2016
Impaired von Willebrand factor adhesion and platelet response in thrombospondin-2 knockout mice
Kristofik N, Calabro NE, Tian W, Meng A, MacLauchlan S, Wang Y, Breuer CK, Tellides G, Niklason LE, Kyriakides TR. Impaired von Willebrand factor adhesion and platelet response in thrombospondin-2 knockout mice. Blood 2016, 128: 1642-1650. PMID: 27471233, PMCID: PMC5034742, DOI: 10.1182/blood-2016-03-702845.Peer-Reviewed Original Research
2014
Mesenchymal stromal cells form vascular tubes when placed in fibrin sealant and accelerate wound healing in vivo
Mendez JJ, Ghaedi M, Sivarapatna A, Dimitrievska S, Shao Z, Osuji CO, Steinbacher DM, Leffell DJ, Niklason LE. Mesenchymal stromal cells form vascular tubes when placed in fibrin sealant and accelerate wound healing in vivo. Biomaterials 2014, 40: 61-71. PMID: 25433608, PMCID: PMC4268422, DOI: 10.1016/j.biomaterials.2014.11.011.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsBiomarkersCollagenDisease Models, AnimalEnzyme-Linked Immunosorbent AssayFemaleFibrin Tissue AdhesiveFibroblast Growth Factor 2Flow CytometryHumansImmunohistochemistryMaleMesenchymal Stem CellsMice, Inbred C57BLMiddle AgedNeovascularization, PhysiologicReal-Time Polymerase Chain ReactionRheologySubcutaneous TissueWound HealingConceptsAdipose-derived mesenchymal stromal cellsMesenchymal stromal cellsGranulation tissueStromal cellsPericyte marker NG2VE-cadherinWound healingPublic health problemMarkers of endotheliumDays of healingSubcutaneous injectionPresence of bFGFFibrin gelAmount of bFGFHAT-MSCsFibrin sealantWound sizeHealth problemsChronic woundsConfocal imaging analysisInsufficient angiogenesis