2015
In Acute Stroke, Can CT Perfusion-Derived Cerebral Blood Volume Maps Substitute for Diffusion-Weighted Imaging in Identifying the Ischemic Core?
Copen W, Morais L, Wu O, Schwamm L, Schaefer P, González R, Yoo A. In Acute Stroke, Can CT Perfusion-Derived Cerebral Blood Volume Maps Substitute for Diffusion-Weighted Imaging in Identifying the Ischemic Core? PLOS ONE 2015, 10: e0133566. PMID: 26193486, PMCID: PMC4508041, DOI: 10.1371/journal.pone.0133566.Peer-Reviewed Original ResearchConceptsComputed tomography perfusion imagingDiffusion-weighted magnetic resonance imagingCerebral blood volumeInfarct volumeSensitivity/specificityCBV mapsDWI lesionsIschemic coreCore lesionsDWI-positive patientsRegional cerebral blood volumeAcute ischemic strokeFinal infarct volumeTreatment of patientsTomography perfusion imagingPresence of infarctionMagnetic resonance imagingDiffusion-weighted imagingAcute strokeIschemic strokeSymptom onsetLesion volumeIndividual patientsInter-rater agreementPatients
2014
Time and Diffusion Lesion Size in Major Anterior Circulation Ischemic Strokes
Hakimelahi R, Vachha B, Copen W, Papini G, He J, Higazi M, Lev M, Schaefer P, Yoo A, Schwamm L, González R. Time and Diffusion Lesion Size in Major Anterior Circulation Ischemic Strokes. Stroke 2014, 45: 2936-2941. PMID: 25190444, DOI: 10.1161/strokeaha.114.005644.Peer-Reviewed Original ResearchConceptsAnterior circulation ischemic strokeMiddle cerebral artery occlusionDiffusion-weighted imagingCerebral artery occlusionStroke onsetIschemic strokeInfarct sizeDWI lesionsInfarct volumeArtery occlusionIntravenous tissue-type plasminogen activatorProximal middle cerebral arteryDistal internal carotid arteryAcute infarct volumeDWI lesion volumeMajority of patientsMiddle cerebral arteryInternal carotid arteryAcute infarct sizeSame inclusion criteriaTraditional time windowTissue-type plasminogen activatorCerebral perfusionConsecutive patientsInfarct growth
2012
Reliability of cerebral blood volume maps as a substitute for diffusion‐weighted imaging in acute ischemic stroke
deIpolyi A, Wu O, Macklin E, Schaefer P, Schwamm L, Gonzalez R, Copen W. Reliability of cerebral blood volume maps as a substitute for diffusion‐weighted imaging in acute ischemic stroke. Journal Of Magnetic Resonance Imaging 2012, 36: 1083-1087. PMID: 22761110, PMCID: PMC4110961, DOI: 10.1002/jmri.23740.Peer-Reviewed Original ResearchConceptsDiffusion-weighted MRIAcute ischemic strokeCerebral blood volume mapsBlood volume mapsCBV mapsDWI lesionsIschemic strokeProportion of lesionsScan durationDiffusion-weighted imagingAcute strokeStroke onsetInfarct coreContralateral hemisphereRegional CBVMR perfusionVolume mapsLesion centerLesionsCBVStrokeShort durationPerfusionDurationLinear regression
2002
‘Footprints’ of Transient Ischemic Attacks: A Diffusion-Weighted MRI Study
Ay H, Oliveira-Filho J, Buonanno F, Schaefer P, Furie K, Chang Y, Rordorf G, Schwamm L, Gonzalez R, Koroshetz W. ‘Footprints’ of Transient Ischemic Attacks: A Diffusion-Weighted MRI Study. Cerebrovascular Diseases 2002, 14: 177-186. PMID: 12403950, DOI: 10.1159/000065682.Peer-Reviewed Original ResearchConceptsTransient ischemic attackFast fluid attenuated inversion recoveryDiffusion-weighted imagingIschemic attackDWI lesionsFocal neurologic symptomsHalf of patientsDiffusion-weighted MRI studiesFluid attenuated inversion recoveryAttenuated inversion recoveryBrain infarctionClinical characteristicsNeurologic symptomsConsecutive patientsIndependent predictorsIschemic injuryMotor symptomsRecent infarctionCerebrovascular abnormalitiesClinical syndromeVascular territoriesStroke mechanismMRI studiesPatientsInfarction