, PMCID: PMC8384723, DOI: 10.1161/strokeaha.120.033299.Peer-Reviewed Original ResearchConceptsQuality-adjusted life expectancySecondary prophylaxisAdverse drug reactionsADR riskLate seizuresPrimary prophylaxisMale patientsFemale patientsLifetime riskLS riskAcute ischemic stroke hospitalizationsLong-term secondary prophylaxisAcute ischemic stroke patientsHigher ADR risksAcute ischemic strokeIschemic stroke patientsIschemic stroke hospitalizationsCommon clinical scenariosShort-term therapyAnticonvulsant prophylaxisLifetime prophylaxisPersistent seizuresSeizure prophylaxisEarly seizuresIschemic stroke
2018
Effect of a Multifaceted Quality Improvement Intervention on Hospital Personnel Adherence to Performance Measures in Patients With Acute Ischemic Stroke in China: A Randomized Clinical Trial
Wang Y, Li Z, Zhao X, Wang C, Wang X, Wang D, Liang L, Liu L, Wang C, Li H, Shen H, Bettger J, Pan Y, Jiang Y, Yang X, Zhang C, Han X, Meng X, Yang X, Kang H, Yuan W, Fonarow G, Peterson E, Schwamm L, Xian Y, Wang Y. Effect of a Multifaceted Quality Improvement Intervention on Hospital Personnel Adherence to Performance Measures in Patients With Acute Ischemic Stroke in China: A Randomized Clinical Trial. JAMA 2018, 320: 245-254. PMID: 29959443, DOI: 10.1001/jama.2018.8802.Peer-Reviewed Original ResearchConceptsMultifaceted quality improvement interventionAcute ischemic strokeQuality improvement interventionsEvidence-based performance measuresIschemic strokeImprovement interventionsControl groupUsual careClinical trialsIntervention groupEvidence-based stroke careCluster-randomized clinical trialClinical vascular eventsCo-primary outcomesLong-term outcomesHospital mortalityStroke RegistryVascular eventsSecondary outcomesPrimary outcomeStroke careCare protocolsClinical pathwayMAIN OUTCOMEPatients
2015
Patient-Centered Research into Outcomes Stroke Patients Prefer and Effectiveness Research: Implementing the patient-driven research paradigm to aid decision making in stroke care
Xian Y, O’Brien E, Fonarow G, Olson D, Schwamm L, Hannah D, Lindholm B, Maisch L, Lytle B, Greiner M, Wu J, Peterson E, Pencina M, Hernandez A. Patient-Centered Research into Outcomes Stroke Patients Prefer and Effectiveness Research: Implementing the patient-driven research paradigm to aid decision making in stroke care. American Heart Journal 2015, 170: 36-45.e11. PMID: 26093862, DOI: 10.1016/j.ahj.2015.04.008.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAgedAged, 80 and overAnticoagulantsAntidepressive AgentsCohort StudiesDecision MakingDepressionFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMiddle AgedPatient Care PlanningPatient Outcome AssessmentPatient PreferencePatient SatisfactionProspective StudiesQuality of LifeRetrospective StudiesSecondary PreventionStrokeTreatment OutcomeConceptsComparative effectiveness researchPatient prefersStroke careStroke patientsTreatment optionsEffectiveness researchMajor adverse cardiovascular eventsAdverse cardiovascular eventsIndividual patient preferencesHealth care providersOutcomes Research InstitutePatient-centered comparative effectiveness researchOutcomes research studiesHealth care communityGuidelines-StrokeCardiovascular eventsOral anticoagulantsPatient-centered outcomes research studiesStatin therapyPatient characteristicsPrimary outcomeClinical effectivenessComparative safetyPatient preferencesClinical trials
2014
Temporal Trends for Secondary Prevention Measures Among Patients Hospitalized with Coronary Artery Disease
Kumbhani D, Fonarow G, Cannon C, Hernandez A, Peterson E, Peacock W, Laskey W, Deedwania P, Grau-Sepulveda M, Schwamm L, Bhatt D, Committee and Investigators G. Temporal Trends for Secondary Prevention Measures Among Patients Hospitalized with Coronary Artery Disease. The American Journal Of Medicine 2014, 128: 426.e1-426.e9. PMID: 25433302, DOI: 10.1016/j.amjmed.2014.11.013.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAdultAgedAngiotensin Receptor AntagonistsAngiotensin-Converting Enzyme InhibitorsAspirinCardiovascular AgentsCoronary Artery BypassCoronary Artery DiseaseDirective CounselingFemaleGuideline AdherenceHumansHypolipidemic AgentsInpatientsMaleMiddle AgedPatient DischargePercutaneous Coronary InterventionPractice Guidelines as TopicRegistriesSecondary PreventionSmoking CessationUnited StatesConceptsCoronary artery bypass graft surgeryArtery bypass graft surgeryCoronary artery diseaseBypass graft surgerySecondary prevention measuresPercutaneous coronary intervention groupArtery diseaseGraft surgeryIntervention groupOverall adherenceGuidelines-Coronary Artery Disease registryPrevention measuresContemporary temporal trendsTime pointsPercutaneous coronary interventionPercutaneous coronary revascularizationEligible patientsCoronary revascularizationMultivariable adjustmentSurgery groupCoronary interventionRevascularization strategyCare measuresHospital adherenceTreatment groups
2013
Factors Influencing the Decline in Stroke Mortality
Lackland DT, Roccella EJ, Deutsch AF, Fornage M, George MG, Howard G, Kissela BM, Kittner SJ, Lichtman JH, Lisabeth LD, Schwamm LH, Smith EE, Towfighi A. Factors Influencing the Decline in Stroke Mortality. Stroke 2013, 45: 315-353. PMID: 24309587, PMCID: PMC5995123, DOI: 10.1161/01.str.0000437068.30550.cf.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAgedAged, 80 and overAir PollutionAmerican Heart AssociationAspirinAssociationAtrial FibrillationBlood PressureClinical Trials as TopicDiabetes MellitusExerciseFemaleHeart DiseasesHumansHyperlipidemiasHypertensionIncidenceInternational Classification of DiseasesMaleMiddle AgedObesityObservational Studies as TopicPlatelet Aggregation InhibitorsPopulationPrevalenceSecondary PreventionSex FactorsSmokingStrokeThrombolytic TherapyUnited StatesYoung AdultConceptsStroke mortalityCause of deathStroke riskAmerican Heart Association Stroke Council's Scientific Statement Oversight CommitteeAmerican Heart Association's Manuscript Oversight CommitteeAmerican Heart Association Science AdvisoryScientific Statements Oversight Committee reviewStroke Council Leadership reviewLower case fatality rateEvidence-based public health programsMajor public health burdenControl of hypertensionChronic lung diseaseFourth leading causeCase fatality rateTreatment of hypertensionPublic health burdenWriting group membersAttributable risk estimatesPublic health guidelinesYears of ageMajor public healthPublic health programsCombination of interventionsDyslipidemia control
2012
Death and Rehospitalization after Transient Ischemic Attack or Acute Ischemic Stroke: One-year Outcomes from the Adherence Evaluation of Acute Ischemic Stroke–Longitudinal Registry
Olson D, Cox M, Pan W, Sacco R, Fonarow G, Zorowitz R, LaBresh K, Schwamm L, Williams L, Goldstein L, Bushnell C, Peterson E, Registry A. Death and Rehospitalization after Transient Ischemic Attack or Acute Ischemic Stroke: One-year Outcomes from the Adherence Evaluation of Acute Ischemic Stroke–Longitudinal Registry. Journal Of Stroke And Cerebrovascular Diseases 2012, 22: e181-e188. PMID: 23273788, DOI: 10.1016/j.jstrokecerebrovasdis.2012.11.001.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBrain IschemiaFemaleHospitalizationHumansIschemic Attack, TransientMaleMiddle AgedRegistriesSecondary PreventionStrokeConceptsTransient ischemic attackAcute ischemic strokeIschemic stroke Longitudinal (AVAIL) registryAIS patientsIschemic attackTIA patientsIschemic strokeAdherence evaluationPrimary composite outcomeOne-year outcomesRehospitalization of patientsRate of deathCause deathGuidelines-StrokePostdischarge riskCause mortalityCause rehospitalizationComposite outcomeHospital dischargeMedication useAdjusted ratesRehospitalizationPreventive guidelinesPatientsOne-yearAchievement of Guideline-Concordant Care and In-Hospital Outcomes in Patients With Coronary Artery Disease in Teaching and Nonteaching Hospitals
Tam L, Fonarow G, Bhatt D, Grau-Sepulveda M, Hernandez A, Peterson E, Schwamm L, Giugliano R. Achievement of Guideline-Concordant Care and In-Hospital Outcomes in Patients With Coronary Artery Disease in Teaching and Nonteaching Hospitals. Circulation Cardiovascular Quality And Outcomes 2012, 6: 58-65. PMID: 23233750, DOI: 10.1161/circoutcomes.112.965525.Peer-Reviewed Original ResearchMeSH KeywordsAgedAmerican Heart AssociationCoronary Artery DiseaseDrug Therapy, CombinationEvidence-Based PracticeFemaleGuideline AdherenceGuidelines as TopicHospital MortalityHospitalsHospitals, TeachingHumansInpatientsMaleMiddle AgedOutcome Assessment, Health CareQuality Assurance, Health CareRetrospective StudiesSecondary PreventionTreatment OutcomeUnited StatesConceptsGuideline-concordant careGuidelines-Coronary Artery Disease programSecondary prevention therapiesCoronary artery diseaseTeaching hospitalHospital mortalityArtery diseasePrevention therapyAngiotensin-converting enzyme inhibitors/angiotensin receptor blockersEnzyme inhibitors/angiotensin receptor blockersEvidence-based secondary prevention therapiesDisease programsGuideline-recommended therapiesAngiotensin receptor blockersIn-Hospital OutcomesLength of stayLow-density lipoproteinGreatest incremental improvementReceptor blockersSystolic dysfunctionPrimary outcomeSmoking cessationLipid therapyOdds ratioNonteaching hospitalsRegional Variation in Recommended Treatments for Ischemic Stroke and TIA
Allen NB, Kaltenbach L, Goldstein LB, Olson DM, Smith EE, Peterson ED, Schwamm L, Lichtman JH. Regional Variation in Recommended Treatments for Ischemic Stroke and TIA. Stroke 2012, 43: 1858-1864. PMID: 22588262, DOI: 10.1161/strokeaha.112.652305.Peer-Reviewed Original ResearchConceptsDefect-free careLipid-lowering medicationsTissue-type plasminogen activatorLower oddsIschemic strokeIntravenous tissue-type plasminogen activatorSecondary stroke prevention treatmentDeep vein thrombosis prophylaxisTissue-type plasminogen activator administrationNational quality improvement programPlasminogen activatorGuideline-recommended treatmentGuidelines-Stroke hospitalsTransient ischemic attackQuarter of patientsStroke prevention treatmentBetter patient outcomesWeight loss educationQuality Improvement ProgramEligible patientsIschemic attackThrombosis prophylaxisPatient demographicsStroke treatmentMedical history
2011
Secondary preventive medication persistence and adherence 1 year after stroke
Bushnell C, Olson D, Zhao X, Pan W, Zimmer L, Goldstein L, Alberts M, Fagan S, Fonarow G, Johnston S, Kidwell C, LaBresh K, Ovbiagele B, Schwamm L, Peterson E. Secondary preventive medication persistence and adherence 1 year after stroke. Neurology 2011, 77: 1182-1190. PMID: 21900638, PMCID: PMC3265047, DOI: 10.1212/wnl.0b013e31822f0423.Peer-Reviewed Original ResearchMeSH KeywordsAgedCohort StudiesFemaleFollow-Up StudiesHumansLongitudinal StudiesMaleMedication AdherenceMiddle AgedRegistriesSecondary PreventionStrokeConceptsSecondary prevention medicationsPrevention medicationsSystem-level factorsMedication persistenceHospital dischargeIndependent predictorsIschemic stroke Longitudinal (AVAIL) registryGuidelines-Stroke programSecondary preventive medicationsUse of warfarinPrimary care providersAmerican Heart AssociationHealth care providers' instructionsLong-term useHospitalization dischargeModifiable patientDiabetes medicationsIschemic strokePreventive medicationsStroke patientsHeart AssociationCare providersMedicationsSide effectsPatients
2010
Persistence With Stroke Prevention Medications 3 Months After Hospitalization
Bushnell C, Zimmer L, Pan W, Olson D, Zhao X, Meteleva T, Schwamm L, Ovbiagele B, Williams L, LaBresh K, Peterson E. Persistence With Stroke Prevention Medications 3 Months After Hospitalization. JAMA Neurology 2010, 67: 1456-1463. PMID: 20697032, PMCID: PMC10197116, DOI: 10.1001/archneurol.2010.190.Peer-Reviewed Original ResearchConceptsSecondary prevention medicationsPrevention medicationsLong-term secondary stroke preventionGuidelines-Stroke programStroke prevention medicationsLipid-lowering therapyPatients 18 yearsSecondary stroke preventionTransient ischemic attackMonths of hospitalizationObservational cohort designAmerican Heart AssociationMedication-taking behaviorCombination of patientQuality of lifeSystem-level factorsAntihypertensive therapyIschemic attackAntiplatelet therapyDiabetes medicationsMedication classesStroke preventionAcute strokeHospital dischargeIschemic stroke
2009
The Adherence eValuation After Ischemic Stroke Longitudinal (AVAIL) Registry: Design, rationale, and baseline patient characteristics
Bushnell C, Zimmer L, Schwamm L, Goldstein L, Clapp-Channing N, Harding T, Drew L, Zhao X, Peterson E. The Adherence eValuation After Ischemic Stroke Longitudinal (AVAIL) Registry: Design, rationale, and baseline patient characteristics. American Heart Journal 2009, 157: 428-435.e2. PMID: 19249411, DOI: 10.1016/j.ahj.2008.11.002.Peer-Reviewed Original ResearchConceptsIschemic stroke Longitudinal (AVAIL) registryTransient ischemic attackIschemic attackRecurrent strokePrevention medicationsLongitudinal registryAdherence evaluationSecondary preventive therapyBaseline patient characteristicsModified Rankin scoreSecondary prevention measuresMedication-taking behaviorSystem-level barriersLevel of adherenceFuture strokeCardiovascular eventsRankin scoreVascular eventsAcute hospitalizationHospital dischargePatient characteristicsPreventive therapySecondary outcomesMedication usePrimary outcome
2008
Differential Use of Warfarin for Secondary Stroke Prevention in Patients With Various Types of Atrial Fibrillation
Lewis W, Fonarow G, LaBresh K, Cannon C, Pan W, Super D, Sorof S, Schwamm L. Differential Use of Warfarin for Secondary Stroke Prevention in Patients With Various Types of Atrial Fibrillation. The American Journal Of Cardiology 2008, 103: 227-231. PMID: 19121441, PMCID: PMC3086549, DOI: 10.1016/j.amjcard.2008.08.062.Peer-Reviewed Original ResearchConceptsECG-documented atrial fibrillationType of AFAtrial fibrillationQuality Improvement ProgramEligible patientsStroke preventionHistory of AFForm of AFSuch high-risk groupsSecondary stroke preventionTransient ischemic attackParoxysmal atrial fibrillationHigh-risk groupAnticoagulation guidelinesIschemic attackWarfarin useAnticoagulation therapyThromboembolic eventsElderly patientsHospital dischargeIschemic strokePresent admissionWarfarin therapyWarfarin treatmentMedical historyUpdate to the AHA/ASA Recommendations for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack
Adams R, Albers G, Alberts M, Benavente O, Furie K, Goldstein L, Gorelick P, Halperin J, Harbaugh R, Johnston S, Katzan I, Kelly-Hayes M, Kenton E, Marks M, Sacco R, Schwamm L. Update to the AHA/ASA Recommendations for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack. Stroke 2008, 39: 1647-1652. PMID: 18322260, PMCID: PMC4198335, DOI: 10.1161/strokeaha.107.189063.Peer-Reviewed Original Research
2006
Guidelines for Prevention of Stroke in Patients With Ischemic Stroke or Transient Ischemic Attack
Sacco R, Adams R, Albers G, Alberts M, Benavente O, Furie K, Goldstein L, Gorelick P, Halperin J, Harbaugh R, Johnston S, Katzan I, Kelly-Hayes M, Kenton E, Marks M, Schwamm L, Tomsick T. Guidelines for Prevention of Stroke in Patients With Ischemic Stroke or Transient Ischemic Attack. Circulation 2006, 113: e409-49. PMID: 16534023, DOI: 10.1161/circ.113.10.e409.Peer-Reviewed Original ResearchMeSH KeywordsAmerican Heart AssociationBrain IschemiaHealth PersonnelHumansIschemic Attack, TransientRisk FactorsSecondary PreventionStrokeConceptsTransient ischemic attackEvidence-based recommendationsIschemic strokeIschemic attackCerebral venous sinus thrombosisTimely evidence-based recommendationsUse of anticoagulationVenous sinus thrombosisPrevention of strokeHigh-risk populationSickle cell diseaseImplementation of guidelinesAntithrombotic treatmentRecurrent strokeSinus thrombosisNoncardioembolic strokePostmenopausal hormonesAntiplatelet agentsArterial dissectionHypercoagulable statePatent foramenAtherosclerotic diseaseCerebral hemorrhageRisk factorsInterventional approaches