Public Health Impacts of Vaccines for COVID-19 and Beyond: Opportunities to Overcome Technical and Regulatory Barriers for Randomized Trials.
Kennedy-Shaffer L. Public Health Impacts of Vaccines for COVID-19 and Beyond: Opportunities to Overcome Technical and Regulatory Barriers for Randomized Trials. American Journal Of Public Health 2023, 113: 778-785. PMID: 37104734, PMCID: PMC10262256, DOI: 10.2105/ajph.2023.307302.Peer-Reviewed Original ResearchConceptsPublic health impactCOVID-19 pandemicPopulation healthEvidence baseCOVID-19Health impactsInfectious disease outbreaksCommunity levelRandomized trialsIndividual levelRegulatory barriersPivotal trialsClinical benefitTrialsClinical trialsVaccine trialsPrevent infectionStrategic deploymentVaccineHealthEstimating Vaccine Efficacy Against Transmission via Effect on Viral Load
Kennedy-Shaffer L, Kahn R, Lipsitch M. Estimating Vaccine Efficacy Against Transmission via Effect on Viral Load. Epidemiology 2021, 32: 820-828. PMID: 34469363, PMCID: PMC8478108, DOI: 10.1097/ede.0000000000001415.Peer-Reviewed Original ResearchConceptsViral load measurementsVaccine efficacyViral loadMeasure of vaccine efficacyRandomized controlled trialsEstimates of vaccine efficacyVirological testingAsymptomatic infectionVaccine effectivenessSevere diseaseControlled trialsViral variantsSARS-CoV-2Estimate efficacyEfficacySARS-CoV-2 pandemicVaccineLoad measurementsInfectionVirus transmission