2022
Prevalence and Predictors of Seizure Clusters in Pediatric Patients With Epilepsy: The Harvard-Yale Pediatric Seizure Cluster Study
Jafarpour S, Fong MWK, Detyniecki K, Khan A, Jackson-Shaheed E, Wang X, Lewis S, Benjamin R, Gaínza-Lein M, O'Bryan J, Hirsch LJ, Loddenkemper T. Prevalence and Predictors of Seizure Clusters in Pediatric Patients With Epilepsy: The Harvard-Yale Pediatric Seizure Cluster Study. Pediatric Neurology 2022, 137: 22-29. PMID: 36208614, DOI: 10.1016/j.pediatrneurol.2022.08.014.Peer-Reviewed Original ResearchConceptsSeizure clustersRescue medicationPediatric patientsSeizure frequencyIntermediate-risk groupEmergency department visitsHigh seizure frequencyTwo-center studyEmergency room visitsHigh-risk groupActive seizuresMore seizuresDepartment visitsStatus epilepticusRoom visitsAdverse outcomesEpilepsy severityIsolated seizureSeizure diariesRisk factorsRisk groupsGreater oddsPatientsMedicationsSeizuresUpdated review of rescue treatments for seizure clusters and prolonged seizures
Blond BN, Hirsch LJ. Updated review of rescue treatments for seizure clusters and prolonged seizures. Expert Review Of Neurotherapeutics 2022, 22: 567-577. PMID: 35862983, DOI: 10.1080/14737175.2022.2105207.Peer-Reviewed Original ResearchConceptsRescue medicationProlonged seizuresSeizure clustersTreatment of epilepsyQuality of lifeOngoing seizuresFurther seizuresRefractory seizuresRecurrent seizuresRescue treatmentSeizure activitySeizure episodesIntranasal formulationRisk factorsClinical careEffective treatmentMedicationsSeizuresEpilepsyMorbidityClinical opportunitiesAdverse effectsTreatmentReviewEpidemiology
2021
Anti-seizure medications and efficacy against focal to bilateral tonic-clonic seizures: A systematic review with relevance for SUDEP prevention
Cutillo G, Tolba H, Hirsch LJ. Anti-seizure medications and efficacy against focal to bilateral tonic-clonic seizures: A systematic review with relevance for SUDEP prevention. Epilepsy & Behavior 2021, 117: 107815. PMID: 33640562, DOI: 10.1016/j.yebeh.2021.107815.Peer-Reviewed Original ResearchConceptsAnti-seizure medicationsBilateral tonic-clonic seizuresTonic-clonic seizuresSUDEP preventionSystematic reviewPlacebo-controlled clinical trialFocal impaired awareness seizuresRisk of SUDEPSudden unexpected deathMajor risk factorAwareness seizuresRisk factorsClinical trialsUnexpected deathFBTCSHigh dosesSeizuresStrong associationSUDEPPreventionMedicationsTiagabineEfficacyLamotrigineBrivaracetam
2020
Seizure clusters, rescue treatments, seizure action plans: Unmet needs and emerging formulations
Gidal B, Klein P, Hirsch LJ. Seizure clusters, rescue treatments, seizure action plans: Unmet needs and emerging formulations. Epilepsy & Behavior 2020, 112: 107391. PMID: 32898744, DOI: 10.1016/j.yebeh.2020.107391.Peer-Reviewed Original ResearchMisperceptions on the chance of seizure freedom with antiseizure medications after two failed trials
Blond BN, Hirsch LJ, Mattson RH. Misperceptions on the chance of seizure freedom with antiseizure medications after two failed trials. Epilepsia 2020, 61: 1789-1790. PMID: 32640071, DOI: 10.1111/epi.16594.Peer-Reviewed Original ResearchChoosing Anticonvulsant Medications to Manage Status Epilepticus
Wu K, Hirsch LJ, Babl FE, Josephson SA. Choosing Anticonvulsant Medications to Manage Status Epilepticus. New England Journal Of Medicine 2020, 382: 2569-2572. PMID: 32579819, DOI: 10.1056/nejmclde2004317.Peer-Reviewed Original ResearchNeuropsychiatric Aspects of Epilepsy
Tolchin B, Hirsch LJ, LaFrance WC. Neuropsychiatric Aspects of Epilepsy. Psychiatric Clinics Of North America 2020, 43: 275-290. PMID: 32439022, DOI: 10.1016/j.psc.2020.02.002.Peer-Reviewed Original ResearchConceptsNeuropsychiatric disordersNeuropsychiatric aspectsCertain neuropsychiatric disordersAntiseizure medicationsClinical outcomesTherapeutic optionsEpidemiologic studiesEpilepsyMultidisciplinary teamNeuropsychiatric impactDisordersBidirectional relationshipTreatmentClose collaborationComorbiditiesMedicationsPathophysiologySocial factorsDiagnosis
2019
Treatment of Patients With Psychogenic Nonepileptic Attacks
Tolchin B, Martino S, Hirsch LJ. Treatment of Patients With Psychogenic Nonepileptic Attacks. JAMA 2019, 321: 1967-1968. PMID: 31026015, DOI: 10.1001/jama.2019.3520.Peer-Reviewed Original ResearchHighlights From the Annual Meeting of the American Epilepsy Society 2018
Jobst BC, Ben-Menachem E, Chapman KE, Fu A, Goldman A, Hirsch LJ, Jehi LE, Kossoff EH, Plueger M, Rho JM, Schevon CA, Shinnar S, Sperling MR, Simeone TA, Wagner JL, Lado F. Highlights From the Annual Meeting of the American Epilepsy Society 2018. Epilepsy Currents 2019, 19: 152-158. PMID: 31050308, PMCID: PMC6610384, DOI: 10.1177/1535759719844486.Peer-Reviewed Original ResearchEpilepsy professionalsNovel antiseizure medicationsFebrile status epilepticusAspects of epilepsyLives of patientsAntiseizure medicationsStatus epilepticusPathophysiologic relationshipClinical practiceEpilepsyLater lifeEducational symposiumSeizuresSociety meetingsStimulation treatmentAnnual MeetingSevere consequencesEpilepticusMedicationsPatientsProfessionalsHospitalSleepNew onset refractory status epilepticus research: What is on the horizon?
Gofton TE, Gaspard N, Hocker SE, Loddenkemper T, Hirsch LJ. New onset refractory status epilepticus research: What is on the horizon? Neurology 2019, 92: 802-810. PMID: 30894443, DOI: 10.1212/wnl.0000000000007322.Peer-Reviewed Original ResearchConceptsNew-onset refractory status epilepticusRefractory status epilepticusStatus epilepticusFebrile infection-related epilepsy syndromeMore rescue medicationsRescue medicationNew onsetActive epilepsyClinical featuresClinical presentationEpilepsy syndromesMetabolic causesNeurologic disordersPediatric EvaluationSpecific diagnosisAge groupsEpilepticusFamily supportFuture collaborative researchMedicationsPatientsFeverEpilepsyPathophysiologySyndrome
2018
Seizure cluster: Definition, prevalence, consequences, and management
Jafarpour S, Hirsch LJ, Gaínza-Lein M, Kellinghaus C, Detyniecki K. Seizure cluster: Definition, prevalence, consequences, and management. Seizure 2018, 68: 9-15. PMID: 29871784, DOI: 10.1016/j.seizure.2018.05.013.Peer-Reviewed Original ResearchConceptsRescue medicationSeizure clustersAcute managementEpilepsy patientsRectal diazepam gelTertiary epilepsy centerEmergency room visitsHealth care utilizationRefractory epilepsy patientsQuality of lifeAcute seizuresBuccal midazolamClinical characteristicsMost patientsCare utilizationEpilepsy centersRoom visitsRisk factorsOnly FDAHigh riskMedicationsPatientsSeizuresPrevalenceCaregivers
2015
Rates and predictors of patient-reported cognitive side effects of antiepileptic drugs: An extended follow-up
Javed A, Cohen B, Detyniecki K, Hirsch LJ, Legge A, Chen B, Bazil C, Kato K, Buchsbaum R, Choi H. Rates and predictors of patient-reported cognitive side effects of antiepileptic drugs: An extended follow-up. Seizure 2015, 29: 34-40. PMID: 26076842, DOI: 10.1016/j.seizure.2015.03.013.Peer-Reviewed Original ResearchConceptsCognitive side effectsAntiepileptic medicationsSide effectsMultiple logistic regression analysisMore antiepileptic medicationsLogistic regression analysisQuality of lifeIndependent predictorsRetrospective studyAntiepileptic drugsAdult outpatientsMedical recordsAdverse effectsIntellectual disabilityPolytherapyLevetiracetamGabapentinRegression analysisLamotrigineLower ratesPredictorsCarbamazepineMonotherapyMedicationsRelative frequency
2013
Intracranially recorded interictal spikes: Relation to seizure onset area and effect of medication and time of day
Goncharova II, Spencer SS, Duckrow RB, Hirsch LJ, Spencer DD, Zaveri HP. Intracranially recorded interictal spikes: Relation to seizure onset area and effect of medication and time of day. Clinical Neurophysiology 2013, 124: 2119-2128. PMID: 23856192, DOI: 10.1016/j.clinph.2013.05.027.Peer-Reviewed Original ResearchStatus Epilepticus
Hirsch LJ, Gaspard N. Status Epilepticus. CONTINUUM Lifelong Learning In Neurology 2013, 19: 767-794. PMID: 23739110, PMCID: PMC10564021, DOI: 10.1212/01.con.0000431395.16229.5a.Peer-Reviewed Original ResearchConceptsStatus epilepticusRapid Anticonvulsant MedicationRefractory status epilepticusNeurocritical Care SocietyArrival TrialAnticonvulsant medicationMedical complicationsNonconvulsive seizuresTreatment protocolEpilepticusCurrent evidenceAnesthetic drugsAvailable guidelinesRapid treatmentSuccessful managementEarly considerationTreatmentDiagnosisRecent findingsGuidelinesMedicationsComplicationsOvertreatmentSeizuresManagement
2008
Cross-sensitivity of skin rashes with antiepileptic drug use
Hirsch LJ, Arif H, Nahm EA, Buchsbaum R, Resor SR, Bazil CW. Cross-sensitivity of skin rashes with antiepileptic drug use. Neurology 2008, 71: 1527-1534. PMID: 18981374, DOI: 10.1212/01.wnl.0000334295.50403.4c.Peer-Reviewed Original ResearchConceptsRate of rashAntiepileptic drugsValproic acidSpecific antiepileptic drugsAntiepileptic drug useMore antiepileptic drugsCertain antiepileptic drugsAED selectionSkin rashIndividual patientsRashPatientsLamotrigineOxcarbazepineDrug usePhenytoinCarbamazepineLevetiracetamZonisamideGabapentinTiagabineVigabatrinClobazamDrugsMedicationsLevitating Levetiracetam's Status for Status Epilepticus
Hirsch LJ. Levitating Levetiracetam's Status for Status Epilepticus. Epilepsy Currents 2008, 8: 125-126. PMID: 18852834, PMCID: PMC2566612, DOI: 10.1111/j.1535-7511.2008.00266.x.Peer-Reviewed Original ResearchTreatment of SEStatus epilepticusBenzodiazepine-refractory status epilepticusRefractory focal status epilepticusNew anticonvulsive drugsRefractory status epilepticusFocal status epilepticusSevere side effectsCombination of drugsIntravenous levetiracetamAntiepileptic medicationsOral medicationsAnticonvulsive drugsIntravenous formulationSide effectsPatientsEpileptic seizuresEpilepticusMedicationsLevetiracetamTreatmentDrugsEpisodesStatusSeizuresUpdates in the Management of Seizures and Status Epilepticus in Critically Ill Patients
Khaled K, Hirsch LJ. Updates in the Management of Seizures and Status Epilepticus in Critically Ill Patients. Neurologic Clinics 2008, 26: 385-408. PMID: 18514819, DOI: 10.1016/j.ncl.2008.03.017.Peer-Reviewed Original ResearchConceptsStatus epilepticusIll patientsManagement of seizuresOrgan transplant patientsRenal failure patientsReversal of factorsFirstline treatmentSystemic sequelaeTransplant patientsAntiseizure medicationsFailure patientsSeizure thresholdEarly recognitionElectroencephalogram monitoringMaximal responseSpecific treatmentPatientsMetabolic imbalanceEpilepticusMedicationsSeizuresTreatmentSequelaeFeverHypoxia
2006
In Nonconvulsive Status Epilepticus (NCSE), Treat to Burst‐Suppression: Pro and Con
Jordan KG, Hirsch LJ. In Nonconvulsive Status Epilepticus (NCSE), Treat to Burst‐Suppression: Pro and Con. Epilepsia 2006, 47: 41-45. PMID: 17044825, DOI: 10.1111/j.1528-1167.2006.00659.x.Peer-Reviewed Original ResearchConceptsNonconvulsive status epilepticusNonconvulsive seizuresRefractory nonconvulsive status epilepticusPermanent neuronal injuryAcute brain injuryIntensive care interventionsHigh mortality rateNeuronal injuryStatus epilepticusIatrogenic complicationsBrain damageBrain injuryCare interventionsDr. HirschBurst suppressionMortality rateExpert managementSeizuresInjuryMost casesEpilepticusMedicationsComplicationsDr. JordanAdvances in the Management of Seizures and Status Epilepticus in Critically Ill Patients
Khaled K, Hirsch LJ. Advances in the Management of Seizures and Status Epilepticus in Critically Ill Patients. Critical Care Clinics 2006, 22: 637-659. PMID: 17239748, DOI: 10.1016/j.ccc.2006.06.004.Peer-Reviewed Original ResearchConceptsStatus epilepticusIll patientsAnti-seizure medicationsFirst-line treatmentManagement of seizuresOrgan transplant patientsRenal failure patientsReversal of factorsSystemic sequelaeTransplant patientsFailure patientsSeizure thresholdEarly recognitionElectroencephalogram monitoringMaximal responseSpecific treatmentPatientsMetabolic imbalanceEpilepticusMedicationsSeizuresTreatmentSequelaeFeverHypoxia