2020
Prehospital Stroke Care and Regionalized Stroke Systems
Zachrison K, Schwamm L. Prehospital Stroke Care and Regionalized Stroke Systems. 2020, 35-58. DOI: 10.1017/9781316286234.004.Peer-Reviewed Original ResearchPrehospital stroke careStroke careStroke systemsAcute stroke treatmentPrevention of strokeEndovascular reperfusion therapyCause of disabilityMagnetic brain stimulationCause of deathReperfusion therapyStroke preventionStroke treatmentSurgical treatmentStroke patientsStroke recoveryBrain stimulationReview GroupAppropriate interventionsOptimal evidenceTherapeutic topicsStrokeCliniciansTreatmentCarePreventionCryptogenic stroke: Contemporary trends, treatments, and outcomes in the United States.
Prabhakaran S, Messé S, Kleindorfer D, Smith E, Fonarow G, Xu H, Zhao X, Lytle B, Cigarroa J, Schwamm L. Cryptogenic stroke: Contemporary trends, treatments, and outcomes in the United States. Neurology Clinical Practice 2020, 10: 396-405. PMID: 33299667, PMCID: PMC7717635, DOI: 10.1212/cpj.0000000000000736.Peer-Reviewed Original ResearchCryptogenic strokeIschemic strokeStroke etiologyDischarge outcomesHospital treatmentHospital characteristicsMultivariable logistic regressionGWTG-StrokeStroke RegistryNationwide registryMultivariable analysisPatientsLower mortalityHigh mortalityNationwide dataLogistic regressionSubtypesStrokeNational InstituteScale scaleOutcomesTreatmentRegistryHospitalEtiologyProbing the Effective Treatment Thresholds for Alteplase in Acute Ischemic Stroke With Regression Discontinuity Designs
Naidech A, Lawlor P, Xu H, Fonarow G, Xian Y, Smith E, Schwamm L, Matsouaka R, Prabhakaran S, Marinescu I, Kording K. Probing the Effective Treatment Thresholds for Alteplase in Acute Ischemic Stroke With Regression Discontinuity Designs. Frontiers In Neurology 2020, 11: 961. PMID: 32982952, PMCID: PMC7492202, DOI: 10.3389/fneur.2020.00961.Peer-Reviewed Original ResearchTreatment thresholdOutcomes of patientsAcute ischemic strokeCohort of patientsPatient demographic characteristicsIschemic strokeControlled TrialsStroke interventionClinical outcomesClinical careEffective treatmentLarger sample sizeMedical interventionsPatientsDemographic characteristicsGold standardAlteplaseInterventionTreatmentContinuous variablesOutcomesLimited populationSample sizeTreatment timePotential reasonsEstablishment of an internationally agreed minimum data set for acute telestroke
Cadilhac D, Bagot K, Demaerschalk B, Hubert G, Schwamm L, Watkins C, Lightbody C, Kim J, Vu M, Pompeani N, Switzer J, Caudill J, Estrada J, Viswanathan A, Hubert N, Ohannessian R, Hargroves D, Roberts N, Ingall T, Hess D, Ranta A, Padma V, Bladin C. Establishment of an internationally agreed minimum data set for acute telestroke. Journal Of Telemedicine And Telecare 2020, 27: 582-589. PMID: 31937198, DOI: 10.1177/1357633x19899262.Peer-Reviewed Original ResearchConceptsTelestroke programsMinimum datasetExpert panelProcess of careGeneral clinical careInternational expert panelReliable international comparisonsTelestroke consultationThrombolysis treatmentPatient characteristicsEndovascular treatmentAcute careClinical managementPatient outcomesClinical careNeurosurgery treatmentDischarge informationInitial scoping reviewCareScoping ReviewTelestrokeHospitalTreatmentAustralasia-Pacific regionDelphi technique
2019
Thrombolysis in young adults with stroke: Findings from Get With The Guidelines-Stroke.
Dodds J, Xian Y, Sheng S, Fonarow G, Bhatt D, Matsouaka R, Schwamm L, Peterson E, Smith E. Thrombolysis in young adults with stroke: Findings from Get With The Guidelines-Stroke. Neurology 2019, 92: e2784-e2792. PMID: 31092622, DOI: 10.1212/wnl.0000000000007653.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeTissue plasminogen activatorIschemic strokeOlder patientsYounger patientsYears of ageSymptomatic intracranial hemorrhage rateYoung adultsGuidelines-Stroke registryIntracranial hemorrhage rateGuidelines-StrokeHospital mortalityHospital arrivalHemorrhage rateIntracranial hemorrhageMultivariable modelPatientsBetter outcomesStrokePlasminogen activatorTPA treatmentTreatmentAdultsAgeOutcomes
2012
Use of Tissue-Type Plasminogen Activator Before and After Publication of the European Cooperative Acute Stroke Study III in Get With The Guidelines-Stroke
Messé S, Fonarow G, Smith E, Kaltenbach L, Olson D, Kasner S, Schwamm L. Use of Tissue-Type Plasminogen Activator Before and After Publication of the European Cooperative Acute Stroke Study III in Get With The Guidelines-Stroke. Circulation Cardiovascular Quality And Outcomes 2012, 5: 321-326. PMID: 22550132, DOI: 10.1161/circoutcomes.111.964064.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overEuropeFemaleFibrinolytic AgentsGuideline AdherenceHumansInfusions, IntravenousLinear ModelsMaleMiddle AgedMultivariate AnalysisOdds RatioOutcome and Process Assessment, Health CarePractice Guidelines as TopicStrokeThrombolytic TherapyTime FactorsTissue Plasminogen ActivatorTreatment OutcomeUnited StatesConceptsAcute ischemic strokeEuropean Cooperative Acute Stroke Study (ECASS) IIIECASS IIITreatment of patientsUse of tPAEligible patientsHours of AISProportion of patientsStudy IIITissue-type plasminogen activatorGuidelines-StrokeIschemic strokeMedian doorNeedle timePatientsClinical practiceTreatment ratesPlasminogen activatorSignificant increaseHoursLater time windowAdverse affectsTPATreatmentProportion
2011
A Qualitative Assessment of Practices Associated With Shorter Door-to-Needle Time for Thrombolytic Therapy in Acute Ischemic Stroke
Olson D, Constable M, Britz G, Lin C, Zimmer L, Schwamm L, Fonarow G, Peterson E. A Qualitative Assessment of Practices Associated With Shorter Door-to-Needle Time for Thrombolytic Therapy in Acute Ischemic Stroke. Journal Of Neuroscience Nursing 2011, 43: 329-336. PMID: 22089410, DOI: 10.1097/jnn.0b013e318234e7fb.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeNeedle timeIschemic strokeStroke patientsGoal of doorQualitative telephone interviewsThrombolytic therapyEarly treatmentImproved outcomesTPA deliveryRapid triageHermeneutic phenomenological frameworkTelephone interviewsPatientsU.S. hospitalsStrokeHospitalFaster treatmentTreatmentNovel factorOvercoming barriersElicit strategiesAlteplaseQualitative assessmentTherapyThrombolysis Treatment for Acute Stroke: Issues of Efficacy and Utilization in Women
Reeves M, Wilkins T, Lisabeth L, Schwamm L. Thrombolysis Treatment for Acute Stroke: Issues of Efficacy and Utilization in Women. Women's Health 2011, 7: 383-390. PMID: 21612358, DOI: 10.2217/whe.11.31.Peer-Reviewed Original ResearchConceptsThrombolysis treatmentIschemic strokeObservational studyTPA treatmentSex differencesAcute ischemic strokeComparable control groupImportant sex differencesIssues of efficacyThrombolysis trialsAcute strokeStroke communityTreatment efficacyControl groupGreater efficacyTrial dataStrokeWomenEfficacyLow utilizationGood evidenceMore studiesTreatmentMenWide variability
2010
Recent Nationwide Trends in Discharge Statin Treatment of Hospitalized Patients With Stroke
Ovbiagele B, Schwamm L, Smith E, Hernandez A, Olson D, Pan W, Fonarow G, Saver J. Recent Nationwide Trends in Discharge Statin Treatment of Hospitalized Patients With Stroke. Stroke 2010, 41: 1508-1513. PMID: 20508182, DOI: 10.1161/strokeaha.109.573618.Peer-Reviewed Original ResearchConceptsTransient ischemic attackDischarge statin prescriptionIschemic attackStatin treatmentStatin useStatin prescriptionRecent nationwide trendsNationwide trendsCholesterol Levels (SPARCL) trialEligible patientsGuidelines-StrokeStroke preventionAcute strokeIschemic strokeVascular riskHospitalized patientsAtherosclerotic strokeFemale sexNonsignificant increasePatientsClinical practiceStrokeStudy periodAggressive reductionTreatment
2009
A Review of the Evidence for the Use of Telemedicine Within Stroke Systems of Care
Schwamm L, Holloway R, Amarenco P, Audebert H, Bakas T, Chumbler N, Handschu R, Jauch E, Knight W, Levine S, Mayberg M, Meyer B, Meyers P, Skalabrin E, Wechsler L. A Review of the Evidence for the Use of Telemedicine Within Stroke Systems of Care. Stroke 2009, 40: 2616-2634. PMID: 19423852, DOI: 10.1161/strokeaha.109.192360.Peer-Reviewed Original ResearchConceptsUse of telemedicineStroke systemsStroke treatmentAmerican Heart Association/American CollegeStroke care deliveryAcute stroke treatmentEvidence-based reviewEvidence-based recommendationsEmergency medical servicesSecondary preventionNeurological assessmentPrimary preventionEmergency departmentCardiology FoundationConsensus recommendationsAmerican CollegeClass of evidenceCare deliveryAvailable evidenceCare frameworkMedical servicesPreventionTelemedicineTreatmentLevel of certainty
2007
Endovascular Approaches to Acute Stroke
Nogueira R, Dabus G, Hirsch J, Schwamm L. Endovascular Approaches to Acute Stroke. 2007, 63-96. DOI: 10.1002/9780470183397.ch4.Peer-Reviewed Original Research