2023
Rationale and design of the GOLDEN BRIDGE II: a cluster-randomised multifaceted intervention trial of an artificial intelligence-based cerebrovascular disease clinical decision support system to improve stroke outcomes and care quality in China
Li Z, Zhang X, Ding L, Jing J, Gu H, Jiang Y, Meng X, Du C, Wang C, Wang M, Xu M, Zhang Y, Hu M, Li H, Gong X, Dong K, Zhao X, Wang Y, Liu L, Xian Y, Peterson E, Fonarow G, Schwamm L, Wang Y. Rationale and design of the GOLDEN BRIDGE II: a cluster-randomised multifaceted intervention trial of an artificial intelligence-based cerebrovascular disease clinical decision support system to improve stroke outcomes and care quality in China. Stroke And Vascular Neurology 2023, svn-2023-002411. PMID: 37699726, DOI: 10.1136/svn-2023-002411.Peer-Reviewed Original ResearchClinical decision support systemVascular eventsIntervention trialsIntervention groupControl groupGuideline-based treatment recommendationsCare qualityNew vascular eventsStroke care qualityAcute ischemic strokeComposite vascular eventsII trialUsual careIschemic strokeStroke etiologyStroke onsetStroke outcomePrimary outcomeTreat principleClinical outcomesStroke careCerebrovascular diseaseEligible participantsTreatment recommendationsIntervention studies
2020
Advances in Stroke
Silva G, Schwamm L. Advances in Stroke. Stroke 2020, 52: 351-355. PMID: 33349024, DOI: 10.1161/strokeaha.120.033239.Peer-Reviewed Original Research
2018
Evaluation of a score for the prehospital distinction between cerebrovascular disease and stroke mimic patients
Geisler F, Ali S, Ebinger M, Kunz A, Rozanski M, Waldschmidt C, Weber J, Wendt M, Winter B, Schwamm L, Audebert H. Evaluation of a score for the prehospital distinction between cerebrovascular disease and stroke mimic patients. International Journal Of Stroke 2018, 14: 400-408. PMID: 30303808, DOI: 10.1177/1747493018806194.Peer-Reviewed Original ResearchConceptsStroke mimic patientsIndividual patient characteristicsMimic patientsCerebrovascular diseaseStroke mimicsPatient characteristicsFocal neurological deficitsCerebrovascular disease patientsCertain patient characteristicsMobile stroke unitPre-hospital settingSevere strokeArterial hypertensionNeurological deficitsStroke unitAtrial fibrillationDisease patientsSudden onsetEmergency physiciansHospital destinationPatientsDiscriminative valueFinal analysisDiseaseStrokeValidating the TeleStroke Mimic Score
Ali S, Hubert G, Switzer J, Majersik J, Backhaus R, Shepard L, Vedala K, Schwamm L. Validating the TeleStroke Mimic Score. Stroke 2018, 49: 688-692. PMID: 29374105, PMCID: PMC5829006, DOI: 10.1161/strokeaha.117.018758.Peer-Reviewed Original ResearchConceptsStroke mimicsIschemic cerebrovascular diseaseTelestroke networkTelestroke consultationCerebrovascular diseaseReceiver-operating characteristic curve analysisAcute stroke evaluationExternal validation cohortRisk prediction scoreStroke care networksCharacteristic curve analysisStroke evaluationValidation cohortClinical differencesOriginal cohortFinal diagnosisTelestroke consultsScore's abilityGeorgia Regents UniversityDiverse cohortCare networkCurve analysisCohortConfidence intervalsPrediction score
2015
Increased Risk of Cerebrovascular Disease Among Patients With Neurofibromatosis Type 1
Terry A, Jordan J, Schwamm L, Plotkin S. Increased Risk of Cerebrovascular Disease Among Patients With Neurofibromatosis Type 1. Stroke 2015, 47: 60-65. PMID: 26645253, DOI: 10.1161/strokeaha.115.011406.Peer-Reviewed Original ResearchConceptsNeurofibromatosis type 1Ischemic strokeIntracerebral hemorrhageGeneral populationCases of NF1US Nationwide Inpatient SampleType 1Hemorrhagic stroke typesNew neurological symptomsStroke risk factorsRisk of strokeOdds of strokeTime of strokeNationwide Inpatient SampleMultivariable logistic regressionCase-control studyType of strokeYounger mean ageAdult patientsPediatric patientsHemorrhagic strokeNeurological symptomsCerebrovascular diseaseMean ageInpatient SampleTelestroke
Rubin M, Demaerschalk B, Schwamm L, Wechsler L. Telestroke. 2015, 47-57. DOI: 10.1007/978-1-4939-2349-6_5.Peer-Reviewed Original ResearchSecondary preventionStroke careHealth Stroke Scale scoreMajor public health problemStroke Scale scoreAcute ischemic strokeAcute stroke carePrimary stroke centerAcute stroke evaluationPrevention of complicationsEducation of patientsPublic health problemPrehospital emergency medical systemEmergency medical systemExcellent interrater agreementStroke practiceStroke providersTelestroke modelIschemic strokeStroke centersStroke evaluationCerebrovascular diseaseEvidence-based practicePoststroke outcomesBedside assessment
2014
The TeleStroke Mimic (TM)‐Score: A Prediction Rule for Identifying Stroke Mimics Evaluated in a Telestroke Network
Ali SF, Viswanathan A, Singhal AB, Rost NS, Forducey PG, Davis LW, Schindler J, Likosky W, Schlegel S, Solenski N, Schwamm LH, Network O. The TeleStroke Mimic (TM)‐Score: A Prediction Rule for Identifying Stroke Mimics Evaluated in a Telestroke Network. Journal Of The American Heart Association 2014, 3: e000838. PMID: 24958778, PMCID: PMC4309074, DOI: 10.1161/jaha.114.000838.Peer-Reviewed Original ResearchConceptsStroke mimicsIschemic cerebrovascular diseaseTelestroke networkReceiver-operating characteristic curve analysisCurve analysisHealth Stroke ScaleVascular risk profileVascular risk factorsAcute stroke evaluationExternal validation cohortFinal clinical diagnosisLower mean ageROC curve analysisCharacteristic curve analysisStepwise logistic regressionTelestroke consultationStroke ScaleFacial weaknessConsecutive patientsDerivation cohortPrior seizuresStroke evaluationAlternate diagnosisCerebrovascular diseaseValidation cohort
2012
Standardizing the Structure of Stroke Clinical and Epidemiologic Research Data
Saver J, Warach S, Janis S, Odenkirchen J, Becker K, Benavente O, Broderick J, Dromerick A, Duncan P, Elkind M, Johnston K, Kidwell C, Meschia J, Schwamm L. Standardizing the Structure of Stroke Clinical and Epidemiologic Research Data. Stroke 2012, 43: 967-973. PMID: 22308239, PMCID: PMC3493110, DOI: 10.1161/strokeaha.111.634352.Peer-Reviewed Original ResearchConceptsCommon data elementsNeurological disordersStroke Common Data ElementsLong-term therapyClinical practice guidelinesNational InstituteCase report formsPrior health statusPatient-oriented researchAcute therapyHospital courseStroke presentationCerebrovascular diseaseMedical historyNational registryClinical trialsStroke typePractice guidelinesHealth statusEnd pointVital signsClinical researchReport formsData elementsTherapy
2010
Stroke: working toward a prioritized world agenda
Hachinski V, Donnan G, Gorelick P, Hacke W, Cramer S, Kaste M, Fisher M, Brainin M, Buchan A, Lo E, Skolnick B, Furie K, Hankey G, Kivipelto M, Morris J, Rothwell P, Sacco R, Smith S, Wang Y, Bryer A, Ford G, Iadecola C, Martins S, Saver J, Skvortsova V, Bayley M, Bednar M, Duncan P, Enney L, Finklestein S, Jones T, Kalra L, Kleim J, Nitkin R, Teasell R, Weiller C, Desai B, Goldberg M, Heiss W, Saarelma O, Schwamm L, Shinohara Y, Trivedi B, Wahlgren N, Wong L, Hakim A, Norrving B, Prudhomme S, Bornstein N, Davis S, Goldstein L, Leys D, Tuomilehto J. Stroke: working toward a prioritized world agenda. International Journal Of Stroke 2010, 5: 238-256. PMID: 20636706, PMCID: PMC3712839, DOI: 10.1111/j.1747-4949.2010.00442.x.Peer-Reviewed Original ResearchConceptsStroke careChronic disease prevention initiativeStroke-related informationEmergency stroke careDisease prevention initiativesPublic health communication strategiesConsequences of strokeRigorous clinical researchHealth communication strategiesStroke preventionStroke centersStroke unitClinical strokeSubclinical strokeBrain recoveryCerebrovascular diseaseStroke recoveryBrain healthPoststroke rehabilitationTelestroke networkClinical careHuman studiesEpidemiological disciplinesSurrogate assessmentStrokeStroke: Working Toward a Prioritized World Agenda
Hachinski V, Donnan G, Gorelick P, Hacke W, Cramer S, Kaste M, Fisher M, Brainin M, Buchan A, Lo E, Skolnick B, Furie K, Hankey G, Kivipelto M, Morris J, Rothwell P, Sacco R, Smith S, Wang Y, Bryer A, Ford G, Iadecola C, Martins S, Saver J, Skvortsova V, Bayley M, Bednar M, Duncan P, Enney L, Finklestein S, Jones T, Kalra L, Kleim J, Nitkin R, Teasell R, Weiller C, Desai B, Goldberg M, Heiss W, Saarelma O, Schwamm L, Shinohara Y, Trivedi B, Wahlgren N, Wong L, Hakim A, Norrving B, Prudhomme S, Bornstein N, Davis S, Goldstein L, Leys D, Tuomilehto J. Stroke: Working Toward a Prioritized World Agenda. Stroke 2010, 41: 1084-1099. PMID: 20498453, PMCID: PMC3712843, DOI: 10.1161/strokeaha.110.586156.Peer-Reviewed Original ResearchConceptsStroke careChronic disease prevention initiativeStroke-related informationEmergency stroke careDisease prevention initiativesPublic health communication strategiesConsequences of strokeRigorous clinical researchHealth communication strategiesStroke preventionStroke centersStroke unitClinical strokeSubclinical strokeBrain recoveryCerebrovascular diseaseStroke recoveryBrain healthPoststroke rehabilitationTelestroke networkClinical careHuman studiesEpidemiological disciplinesSurrogate assessmentStrokeStroke: Working toward a Prioritized World Agenda
Hachinski V, Donnan G, Gorelick P, Hacke W, Cramer S, Kaste M, Fisher M, Brainin M, Buchan A, Lo E, Skolnick B, Furie K, Hankey G, Kivipelto M, Morris J, Rothwell P, Sacco R, Smith S, Wang Y, Bryer A, Ford G, Iadecola C, Martins S, Saver J, Skvortsova V, Bayley M, Bednar M, Duncan P, Enney L, Finklestein S, Jones T, Kalra L, Kleim J, Nitkin R, Teasell R, Weiller C, Desai B, Goldberg M, Heiss W, Saarelma O, Schwamm L, Shinohara Y, Trivedi B, Wahlgren N, Wong L, Hakim A, Norrving B, Prudhomme S, Bornstein N, Davis S, Goldstein L, Leys D, Tuomilehto J. Stroke: Working toward a Prioritized World Agenda. Cerebrovascular Diseases 2010, 30: 127-147. PMID: 20516682, PMCID: PMC3221270, DOI: 10.1159/000315099.Peer-Reviewed Original ResearchConceptsStroke careChronic disease prevention initiativeStroke-related informationEmergency stroke careDisease prevention initiativesPublic health communication strategiesConsequences of strokeRigorous clinical researchHealth communication strategiesStroke preventionStroke centersStroke unitClinical strokeSubclinical strokeBrain recoveryCerebrovascular diseaseStroke recoveryBrain healthPoststroke rehabilitationTelestroke networkClinical careHuman studiesEpidemiological disciplinesSurrogate assessmentStroke
2008
Hospital Treatment of Patients With Ischemic Stroke or Transient Ischemic Attack Using the “Get With The Guidelines” Program
LaBresh K, Reeves M, Frankel M, Albright D, Schwamm L. Hospital Treatment of Patients With Ischemic Stroke or Transient Ischemic Attack Using the “Get With The Guidelines” Program. JAMA Internal Medicine 2008, 168: 411-417. PMID: 18299497, DOI: 10.1001/archinternmed.2007.101.Peer-Reviewed Original ResearchConceptsTransient ischemic attackIschemic strokeThrombolytic medicationIschemic attackAntithrombotic medicationLow-density lipoprotein levelsDeep venous thrombosisHours of onsetSecondary prevention measuresTreatment of patientsDiabetes mellitus treatmentMeasures of careEvidence-based interventionsQuality improvement measuresEligible patientsGuidelines-StrokeCessation counselingVenous thrombosisLipoprotein levelsStroke careAcute careAnticoagulation agentsAtrial fibrillationCerebrovascular diseaseHospital treatment
2006
Risk factors for stroke after acute coronary syndromes in the Orbofiban in Patients with Unstable Coronary Syndromes–Thrombolysis In Myocardial Infarction (OPUS-TIMI) 16 study
Smith E, Cannon C, Murphy S, Feske S, Schwamm L. Risk factors for stroke after acute coronary syndromes in the Orbofiban in Patients with Unstable Coronary Syndromes–Thrombolysis In Myocardial Infarction (OPUS-TIMI) 16 study. American Heart Journal 2006, 151: 338-344. PMID: 16442896, DOI: 10.1016/j.ahj.2005.03.031.Peer-Reviewed Original ResearchConceptsTransient ischemic attackAcute coronary syndromeHistory of hypertensionPrior ischemic strokeIschemic strokeCerebrovascular eventsIntracranial hemorrhageRisk factorsCoronary syndromeHistory of TIAUnstable Coronary Syndromes-ThrombolysisHemorrhagic cerebrovascular eventsPlacebo-controlled trialCoronary artery diseaseLong-term patientsSignificant excess riskIschemic attackStroke outcomeArtery diseaseCoronary angiographyOverall incidenceCerebrovascular diseaseExcess riskHeart ratePatients