2023
Left ventricular hypertrophy and left atrial size are associated with ischemic strokes among non-vitamin K antagonist oral anticoagulant users
Das A, Gökçal E, Fouks A, Horn M, Regenhardt R, Viswanathan A, Singhal A, Schwamm L, Greenberg S, Gurol M. Left ventricular hypertrophy and left atrial size are associated with ischemic strokes among non-vitamin K antagonist oral anticoagulant users. Journal Of Neurology 2023, 270: 5578-5588. PMID: 37548681, PMCID: PMC11111216, DOI: 10.1007/s00415-023-11916-7.Peer-Reviewed Original ResearchPrior cerebrovascular eventsAtrial volume indexVentricular hypertrophyCerebrovascular eventsNOAC usersAtrial sizeIS recurrenceSevere white matter hyperintensitiesVolume indexCerebral small vessel diseaseOral anticoagulant usersChronic renal failureRisk of strokeCox regression analysisQuaternary care centerSmall vessel diseaseAge-matched controlsWhite matter hyperintensitiesMultivariable regression modelsAnticoagulant usersApixaban useDabigatran useResults112 patientsMultivariable adjustmentOral anticoagulants
2022
Clinical and neuroimaging risk factors associated with the development of intracerebral hemorrhage while taking direct oral anticoagulants
Das A, Gökçal E, Regenhardt R, Warren A, Biffi A, Goldstein J, Kimberly W, Viswanathan A, Schwamm L, Rosand J, Greenberg S, Gurol M. Clinical and neuroimaging risk factors associated with the development of intracerebral hemorrhage while taking direct oral anticoagulants. Journal Of Neurology 2022, 269: 6589-6596. PMID: 35997817, PMCID: PMC10947801, DOI: 10.1007/s00415-022-11333-2.Peer-Reviewed Original ResearchConceptsCortical superficial siderosisPrior ischemic strokeDOAC usersCerebral microbleedsWhite matter hyperintensitiesIschemic strokeSevere white matter hyperintensitiesOral anticoagulant usageDirect oral anticoagulantsSingle referral centerHigh hemorrhagic riskCoronary artery diseaseAge-matched controlsMultivariable regression modelsDOAC therapyICH cohortPrior strokeOral anticoagulantsSuperficial siderosisBaseline demographicsReferral centerSmoking historyArtery diseaseConclusionsRisk factorsHemorrhage risk
2015
FLAIR Vascular Hyperintensity is a Surrogate of Collateral Flow and Leukoaraiosis in Patients With Acute Stroke Due to Proximal Artery Occlusion
Karadeli H, Giurgiutiu D, Cloonan L, Fitzpatrick K, Kanakis A, Ozcan M, Schwamm L, Rost N. FLAIR Vascular Hyperintensity is a Surrogate of Collateral Flow and Leukoaraiosis in Patients With Acute Stroke Due to Proximal Artery Occlusion. Journal Of Neuroimaging 2015, 26: 219-223. PMID: 26250448, PMCID: PMC4744593, DOI: 10.1111/jon.12274.Peer-Reviewed Original ResearchConceptsProximal artery occlusionCollateral flow gradeFlow gradeAIS patientsWhite matter hyperintensitiesWMH volumeCT angiographyFVH scoreVascular hyperintensityArtery occlusionIntravenous tissue plasminogen activator administrationInversion recovery vascular hyperintensityAcute ischemic stroke patientsTissue plasminogen activator administrationAdmission CT angiographyBaseline CT angiographyCollateral vessel statusFLAIR vascular hyperintensityLeptomeningeal collateral statusMedian WMH volumeSalvageable brain tissueConsecutive AIS patientsIschemic stroke patientsWorse clinical outcomesAcute MRI