2015
Patient-Centered Research into Outcomes Stroke Patients Prefer and Effectiveness Research: Implementing the patient-driven research paradigm to aid decision making in stroke care
Xian Y, O’Brien E, Fonarow G, Olson D, Schwamm L, Hannah D, Lindholm B, Maisch L, Lytle B, Greiner M, Wu J, Peterson E, Pencina M, Hernandez A. Patient-Centered Research into Outcomes Stroke Patients Prefer and Effectiveness Research: Implementing the patient-driven research paradigm to aid decision making in stroke care. American Heart Journal 2015, 170: 36-45.e11. PMID: 26093862, DOI: 10.1016/j.ahj.2015.04.008.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAgedAged, 80 and overAnticoagulantsAntidepressive AgentsCohort StudiesDecision MakingDepressionFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMiddle AgedPatient Care PlanningPatient Outcome AssessmentPatient PreferencePatient SatisfactionProspective StudiesQuality of LifeRetrospective StudiesSecondary PreventionStrokeTreatment OutcomeConceptsComparative effectiveness researchPatient prefersStroke careStroke patientsTreatment optionsEffectiveness researchMajor adverse cardiovascular eventsAdverse cardiovascular eventsIndividual patient preferencesHealth care providersOutcomes Research InstitutePatient-centered comparative effectiveness researchOutcomes research studiesHealth care communityGuidelines-StrokeCardiovascular eventsOral anticoagulantsPatient-centered outcomes research studiesStatin therapyPatient characteristicsPrimary outcomeClinical effectivenessComparative safetyPatient preferencesClinical trials
2008
Warfarin Reversal in Anticoagulant-Associated Intracerebral Hemorrhage
Goldstein J, Rosand J, Schwamm L. Warfarin Reversal in Anticoagulant-Associated Intracerebral Hemorrhage. Neurocritical Care 2008, 9: 277-283. PMID: 18214714, DOI: 10.1007/s12028-008-9049-z.Peer-Reviewed Original ResearchConceptsFresh frozen plasmaIntravenous vitamin KProthrombin complex concentrateIntracerebral hemorrhageVitamin KWarfarin reversalClinical trialsCoagulation factorsCoagulation factor productsHalf of patientsMajority of survivorsDependent coagulation factorsHospital presentationDefinitive therapyTreatment optionsComplex concentrateAdjunct agentFrozen plasmaPermanent disabilityProcoagulant effectTreatment strategiesExpert guidelinesFactor VIIReal-world settingFactor products