2021
Mineralocorticoid Receptor in Smooth Muscle Contributes to Pressure Overload–Induced Heart Failure
Kim S, Biwer L, Moss M, Man J, Aronovitz M, Martin G, Carrillo-Salinas F, Salvador A, Alcaide P, Jaffe I. Mineralocorticoid Receptor in Smooth Muscle Contributes to Pressure Overload–Induced Heart Failure. Circulation Heart Failure 2021, 14: e007279. PMID: 33517669, PMCID: PMC7887087, DOI: 10.1161/circheartfailure.120.007279.Peer-Reviewed Original ResearchConceptsSmooth muscle cellsMR-intact littermatesAdverse cardiac remodelingMineralocorticoid receptorCardiac remodelingSMC-MRAortic constrictionPressure Overload-Induced Heart FailureInhibition of MRRole of MRPressure overload-induced hypertrophyCardiac blood supplyHeart failure hospitalizationCardiac capillary densityCoronary flow reserveTransverse aortic constrictionIntracardiac pressure measurementsOverload-induced hypertrophyFibrotic gene expressionFetal gene expressionFailure hospitalizationExercise capacityExercise testingEjection fractionHeart failure
2012
Protection against L‐NAME‐induced reduction in cardiac output persists even after cessation of angiotensin‐converting enzyme inhibitor treatment
Biwer L, Broderick T, Xu H, Carroll C, Hale T. Protection against L‐NAME‐induced reduction in cardiac output persists even after cessation of angiotensin‐converting enzyme inhibitor treatment. Acta Physiologica 2012, 207: 156-165. PMID: 22834875, DOI: 10.1111/j.1748-1716.2012.02474.x.Peer-Reviewed Original ResearchConceptsL-NAMEMyocardial injuryCardiac functionEnalapril treatmentACE inhibitionCardiac outputL ratsL-NAME-induced reductionNitric oxide synthase inhibitorShort-term angiotensinTransient ACE inhibitionEnzyme inhibitor treatmentHeart failure treatmentCessation of treatmentOxide synthase inhibitorArginine methyl esterEosin-stained sectionsArterial pressureHypertensive ratsCardiac changesCardiac dysfunctionWashout periodCoronary flowMyocardial infarctionFailure treatment