2021
Neuromodulation in epilepsy: state-of-the-art approved therapies
Ryvlin P, Rheims S, Hirsch LJ, Sokolov A, Jehi L. Neuromodulation in epilepsy: state-of-the-art approved therapies. The Lancet Neurology 2021, 20: 1038-1047. PMID: 34710360, DOI: 10.1016/s1474-4422(21)00300-8.Peer-Reviewed Original ResearchConceptsVagus nerve stimulationANT-DBSAdverse eventsNeuromodulation therapiesResponsive neurostimulationCurative surgical treatmentFrequent adverse eventsRefractory focal epilepsyHigh-level evidenceDeep brain stimulationForms of neuromodulationClosed-loop therapyAntiepileptic treatmentSeizure frequencySurgical treatmentNerve stimulationIntracranial hemorrhageIntractable seizuresEpileptogenic zoneFocal epilepsyAnterior nucleusLong-term reductionBrain stimulationTherapyImplant sites
2014
The consequences of refractory epilepsy and its treatment
Laxer KD, Trinka E, Hirsch LJ, Cendes F, Langfitt J, Delanty N, Resnick T, Benbadis SR. The consequences of refractory epilepsy and its treatment. Epilepsy & Behavior 2014, 37: 59-70. PMID: 24980390, DOI: 10.1016/j.yebeh.2014.05.031.Peer-Reviewed Original ResearchConceptsRefractory epilepsyPractical clinical recommendationsNew drug therapiesPersistent seizuresOngoing seizuresSurgical treatmentAntiepileptic drugsUncontrolled seizuresDrug therapyEpilepsy expertsEpileptogenic processPsychosocial burdenClinical recommendationsNeuropsychiatric impairmentNervous systemEpilepsyProgressive epilepsySeizuresDiagnostic proceduresVocational consequencesAdverse effectsPatientsRiskTreatmentBurden
2004
“Tectonic” hippocampal malformations in patients with temporal lobe epilepsy
Sloviter RS, Kudrimoti HS, Laxer KD, Barbaro NM, Chan S, Hirsch LJ, Goodman RR, Pedley TA. “Tectonic” hippocampal malformations in patients with temporal lobe epilepsy. Epilepsy Research 2004, 59: 123-153. PMID: 15246116, DOI: 10.1016/j.eplepsyres.2004.04.001.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyDentate gyrusHippocampal sclerosisFebrile seizuresLobe epilepsyEarly febrile seizuresTypical hippocampal sclerosisNeuronal marker NeuN.Subgroup of patientsAntecedent febrile seizuresTemporal lobe structuresMinor cell lossSubsequent epilepsyNeuronal lossSurgical treatmentHippocampal atrophySynaptic markersHippocampal anomaliesRetrospective analysisEpilepsy patientsHippocampal malformationsPatientsCell lossHippocampusConventional imaging methods