2018
Evaluation of a score for the prehospital distinction between cerebrovascular disease and stroke mimic patients
Geisler F, Ali S, Ebinger M, Kunz A, Rozanski M, Waldschmidt C, Weber J, Wendt M, Winter B, Schwamm L, Audebert H. Evaluation of a score for the prehospital distinction between cerebrovascular disease and stroke mimic patients. International Journal Of Stroke 2018, 14: 400-408. PMID: 30303808, DOI: 10.1177/1747493018806194.Peer-Reviewed Original ResearchConceptsStroke mimic patientsIndividual patient characteristicsMimic patientsCerebrovascular diseaseStroke mimicsPatient characteristicsFocal neurological deficitsCerebrovascular disease patientsCertain patient characteristicsMobile stroke unitPre-hospital settingSevere strokeArterial hypertensionNeurological deficitsStroke unitAtrial fibrillationDisease patientsSudden onsetEmergency physiciansHospital destinationPatientsDiscriminative valueFinal analysisDiseaseStroke
2016
Sex and Age Interactions and Differences in Outcomes After Intracerebral Hemorrhage
James M, Cox M, Xian Y, Smith E, Bhatt D, Schulte P, Hernandez A, Fonarow G, Schwamm L. Sex and Age Interactions and Differences in Outcomes After Intracerebral Hemorrhage. Journal Of Women's Health 2016, 26: 380-388. PMID: 27754758, DOI: 10.1089/jwh.2016.5849.Peer-Reviewed Original ResearchConceptsIntracerebral hemorrhageSex-based interactionsTotal study populationWorse neurological deficitsAge/sexSex differencesAntiplatelet therapyHospital mortalityIschemic strokeNeurological deficitsPatient ageIndependent ambulationICH patientsStroke databaseAtrial fibrillationEarly outcomesPoor outcomeStudy populationCholesterol reducersLogistic regressionWomenTreatment differencesAgeMenHemorrhage
2005
Poor Outcomes in Patients Who Do Not Receive Intravenous Tissue Plasminogen Activator Because of Mild or Improving Ischemic Stroke
Smith E, Abdullah A, Petkovska I, Rosenthal E, Koroshetz W, Schwamm L. Poor Outcomes in Patients Who Do Not Receive Intravenous Tissue Plasminogen Activator Because of Mild or Improving Ischemic Stroke. Stroke 2005, 36: 2497-2499. PMID: 16210552, DOI: 10.1161/01.str.0000185798.78817.f3.Peer-Reviewed Original ResearchConceptsIntravenous tissue plasminogen activatorTissue plasminogen activatorNeurological worseningPoor outcomeHealth Stroke Scale scoreProspective single-center studyPlasminogen activatorStroke Scale scoreSingle-center studyIschemic stroke symptomsTPA eligibilityHome dischargeIschemic strokeNeurological deficitsSymptom onsetStroke symptomsSeverity criteriaPatientsScale scoreNational InstituteSubstantial minoritySymptomsStrokeWorseningOutcomes
1999
Diffusion- and Perfusion-Weighted Imaging in Vasospasm After Subarachnoid Hemorrhage
Rordorf G, Koroshetz W, Copen W, Gonzalez G, Yamada K, Schaefer P, Schwamm L, Ogilvy C, Sorensen A. Diffusion- and Perfusion-Weighted Imaging in Vasospasm After Subarachnoid Hemorrhage. Stroke 1999, 30: 599-605. PMID: 10066858, DOI: 10.1161/01.str.30.3.599.Peer-Reviewed Original ResearchConceptsRelative cerebral blood flowRelative cerebral blood volumeAngiographic vasospasmIschemic injurySymptomatic vasospasmNeurological deficitsClinical signsSevere angiographic vasospasmCerebral tissue perfusionEarly ischemic injurySubarachnoid hemorrhage patientsCerebral blood flowIntravenous contrast bolusPerfusion-Weighted ImagingCerebral blood volumeDWI abnormalitiesAsymptomatic patientsHemodynamic abnormalitiesNormal angiogramsAngiographic spasmImaging abnormalitiesIschemic lesionsHemorrhage patientsSubarachnoid hemorrhageClinical management
1997
Pharmacological elevation of blood pressure in acute stroke. Clinical effects and safety.
Rordorf G, Cramer S, Efird J, Schwamm L, Buonanno F, Koroshetz W. Pharmacological elevation of blood pressure in acute stroke. Clinical effects and safety. Stroke 1997, 28: 2133-8. PMID: 9368553, DOI: 10.1161/01.str.28.11.2133.Peer-Reviewed Original ResearchConceptsBlood pressure thresholdAcute strokeBlood pressureInduced hypertensionCerebral arterySystolic blood pressure thresholdNeurological intensive care unitPhenylephrine-Induced HypertensionAcute cerebral ischemiaSubset of patientsIntensive care unitPressure thresholdCardiac morbidityIschemic deficitsIschemic symptomsPressor agentsBaseline characteristicsIschemic strokeNeurological deficitsCerebral ischemiaCerebral perfusionBrain edemaCare unitClinical effectsIntracerebral hemorrhageDiffusion-weighted imaging discriminates between cytotoxic and vasogenic edema in a patient with eclampsia.
Schaefer P, Buonanno F, Gonzalez R, Schwamm L. Diffusion-weighted imaging discriminates between cytotoxic and vasogenic edema in a patient with eclampsia. Stroke 1997, 28: 1082-5. PMID: 9158653, DOI: 10.1161/01.str.28.5.1082.Peer-Reviewed Original ResearchConceptsT2 hyperintense signal abnormalityDiffusion-weighted imagingHyperintense signal abnormalitiesVasogenic edemaSignal abnormalitiesRoutine MRIMajority of patientsPermanent neurological impairmentReversible neurological deficitsSubcortical white matterAdjacent gray matterDifferent treatment protocolsPathophysiology of eclampsiaEcho-planar diffusion-weighted imagingEclamptic patientsIschemic encephalopathyNeurological deficitsPosterior predominancePatient groupDiffusion-weighted imagesCytotoxic edemaNeurological impairmentPremature twinsTreatment protocolEdema