2022
No short-term mortality from benzodiazepine use post-acute ischemic stroke after accounting for bias
Moura L, Yan Z, Donahue M, Smith L, Schwamm L, Hsu J, Newhouse J, Haneuse S, Blacker D, Hernandez-Diaz S. No short-term mortality from benzodiazepine use post-acute ischemic stroke after accounting for bias. Journal Of Clinical Epidemiology 2022, 154: 136-145. PMID: 36572369, PMCID: PMC10033385, DOI: 10.1016/j.jclinepi.2022.12.013.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeRisk differenceIschemic strokeBenzodiazepine useShort-term mortalityImmortal time biasElectronic health recordsAIS admissionsBenzodiazepine initiationStroke RegistryPoststroke mortalityTreatment initiationMortality riskPatientsFurther adjustmentMortalityBenzodiazepinesOlder adultsTime biasHealth recordsImmortal timeStrokeRiskDaysContraindicationsComparative Effectiveness and Safety of Seizure Prophylaxis Among Adults After Acute Ischemic Stroke
Moura L, Donahue M, Yan Z, Smith L, Hsu J, Newhouse J, Schwamm L, Haneuse S, Hernandez-Diaz S, Blacker D. Comparative Effectiveness and Safety of Seizure Prophylaxis Among Adults After Acute Ischemic Stroke. Stroke 2022, 54: 527-536. PMID: 36544249, PMCID: PMC9870933, DOI: 10.1161/strokeaha.122.039946.Peer-Reviewed Original ResearchConceptsSeizure prophylaxisRisk differenceAntiseizure drugsEarly seizure prophylaxisSevere AIS patientsAcute ischemic strokePrespecified subgroup analysisHealth care factorsInverse probability weightsElectronic health recordsAIS admissionsPoststroke mortalityStroke RegistryIschemic strokeAIS patientsStroke settingsCare factorsSubgroup analysisProphylaxisMortality riskHigh riskPatientsComparative effectivenessExcess deathsTrial data
2019
Medicare Shared Savings ACOs and Hospice Care for Ischemic Stroke Patients
Kaufman B, O'Brien E, Stearns S, Matsouaka R, Holmes G, Weinberger M, Schwamm L, Smith E, Fonarow G, Xian Y, Taylor D. Medicare Shared Savings ACOs and Hospice Care for Ischemic Stroke Patients. Journal Of The American Geriatrics Society 2019, 67: 1402-1409. PMID: 30835818, DOI: 10.1111/jgs.15852.Peer-Reviewed Original ResearchConceptsIschemic stroke patientsHigher mortality riskHospice enrollmentStroke patientsAccountable care organizationsMortality riskMedicare Shared Savings ProgramComfort measuresLife careIncident ischemic stroke patientsLow-mortality risk groupsGWTG-Stroke hospitalsIncident ischemic strokeMortality risk groupsPalliative care servicesService Medicare beneficiariesQuality of endMedicare hospice benefitSevere strokeIschemic strokePoor prognosisNational registryReduced oddsRisk groupsHospice care
2012
Care and Outcomes of Hispanic Patients Admitted With Heart Failure With Preserved or Reduced Ejection Fraction
Vivo R, Krim S, Krim N, Zhao X, Hernandez A, Peterson E, Piña I, Bhatt D, Schwamm L, Fonarow G. Care and Outcomes of Hispanic Patients Admitted With Heart Failure With Preserved or Reduced Ejection Fraction. Circulation Heart Failure 2012, 5: 167-175. PMID: 22414939, DOI: 10.1161/circheartfailure.111.963546.Peer-Reviewed Original ResearchConceptsNon-Hispanic whitesEjection fractionHeart failureQuality of careHF patientsNon-Hispanic white patientsLeft ventricular ejection fractionGuidelines-Heart FailureVentricular ejection fractionOverweight/obesityLower mortality riskPercent of HispanicsHospital survivalInpatient mortalityWhite patientsHispanic patientsHispanic ethnicityMortality riskHigh riskEquitable carePerformance improvement programMultivariate analysisPatientsStudy periodCareRelationship of National Institutes of Health Stroke Scale to 30‐Day Mortality in Medicare Beneficiaries With Acute Ischemic Stroke
Fonarow G, Saver J, Smith E, Broderick J, Kleindorfer D, Sacco R, Pan W, Olson D, Hernandez A, Peterson E, Schwamm L. Relationship of National Institutes of Health Stroke Scale to 30‐Day Mortality in Medicare Beneficiaries With Acute Ischemic Stroke. Journal Of The American Heart Association 2012, 1: 42-50. PMID: 23130117, PMCID: PMC3487316, DOI: 10.1161/jaha.111.000034.Peer-Reviewed Original ResearchAcute ischemic strokeHealth Stroke ScaleIschemic strokeMedicare beneficiariesNIHSS scoreStroke ScaleStroke severityMortality riskMortality rateGuidelines-Stroke hospitalsMedian NIHSS scoreSubstantial prognostic informationInitial stroke severityDiscrimination of riskService Medicare beneficiariesNational InstituteContinuous variablesMean ageC-statisticPrognostic informationRisk discriminationNIHSSClinical informationGraded relationStroke