2010
Cost-Effectiveness of CT Perfusion for Selecting Patients for Intravenous Thrombolysis: A US Hospital Perspective
Jackson D, Earnshaw S, Farkouh R, Schwamm L. Cost-Effectiveness of CT Perfusion for Selecting Patients for Intravenous Thrombolysis: A US Hospital Perspective. American Journal Of Neuroradiology 2010, 31: 1669-1674. PMID: 20538823, PMCID: PMC7965001, DOI: 10.3174/ajnr.a2138.Peer-Reviewed Original ResearchConceptsHospital perspectiveUnenhanced CTExtent of penumbraLife-year savedUS hospital perspectiveAcute stroke evaluationSelection of patientsCT-based methodClinical trial dataDecision analytic modelCTP selectionIntravenous thrombolysisIschemic strokeClinical outcomesStroke evaluationPatient populationCT perfusionFavorable outcomeRoutine CTClinical trialsPatientsTrial dataMultivariate sensitivity analysisHospitalTPA treatment
2005
The Evolving Role of Acute Stroke Imaging in Intravenous Thrombolytic Therapy: Patient Selection and Outcomes Assessment
Sims J, Schwamm L. The Evolving Role of Acute Stroke Imaging in Intravenous Thrombolytic Therapy: Patient Selection and Outcomes Assessment. Neuroimaging Clinics Of North America 2005, 15: 421-440. PMID: 16198950, DOI: 10.1016/j.nic.2005.06.001.Peer-Reviewed Original ResearchConceptsPatient selectionIntravenous thrombolytic therapyStroke pathophysiologyThrombolytic trialsPenumbral tissueAcute strokeLarge infarctionCerebral ischemiaRisk stratificationThrombolytic therapyCT perfusionStroke mechanismBrain hemorrhageTherapeutic successCT angiographyUnenhanced CTOutcome assessmentPotential future roleEarly signsEarly trialsMR imagingThrombolysisInfarctionTrialsEvolving role