2024
Tenecteplase for Stroke at 4.5 to 24 Hours with Perfusion-Imaging Selection
Albers G, Jumaa M, Purdon B, Zaidi S, Streib C, Shuaib A, Sangha N, Kim M, Froehler M, Schwartz N, Clark W, Kircher C, Yang M, Massaro L, Lu X, Rippon G, Broderick J, Butcher K, Lansberg M, Liebeskind D, Nouh A, Schwamm L, Campbell B. Tenecteplase for Stroke at 4.5 to 24 Hours with Perfusion-Imaging Selection. New England Journal Of Medicine 2024, 390: 701-711. PMID: 38329148, DOI: 10.1056/nejmoa2310392.Peer-Reviewed Original ResearchConceptsModified Rankin ScaleSymptomatic intracranial hemorrhageInternal carotid arteryMiddle cerebral arteryRankin ScalePlacebo groupTenecteplase groupIntracranial hemorrhageIncidence of symptomatic intracranial hemorrhageCerebral arteryIncidence of symptomatic intracerebral hemorrhageCarotid arteryPlacebo-controlled trialSymptomatic intracerebral hemorrhageEvidence of occlusionSafety populationDouble-blindPerfusion-imagingMedian timeClinical outcomesIntracerebral hemorrhagePlaceboPerfusion imagingPrimary outcomeOdds ratio
2016
Case 13-2016 — A 49-Year-Old Woman with Sudden Hemiplegia and Aphasia during a Transatlantic Flight
Schwamm L, Jaff M, Dyer K, Gonzalez R, Huck A. Case 13-2016 — A 49-Year-Old Woman with Sudden Hemiplegia and Aphasia during a Transatlantic Flight. New England Journal Of Medicine 2016, 374: 1671-1680. PMID: 27119240, DOI: 10.1056/nejmcpc1501151.Peer-Reviewed Original Research
2013
Outcomes in Severe Middle Cerebral Artery Ischemic Stroke
Walcott BP, Miller JC, Kwon CS, Sheth SA, Hiller M, Cronin CA, Schwamm LH, Simard JM, Kahle KT, Kimberly WT, Sheth KN. Outcomes in Severe Middle Cerebral Artery Ischemic Stroke. Neurocritical Care 2013, 21: 20-26. PMID: 23839704, PMCID: PMC3880600, DOI: 10.1007/s12028-013-9838-x.Peer-Reviewed Original ResearchMeSH KeywordsBrain EdemaFemaleHumansInfarction, Anterior Cerebral ArteryInfarction, Middle Cerebral ArteryMaleMiddle AgedPatient Outcome AssessmentSeverity of Illness IndexConceptsMiddle cerebral artery strokeMiddle cerebral artery ischemic strokeCerebral artery involvementMidline brain shiftPatient-centered outcomesLogistic regression analysisPatient-specific variablesArtery involvementEdema subgroupsMCA strokeInfarct volumeSevere strokeUnderwent tracheostomyAdult patientsIschemic strokeLife-sustaining proceduresRetrospective cohortSymptom onsetDecompressive craniectomyArtery strokeStudy criteriaUnderwent gastrostomyExclusion criteriaMortality rateMultivariate analysis
2012
Rapid identification of a major diffusion/perfusion mismatch in distal internal carotid artery or middle cerebral artery ischemic stroke
Hakimelahi R, Yoo A, He J, Schwamm L, Lev M, Schaefer P, González R. Rapid identification of a major diffusion/perfusion mismatch in distal internal carotid artery or middle cerebral artery ischemic stroke. BMC Neurology 2012, 12: 132. PMID: 23121836, PMCID: PMC3519648, DOI: 10.1186/1471-2377-12-132.Peer-Reviewed Original ResearchConceptsDiffusion/perfusion mismatchDWI lesion volumeInternal carotid arteryLesion volumePerfusion mismatchConsecutive patientsCarotid arteryMiddle cerebral artery ischemic strokeDiffusion/perfusion MRITerminal internal carotid arteryProximal middle cerebral arteryDistal internal carotid arteryLarger mismatch volumeProximal MCA occlusionMiddle cerebral arteryDiffusion lesion volumeSame inclusion criteriaTerminal ICAArtery occlusionIschemic strokeMCA occlusionStroke onsetCerebral arteryStroke patientsPatient assessment
2008
Role of Recanalization in Acute Stroke Outcome: Rationale for a CT Angiogram-Based “Benefit of Recanalization” Model
Rosenthal E, Schwamm L, Roccatagliata L, Coutts S, Demchuk A, Schaefer P, Gonzalez R, Hill M, Halpern E, Lev M. Role of Recanalization in Acute Stroke Outcome: Rationale for a CT Angiogram-Based “Benefit of Recanalization” Model. American Journal Of Neuroradiology 2008, 29: 1471-1475. PMID: 18599577, PMCID: PMC8119059, DOI: 10.3174/ajnr.a1153.Peer-Reviewed Original ResearchConceptsOnly independent predictorLesion volumeComplete recanalizationRecanalization statusClinical outcomesNIHSS scoreIndependent predictorsIncomplete recanalizationCTA-SI Alberta Stroke Program Early CT ScoreAcute middle cerebral artery strokeAlberta Stroke Program Early CT ScoreHealth Stroke Scale scoreMedian admission NIHSS scoreMiddle cerebral artery strokeCT angiographic source imagesAcute stroke outcomeAdmission National InstitutesBenefit of recanalizationEarly successful recanalizationMCA M1 occlusionRole of recanalizationStroke Scale scoreAdmission NIHSS scoreMRS score 0CT/CTA
2006
Case 16-2006
Cabot R, Harris N, Shepard J, Ebeling S, Peters C, Thomas S, Schwamm L, Lev M. Case 16-2006. New England Journal Of Medicine 2006, 354: 2263-2271. PMID: 16723618, DOI: 10.1056/nejmcpc069007.Peer-Reviewed Original ResearchNeuroanatomic correlates of stroke-related myocardial injury
Ay H, Koroshetz W, Benner T, Vangel M, Melinosky C, Arsava E, Ayata C, Zhu M, Schwamm L, Sorensen A. Neuroanatomic correlates of stroke-related myocardial injury. Neurology 2006, 66: 1325-1329. PMID: 16525122, DOI: 10.1212/01.wnl.0000206077.13705.6d.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBiomarkersBrain IschemiaCardiomyopathiesCase-Control StudiesCerebral CortexCerebral InfarctionDiffusion Magnetic Resonance ImagingFemaleHumansInfarction, Middle Cerebral ArteryMaleMiddle AgedMyocardial InfarctionMyocardiumNecrosisParietal LobeSingle-Blind MethodSympathetic Nervous SystemTroponin TConceptsCTnT elevationMyocardial injuryIschemic strokeRight middle cerebral artery infarctionSerum cardiac troponin T levelsCardiac troponin T elevationBrain regionsMiddle cerebral artery infarctionCardiac troponin T levelsPrimary cardiac causeTroponin T elevationAcute ischemic strokeTroponin T levelsCerebral artery infarctionCoronary artery diseaseSex-matched patientsRight inferior parietal lobuleSpecific brain regionsInferior parietal lobuleFrequency of rightBrain infarctionCardiac causesInfarction volumeSymptom onsetArtery disease
2004
Case 5-2004 — A 57-Year-Old Man with Slurred Speech and Left Hemiparesis
Cabot R, Harris N, Shepard J, Ebeling S, Ellender S, Peters C, Carter B, Rabinov J, Pfannl R, Schwamm L. Case 5-2004 — A 57-Year-Old Man with Slurred Speech and Left Hemiparesis. New England Journal Of Medicine 2004, 350: 707-716. PMID: 14960747, DOI: 10.1056/nejmcpc030037.Peer-Reviewed Original Research
2002
Anatomy of Stroke, Part II
Caviness V, Makris N, Montinaro E, Sahin N, Bates J, Schwamm L, Caplan D, Kennedy D. Anatomy of Stroke, Part II. Stroke 2002, 33: 2557-2564. PMID: 12411642, DOI: 10.1161/01.str.0000036084.82955.c7.Peer-Reviewed Original ResearchAnatomy of Stroke, Part I
Caviness V, Makris N, Montinaro E, Sahin N, Bates J, Schwamm L, Caplan D, Kennedy D. Anatomy of Stroke, Part I. Stroke 2002, 33: 2549-2556. PMID: 12411641, DOI: 10.1161/01.str.0000036083.90045.08.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBrainBrain MappingCerebrovascular CirculationFemaleHumansImaging, Three-DimensionalInfarction, Middle Cerebral ArteryIntracranial ThrombosisMagnetic Resonance ImagingMaleMiddle AgedStrokeTimeConceptsMCA territoryVolumetric analysisDistribution of infarctsTopography of infarctionTreatment of strokePerfusion-weighted imagingCorrelation of outcomesEmbolic strokeAcute eventClinical correlatesUnderlying pathophysiologyVascular territoriesLesion volumeStroke lesionsClinical diagnosisStrokeTherapeutic agentsMRINeuroanatomic structuresInfarctsTopographic patternsInvolvementPotential benefitsPerfusion compartmentsInfarction
2001
Utility of Perfusion-Weighted CT Imaging in Acute Middle Cerebral Artery Stroke Treated With Intra-Arterial Thrombolysis:
Lev M, Segal A, Farkas J, Hossain S, Putman C, Hunter G, Budzik R, Harris G, Buonanno F, Ezzeddine M, Chang Y, Koroshetz W, Gonzalez R, Schwamm L. Utility of Perfusion-Weighted CT Imaging in Acute Middle Cerebral Artery Stroke Treated With Intra-Arterial Thrombolysis:. Stroke 2001, 32: 2021-2028. PMID: 11546891, DOI: 10.1161/hs0901.095680.Peer-Reviewed Original ResearchConceptsFinal infarct volumeAcute middle cerebral artery strokeNIH Stroke Scale scoreMiddle cerebral artery strokeMCA stem occlusionIntra-arterial thrombolysisStroke Scale scoreComplete recanalizationClinical outcomesInfarct volumeLesion volumeArtery strokeOutcome groupAdmission NIH Stroke Scale scoreInitial NIH Stroke Scale scoreScale scoreEarly complete recanalizationFinal lesion volumeUtility of perfusionPoor outcome groupModified Rankin ScalePoor clinical outcomeRankin ScaleStroke onsetConsecutive patients