2019
Hospital distance, socioeconomic status, and timely treatment of ischemic stroke.
Ader J, Wu J, Fonarow GC, Smith EE, Shah S, Xian Y, Bhatt DL, Schwamm LH, Reeves MJ, Matsouaka RA, Sheth KN. Hospital distance, socioeconomic status, and timely treatment of ischemic stroke. Neurology 2019, 93: e747-e757. PMID: 31320472, PMCID: PMC6711658, DOI: 10.1212/wnl.0000000000007963.Peer-Reviewed Original ResearchConceptsTPA administrationHome zip codeSocioeconomic statusHospital mortalityTime quartilesLower oddsHierarchical multivariable logistic regression modelsTissue plasminogen activator administrationPatient's home zip codeMultivariable logistic regression modelZip code median household incomeGuidelines-Stroke registryPatients' socioeconomic statusRetrospective observational studyLow socioeconomic statusEmergency medical servicesLogistic regression modelsLowest SES quintileHigher socioeconomic statusShorter OTTIschemic strokeSecondary outcomesPatient agePrimary outcomeObservational study
2016
Sex and Age Interactions and Differences in Outcomes After Intracerebral Hemorrhage
James M, Cox M, Xian Y, Smith E, Bhatt D, Schulte P, Hernandez A, Fonarow G, Schwamm L. Sex and Age Interactions and Differences in Outcomes After Intracerebral Hemorrhage. Journal Of Women's Health 2016, 26: 380-388. PMID: 27754758, DOI: 10.1089/jwh.2016.5849.Peer-Reviewed Original ResearchConceptsIntracerebral hemorrhageSex-based interactionsTotal study populationWorse neurological deficitsAge/sexSex differencesAntiplatelet therapyHospital mortalityIschemic strokeNeurological deficitsPatient ageIndependent ambulationICH patientsStroke databaseAtrial fibrillationEarly outcomesPoor outcomeStudy populationCholesterol reducersLogistic regressionWomenTreatment differencesAgeMenHemorrhage
2013
Age Differences in the Use of Implantable Cardioverter‐Defibrillators Among Older Patients Hospitalized with Heart Failure
HESS P, GRAU‐SEPULVEDA M, HERNANDEZ A, PETERSON E, BHATT D, SCHWAMM L, YANCY C, FONAROW G, AL‐KHATIB S, Committee and Hospitals F. Age Differences in the Use of Implantable Cardioverter‐Defibrillators Among Older Patients Hospitalized with Heart Failure. Journal Of Cardiovascular Electrophysiology 2013, 24: 664-671. PMID: 23437793, PMCID: PMC4076932, DOI: 10.1111/jce.12100.Peer-Reviewed Original ResearchConceptsLeft ventricular ejection fractionHeart failureAge groupsPatient ageGuideline-eligible patientsGuidelines-HF ProgramAbsence of contraindicationsVentricular ejection fractionAmerican Heart AssociationUse of ICDsImplantable cardioverter defibrillatorOlder age groupsSame age groupOlder patientsEjection fractionICD useICD placementHeart AssociationAge-related differencesPractice guidelinesCardioverter defibrillatorPatientsHospitalizationICDAge
2012
Reperfusion Strategies and Quality of Care in 5339 Patients Age 80 Years or Older Presenting With ST‐Elevation Myocardial Infarction: Analysis from Get With The Guidelines‐Coronary Artery Disease
Medina H, Cannon C, Fonarow G, Grau‐Sepulveda M, Hernandez A, Peacock W, Laskey W, Peterson E, Schwamm L, Bhatt D, Committee and Investigators O. Reperfusion Strategies and Quality of Care in 5339 Patients Age 80 Years or Older Presenting With ST‐Elevation Myocardial Infarction: Analysis from Get With The Guidelines‐Coronary Artery Disease. Clinical Cardiology 2012, 35: 632-640. PMID: 22744844, PMCID: PMC6652419, DOI: 10.1002/clc.22036.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAged, 80 and overAngioplasty, Balloon, CoronaryAntihypertensive AgentsConfidence IntervalsCoronary Artery DiseaseFemaleFibrinolytic AgentsHospital MortalityHumansHypolipidemic AgentsMaleMyocardial InfarctionMyocardial ReperfusionOdds RatioPlatelet Aggregation InhibitorsPractice Guidelines as TopicQuality of Health CareRegistriesThrombolytic TherapyConceptsPrimary percutaneous coronary interventionHospital mortalityReperfusion strategyNR patientsPatient ageUse of PCIGuidelines-Coronary Artery Disease databaseGuidelines-Coronary Artery DiseasePatients age 80 yearsST-elevation myocardial infarctionLower body mass indexGWTG-CAD hospitalsMain reperfusion strategyProportion of patientsPercutaneous coronary interventionAge 80 yearsBody mass indexLength of stayEvidence-based therapiesQuality of carePPCI patientsUnderwent thrombolysisHospital outcomesOld presentingRenal insufficiency
2008
CT Angiography-Source Image Hypoattenuation Predicts Clinical Outcome in Posterior Circulation Strokes Treated With Intra-Arterial Therapy
Schaefer P, Yoo A, Bell D, Barak E, Romero J, Nogueira R, Lev M, Schwamm L, Gonzalez R, Hirsch J. CT Angiography-Source Image Hypoattenuation Predicts Clinical Outcome in Posterior Circulation Strokes Treated With Intra-Arterial Therapy. Stroke 2008, 39: 3107-3109. PMID: 18703807, DOI: 10.1161/strokeaha.108.517680.Peer-Reviewed Original ResearchConceptsIntra-arterial thrombolysisVertebrobasilar occlusionClinical outcomesParenchymal hypoattenuationRankin scorePosterior circulation strokeHealth Stroke ScaleIntra-arterial therapyOnly independent predictorIndependent outcome predictorsMedial temporal lobeInferior parietal lobeStroke ScaleClot locationPatient ageCTA-SIIndependent predictorsOutcome predictorsOccipital lobeHypoattenuationTemporal lobeThrombolysisParietal lobePatientsMidbrain
2001
Ischemic Stroke: Effects of Etiology and Patient Age on the Time Course of the Core Apparent Diffusion Coefficient
Copen W, Schwamm L, González R, Wu O, Harmath C, Schaefer P, Koroshetz W, Sorensen A. Ischemic Stroke: Effects of Etiology and Patient Age on the Time Course of the Core Apparent Diffusion Coefficient. Radiology 2001, 221: 27-34. PMID: 11568317, DOI: 10.1148/radiol.2211001397.Peer-Reviewed Original ResearchConceptsPatient ageApparent diffusion coefficientInfarct etiologyYounger patientsTime courseMagnetic resonance imaging examinationsRelative ADCEffect of etiologyRelative apparent diffusion coefficientLesion apparent diffusion coefficientNormal-appearing brainSignificant age-related differencesEtiology of lesionsStroke onsetIschemic strokeMedian ageOlder patientsSubgroup analysisAge-related differencesImaging examinationsPatientsADC progressionEtiologyLacunesAge