2021
Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection
Oliva Chávez AS, Wang X, Marnin L, Archer NK, Hammond HL, Carroll EEM, Shaw DK, Tully BG, Buskirk AD, Ford SL, Butler LR, Shahi P, Morozova K, Clement CC, Lawres L, Neal A, Mamoun CB, Mason KL, Hobbs BE, Scoles GA, Barry EM, Sonenshine DE, Pal U, Valenzuela JG, Sztein MB, Pasetti MF, Levin ML, Kotsyfakis M, Jay SM, Huntley JF, Miller LS, Santambrogio L, Pedra JHF. Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection. Nature Communications 2021, 12: 3696. PMID: 34140472, PMCID: PMC8211691, DOI: 10.1038/s41467-021-23900-8.Peer-Reviewed Original ResearchMeSH KeywordsAnaplasma phagocytophilumAnimalsArthropodsBacterial InfectionsCell LineDermacentorExtracellular VesiclesFrancisella tularensisGene OntologyHumansInflammationIntravital MicroscopyIxodesMaleMiceMice, Inbred C57BLMice, KnockoutMicroscopy, Electron, TransmissionProteomicsR-SNARE ProteinsSkinTandem Mass SpectrometryTicksT-LymphocytesVesicle-Associated Membrane Protein 2ConceptsExtracellular vesiclesBiology of arthropodsSynaptobrevin 2Pathogen Francisella tularensisMammalian hostsArthropodsVector feedingDistinct outcomesPathogen transmissionVesiclesMicrobial spreadingVector-borne diseasesFrancisella tularensisBacterial infectionsTicks DermacentorIxodes scapularisAnaplasma phagocytophilumBiologySkin immunitySnareDendritic epidermal T cellsPathogensHostT cellsTularensis
2016
Genome-wide diversity and gene expression profiling of Babesia microti isolates identify polymorphic genes that mediate host-pathogen interactions
Silva JC, Cornillot E, McCracken C, Usmani-Brown S, Dwivedi A, Ifeonu OO, Crabtree J, Gotia HT, Virji AZ, Reynes C, Colinge J, Kumar V, Lawres L, Pazzi JE, Pablo JV, Hung C, Brancato J, Kumari P, Orvis J, Tretina K, Chibucos M, Ott S, Sadzewicz L, Sengamalay N, Shetty AC, Su Q, Tallon L, Fraser CM, Frutos R, Molina DM, Krause PJ, Ben Mamoun C. Genome-wide diversity and gene expression profiling of Babesia microti isolates identify polymorphic genes that mediate host-pathogen interactions. Scientific Reports 2016, 6: 35284. PMID: 27752055, PMCID: PMC5082761, DOI: 10.1038/srep35284.Peer-Reviewed Original ResearchConceptsGene expression profilingExpression profilingGenome-wide diversityHost-parasite interactionsHost-pathogen interactionsParasite secretomeParasite evolutionIntraerythrocytic protozoan parasiteGenome compositionGenetic diversityImmuno-proteomic approachSurface proteomeGenetic variationMammalian hostsSmall mammalsSelective pressurePolymorphic genesGenesFirst insightProtozoan parasiteBabesia microtiSecretomeProteome arrayStrong host immune responseHost immune response