2023
A privacy-preserving and computation-efficient federated algorithm for generalized linear mixed models to analyze correlated electronic health records data
Yan Z, Zachrison K, Schwamm L, Estrada J, Duan R. A privacy-preserving and computation-efficient federated algorithm for generalized linear mixed models to analyze correlated electronic health records data. PLOS ONE 2023, 18: e0280192. PMID: 36649349, PMCID: PMC9844867, DOI: 10.1371/journal.pone.0280192.Peer-Reviewed Original ResearchConceptsFederated algorithmPrivacy-preserving data integrationEHR dataElectronic health record dataComputation resource requirementsHealth record dataLongitudinal EHR dataPrivacy protectionData integrationResource requirementsMultiple healthcare facilitiesNumerical experimentsComputational efficiencyGeneralized linear mixed modelRecord dataCorrelated dataSite‐level heterogeneityAlgorithmNetworkSummary statisticsResearch NetworkLimited amountDatasetLinear mixed modelsGLMM
2013
Measuring and Changing the Quality of Care via National Registries
Schwamm L. Measuring and Changing the Quality of Care via National Registries. Stroke 2013, 44: s132-s135. PMID: 23709711, DOI: 10.1161/strokeaha.111.000049.Peer-Reviewed Original Research
2008
Intravenous desmoteplase in patients with acute ischaemic stroke selected by MRI perfusion–diffusion weighted imaging or perfusion CT (DIAS-2): a prospective, randomised, double-blind, placebo-controlled study
Hacke W, Furlan A, Al-Rawi Y, Davalos A, Fiebach J, Gruber F, Kaste M, Lipka L, Pedraza S, Ringleb P, Rowley H, Schneider D, Schwamm L, Leal J, Söhngen M, Teal P, Wilhelm-Ogunbiyi K, Wintermark M, Warach S. Intravenous desmoteplase in patients with acute ischaemic stroke selected by MRI perfusion–diffusion weighted imaging or perfusion CT (DIAS-2): a prospective, randomised, double-blind, placebo-controlled study. The Lancet Neurology 2008, 8: 141-150. PMID: 19097942, PMCID: PMC2730486, DOI: 10.1016/s1474-4422(08)70267-9.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overBrain IschemiaCerebral HemorrhageDouble-Blind MethodFemaleFibrinolytic AgentsHumansInjections, IntravenousMagnetic Resonance ImagingMaleMiddle AgedPerfusionPlasminogen ActivatorsProspective StudiesSample SizeStrokeTomography, X-Ray ComputedTreatment FailureYoung AdultConceptsSymptomatic intracranial hemorrhageClinical response rateAcute ischemic strokeDiffusion-weighted imagingResponse rateNIHSS scoreIschemic strokeIntracranial hemorrhageLesion volumeDay 90Mortality ratePerfusion imagingScale scoreHealth Stroke Scale scoreMedian baseline NIHSS scoreModified Rankin Scale scoreMagnetic resonance perfusion imagingComposite of improvementBaseline NIHSS scorePlacebo-controlled studyStroke Scale scoreDose-ranging studyRankin Scale scoreSymptoms of strokeOnset of stroke