2020
When and How to Treat Status Epilepticus: The Tortoise or the Hare?
Fong MWK, Hirsch LJ. When and How to Treat Status Epilepticus: The Tortoise or the Hare? Journal Of Clinical Neurophysiology 2020, 37: 393-398. PMID: 32890060, DOI: 10.1097/wnp.0000000000000656.Peer-Reviewed Original ResearchConceptsType of SEStatus epilepticusTreatment of SECessation of seizuresCurrent treatment guidelinesConvulsive status epilepticusTreatment guidelinesFull dosesNeuronal responsesVariety of subtypesPromising future approachUnnecessary harmEpilepticusPatientsTherapyTreatmentFuture approachesCollective term
2016
Treatment of Convulsive Status Epilepticus
Grover EH, Nazzal Y, Hirsch LJ. Treatment of Convulsive Status Epilepticus. Current Treatment Options In Neurology 2016, 18: 11. PMID: 26920416, DOI: 10.1007/s11940-016-0394-5.Peer-Reviewed Original ResearchAnti-epileptic drugsNon-convulsive SEStatus epilepticusRefractory SEPreferred second-line agentNon-convulsive status epilepticusAnti-seizure medicationsHome rescue medicationThird-line agentsAcute side effectsConvulsive status epilepticusFirst-line treatmentNon-convulsive seizuresSecond-line agentsLower health care costsEmergency room visitsImmuno-modulatory agentsRecovery of consciousnessUse of benzodiazepinesQuality of lifeHealth care costsConsecutive seizuresParaneoplastic etiologyRescue medicationBuccal midazolam
2009
Continuous Electroencephalogram Monitoring in the Intensive Care Unit
Friedman D, Claassen J, Hirsch LJ. Continuous Electroencephalogram Monitoring in the Intensive Care Unit. Anesthesia & Analgesia 2009, 109: 506-523. PMID: 19608827, DOI: 10.1213/ane.0b013e3181a9d8b5.Peer-Reviewed Original ResearchConceptsContinuous EEG monitoringNonconvulsive seizuresIll patientsIntracranial pressureBrain functionContinuous electroencephalogram monitoringConvulsive status epilepticusIntensive care unitMajority of seizuresMultimodality brain monitoringPharmacological comaNeurologic outcomeNeurologic statusNeuronal injuryBrain ischemiaStatus epilepticusCare unitSecondary injurySubarachnoid hemorrhageCEEG monitoringClinical examinationElectroencephalogram monitoringSystemic abnormalitiesIntracranial EEG recordingsHigh risk
2007
Generalized convulsive status epilepticus after nontraumatic subarachnoid hemorrhage: the nationwide inpatient sample.
Claassen J, Bateman BT, Willey JZ, Inati S, Hirsch LJ, Mayer SA, Sacco RL, Schumacher HC. Generalized convulsive status epilepticus after nontraumatic subarachnoid hemorrhage: the nationwide inpatient sample. Neurosurgery 2007, 61: 60-4; discussion 64-5. PMID: 17621019, DOI: 10.1227/01.neu.0000279724.05898.e7.Peer-Reviewed Original ResearchConceptsNontraumatic subarachnoid hemorrhageConvulsive status epilepticusNationwide Inpatient SampleSubarachnoid hemorrhageRenal diseaseStatus epilepticusInpatient SampleNonfederal United States hospitalsGeneralized convulsive status epilepticusDatabase of admissionsDuration of hospitalizationMultivariate logistic regressionUnited States hospitalsHospital mortalityHospital stayAdult patientsYounger patientsIndependent predictorsPatient mortalityEmergency departmentPatientsLinear regression analysisState HospitalNeurosurgical proceduresLogistic regressionThe Status of Intravenous Valproate for Status
Hirsch LJ. The Status of Intravenous Valproate for Status. Epilepsy Currents 2007, 7: 96-98. PMID: 17694164, PMCID: PMC1941916, DOI: 10.1111/j.1535-7511.2007.00185.x.Peer-Reviewed Original ResearchConvulsive status epilepticus after ischemic stroke and intracerebral hemorrhage: frequency, predictors, and impact on outcome in a large administrative dataset
Bateman BT, Claassen J, Willey JZ, Hirsch LJ, Mayer SA, Sacco RL, Schumacher HC. Convulsive status epilepticus after ischemic stroke and intracerebral hemorrhage: frequency, predictors, and impact on outcome in a large administrative dataset. Neurocritical Care 2007, 7: 187-193. PMID: 17503112, DOI: 10.1007/s12028-007-0056-2.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeConvulsive status epilepticusIntracerebral hemorrhageIschemic strokeICH cohortRenal diseaseStatus epilepticusSodium imbalanceAlcohol abuseAIS cohortDiagnosis of AISAppropriate ICD-9-CM codesICD-9-CM codesHigh rateNationwide Inpatient SampleAfrican American raceMultivariate logistic regressionLower ratesResultsThe cohortHemorrhagic transformationDiabetes mellitusHemorrhagic strokeIndependent predictorsSerious complicationsHispanic race
2006
Nonconvulsive Status Epilepticus in Children: Clinical and EEG Characteristics
Tay SK, Hirsch LJ, Leary L, Jette N, Wittman J, Akman CI. Nonconvulsive Status Epilepticus in Children: Clinical and EEG Characteristics. Epilepsia 2006, 47: 1504-1509. PMID: 16981867, DOI: 10.1111/j.1528-1167.2006.00623.x.Peer-Reviewed Original ResearchConceptsNonconvulsive status epilepticusConvulsive status epilepticusPeriodic lateralized epileptiform dischargesPediatric patientsStatus epilepticusEpileptiform dischargesDiagnosis of NCSEAcute hypoxic-ischemic injuryAntiepileptic drug regimenAcute medical illnessHypoxic-ischemic injuryComprehensive Epilepsy CenterContinuous electroencephalographic monitoringPeriodic epileptiform dischargesHeterogeneous clinical conditionYears of ageFrequent etiologyNeurological outcomeChart reviewDrug regimenAcute infectionAcute settingConvulsive seizuresPrompt recognitionRefractory epilepsy
2003
Treatment of status epilepticus: a survey of neurologists
Claassen J, Hirsch LJ, Mayer SA. Treatment of status epilepticus: a survey of neurologists. Journal Of The Neurological Sciences 2003, 211: 37-41. PMID: 12767495, DOI: 10.1016/s0022-510x(03)00036-4.Peer-Reviewed Original ResearchConceptsAntiepileptic drugsStatus epilepticusCurrent treatment preferencesElimination of seizuresFourth-line treatmentTreatment of RSESecond-line therapyConvulsive status epilepticusFirst-line therapyNew antiepileptic drugsTraditional treatment paradigmSurvey of neurologistsIntravenous lorazepamSE refractoryTitration goalsMulticenter trialTreatment paradigmTreatment preferencesCritical careValproic acidBurst suppressionAmerican AcademyEpilepticusEpilepsy SectionTherapy
2002
The current state of treatment of status epilepticus
Hirsch LJ, Claassen J. The current state of treatment of status epilepticus. Current Neurology And Neuroscience Reports 2002, 2: 345-356. PMID: 12044254, DOI: 10.1007/s11910-002-0010-9.Peer-Reviewed Original ResearchConceptsStatus epilepticusRefractory status epilepticusConvulsive status epilepticusNonconvulsive status epilepticusCertain EEG patternsAmbulatory patientsConfusional stateIll patientsClinical trialsEarly treatmentAnesthetic agentsEpilepticusClinical careEEG patternsPatientsTreatmentElectroencephalogram (EEG) recordingsMidazolamPropofolDiagnosis