2018
STAIR X
Liebeskind D, Derdeyn C, Wechsler L, Albers G, Ankerud E, Boltze J, Broderick J, Campbell B, Elkind M, En’Wezoh D, Furlan A, Gorelick P, Grotta J, Hess D, Hancock A, Hill M, Holt W, Hutchison R, Kim W, Lansberg M, LaScalza S, Latour L, Liberman M, Luby M, Lyden P, Majidi S, Mansi C, Nogueira R, Saver J, Savitz S, Schwamm L, Selim M, Sheth K, Simpkins A, Singhal A, Solberg Y, Steinberg G, Taylor T, Tymianski M, Yoo A. STAIR X. Stroke 2018, 49: 2241-2247. PMID: 30355006, DOI: 10.1161/strokeaha.118.021424.Peer-Reviewed Original ResearchBiomarkersCerebral AngiographyDevice ApprovalEducationEndovascular ProceduresGuidelines as TopicHumansIntracranial HemorrhagesPrecision MedicineRandomized Controlled Trials as TopicRegistriesResearch DesignStrokeThrombectomyThrombolytic TherapyTreatment OutcomeUnited StatesUnited States Food and Drug AdministrationIsolated Upper Limb Weakness From Ischemic Stroke: Mechanisms and Outcome
Topcuoglu M, Rocha E, Siddiqui A, Mills B, Silva G, Schwamm L, Lamuraglia G, Singhal A. Isolated Upper Limb Weakness From Ischemic Stroke: Mechanisms and Outcome. Journal Of Stroke And Cerebrovascular Diseases 2018, 27: 2712-2719. PMID: 30033098, DOI: 10.1016/j.jstrokecerebrovasdis.2018.05.050.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBrain IschemiaCarotid StenosisCerebral AngiographyComputed Tomography AngiographyDiffusion Magnetic Resonance ImagingDisability EvaluationEmbolismFemaleHeart DiseasesHumansMagnetic Resonance AngiographyMaleMiddle AgedMotor ActivityMotor CortexMuscle StrengthMuscle WeaknessMuscle, SkeletalPlaque, AtheroscleroticPrognosisRecovery of FunctionRetrospective StudiesRisk FactorsRupture, SpontaneousStrokeUpper ExtremityConceptsCarotid artery stenosisArtery stenosisCarotid stenosisSubcortical white matter infarctsClinical imaging featuresUpper extremity weaknessDiffusion-weighted magnetic resonance imagingUpper limb weaknessRecurrent stroke riskWhite matter infarctsMagnetic resonance imagingCardioembolic mechanismRecurrent strokeBrainstem infarctsExtremity weaknessMultiple infarctsIschemic strokeLimb weaknessStroke riskMotor stripStroke evaluationMean agePlaque ulcerationStroke mechanismInfarcts
2016
Case 13-2016 — A 49-Year-Old Woman with Sudden Hemiplegia and Aphasia during a Transatlantic Flight
Schwamm L, Jaff M, Dyer K, Gonzalez R, Huck A. Case 13-2016 — A 49-Year-Old Woman with Sudden Hemiplegia and Aphasia during a Transatlantic Flight. New England Journal Of Medicine 2016, 374: 1671-1680. PMID: 27119240, DOI: 10.1056/nejmcpc1501151.Peer-Reviewed Original Research
2015
FLAIR Vascular Hyperintensity is a Surrogate of Collateral Flow and Leukoaraiosis in Patients With Acute Stroke Due to Proximal Artery Occlusion
Karadeli H, Giurgiutiu D, Cloonan L, Fitzpatrick K, Kanakis A, Ozcan M, Schwamm L, Rost N. FLAIR Vascular Hyperintensity is a Surrogate of Collateral Flow and Leukoaraiosis in Patients With Acute Stroke Due to Proximal Artery Occlusion. Journal Of Neuroimaging 2015, 26: 219-223. PMID: 26250448, PMCID: PMC4744593, DOI: 10.1111/jon.12274.Peer-Reviewed Original ResearchConceptsProximal artery occlusionCollateral flow gradeFlow gradeAIS patientsWhite matter hyperintensitiesWMH volumeCT angiographyFVH scoreVascular hyperintensityArtery occlusionIntravenous tissue plasminogen activator administrationInversion recovery vascular hyperintensityAcute ischemic stroke patientsTissue plasminogen activator administrationAdmission CT angiographyBaseline CT angiographyCollateral vessel statusFLAIR vascular hyperintensityLeptomeningeal collateral statusMedian WMH volumeSalvageable brain tissueConsecutive AIS patientsIschemic stroke patientsWorse clinical outcomesAcute MRI
2014
Time and Diffusion Lesion Size in Major Anterior Circulation Ischemic Strokes
Hakimelahi R, Vachha B, Copen W, Papini G, He J, Higazi M, Lev M, Schaefer P, Yoo A, Schwamm L, González R. Time and Diffusion Lesion Size in Major Anterior Circulation Ischemic Strokes. Stroke 2014, 45: 2936-2941. PMID: 25190444, DOI: 10.1161/strokeaha.114.005644.Peer-Reviewed Original ResearchConceptsAnterior circulation ischemic strokeMiddle cerebral artery occlusionDiffusion-weighted imagingCerebral artery occlusionStroke onsetIschemic strokeInfarct sizeDWI lesionsInfarct volumeArtery occlusionIntravenous tissue-type plasminogen activatorProximal middle cerebral arteryDistal internal carotid arteryAcute infarct volumeDWI lesion volumeMajority of patientsMiddle cerebral arteryInternal carotid arteryAcute infarct sizeSame inclusion criteriaTraditional time windowTissue-type plasminogen activatorCerebral perfusionConsecutive patientsInfarct growth
2013
A Trial of Imaging Selection and Endovascular Treatment for Ischemic Stroke
Kidwell C, Jahan R, Gornbein J, Alger J, Nenov V, Ajani Z, Feng L, Meyer B, Olson S, Schwamm L, Yoo A, Marshall R, Meyers P, Yavagal D, Wintermark M, Guzy J, Starkman S, Saver J. A Trial of Imaging Selection and Endovascular Treatment for Ischemic Stroke. New England Journal Of Medicine 2013, 368: 914-923. PMID: 23394476, PMCID: PMC3690785, DOI: 10.1056/nejmoa1212793.Peer-Reviewed Original ResearchConceptsFavorable penumbral patternAcute ischemic strokeStandard carePenumbral patternIschemic strokeRankin ScaleNinety-day mortalitySymptomatic intracranial hemorrhageAnterior circulation strokeModified Rankin ScaleMagnetic resonance imagingEligible patientsEmbolectomy groupMechanical embolectomyEndovascular thrombectomyEndovascular therapySuch patientsClinical outcomesEndovascular treatmentIntracranial hemorrhageMean ageImaging selectionImaging patternsEmbolectomyPatientsIschemic Stroke and Transient Ischemic Attack in Young Adults: Risk Factors, Diagnostic Yield, Neuroimaging, and Thrombolysis
Ji R, Schwamm L, Pervez M, Singhal A. Ischemic Stroke and Transient Ischemic Attack in Young Adults: Risk Factors, Diagnostic Yield, Neuroimaging, and Thrombolysis. JAMA Neurology 2013, 70: 51-57. PMID: 23108720, DOI: 10.1001/jamaneurol.2013.575.Peer-Reviewed Original ResearchConceptsTransient ischemic attackTertiary stroke centerIschemic strokeYoung adultsIschemic attackHospital dischargeStroke centersStroke etiologyRisk factorsIschemic stroke/transient ischemic attackBetter outcomesStroke/transient ischemic attackHealth Stroke Scale scoreTraditional vascular risk factorsDiagnostic testsGuidelines-Stroke databaseMedian National InstitutesSymptomatic brain hemorrhageUndetermined stroke etiologyStroke Scale scoreVascular risk factorsMiddle cerebral arteryShort-term outcomesAge 35 yearsInternal carotid artery
2011
Imaging Stroke Patients with Unclear Onset Times
Wu O, Schwamm L, Sorensen A. Imaging Stroke Patients with Unclear Onset Times. Neuroimaging Clinics Of North America 2011, 21: 327-344. PMID: 21640303, PMCID: PMC3109317, DOI: 10.1016/j.nic.2011.02.008.Peer-Reviewed Original ResearchMeSH KeywordsCerebral AngiographyDiffusion Magnetic Resonance ImagingHumansImage EnhancementPerfusion ImagingStroke
2010
LICORICE-ASSOCIATED REVERSIBLE CEREBRAL VASOCONSTRICTION WITH PRES(CME)
Chatterjee N, Domoto-Reilly K, Fecci P, Schwamm L, Singhal A. LICORICE-ASSOCIATED REVERSIBLE CEREBRAL VASOCONSTRICTION WITH PRES(CME). Neurology 2010, 75: 1939-1941. PMID: 21098410, PMCID: PMC2995386, DOI: 10.1212/wnl.0b013e3181feb299.Peer-Reviewed Original ResearchAdministration, OralBrainCerebral AngiographyCerebrovascular CirculationCerebrovascular DisordersFemaleGlycyrrhizaHeadache Disorders, PrimaryHumansHydrocortisoneHypertensionMagnetic Resonance ImagingMiddle AgedNimodipinePosterior Leukoencephalopathy SyndromeSeizuresTomography, X-Ray ComputedTreatment OutcomeVasoconstrictionVasodilator AgentsVerapamilVision Disorders
2009
False Positive CT Angiography in Brain Death
Greer DM, Strozyk D, Schwamm LH. False Positive CT Angiography in Brain Death. Neurocritical Care 2009, 11: 272-275. PMID: 19390993, DOI: 10.1007/s12028-009-9220-1.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrain DeathBrain EdemaCerebral AngiographyCerebrovascular CirculationCircle of WillisDiagnosis, DifferentialElectroencephalographyFalse Positive ReactionsFemaleHeart ArrestHumansTechnetium Tc 99m ExametazimeTomography, Emission-Computed, Single-PhotonTomography, X-Ray ComputedUltrasonography, Doppler, TranscranialConceptsCerebral circulatory arrestBrain criteriaCirculatory arrestBrain deathPositive CT angiographyCerebral blood flowSingle photon emissionTranscranial DopplerNewer testsClinical examinationTomographic angiographyConventional angiographyCT angiographyBlood flowAncillary testsEase of performanceAngiographyDetermination of deathGold standardConfirmatory testDeathPhoton emissionAcceptable testArrestPatientsEndovascular Approaches to Acute Stroke, Part 1: Drugs, Devices, and Data
Nogueira R, Schwamm L, Hirsch J. Endovascular Approaches to Acute Stroke, Part 1: Drugs, Devices, and Data. American Journal Of Neuroradiology 2009, 30: 649-661. PMID: 19279271, PMCID: PMC7051752, DOI: 10.3174/ajnr.a1486.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseCerebral AngiographyCerebral RevascularizationHumansStrokeThrombectomyThrombolytic TherapyConceptsRecombinant tissue plasminogen activatorIntravenous recombinant tissue plasminogen activatorLonger treatment windowsAcute stroke treatmentHigher recanalization ratesTissue plasminogen activatorPublic health concernMechanical revascularizationAcute strokeReperfusion techniquesEndovascular therapyStroke treatmentEndovascular approachRecanalization ratePharmacologic strategiesTreatment windowUS FoodDrug AdministrationWire disruptionTheoretic advantagesPreclinical trialsHealth concernPlasminogen activatorTherapyStrokeExistence of the Diffusion-Perfusion Mismatch within 24 Hours after Onset of Acute Stroke: Dependence on Proximal Arterial Occlusion
Copen W, Rezai Gharai L, Barak E, Schwamm L, Wu O, Kamalian S, Gonzalez R, Schaefer P. Existence of the Diffusion-Perfusion Mismatch within 24 Hours after Onset of Acute Stroke: Dependence on Proximal Arterial Occlusion. Radiology 2009, 250: 878-86. PMID: 19164120, DOI: 10.1148/radiol.2503080811.Peer-Reviewed Original ResearchConceptsProximal arterial occlusionAcute ischemic stroke trialsIschemic stroke trialsAcute strokeArterial occlusionStroke trialsLesion volumePerfusion-weighted magnetic resonance imagesDiffusion-perfusion mismatchMean transit time mapsTransit time mapsHIPAA-compliant studyPAO patientsAngiographic evidenceStroke onsetDose escalationTomographic angiographyEligibility criteriaPatientsInstitutional reviewMagnetic resonance imagesMR angiographyDesmoteplaseSignificant differencesAngiography
2008
CT Angiography-Source Image Hypoattenuation Predicts Clinical Outcome in Posterior Circulation Strokes Treated With Intra-Arterial Therapy
Schaefer P, Yoo A, Bell D, Barak E, Romero J, Nogueira R, Lev M, Schwamm L, Gonzalez R, Hirsch J. CT Angiography-Source Image Hypoattenuation Predicts Clinical Outcome in Posterior Circulation Strokes Treated With Intra-Arterial Therapy. Stroke 2008, 39: 3107-3109. PMID: 18703807, DOI: 10.1161/strokeaha.108.517680.Peer-Reviewed Original ResearchConceptsIntra-arterial thrombolysisVertebrobasilar occlusionClinical outcomesParenchymal hypoattenuationRankin scorePosterior circulation strokeHealth Stroke ScaleIntra-arterial therapyOnly independent predictorIndependent outcome predictorsMedial temporal lobeInferior parietal lobeStroke ScaleClot locationPatient ageCTA-SIIndependent predictorsOutcome predictorsOccipital lobeHypoattenuationTemporal lobeThrombolysisParietal lobePatientsMidbrainRole of Recanalization in Acute Stroke Outcome: Rationale for a CT Angiogram-Based “Benefit of Recanalization” Model
Rosenthal E, Schwamm L, Roccatagliata L, Coutts S, Demchuk A, Schaefer P, Gonzalez R, Hill M, Halpern E, Lev M. Role of Recanalization in Acute Stroke Outcome: Rationale for a CT Angiogram-Based “Benefit of Recanalization” Model. American Journal Of Neuroradiology 2008, 29: 1471-1475. PMID: 18599577, PMCID: PMC8119059, DOI: 10.3174/ajnr.a1153.Peer-Reviewed Original ResearchConceptsOnly independent predictorLesion volumeComplete recanalizationRecanalization statusClinical outcomesNIHSS scoreIndependent predictorsIncomplete recanalizationCTA-SI Alberta Stroke Program Early CT ScoreAcute middle cerebral artery strokeAlberta Stroke Program Early CT ScoreHealth Stroke Scale scoreMedian admission NIHSS scoreMiddle cerebral artery strokeCT angiographic source imagesAcute stroke outcomeAdmission National InstitutesBenefit of recanalizationEarly successful recanalizationMCA M1 occlusionRole of recanalizationStroke Scale scoreAdmission NIHSS scoreMRS score 0CT/CTA
2005
Hypoattenuation on CT angiographic source images predicts risk of intracerebral hemorrhage and outcome after intra-arterial reperfusion therapy.
Schwamm L, Rosenthal E, Swap C, Rosand J, Rordorf G, Buonanno F, Vangel M, Koroshetz W, Lev M. Hypoattenuation on CT angiographic source images predicts risk of intracerebral hemorrhage and outcome after intra-arterial reperfusion therapy. American Journal Of Neuroradiology 2005, 26: 1798-803. PMID: 16091532, PMCID: PMC7975152.Peer-Reviewed Original ResearchMeSH KeywordsAgedArterial Occlusive DiseasesBasilar ArteryCerebral AngiographyCerebral HemorrhageCerebral InfarctionFemaleFibrinolytic AgentsHematomaHumansMaleMiddle AgedMiddle Cerebral ArteryPredictive Value of TestsRetrospective StudiesRisk AssessmentTissue Plasminogen ActivatorTomography, X-Ray ComputedConceptsIntra-arterial reperfusion therapyHemorrhagic transformationPoor clinical outcomeCTA source imagesReperfusion therapyClinical outcomesCT angiographic source imagesCatheter-based reperfusionReal-time risk stratificationSymptomatic hemorrhagic transformationReceiver operator characteristic curveBlood glucose levelsOperator characteristic curveAxial source imagesNormal contralateral tissueConsecutive patientsVascular insufficiencyIntracerebral hemorrhageRisk stratificationStroke patientsPoor outcomeSignificant complicationsRisk factorsContralateral tissueLesion volume
2004
ASPECTS on CTA Source Images Versus Unenhanced CT
Coutts S, Lev M, Eliasziw M, Roccatagliata L, Hill M, Schwamm L, Pexman J, Koroshetz W, Hudon M, Buchan A, Gonzalez R, Demchuk A. ASPECTS on CTA Source Images Versus Unenhanced CT. Stroke 2004, 35: 2472-2476. PMID: 15486327, DOI: 10.1161/01.str.0000145330.14928.2a.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBrain InfarctionCerebral AngiographyFemaleHumansMaleMiddle AgedTomography, X-Ray ComputedConceptsAlberta Stroke Program Early CT ScoreCTA-SI Alberta Stroke Program Early CT ScoreCT angiography source imagesBaseline Alberta Stroke Program Early CT ScoreIschemic changesFavorable outcomeNCCT-Alberta Stroke Program Early CT ScoreAcute ischemic strokeFinal infarct sizeFinal infarct volumeFavorable patient outcomesNormal CT scanRate ratioCTA source imagesM2 occlusionsInfarct volumeIschemic strokeProximal occlusionSymptom onsetClinical outcomesMedian timeCT scoreInfarct sizePatient outcomesBaseline NCCT
2001
CT Angiography in the Rapid Triage of Patients with Hyperacute Stroke to Intraarterial Thrombolysis: Accuracy in the Detection of Large Vessel Thrombus
Lev M, Farkas J, Rodriguez V, Schwamm L, Hunter G, Putman C, Rordorf G, Buonanno F, Budzik R, Koroshetz W, Gonzalez R. CT Angiography in the Rapid Triage of Patients with Hyperacute Stroke to Intraarterial Thrombolysis: Accuracy in the Detection of Large Vessel Thrombus. Journal Of Computer Assisted Tomography 2001, 25: 520-528. PMID: 11473180, DOI: 10.1097/00004728-200107000-00003.Peer-Reviewed Original Research
1998
Assessment of cerebral perfusion and arterial anatomy in hyperacute stroke with three-dimensional functional CT: early clinical results.
Hunter G, Hamberg L, Ponzo J, Huang-Hellinger F, Morris P, Rabinov J, Farkas J, Lev M, Schaefer P, Ogilvy C, Schwamm L, Buonanno F, Koroshetz W, Wolf G, González R. Assessment of cerebral perfusion and arterial anatomy in hyperacute stroke with three-dimensional functional CT: early clinical results. American Journal Of Neuroradiology 1998, 19: 29-37. PMID: 9432154, PMCID: PMC8337333.Peer-Reviewed Original ResearchConceptsHyperacute strokeFunctional CTIschemic changesEarly clinical resultsCerebral blood volumeContrast-enhanced scansHelical CT techniqueOcclusion of vesselsHyperacute groupCerebral perfusionPBV mapsArterial anatomyPatient populationBrain stemClinical resultsCT angiogramContrast administrationRegional perfusionCT angiographyBlood volumePatientsPBV valuesWhite matterGray matterClinical feasibility