2019
Intravenous Tissue Plasminogen Activator in Stroke Mimics
Ali-Ahmed F, Federspiel J, Liang L, Xu H, Sevilis T, Hernandez A, Kosinski A, Prvu Bettger J, Smith E, Bhatt D, Schwamm L, Fonarow G, Peterson E, Xian Y. Intravenous Tissue Plasminogen Activator in Stroke Mimics. Circulation Cardiovascular Quality And Outcomes 2019, 12: e005609. PMID: 31412730, PMCID: PMC6699639, DOI: 10.1161/circoutcomes.119.005609.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, IntravenousAdultAgedAged, 80 and overBrain IschemiaDiagnosis, DifferentialFemaleFibrinolytic AgentsHumansIntracranial HemorrhagesMaleMiddle AgedPredictive Value of TestsRegistriesRisk AssessmentRisk FactorsStrokeThrombolytic TherapyTissue Plasminogen ActivatorTreatment OutcomeUnited StatesUnnecessary ProceduresConceptsTransient ischemic attackStroke mimicsIschemic strokeIschemic attackPrior stroke/transient ischemic attackStroke/transient ischemic attackIntravenous tissue plasminogen activatorGuidelines-Stroke registrySymptomatic intracranial hemorrhageCardiovascular risk factorsHealth Stroke ScaleHospital mortality rateAcute ischemic strokeStroke-like symptomsTissue plasminogen activatorUse of tPANonstroke diagnosisThrombolysis safetyIntravenous tPAStroke ScaleComplication rateIntracranial hemorrhagePresumed strokeRisk factorsFunctional disorders
2018
Association of Intracerebral Hemorrhage Among Patients Taking Non–Vitamin K Antagonist vs Vitamin K Antagonist Oral Anticoagulants With In-Hospital Mortality
Inohara T, Xian Y, Liang L, Matsouaka R, Saver J, Smith E, Schwamm L, Reeves M, Hernandez A, Bhatt D, Peterson E, Fonarow G. Association of Intracerebral Hemorrhage Among Patients Taking Non–Vitamin K Antagonist vs Vitamin K Antagonist Oral Anticoagulants With In-Hospital Mortality. JAMA 2018, 319: 463-473. PMID: 29372247, PMCID: PMC5839299, DOI: 10.1001/jama.2017.21917.Peer-Reviewed Original ResearchConceptsHospital mortalityDual antiplatelet agentsIntracerebral hemorrhagePrior useOral anticoagulantsAntiplatelet agentsLower riskVitamin K Antagonist Oral AnticoagulantsK Antagonist Oral AnticoagulantsNon-vitamin K antagonistsGuidelines-Stroke hospitalsPrior antiplatelet therapyHospital mortality rateOral anticoagulant useRetrospective cohort studyWarfarin-treated patientsUse of OACInteraction p valuePrior strokeAnticoagulation therapyAntiplatelet therapyK antagonistsAnticoagulant useCohort studyHospital arrival
2015
Treatment and Outcome of Thrombolysis-Related Hemorrhage: A Multicenter Retrospective Study
Yaghi S, Boehme A, Dibu J, Guerrero C, Ali S, Martin-Schild S, Sands K, Noorian A, Blum C, Chaudhary S, Schwamm L, Liebeskind D, Marshall R, Willey J. Treatment and Outcome of Thrombolysis-Related Hemorrhage: A Multicenter Retrospective Study. JAMA Neurology 2015, 72: 1-7. PMID: 26501741, PMCID: PMC4845894, DOI: 10.1001/jamaneurol.2015.2371.Peer-Reviewed Original ResearchConceptsSymptomatic intracerebral hemorrhageRecombinant tissue plasminogen activatorMulticenter retrospective studyHematoma expansionHospital mortalityMedian timeRetrospective studyIntravenous recombinant tissue plasminogen activatorHealth Stroke Scale scoreParenchymal hematoma type 2Code status changeOutcome of thrombolysisStroke-Monitoring StudyComprehensive stroke centerHospital mortality rateOutcomes of patientsStroke Scale scoreTissue plasminogen activatorIschemic strokePrimary outcomeRtPA therapySecondary outcomesStroke centersSymptom onsetIntracerebral hemorrhage
2014
Patterns of Care Quality and Prognosis Among Hospitalized Ischemic Stroke Patients With Chronic Kidney Disease
Ovbiagele B, Schwamm L, Smith E, Grau‐Sepulveda M, Saver J, Bhatt D, Hernandez A, Peterson E, Fonarow G. Patterns of Care Quality and Prognosis Among Hospitalized Ischemic Stroke Patients With Chronic Kidney Disease. Journal Of The American Heart Association 2014, 3: e000905. PMID: 24904017, PMCID: PMC4309090, DOI: 10.1161/jaha.114.000905.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseIschemic stroke patientsSevere renal dysfunctionGlomerular filtration rateStroke patientsRenal dysfunctionQuality of careKidney diseaseHospitalized ischemic stroke patientsGuideline-based therapyGuideline-recommended therapiesGuidelines-Stroke programGWTG-Stroke programStroke performance measuresHospital mortality rateNormal kidney functionHospital mortalityHospital prognosisInpatient mortalityIschemic strokeCare complianceKidney functionModerate dysfunctionKidney failureFiltration rate
2013
Insurance Status and Outcome after Intracerebral Hemorrhage: Findings from Get With The Guidelines-Stroke
James M, Grau-Sepulveda M, Olson D, Smith E, Hernandez A, Peterson E, Schwamm L, Bhatt D, Fonarow G. Insurance Status and Outcome after Intracerebral Hemorrhage: Findings from Get With The Guidelines-Stroke. Journal Of Stroke And Cerebrovascular Diseases 2013, 23: 283-292. PMID: 23537567, DOI: 10.1016/j.jstrokecerebrovasdis.2013.02.016.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCerebral HemorrhageChi-Square DistributionFemaleGuideline AdherenceHealth Services AccessibilityHealthcare DisparitiesHumansInsurance CoverageInsurance, HealthLogistic ModelsMaleMedicaidMedically UninsuredMedicareMiddle AgedMultivariate AnalysisOdds RatioPatient DischargePractice Guidelines as TopicPractice Patterns, Physicians'Private SectorQuality of Health CareRegistriesRetrospective StudiesRisk FactorsTreatment OutcomeUnited StatesConceptsInsurance statusIntracerebral hemorrhageCare measuresOdds ratioND groupHospital mortality rateProspective stroke registryPrivate insurance groupHigher mortality riskHigher odds ratioEvidence-based qualityInsurance groupsHospital-specific variablesGuidelines-StrokeHospital outcomesStroke RegistryDischarge destinationIndependent ambulationComorbid conditionsStroke databaseAdjusted analysisICH patientsFunctional statusCare indicatorsMedicare patients
2012
Care and Outcomes of Asian-American Acute Myocardial Infarction Patients
Qian F, Ling F, Deedwania P, Hernandez A, Fonarow G, Cannon C, Peterson E, Peacock W, Kaltenbach L, Laskey W, Schwamm L, Bhatt D. Care and Outcomes of Asian-American Acute Myocardial Infarction Patients. Circulation Cardiovascular Quality And Outcomes 2012, 5: 126-133. PMID: 22235068, DOI: 10.1161/circoutcomes.111.961987.Peer-Reviewed Original ResearchConceptsGuidelines-Coronary Artery Disease programAcute myocardial infarctionAMI patientsDisease programsBalloon timeWhite patientsAcute myocardial infarction patientsAMI performance measuresDefect-free careHospital mortality rateEvidence-based careAmerican Heart AssociationMyocardial infarction patientsAsian American patientsUnited States CentersHospital mortalityCessation counselingUnadjusted mortalityHeart failureHeart AssociationInfarction patientsMyocardial infarctionHigh prevalenceClinical careMortality rate
2011
Prestroke Dementia is Associated With Poor Outcomes After Reperfusion Therapy Among Elderly Stroke Patients
Busl K, Nogueira R, Yoo A, Hirsch J, Schwamm L, Rost N. Prestroke Dementia is Associated With Poor Outcomes After Reperfusion Therapy Among Elderly Stroke Patients. Journal Of Stroke And Cerebrovascular Diseases 2011, 22: 718-724. PMID: 22182760, PMCID: PMC3310930, DOI: 10.1016/j.jstrokecerebrovasdis.2011.11.005.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAged, 80 and overDementiaDisability EvaluationFemaleFibrinolytic AgentsHospicesHospital MortalityHumansInfusions, Intra-ArterialInfusions, IntravenousLogistic ModelsMaleMultivariate AnalysisOdds RatioPatient DischargeRehabilitation CentersRetrospective StudiesRisk FactorsSkilled Nursing FacilitiesStrokeThrombolytic TherapyTime FactorsTissue Plasminogen ActivatorTreatment OutcomeConceptsIntra-arterial reperfusion therapyTissue plasminogen activatorReperfusion therapyPrestroke dementiaHospital mortalityDischarge destinationPoor outcomeStroke patientsElderly acute stroke patientsMultivariate logistic regression modelAcute reperfusion therapyGuidelines-Stroke databaseSymptomatic intracranial hemorrhageHealth Stroke ScaleHospital mortality rateAcute stroke patientsPowerful independent predictorVascular risk factorsElderly stroke patientsPresence of dementiaLikelihood of deathYears of ageLogistic regression modelsStroke ScaleSecondary outcomes
2010
Characteristics, Performance Measures, and In-Hospital Outcomes of the First One Million Stroke and Transient Ischemic Attack Admissions in Get With The Guidelines-Stroke
Fonarow G, Reeves M, Smith E, Saver J, Zhao X, Olson D, Hernandez A, Peterson E, Schwamm L. Characteristics, Performance Measures, and In-Hospital Outcomes of the First One Million Stroke and Transient Ischemic Attack Admissions in Get With The Guidelines-Stroke. Circulation Cardiovascular Quality And Outcomes 2010, 3: 291-302. PMID: 20177051, DOI: 10.1161/circoutcomes.109.921858.Peer-Reviewed Original ResearchConceptsHospital mortality rateIntracerebral hemorrhageQuality of careIschemic strokeSubarachnoid hemorrhageMortality rateTransient ischemic attack admissionsTransient ischemic attack patientsIn-Hospital OutcomesAcute ischemic strokeIschemic stroke patientsAdjusted odds ratioLength of stayQuality improvement effortsGuidelines-StrokeGWTG-StrokeTIA admissionsTIA careTIA patientsHospital outcomesAcute strokeStroke patientsMean ageAttack patientsNational surveillance