A Novel Dual-Function Nitric Oxide Donor Therapy for Preeclampsia—A Proof-of-Principle Study in a Murine Model
Pintye D, Sziva R, Biwer L, Karreci E, Jacas S, Mastyugin M, Török M, Young B, Jagtap P, Southan G, Jaffe I, Zsengellér Z. A Novel Dual-Function Nitric Oxide Donor Therapy for Preeclampsia—A Proof-of-Principle Study in a Murine Model. Antioxidants 2023, 12: 2036. PMID: 38136156, PMCID: PMC10741224, DOI: 10.3390/antiox12122036.Peer-Reviewed Original ResearchBlood pressureOxidative stressNitric oxide donor therapyPlasma cystatin C.Plasma nitrate levelsHealthy female miceModel of preeclampsiaNitric oxide bioavailabilityEx vivo treatmentPotential therapeutic effectsReduced oxidative stressNovel therapeutic agentsDays of treatmentAnti-angiogenic responseDonor therapyPlacental damageReduced hypertensionHypertensive disordersSubstantial morbidityFetal pathophysiologyResistance vesselsGlomerular endotheliosisPE symptomsVascular disordersFemale miceMineralocorticoid and Estrogen Receptors in Endothelial Cells Coordinately Regulate Microvascular Function in Obese Female Mice
Biwer L, Carvajal B, Lu Q, Man J, Jaffe I. Mineralocorticoid and Estrogen Receptors in Endothelial Cells Coordinately Regulate Microvascular Function in Obese Female Mice. Hypertension 2021, 77: 2117-2126. PMID: 33934622, PMCID: PMC8119365, DOI: 10.1161/hypertensionaha.120.16911.Peer-Reviewed Original Research