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Lawrence Young, MD

Professor of Medicine (Cardiology) and of Cellular And Molecular Physiology
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About

Titles

Professor of Medicine (Cardiology) and of Cellular And Molecular Physiology

Appointments

Education & Training

Fellow
Yale School of Medicine (1986)
Resident
Yale-New Haven Hospital (1983)
MD
Yale University (1980)
AB
Brown University, Biochemistry (1976)

Research

Overview

Our laboratory is studying the cellular and molecular mechanisms responsible for the metabolic adaptation to the hypoxic stress associated with myocardial ischemia, recently focusing on the AMP-activated protein kinase (AMPK) signaling pathway. AMPK has emerged as a key regulator of glucose transporter (GLUT4) translocation, cellular metabolism, ion channel activity, and cell survival and apoptosis in the heart.

Combining physiologic models of ischemia with cellular and molecular techniques, we are interested in the cardio-protective action of AMPK in the heart, the upstream mechanisms of AMPK activation and its downstream interaction with other signaling pathways, as well as the discovery of novel AMPK targets. The use of transgenic mouse models allows us to dissect the role of AMPK and other signaling pathways in the intact perfused heart and in vivo. The goal of this research is to develop novel strategies to protect the heart against injury during myocardial ischemia.

  • Stress signaling pathways is the heart.
  • Alterations in metabolism in cardiac disease.
  • AMPK as a target for protecting the heart against ischemic injury.
  • LKB1 regulation of metabolic signaling and cardic growth.
  • Cardiac-derived autocrine-paracrine secreted proteins in the regulation of cardiac signaling pathways.
  • Insulin resistance and diabetes in cardiovascular disease.

Medical Subject Headings (MeSH)

AMP-Activated Protein Kinases; Apoptosis; Cell Survival; Diabetes Mellitus; Glucose Transporter Type 4; Insulin Resistance; Myocardial Ischemia

Research at a Glance

Yale Co-Authors

Frequent collaborators of Lawrence Young's published research.

Publications

2024

2023

2022

Academic Achievements & Community Involvement

  • activity

    J Mol Cell Cardiology

  • activity

    Yale NIH Diabetes Research Center

  • activity

    Metabolic Stress and Atrial Fibrillation

  • activity

    Metabolic stress and the heart: From ischemia to arrhythmia

  • honor

    Best Doctors in America (Cardiology)

Clinical Care

Overview

Lawrence H. Young, MD, is a cardiologist who treats patients suffering from heart conditions, both complex and common. With more than 30 years of experience, Dr. Young also specializes in diagnosing and treating patients with a rare genetic disease called hereditary hemorrhagic telangiectasia (HHT). "Yale is probably the world's leader in understanding and treating patients with HHT," Dr. Young says. HHT is a rare genetic disorder that causes abnormal blood vessel growth and heart failure.

As an intern, Dr. Young spent time treating cardiac patients in the cardiac intensive care unit and "decided then and there I wanted to be a cardiologist," he says. "I enjoy taking care of acutely ill patients, but I also enjoy seeing patients over time and helping them to stay healthy."

At the Yale School of Medicine, Dr. Young is a professor of medicine. He leads an active research group, investigating the intersection of heart health and diabetes.

Clinical Specialties

Cardiovascular Medicine

Fact Sheets

Board Certifications

  • Cardiovascular Disease

    Certification Organization
    AB of Internal Medicine
    Original Certification Date
    1985
  • Internal Medicine

    Certification Organization
    AB of Internal Medicine
    Original Certification Date
    1983

Yale Medicine News

Get In Touch

Contacts

Academic Office Number
Secondary Academic Office Number
Appointment Number
Clinic Fax Number
Mailing Address

Cardiovascular Medicine

PO Box 208056, 333 Cedar Street

New Haven, CT 06520-8056

United States

Administrative Support

Locations

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