Perfect as the enemy of good: tracing transmissions with low-sensitivity tests to mitigate SARS-CoV-2 outbreaks
Kennedy-Shaffer L, Baym M, Hanage W. Perfect as the enemy of good: tracing transmissions with low-sensitivity tests to mitigate SARS-CoV-2 outbreaks. The Lancet Microbe 2021, 2: e219-e224. PMID: 33748803, PMCID: PMC7954468, DOI: 10.1016/s2666-5247(21)00004-5.Peer-Reviewed Original ResearchStatistical Properties of Stepped Wedge Cluster-Randomized Trials in Infectious Disease Outbreaks
Kennedy-Shaffer L, Lipsitch M. Statistical Properties of Stepped Wedge Cluster-Randomized Trials in Infectious Disease Outbreaks. American Journal Of Epidemiology 2020, 189: 1324-1332. PMID: 32648891, PMCID: PMC7604531, DOI: 10.1093/aje/kwaa141.Peer-Reviewed Original ResearchConceptsWedge trialsParallel-arm cluster-randomized trialsStepped wedge cluster randomized trialStatistical propertiesCluster randomized trialStatistical disadvantageStepped wedge trialIndividual randomizationInfectious disease outbreaksCluster randomized designEvaluation of interventionsEvaluate various designsTrial designDetect intervention effectsWedge designRandomized controlled trialsIntervention effectsEffect estimatesControlled trialsParallel-armEpidemic settingsLogistical factorsAdequate powerInfectious disease incidenceRandomized trials