2023
Outcomes of recurrent stroke in patients with atrial fibrillation according to presumed etiology
Pedreira B, Zachrison K, Singhal A, Yan Z, Oliveira-Filho J, Schwamm L. Outcomes of recurrent stroke in patients with atrial fibrillation according to presumed etiology. Arquivos De Neuro-Psiquiatria 2023, 81: 616-623. PMID: 37336506, PMCID: PMC10371407, DOI: 10.1055/s-0043-1769124.Peer-Reviewed Original ResearchConceptsUndetermined stroke etiologyAtrial fibrillationRecurrent strokeStroke etiologyAF patientsFavorable outcomeAcademic comprehensive stroke centerHealth Stroke Scale scoreMedian National InstitutesSingle-center sampleComprehensive stroke centerRecurrent ischemic strokeStroke Scale scoreHistory of strokePotent risk factorDifferent treatment strategiesHospital mortalitySecondary prophylaxisReperfusion therapyCardioembolic strokeIschemic strokeStroke centersDischarge outcomesRisk factorsTreatment strategies
2022
Frequency, predictors and cardiovascular outcomes associated with transthoracic echocardiographic findings during acute ischaemic stroke hospitalisation
Sharma R, Silverman S, Patel S, Schwamm LH, Sanborn DY. Frequency, predictors and cardiovascular outcomes associated with transthoracic echocardiographic findings during acute ischaemic stroke hospitalisation. Stroke And Vascular Neurology 2022, 7: 482-492. PMID: 35697387, PMCID: PMC9811598, DOI: 10.1136/svn-2021-001170.Peer-Reviewed Original ResearchConceptsStroke risk factorsAcute ischemic strokeStroke hospitalisationsTransthoracic echocardiographyRisk factorsClinical utilityAbnormal transthoracic echocardiographyHigh stroke riskCardiac event riskCoronary artery diseaseTransthoracic echocardiographic findingsNet reclassification improvementCategory ICardioembolic sourceRecurrent strokeTTE findingsCardiovascular outcomesEchocardiographic findingsCardiac eventsIschemic strokeOlder patientsStroke riskArtery diseaseSingle centerAtrial fibrillation
2019
The Medicare Shared Savings Program and Outcomes for Ischemic Stroke Patients: a Retrospective Cohort Study
Kaufman B, O’Brien E, Stearns S, Matsouaka R, Holmes G, Weinberger M, Song P, Schwamm L, Smith E, Fonarow G, Xian Y. The Medicare Shared Savings Program and Outcomes for Ischemic Stroke Patients: a Retrospective Cohort Study. Journal Of General Internal Medicine 2019, 34: 2740-2748. PMID: 31452032, PMCID: PMC6854149, DOI: 10.1007/s11606-019-05283-1.Peer-Reviewed Original ResearchConceptsAccountable care organizationsIschemic strokeRecurrent strokeMSSP accountable care organizationsIndex hospital stayIncident ischemic strokeRetrospective cohort studyAcute care utilizationIschemic stroke patientsMedicare Shared Savings Program Accountable Care OrganizationsModerate ischemic strokeConclusionsAmong patientsMain MeasuresOutcomesCause readmissionHospital stayCohort studyHome dischargeCare utilizationStroke patientsTransitional careProbability of dischargeCare coordinationPatient outcomesMedicare claimsService beneficiaries
2018
Isolated Upper Limb Weakness From Ischemic Stroke: Mechanisms and Outcome
Topcuoglu M, Rocha E, Siddiqui A, Mills B, Silva G, Schwamm L, Lamuraglia G, Singhal A. Isolated Upper Limb Weakness From Ischemic Stroke: Mechanisms and Outcome. Journal Of Stroke And Cerebrovascular Diseases 2018, 27: 2712-2719. PMID: 30033098, DOI: 10.1016/j.jstrokecerebrovasdis.2018.05.050.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBrain IschemiaCarotid StenosisCerebral AngiographyComputed Tomography AngiographyDiffusion Magnetic Resonance ImagingDisability EvaluationEmbolismFemaleHeart DiseasesHumansMagnetic Resonance AngiographyMaleMiddle AgedMotor ActivityMotor CortexMuscle StrengthMuscle WeaknessMuscle, SkeletalPlaque, AtheroscleroticPrognosisRecovery of FunctionRetrospective StudiesRisk FactorsRupture, SpontaneousStrokeUpper ExtremityConceptsCarotid artery stenosisArtery stenosisCarotid stenosisSubcortical white matter infarctsClinical imaging featuresUpper extremity weaknessDiffusion-weighted magnetic resonance imagingUpper limb weaknessRecurrent stroke riskWhite matter infarctsMagnetic resonance imagingCardioembolic mechanismRecurrent strokeBrainstem infarctsExtremity weaknessMultiple infarctsIschemic strokeLimb weaknessStroke riskMotor stripStroke evaluationMean agePlaque ulcerationStroke mechanismInfarcts
2014
Guideline-Directed Low-Density Lipoprotein Management in High-Risk Patients With Ischemic Stroke
Saposnik G, Fonarow G, Pan W, Liang L, Hernandez A, Schwamm L, Smith E. Guideline-Directed Low-Density Lipoprotein Management in High-Risk Patients With Ischemic Stroke. Stroke 2014, 45: 3343-3351. PMID: 25300975, DOI: 10.1161/strokeaha.114.006736.Peer-Reviewed Original ResearchConceptsTransient ischemic attackCoronary artery diseaseHigh-risk patientsTIA/strokeIschemic attackIschemic strokeLDL targetsCardiovascular diseasePrevious stroke/transient ischemic attackStroke/transient ischemic attackConcomitant coronary artery diseasePreexistent coronary artery diseasePrevious TIA/strokePrior TIA/strokePrevious coronary artery diseaseMajor vascular risk factorsLow-density lipoprotein valuesGuidelines-Stroke registryAcute ischemic strokeManagement of dyslipidemiaVascular risk factorsCholesterol-lowering therapyLipoprotein managementRecurrent strokeStroke preventionGuidelines for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack
Kernan WN, Ovbiagele B, Black HR, Bravata DM, Chimowitz MI, Ezekowitz MD, Fang MC, Fisher M, Furie KL, Heck DV, Johnston SC, Kasner SE, Kittner SJ, Mitchell PH, Rich MW, Richardson D, Schwamm LH, Wilson JA. Guidelines for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack. Stroke 2014, 45: 2160-2236. PMID: 24788967, DOI: 10.1161/str.0000000000000024.Peer-Reviewed Original ResearchConceptsTransient ischemic attackEvidence-based recommendationsIschemic attackCerebral venous sinus thrombosisTimely evidence-based recommendationsAntiphospholipid antibody syndromeVenous sinus thrombosisPrevention of strokeAortic arch atherosclerosisSickle cell diseaseImplementation of guidelinesAntibody syndromeFuture strokeRecurrent strokeAnticoagulation therapyAntiplatelet therapyAntithrombotic therapySinus thrombosisIschemic strokeNoncardioembolic strokeSecondary preventionArterial dissectionHypercoagulable statePatent foramenIntracranial hemorrhageSecondary Prevention after Ischemic Stroke or Transient Ischemic Attack
Bangalore S, Schwamm L, Smith E, Singh I, Liang L, Fonarow G, Bhatt D, Committee and Investigators G. Secondary Prevention after Ischemic Stroke or Transient Ischemic Attack. The American Journal Of Medicine 2014, 127: 728-738. PMID: 24681258, DOI: 10.1016/j.amjmed.2014.03.011.Peer-Reviewed Original ResearchConceptsTransient ischemic attackIschemic attackIschemic strokeSecondary prevention measuresEvidence-based therapiesSecondary preventionRecurrent strokeEvidence-based secondary preventionInitial transient ischemic attackGuidelines-Stroke registryIntensive statin therapyLipid-lowering medicationsLDL cholesterol measurementsWeight loss recommendationsPrevention measuresCessation counselingStatin therapyAtrial fibrillationHospital characteristicsHospital adherenceObservational studyStroke educationLower oddsPatientsCholesterol measurement
2011
Prediction of Early Stroke Risk in Transient Symptoms With Infarction
Arsava E, Furie K, Schwamm L, Sorensen A, Ay H. Prediction of Early Stroke Risk in Transient Symptoms With Infarction. Stroke 2011, 42: 2186-2190. PMID: 21680907, PMCID: PMC3144273, DOI: 10.1161/strokeaha.110.604280.Peer-Reviewed Original ResearchConceptsTransient ischemic attackReceiver-operating characteristic curveIschemic attackStroke riskTransient symptomsDiffusion-weighted imagesStroke prevention strategiesHigh-risk patientsRisk of strokeEarly stroke riskCharacteristic curveNew infarctionRecurrent strokeClinical deteriorationConsecutive patientsIschemic strokeSymptom onsetIndex lesionRetrospective seriesPrevention strategiesPatientsEarly interventionInfarctionStrokeSubsequent stroke
2010
Guidelines for the Prevention of Stroke in Patients With Stroke or Transient Ischemic Attack
Furie KL, Kasner SE, Adams RJ, Albers GW, Bush RL, Fagan SC, Halperin JL, Johnston SC, Katzan I, Kernan WN, Mitchell PH, Ovbiagele B, Palesch YY, Sacco RL, Schwamm LH, Wassertheil-Smoller S, Turan TN, Wentworth D. Guidelines for the Prevention of Stroke in Patients With Stroke or Transient Ischemic Attack. Stroke 2010, 42: 227-276. PMID: 20966421, DOI: 10.1161/str.0b013e3181f7d043.Peer-Reviewed Original ResearchMeSH KeywordsAnemia, Sickle CellAnticoagulantsAtherosclerosisCerebral HemorrhageEmbolismEvidence-Based MedicineFemaleForamen Ovale, PatentHeart DiseasesHumansHyperhomocysteinemiaIschemic Attack, TransientMalePlatelet Aggregation InhibitorsPregnancyPregnancy Complications, CardiovascularRecurrenceRisk FactorsStrokeThrombophiliaThrombosisConceptsTransient ischemic attackEvidence-based recommendationsIschemic attackIschemic strokeCerebral venous sinus thrombosisTimely evidence-based recommendationsUse of anticoagulationVenous sinus thrombosisPrevention of strokeHigh-risk populationSickle cell diseaseImplementation of guidelinesAntithrombotic treatmentRecurrent strokeSinus thrombosisNoncardioembolic strokePostmenopausal hormonesAntiplatelet agentsArterial dissectionHypercoagulable statePatent foramenAtherosclerotic diseaseCerebral hemorrhageRisk factorsInterventional approachesRace/Ethnicity, Quality of Care, and Outcomes in Ischemic Stroke
Schwamm L, Reeves M, Pan W, Smith E, Frankel M, Olson D, Zhao X, Peterson E, Fonarow G. Race/Ethnicity, Quality of Care, and Outcomes in Ischemic Stroke. Circulation 2010, 121: 1492-1501. PMID: 20308617, DOI: 10.1161/circulationaha.109.881490.Peer-Reviewed Original ResearchConceptsQuality of careWhite patientsRace/ethnicityHospital mortalityIschemic strokeHispanic patientsBlack patientsDeep vein thrombosis prophylaxisEvidence-based care processesGuidelines-Stroke programStroke performance measuresHospital-level variablesQuality Improvement ProgramRace/ethnicity groupsDischarge antithromboticsIntravenous thrombolysisRecurrent strokeThrombosis prophylaxisDiabetes mellitusStroke careAtrial fibrillationMedian lengthSmoking cessationLipid therapyHigher odds
2009
A score to predict early risk of recurrence after ischemic strokeSYMBOLSYMBOL
Ay H, Gungor L, Arsava E, Rosand J, Vangel M, Benner T, Schwamm L, Furie K, Koroshetz W, Sorensen A. A score to predict early risk of recurrence after ischemic strokeSYMBOLSYMBOL. Neurology 2009, 74: 128-135. PMID: 20018608, PMCID: PMC2809031, DOI: 10.1212/wnl.0b013e3181ca9cff.Peer-Reviewed Original ResearchConceptsRecurrent strokeEarly riskPrognostic scoreConsecutive ischemic stroke patientsComprehensive prognostic scoreTIA/strokeAcute stroke careIschemic stroke patientsPredictors of recurrenceRisk of recurrenceCox regression modelEtiologic stroke subtypesPatient management algorithmsBrain infarctsAcute settingIschemic strokeStroke subtypesIndependent predictorsStroke careStroke patientsImaging featuresPrior historySeparate cohortClinical practiceStrokeThe Adherence eValuation After Ischemic Stroke Longitudinal (AVAIL) Registry: Design, rationale, and baseline patient characteristics
Bushnell C, Zimmer L, Schwamm L, Goldstein L, Clapp-Channing N, Harding T, Drew L, Zhao X, Peterson E. The Adherence eValuation After Ischemic Stroke Longitudinal (AVAIL) Registry: Design, rationale, and baseline patient characteristics. American Heart Journal 2009, 157: 428-435.e2. PMID: 19249411, DOI: 10.1016/j.ahj.2008.11.002.Peer-Reviewed Original ResearchConceptsIschemic stroke Longitudinal (AVAIL) registryTransient ischemic attackIschemic attackRecurrent strokePrevention medicationsLongitudinal registryAdherence evaluationSecondary preventive therapyBaseline patient characteristicsModified Rankin scoreSecondary prevention measuresMedication-taking behaviorSystem-level barriersLevel of adherenceFuture strokeCardiovascular eventsRankin scoreVascular eventsAcute hospitalizationHospital dischargePatient characteristicsPreventive therapySecondary outcomesMedication usePrimary outcome
2006
Guidelines for Prevention of Stroke in Patients With Ischemic Stroke or Transient Ischemic Attack
Sacco R, Adams R, Albers G, Alberts M, Benavente O, Furie K, Goldstein L, Gorelick P, Halperin J, Harbaugh R, Johnston S, Katzan I, Kelly-Hayes M, Kenton E, Marks M, Schwamm L, Tomsick T. Guidelines for Prevention of Stroke in Patients With Ischemic Stroke or Transient Ischemic Attack. Circulation 2006, 113: e409-49. PMID: 16534023, DOI: 10.1161/circ.113.10.e409.Peer-Reviewed Original ResearchConceptsTransient ischemic attackEvidence-based recommendationsIschemic strokeIschemic attackCerebral venous sinus thrombosisTimely evidence-based recommendationsUse of anticoagulationVenous sinus thrombosisPrevention of strokeHigh-risk populationSickle cell diseaseImplementation of guidelinesAntithrombotic treatmentRecurrent strokeSinus thrombosisNoncardioembolic strokePostmenopausal hormonesAntiplatelet agentsArterial dissectionHypercoagulable statePatent foramenAtherosclerotic diseaseCerebral hemorrhageRisk factorsInterventional approachesGuidelines for Prevention of Stroke in Patients With Ischemic Stroke or Transient Ischemic Attack
Sacco R, Adams R, Albers G, Alberts M, Benavente O, Furie K, Goldstein L, Gorelick P, Halperin J, Harbaugh R, Johnston S, Katzan I, Kelly-Hayes M, Kenton E, Marks M, Schwamm L, Tomsick T. Guidelines for Prevention of Stroke in Patients With Ischemic Stroke or Transient Ischemic Attack. Stroke 2006, 37: 577-617. PMID: 16432246, DOI: 10.1161/01.str.0000199147.30016.74.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAlcohol DrinkingAnti-Inflammatory Agents, Non-SteroidalBlood PressureBrain IschemiaClinical Trials as TopicComorbidityCoronary DiseaseDiabetes ComplicationsFemaleHumansHypertensionIschemic Attack, TransientMaleMiddle AgedObesityPrevalenceRiskRisk AssessmentRisk FactorsRisk Reduction BehaviorSmokingStrokeUnited StatesConceptsTransient ischemic attackEvidence-based recommendationsIschemic strokeIschemic attackCerebral venous sinus thrombosisTimely evidence-based recommendationsUse of anticoagulationVenous sinus thrombosisPrevention of strokeHigh-risk populationSickle cell diseaseImplementation of guidelinesAntithrombotic treatmentRecurrent strokeSinus thrombosisNoncardioembolic strokePostmenopausal hormonesAntiplatelet agentsArterial dissectionHypercoagulable statePatent foramenAtherosclerotic diseaseCerebral hemorrhageRisk factorsInterventional approaches