2021
Acute Ischemic Stroke in Patients With COVID-19
Srivastava P, Zhang S, Xian Y, Xu H, Rutan C, Alger H, Walchok J, Williams J, de Lemos J, Decker-Palmer M, Alhanti B, Elkind M, Messé S, Smith E, Schwamm L, Fonarow G. Acute Ischemic Stroke in Patients With COVID-19. Stroke 2021, 52: 1826-1829. PMID: 33728926, DOI: 10.1161/strokeaha.121.034301.Peer-Reviewed Original Research
2018
Association of Kidney Function With 30-Day and 1-Year Poststroke Mortality and Hospital Readmission
El Husseini N, Fonarow G, Smith E, Ju C, Sheng S, Schwamm L, Hernandez A, Schulte P, Xian Y, Goldstein L. Association of Kidney Function With 30-Day and 1-Year Poststroke Mortality and Hospital Readmission. Stroke 2018, 49: 2896-2903. PMID: 30571413, PMCID: PMC6338440, DOI: 10.1161/strokeaha.118.022011.Peer-Reviewed Original ResearchConceptsPoststroke mortalityIschemic strokeDialysis statusHospital readmissionKidney functionPoststroke outcomesMultivariable Cox proportional hazards modelsCox proportional hazards modelService Medicare patientsGlomerular filtration rateHospital readmission ratesRisk stratification modelProportional hazards modelEGFR 15Guidelines-StrokeIndex hospitalizationPostdischarge mortalityEGFR 30EGFR 45Readmission ratesRehospitalization ratesCohort studyKidney diseaseFiltration rateIndependent association
2017
Recrudescence of Deficits After Stroke: Clinical and Imaging Phenotype, Triggers, and Risk Factors
Topcuoglu M, Saka E, Silverman S, Schwamm L, Singhal A. Recrudescence of Deficits After Stroke: Clinical and Imaging Phenotype, Triggers, and Risk Factors. JAMA Neurology 2017, 74: 1048-1055. PMID: 28783808, PMCID: PMC5710180, DOI: 10.1001/jamaneurol.2017.1668.Peer-Reviewed Original ResearchConceptsTransient ischemic attackRisk factorsIschemic attackChronic strokeMean ageDiagnostic criteriaPSR groupHealth Stroke Scale scoreIntravenous tissue plasminogen activatorMiddle cerebral artery territoryResearch Patient Data RepositoryCrossover cohort studyHypertensive brain hemorrhagePatients' mean ageStroke Scale scoreFocal neurologic deficitsSmall vessel diseaseCase-control studyPreliminary diagnostic criteriaTissue plasminogen activatorStroke-related deficitsMagnetic resonance imagingWhite matter tractsDiffusion-weighted imagingPatient data repositoryTranslational Stroke Research
Bosetti F, Koenig J, Ayata C, Back S, Becker K, Broderick J, Carmichael S, Cho S, Cipolla M, Corbett D, Corriveau R, Cramer S, Ferguson A, Finklestein S, Ford B, Furie K, Hemmen T, Iadecola C, Jakeman L, Janis S, Jauch E, Johnston K, Kochanek P, Kohn H, Lo E, Lyden P, Mallard C, McCullough L, McGavern L, Meschia J, Moy C, Perez-Pinzon M, Ramadan I, Savitz S, Schwamm L, Steinberg G, Stenzel-Poore M, Tymianski M, Warach S, Wechsler L, Zhang J, Koroshetz W. Translational Stroke Research. Stroke 2017, 48: 2632-2637. PMID: 28751554, PMCID: PMC5599159, DOI: 10.1161/strokeaha.117.017112.Peer-Reviewed Original Research
2014
Outcomes of intravenous tissue plasminogen activator for acute ischaemic stroke in HIV‐infected adults
Sweeney E, Thakur K, Lyons J, Smith B, Willey J, Cervantes‐Arslanian A, Hickey M, Uchino K, Haussen D, Koch S, Schwamm L, Elkind M, Shinohara R, Mateen F. Outcomes of intravenous tissue plasminogen activator for acute ischaemic stroke in HIV‐infected adults. European Journal Of Neurology 2014, 21: 1394-1399. PMID: 25040336, DOI: 10.1111/ene.12506.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeNationwide Inpatient SampleIntravenous tissue plasminogen activatorIV-tPA useIV-tPATissue plasminogen activatorUninfected patientsIschemic strokeAIS patientsUS Nationwide Inpatient SampleSex-adjusted odds ratiosPlasminogen activatorShort-term outcomesRisk of deathIV-tPA administrationProportion of deathsHospital mortalityHospital deathHIV serostatusIntracerebral hemorrhageInpatient SampleOdds ratioHIVAIS casesPatientsImproving Door-to-Needle Times
Ruff I, Ali S, Goldstein J, Lev M, Copen W, McIntyre J, Rost N, Schwamm L. Improving Door-to-Needle Times. Stroke 2014, 45: 504-508. PMID: 24399372, DOI: 10.1161/strokeaha.113.004073.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overClinical ProtocolsComorbidityData Interpretation, StatisticalEarly DiagnosisEmergency Medical ServicesFemaleFibrinolytic AgentsHumansInternational Classification of DiseasesMaleMiddle AgedProspective StudiesQuality ImprovementRetrospective StudiesSocioeconomic FactorsStrokeThrombolytic TherapyTissue Plasminogen ActivatorTomography, X-Ray ComputedTreatment OutcomeConceptsIntravenous tissue-type plasminogen activatorEmergency department arrivalTissue-type plasminogen activatorAcute strokeDTN timeNeedle timeHealth Stroke Scale scorePlasminogen activatorAcute ischemic strokePercentage of patientsStroke Scale scoreAmerican Heart AssociationStroke care modelWilcoxon signed-rank testImproving DoorIschemic strokeStroke guidelinesHeart AssociationPostintervention periodSigned-rank testPre interventionCare modelNational guidelinesPost interventionPatients
2013
Quality of Care and Outcomes for In-Hospital Ischemic Stroke
Cumbler E, Wald H, Bhatt D, Cox M, Xian Y, Reeves M, Smith E, Schwamm L, Fonarow G. Quality of Care and Outcomes for In-Hospital Ischemic Stroke. Stroke 2013, 45: 231-238. PMID: 24253540, DOI: 10.1161/strokeaha.113.003617.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBrain IschemiaCohort StudiesComorbidityConfidence IntervalsDatabases, FactualFemaleGuideline AdherenceHumansMaleMiddle AgedOdds RatioQuality ImprovementQuality of Health CareRegistriesRetrospective StudiesSocioeconomic FactorsStrokeThrombolytic TherapyTreatment OutcomeConceptsHospital strokeIschemic strokeSevere strokePatient characteristicsIn-Hospital Ischemic StrokeProcess-based quality measuresCommunity-onset strokeDefect-free careGuidelines-Stroke databaseRetrospective cohort studyThromboembolic risk factorsProportion of patientsHospital ischemic strokeAmerican Heart AssociationTargeted quality improvement effortsQuality of careProsthetic heart valvesQuality improvement effortsHospital mortalityComorbid illnessesCohort studyHeart failureAtrial fibrillationCarotid stenosisHeart Association
2012
Guideline Adherence After ST-Segment Elevation Versus Non-ST Segment Elevation Myocardial Infarction
Somma K, Bhatt D, Fonarow G, Cannon C, Cox M, Laskey W, Peacock W, Hernandez A, Peterson E, Schwamm L, Saxon L. Guideline Adherence After ST-Segment Elevation Versus Non-ST Segment Elevation Myocardial Infarction. Circulation Cardiovascular Quality And Outcomes 2012, 5: 654-661. PMID: 22949493, DOI: 10.1161/circoutcomes.111.963959.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAged, 80 and overCardiovascular AgentsChi-Square DistributionComorbidityCoronary Artery DiseaseDrug Administration ScheduleFemaleGuideline AdherenceHospitalsHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionOdds RatioPractice Guidelines as TopicPractice Patterns, Physicians'Quality Indicators, Health CareRegistriesRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeUnited StatesConceptsST-segment elevation myocardial infarctionElevation myocardial infarctionSTEMI patientsMedical therapyNSTEMI patientsMyocardial infarctionGuidelines-Coronary Artery Disease registryNon-ST segment elevation myocardial infarctionGuideline-based medical therapyPrior coronary artery diseaseSegment elevation myocardial infarctionLow-density lipoprotein levelsSegment elevation MISimilar medical therapyLipid-lowering medicationsCoronary artery diseaseST-segment elevationGWTG-CADMedical comorbiditiesDischarge medicationsGuideline adherenceArtery diseaseHeart failureAngiotensin receptorsElevation MIAssessing Stroke Patients for Rehabilitation During the Acute Hospitalization: Findings From the Get With The Guidelines–Stroke Program
Bettger J, Kaltenbach L, Reeves M, Smith E, Fonarow G, Schwamm L, Peterson E. Assessing Stroke Patients for Rehabilitation During the Acute Hospitalization: Findings From the Get With The Guidelines–Stroke Program. Archives Of Physical Medicine And Rehabilitation 2012, 94: 38-45. PMID: 22858797, DOI: 10.1016/j.apmr.2012.06.029.Peer-Reviewed Original ResearchConceptsGuidelines-Stroke programStroke patientsAcute hospitalizationAcute strokeAcute hospitalsGWTG-Stroke programAcute stroke patientsProspective cohortStroke unitMultivariable analysisNonwhite raceRehabilitation careAcute assessmentMAIN OUTCOMEStroke diagnosisPatientsRehabilitation servicesHospitalizationRehabilitationHospitalStrokeUnited StatesAssessmentAdmissionCohort
2010
Risk of Thrombolytic Therapy for Acute Ischemic Stroke in Patients With Current Malignancy
Masrur S, Abdullah A, Smith E, Hidalgo R, El-Ghandour A, Rordorf G, Schwamm L. Risk of Thrombolytic Therapy for Acute Ischemic Stroke in Patients With Current Malignancy. Journal Of Stroke And Cerebrovascular Diseases 2010, 20: 124-130. PMID: 20598579, DOI: 10.1016/j.jstrokecerebrovasdis.2009.10.010.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBostonBrain IschemiaChi-Square DistributionComorbidityFemaleFibrinolytic AgentsHospital MortalityHumansIntracranial HemorrhagesLogistic ModelsMaleNeoplasmsOdds RatioRetrospective StudiesRisk AssessmentRisk FactorsStrokeThrombolytic TherapyTissue Plasminogen ActivatorTreatment OutcomeConceptsIntra-arterial therapyTissue plasminogen activatorSymptomatic intracranial hemorrhageCurrent malignancyHospital mortalityMedical comorbiditiesThrombolytic therapyIntracranial hemorrhageIndependent predictorsAIS patientsIntravenous (IV) tPAHealth Stroke Scale scoreStroke Scale scoreAcute ischemic strokeConsecutive AIS patientsHistory of hypertensionHistory of malignancyAmerican Stroke AssociationOnly independent predictorRisks of thrombolysisMost clinical trialsStepwise logistic regressionBrain metastasesIschemic strokePerformance status
2008
Clinical- and Imaging-Based Prediction of Stroke Risk After Transient Ischemic Attack
Ay H, Arsava E, Johnston S, Vangel M, Schwamm L, Furie K, Koroshetz W, Sorensen A. Clinical- and Imaging-Based Prediction of Stroke Risk After Transient Ischemic Attack. Stroke 2008, 40: 181-186. PMID: 18948609, DOI: 10.1161/strokeaha.108.521476.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBrainComorbidityComputer SimulationDiffusion Magnetic Resonance ImagingDisease ProgressionEarly DiagnosisEmergency Medical ServicesFemaleHumansIncidenceIschemic Attack, TransientLogistic ModelsMaleMiddle AgedNeurologic ExaminationPredictive Value of TestsPrognosisReproducibility of ResultsRisk FactorsStrokeConceptsTransient ischemic attackIschemic attackStroke riskClinical featuresDiffusion-weighted imagingAcute infarctsClinical transient ischemic attackDiffusion-weighted imaging findingsEarly stroke riskRelevant clinical settingsCharacteristic curveLogistic regression modelsConsecutive patientsSymptom onsetIndependent predictorsRisk stratificationImaging findingsTherapeutic measuresHospital resourcesEarly riskClinical settingResponse criteriaPredictive instrumentStrokeSubsequent strokeAn Acute Ischemic Stroke Classification Instrument That Includes CT or MR Angiography: The Boston Acute Stroke Imaging Scale
Torres-Mozqueda F, He J, Yeh I, Schwamm L, Lev M, Schaefer P, González R. An Acute Ischemic Stroke Classification Instrument That Includes CT or MR Angiography: The Boston Acute Stroke Imaging Scale. American Journal Of Neuroradiology 2008, 29: 1111-1117. PMID: 18467521, PMCID: PMC8118840, DOI: 10.3174/ajnr.a1000.Peer-Reviewed Original ResearchConceptsAlberta Stroke Program Early CT ScoreAcute ischemic strokeMinor stroke groupIschemic strokeMajor strokeMinor strokeStroke groupNoncontrast CTBoston Acute Stroke Imaging ScaleProximal cerebral artery occlusionMR angiographyCerebral artery occlusionLength of hospitalizationClassification instrumentCTA patientsArtery occlusionDischarge dispositionConsecutive patientsParenchymal ischemiaCT scorePatient outcomesStroke survivorsRehabilitation facilityPatientsStroke
2007
Serum lipid profile on admission for ischemic stroke
Smith E, Abdullah A, Amirfarzan H, Schwamm L. Serum lipid profile on admission for ischemic stroke. Neurology 2007, 68: 660-665. PMID: 17325272, DOI: 10.1212/01.wnl.0000255941.03761.dc.Peer-Reviewed Original ResearchConceptsLipid-lowering agentsLow-density lipoproteinStroke/TIALDL goalLDL targetsNational Cholesterol Education Program Adult Treatment Panel guidelinesAdult Treatment Panel guidelinesLow-density lipoprotein levelsIschemic stroke/TIACharacteristics of patientsSerum lipid profileATPIII guidelinesCardiovascular eventsIschemic strokeLipoprotein levelsLDL levelsLipid profileMultivariable modelPanel guidelinesLipid measurementsNational guidelinesTherapeutic targetGreater riskPatientsCalendar time
2006
Guidelines for Prevention of Stroke in Patients With Ischemic Stroke or Transient Ischemic Attack
Sacco R, Adams R, Albers G, Alberts M, Benavente O, Furie K, Goldstein L, Gorelick P, Halperin J, Harbaugh R, Johnston S, Katzan I, Kelly-Hayes M, Kenton E, Marks M, Schwamm L, Tomsick T. Guidelines for Prevention of Stroke in Patients With Ischemic Stroke or Transient Ischemic Attack. Stroke 2006, 37: 577-617. PMID: 16432246, DOI: 10.1161/01.str.0000199147.30016.74.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAlcohol DrinkingAnti-Inflammatory Agents, Non-SteroidalBlood PressureBrain IschemiaClinical Trials as TopicComorbidityCoronary DiseaseDiabetes ComplicationsFemaleHumansHypertensionIschemic Attack, TransientMaleMiddle AgedObesityPrevalenceRiskRisk AssessmentRisk FactorsRisk Reduction BehaviorSmokingStrokeUnited StatesConceptsTransient ischemic attackEvidence-based recommendationsIschemic strokeIschemic attackCerebral venous sinus thrombosisTimely evidence-based recommendationsUse of anticoagulationVenous sinus thrombosisPrevention of strokeHigh-risk populationSickle cell diseaseImplementation of guidelinesAntithrombotic treatmentRecurrent strokeSinus thrombosisNoncardioembolic strokePostmenopausal hormonesAntiplatelet agentsArterial dissectionHypercoagulable statePatent foramenAtherosclerotic diseaseCerebral hemorrhageRisk factorsInterventional approaches
2004
Improving Quality of Care Through Disease Management
Faxon D, Schwamm L, Pasternak R, Peterson E, McNeil B, Bufalino V, Yancy C, Brass L, Baker D, Bonow R, Smaha L, Jones D, Smith S, Ellrodt G, Allen J, Schwartz S, Fonarow G, Duncan P, Horton K, Smith R, Stranne S, Shine K. Improving Quality of Care Through Disease Management. Circulation 2004, 109: 2651-2654. PMID: 15173048, DOI: 10.1161/01.cir.0000128373.90851.7b.Peer-Reviewed Original Research