2023
Most Promising Approaches to Improve Stroke Outcomes: The Stroke Treatment Academic Industry Roundtable XII Workshop
Wechsler L, Adeoye O, Alemseged F, Bahr-Hosseini M, Deljkich E, Favilla C, Fisher M, Grotta J, Hill M, Kamel H, Khatri P, Lyden P, Mirza M, Nguyen T, Samaniego E, Schwamm L, Selim M, Silva G, Yavagal D, Yenari M, Zachrison K, Boltze J, Yaghi S, Roundtable O. Most Promising Approaches to Improve Stroke Outcomes: The Stroke Treatment Academic Industry Roundtable XII Workshop. Stroke 2023, 54: 3202-3213. PMID: 37886850, DOI: 10.1161/strokeaha.123.044279.Peer-Reviewed Original Research
2022
Evaluation of Evidence-Based Dual Antiplatelet Therapy for Secondary Prevention in US Patients With Acute Ischemic Stroke
Xian Y, Xu H, Smith E, Fonarow G, Bhatt D, Schwamm L, Peterson E. Evaluation of Evidence-Based Dual Antiplatelet Therapy for Secondary Prevention in US Patients With Acute Ischemic Stroke. JAMA Internal Medicine 2022, 182: 559-564. PMID: 35344009, PMCID: PMC8961397, DOI: 10.1001/jamainternmed.2022.0323.Peer-Reviewed Original Research
2021
Outcomes of Endovascular Therapy in Patients With Prestroke Mobility Impairment
Beekman R, Sun JL, Alhanti B, Schwamm LH, Smith EE, Bhatt DL, Xian Y, Shah S, Lytle BL, Fonarow GC, Sheth KN. Outcomes of Endovascular Therapy in Patients With Prestroke Mobility Impairment. Stroke 2021, 52: e725-e728. PMID: 34517771, DOI: 10.1161/strokeaha.121.034464.Peer-Reviewed Original ResearchConceptsEndovascular thrombectomyGuidelines-Stroke registrySymptomatic intracranial hemorrhageMobility impairmentsLogistic regression modelsHospital deathEndovascular therapyClinical benefitIntracranial hemorrhageAdverse outcomesClinical trialsThrombectomyPatientsOutcomesFurther studiesImpairmentRegression modelsNational data setsSafetyHemorrhageRegistryTherapyPopulationHospiceTrialsSeizure Prophylaxis After Spontaneous Intracerebral Hemorrhage
Jones F, Sanches P, Smith J, Zafar S, Blacker D, Hsu J, Schwamm L, Newhouse J, Westover M, Moura L. Seizure Prophylaxis After Spontaneous Intracerebral Hemorrhage. JAMA Neurology 2021, 78: 1128-1136. PMID: 34309642, PMCID: PMC8314179, DOI: 10.1001/jamaneurol.2021.2249.Peer-Reviewed Original ResearchConceptsEarly seizure prophylaxisSpontaneous intracerebral hemorrhageAdverse drug reactionsRisk-guided strategyLate seizuresLong-term therapyHigh riskSeizure prophylaxisPrimary prophylaxisIntracerebral hemorrhageLower riskLong-term adverse drug reactionsLow-risk patientsShort-term prophylaxisDecision analytical modelSecondary therapyProphylaxis strategiesDrug reactionsProphylaxisMAIN OUTCOMESeizuresPatientsClinical decisionTherapyAverage risk
2020
Antiplatelet patterns and outcomes in patients with atrial fibrillation not prescribed an anticoagulant after stroke
Chang K, Xian Y, Zhao X, Mi X, Matsouaka R, Schwamm L, Shah S, Lytle B, Smith E, Bhatt D, Fonarow G, Hsu J. Antiplatelet patterns and outcomes in patients with atrial fibrillation not prescribed an anticoagulant after stroke. International Journal Of Cardiology 2020, 321: 88-94. PMID: 32805327, DOI: 10.1016/j.ijcard.2020.08.011.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeAntiplatelet therapyAntithrombotic therapyIschemic strokeTherapy prescriptionOral anticoagulationUnadjusted ratesGuidelines-Stroke registryService beneficiaries 65Retrospective cohort studyOral anticoagulant therapyAnticoagulant therapyCohort studyComposite endpointPrimary outcomeAtrial fibrillationAtrial flutterPotential confoundersNeurologic/Medicare beneficiariesMedicare feeTherapyStrokePatientsMortality
2018
Neuroimaging Paradigms to Identify Patients for Reperfusion Therapy in Stroke of Unknown Onset
Etherton M, Barreto A, Schwamm L, Wu O. Neuroimaging Paradigms to Identify Patients for Reperfusion Therapy in Stroke of Unknown Onset. Frontiers In Neurology 2018, 9: 327. PMID: 29867736, PMCID: PMC5962731, DOI: 10.3389/fneur.2018.00327.Peer-Reviewed Original ResearchReperfusion therapyIschemic strokeSalvageable ischemic tissueAcute ischemic strokePivotal clinical trialsTreatment of patientsNumber of patientsRisk of infarctionLow treatment ratesUnwitnessed strokeIntravenous alteplaseEndovascular thrombectomyHospital arrivalStroke onsetRevascularization therapySalvageable tissueUnknown onsetClinical trialsClinical dilemmaIschemic tissueStroke researchPatientsTreatment ratesStrokeTherapy
2017
Association Between Previous Use of Antiplatelet Therapy and Intracerebral Hemorrhage Outcomes
Khan N, Siddiqui F, Goldstein J, Cox M, Xian Y, Matsouaka R, Heidenreich P, Peterson E, Bhatt D, Fonarow G, Schwamm L, Smith E. Association Between Previous Use of Antiplatelet Therapy and Intracerebral Hemorrhage Outcomes. Stroke 2017, 48: 1810-1817. PMID: 28596454, DOI: 10.1161/strokeaha.117.016290.Peer-Reviewed Original ResearchConceptsAntiplatelet therapyIntracerebral hemorrhageHospital mortalityPrevious useDiagnosis of ICHCombination antiplatelet therapyGuidelines-Stroke hospitalsPrestroke antiplatelet therapyTerms of comorbiditiesOral anticoagulant therapyIntracerebral hemorrhage outcomesAPT groupHigh-risk profileHospital presentationAnticoagulant therapyBaseline characteristicsAntiplatelet agentsHospital characteristicsHigh riskPatientsRisk profileMortalityTherapyAPT useComorbidities
2016
Patient-reported financial barriers to adherence to treatment in neurology
Moura L, Schwamm E, Moura V, Seitz M, Hoch D, Hsu J, Schwamm L. Patient-reported financial barriers to adherence to treatment in neurology. ClinicoEconomics And Outcomes Research 2016, Volume 8: 685-694. PMID: 27895506, PMCID: PMC5117903, DOI: 10.2147/ceor.s119971.Peer-Reviewed Original ResearchMedication adherenceFinancial barriersPatient-reported failuresEffective medical therapyRoutine outpatient carePatient-reported dataCross-sectional surveyNeurology appointmentPatient characteristicsMedical therapyNeurology clinicMean agePrescription medicationsOutpatient careNeurological conditionsClinical informationNeurological diseasesNeurological disordersPatientsDemographic characteristicsAdherenceNonadherenceTherapyPreferred languageMedications
2015
Endovascular Clot Retrieval Therapy
Smith E, Schwamm L. Endovascular Clot Retrieval Therapy. Stroke 2015, 46: 1462-1467. PMID: 25944330, DOI: 10.1161/strokeaha.115.008385.Peer-Reviewed Original ResearchConceptsStroke systemsEndovascular acute ischemic stroke therapyIntravenous tissue-type plasminogen activatorAcute ischemic stroke therapyIschemic stroke therapyTissue-type plasminogen activatorCapable centersAppropriate patientsStroke therapyEffective therapyRetrieval therapyMeaningful benefitCommunity settingsTherapyPlasminogen activatorEquitable accessInitial recommendationsData entryPatientsRegistryHospitalTrialsTEMPORAL TRENDS IN CARE AND OUTCOMES OF PATIENTS RECEIVING FIBRINOLYTIC THERAPY COMPARED TO PRIMARY PERCUTANEOUS CORONARY INTERVENTION IN THE GET WITH THE GUIDELINES CORONARY ARTERY DISEASE (GWTG-CAD) REGISTRY
Hira R, Bhatt D, Fonarow G, Heidenreich P, Ju C, Virani S, Hernandez A, Schwamm L, Eapen Z, Albert M, Peterson E, Jneid H. TEMPORAL TRENDS IN CARE AND OUTCOMES OF PATIENTS RECEIVING FIBRINOLYTIC THERAPY COMPARED TO PRIMARY PERCUTANEOUS CORONARY INTERVENTION IN THE GET WITH THE GUIDELINES CORONARY ARTERY DISEASE (GWTG-CAD) REGISTRY. Journal Of The American College Of Cardiology 2015, 65: a68. DOI: 10.1016/s0735-1097(15)60068-7.Peer-Reviewed Original ResearchTrends in Endovascular Therapy and Clinical Outcomes Within the Nationwide Get With The Guidelines-Stroke Registry
Menon B, Saver J, Goyal M, Nogueira R, Prabhakaran S, Liang L, Xian Y, Hernandez A, Fonarow G, Schwamm L, Smith E. Trends in Endovascular Therapy and Clinical Outcomes Within the Nationwide Get With The Guidelines-Stroke Registry. Stroke 2015, 46: 989-995. PMID: 25681065, DOI: 10.1161/strokeaha.114.007542.Peer-Reviewed Original ResearchConceptsSymptomatic intracerebral hemorrhageEndovascular therapyClinical outcomesPatient characteristicsIntracerebral hemorrhageBaseline National InstitutesEndovascular therapy useGuidelines-Stroke hospitalsGuidelines-Stroke registryHealth Stroke ScaleAcute ischemic strokeProportion of hospitalsNew thrombectomy deviceHospital mortalityStroke ScaleIschemic strokeIndependent ambulationNumber of hospitalsTherapy useMultivariable analysisPatient outcomesThrombectomy devicesHospitalTherapyStudy period
2014
Quality of Care for Patients With Acute Coronary Syndromes as a Function of Hospital Revascularization Capability: Insights From Get With The Guidelines‐CAD
Thukkani A, Fonarow G, Cannon C, Cox M, Hernandez A, Peterson E, Peacock W, Laskey W, Schwamm L, Bhatt D, Committee and Investigators F. Quality of Care for Patients With Acute Coronary Syndromes as a Function of Hospital Revascularization Capability: Insights From Get With The Guidelines‐CAD. Clinical Cardiology 2014, 37: 285-292. PMID: 24452828, PMCID: PMC6649649, DOI: 10.1002/clc.22246.Peer-Reviewed Original ResearchConceptsAcute coronary syndrome patientsCoronary syndrome patientsGWTG-CAD hospitalsLipid-lowering therapyRevascularization capabilitySyndrome patientsCare qualityAcute coronary syndromeLow-density lipoproteinQuality of careRevascularization cohortCoronary syndromeDiseases HospitalBlood pressureWeight managementHospital typePhysical activityPatientsRevascularization hospitalsUS hospitalsHospitalMultivariate analysisTherapyCareQuality measures
2012
Standardizing the Structure of Stroke Clinical and Epidemiologic Research Data
Saver J, Warach S, Janis S, Odenkirchen J, Becker K, Benavente O, Broderick J, Dromerick A, Duncan P, Elkind M, Johnston K, Kidwell C, Meschia J, Schwamm L. Standardizing the Structure of Stroke Clinical and Epidemiologic Research Data. Stroke 2012, 43: 967-973. PMID: 22308239, PMCID: PMC3493110, DOI: 10.1161/strokeaha.111.634352.Peer-Reviewed Original ResearchConceptsCommon data elementsNeurological disordersStroke Common Data ElementsLong-term therapyClinical practice guidelinesNational InstituteCase report formsPrior health statusPatient-oriented researchAcute therapyHospital courseStroke presentationCerebrovascular diseaseMedical historyNational registryClinical trialsStroke typePractice guidelinesHealth statusEnd pointVital signsClinical researchReport formsData elementsTherapyMajor advances across the spectrum of stroke care
Schwamm L. Major advances across the spectrum of stroke care. Nature Reviews Neurology 2012, 8: 63-64. PMID: 22231192, DOI: 10.1038/nrneurol.2011.225.Peer-Reviewed Original Research
2011
A Qualitative Assessment of Practices Associated With Shorter Door-to-Needle Time for Thrombolytic Therapy in Acute Ischemic Stroke
Olson D, Constable M, Britz G, Lin C, Zimmer L, Schwamm L, Fonarow G, Peterson E. A Qualitative Assessment of Practices Associated With Shorter Door-to-Needle Time for Thrombolytic Therapy in Acute Ischemic Stroke. Journal Of Neuroscience Nursing 2011, 43: 329-336. PMID: 22089410, DOI: 10.1097/jnn.0b013e318234e7fb.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeNeedle timeIschemic strokeStroke patientsGoal of doorQualitative telephone interviewsThrombolytic therapyEarly treatmentImproved outcomesTPA deliveryRapid triageHermeneutic phenomenological frameworkTelephone interviewsPatientsU.S. hospitalsStrokeHospitalFaster treatmentTreatmentNovel factorOvercoming barriersElicit strategiesAlteplaseQualitative assessmentTherapyImaging Stroke Patients with Unclear Onset Times
Wu O, Schwamm L, Sorensen A. Imaging Stroke Patients with Unclear Onset Times. Neuroimaging Clinics Of North America 2011, 21: 327-344. PMID: 21640303, PMCID: PMC3109317, DOI: 10.1016/j.nic.2011.02.008.Peer-Reviewed Original Research
2010
Intravenous (IV) Thrombolysis
Nogueira R, Schwamm L. Intravenous (IV) Thrombolysis. 2010, 221-243. DOI: 10.1007/978-3-642-12751-9_11.Peer-Reviewed Original ResearchThe “Golden Hour” and Acute Brain Ischemia
Saver J, Smith E, Fonarow G, Reeves M, Zhao X, Olson D, Schwamm L. The “Golden Hour” and Acute Brain Ischemia. Stroke 2010, 41: 1431-1439. PMID: 20522809, PMCID: PMC2909671, DOI: 10.1161/strokeaha.110.583815.Peer-Reviewed Original ResearchConceptsIschemic stroke patientsHospital emergency departmentIntravenous thrombolytic therapyAcute brain ischemiaNeedle timeThrombolytic therapyStroke patientsEmergency departmentGolden hourBrain ischemiaGreater stroke severityGuidelines-Stroke databaseQuarter of patientsHours of onsetHours patientsStroke severityDoor timeEarly presentationPatientsWell timeStudy periodTherapyIschemiaOnset timeMinutes
2009
Case volumes of intra-arterial and intravenous treatment of ischemic stroke in the USA
Hirsch J, Yoo A, Nogueira R, Verduzco L, Schwamm L, Pryor J, Rabinov J, González R. Case volumes of intra-arterial and intravenous treatment of ischemic stroke in the USA. Journal Of NeuroInterventional Surgery 2009, 1: 27. PMID: 21994101, DOI: 10.1136/jnis.2009.000166.Peer-Reviewed Original ResearchConceptsIntra-arterial therapyNumber of patientsT-PA useStroke centersIschemic strokeCase volumeStroke therapyIntra-arterial reperfusion therapyIntravenous tissue plasminogen activatorIntra-arterial stroke therapyPercentage of patientsLarge vessel occlusionCases/yearTissue plasminogen activatorMassachusetts General HospitalReperfusion therapyIntravenous treatmentStroke casesGeneral HospitalNumber of casesPatientsTherapyStrokeLiterature searchPlasminogen activatorEndovascular Approaches to Acute Stroke, Part 1: Drugs, Devices, and Data
Nogueira R, Schwamm L, Hirsch J. Endovascular Approaches to Acute Stroke, Part 1: Drugs, Devices, and Data. American Journal Of Neuroradiology 2009, 30: 649-661. PMID: 19279271, PMCID: PMC7051752, DOI: 10.3174/ajnr.a1486.Peer-Reviewed Original ResearchConceptsRecombinant tissue plasminogen activatorIntravenous recombinant tissue plasminogen activatorLonger treatment windowsAcute stroke treatmentHigher recanalization ratesTissue plasminogen activatorPublic health concernMechanical revascularizationAcute strokeReperfusion techniquesEndovascular therapyStroke treatmentEndovascular approachRecanalization ratePharmacologic strategiesTreatment windowUS FoodDrug AdministrationWire disruptionTheoretic advantagesPreclinical trialsHealth concernPlasminogen activatorTherapyStroke