2022
Hippocampal recording via the RNS system reveals marked ipsilateral activation of epileptiform activity during Wada testing
Quraishi IH, Brown FC, Johnson MH, Hirsch LJ. Hippocampal recording via the RNS system reveals marked ipsilateral activation of epileptiform activity during Wada testing. Epilepsy & Behavior 2022, 134: 108854. PMID: 35905518, DOI: 10.1016/j.yebeh.2022.108854.Peer-Reviewed Original ResearchMeSH KeywordsElectroencephalographyEpilepsy, Temporal LobeFunctional LateralityHippocampusHumansMethohexitalSeizuresConceptsResponsive neurostimulation systemWada testingEpileptiform activityElicitation of seizuresTemporal lobe resectionInternal carotid arteryMedial temporal structuresHippocampal vasculatureIpsilateral activationLobe resectionPosterior circulationElectrographic seizuresTemporal lobectomyElectrographic changesIntractable epilepsyClinical correlatesWada testCarotid arteryHippocampal spikesNegative findingsNeurostimulation systemHippocampal EEGHippocampal activityPatientsTransient increase
2021
Patient‐detectable responsive neurostimulation as a seizure warning system
Quraishi IH, Hirsch LJ. Patient‐detectable responsive neurostimulation as a seizure warning system. Epilepsia 2021, 62: e110-e116. PMID: 34018182, PMCID: PMC8629031, DOI: 10.1111/epi.16933.Peer-Reviewed Original ResearchConceptsResponsive neurostimulation systemFocal impaired awareness seizuresProportion of patientsQuality of lifeSeizure warningTolerable symptomsClinical seizuresLatter therapySelect patientsAwareness seizuresEpileptiform activityEarly recognitionResponsive neurostimulationEpileptiform patternsCognitive impairmentPatientsNeurostimulation systemSymptomsSeizuresTherapyTreatment of clustersStimulationSeizure warning systemSeizure recognitionEpilepsy
2019
Treatment of drug-resistant epilepsy in patients with periventricular nodular heterotopia using RNS® System: Efficacy and description of chronic electrophysiological recordings
Nune G, Arcot Desai S, Razavi B, Agostini MA, Bergey GK, Herekar AA, Hirsch LJ, Lee RW, Rutecki PA, Srinivasan S, Van Ness PC, Tcheng TK, Morrell MJ. Treatment of drug-resistant epilepsy in patients with periventricular nodular heterotopia using RNS® System: Efficacy and description of chronic electrophysiological recordings. Clinical Neurophysiology 2019, 130: 1196-1207. PMID: 31163364, DOI: 10.1016/j.clinph.2019.04.706.Peer-Reviewed Original ResearchConceptsPeriventricular nodular heterotopiaClinical seizure frequencySeizure frequencySeizure rateNodular heterotopiaDirect brain-responsive neurostimulationBrain-responsive neurostimulationDrug-resistant epilepsyEffective treatment optionSeizure-onset patternsSeizure propagation patternsChronic electrophysiological recordingsSeizure reductionClinical seizuresSuch patientsElectrographic seizuresPattern of spreadIntractable seizuresTreatment optionsEpileptogenic networksSeizure generationOnset typeMean reductionLead locationPatients
2015
Lateralization of mesial temporal lobe epilepsy with chronic ambulatory electrocorticography
King-Stephens D, Mirro E, Weber PB, Laxer KD, Van Ness PC, Salanova V, Spencer DC, Heck CN, Goldman A, Jobst B, Shields DC, Bergey GK, Eisenschenk S, Worrell GA, Rossi MA, Gross RE, Cole AJ, Sperling MR, Nair DR, Gwinn RP, Park YD, Rutecki PA, Fountain NB, Wharen RE, Hirsch LJ, Miller IO, Barkley GL, Edwards JC, Geller EB, Berg MJ, Sadler TL, Sun FT, Morrell MJ. Lateralization of mesial temporal lobe epilepsy with chronic ambulatory electrocorticography. Epilepsia 2015, 56: 959-967. PMID: 25988840, PMCID: PMC4676303, DOI: 10.1111/epi.13010.Peer-Reviewed Original ResearchConceptsMesial temporal lobe epilepsyChronic ambulatory electrocorticographyElectrographic seizuresTemporal lobe epilepsyMTL epilepsySeizure lateralizationLobe epilepsyTreatment decisionsMTL seizuresInpatient video-electroencephalography (EEG) monitoringIctal ECoG activityInpatient video-EEG monitoringVideo-electroencephalography monitoringVideo-EEG monitoringIntractable epilepsySeizure focusECoG activityLarge cohortAmbulatory settingResponsive neurostimulationPatientsSeizuresEpilepsyIntracranial electrodesECoG
2004
“Tectonic” hippocampal malformations in patients with temporal lobe epilepsy
Sloviter RS, Kudrimoti HS, Laxer KD, Barbaro NM, Chan S, Hirsch LJ, Goodman RR, Pedley TA. “Tectonic” hippocampal malformations in patients with temporal lobe epilepsy. Epilepsy Research 2004, 59: 123-153. PMID: 15246116, DOI: 10.1016/j.eplepsyres.2004.04.001.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultChildChild, PreschoolEpilepsy, Temporal LobeFemaleHippocampusHumansMaleMiddle AgedConceptsTemporal lobe epilepsyDentate gyrusHippocampal sclerosisFebrile seizuresLobe epilepsyEarly febrile seizuresTypical hippocampal sclerosisNeuronal marker NeuN.Subgroup of patientsAntecedent febrile seizuresTemporal lobe structuresMinor cell lossSubsequent epilepsyNeuronal lossSurgical treatmentHippocampal atrophySynaptic markersHippocampal anomaliesRetrospective analysisEpilepsy patientsHippocampal malformationsPatientsCell lossHippocampusConventional imaging methods