2013
Human iPS cell–derived alveolar epithelium repopulates lung extracellular matrix
Ghaedi M, Calle EA, Mendez JJ, Gard AL, Balestrini J, Booth A, Bove PF, Gui L, White ES, Niklason LE. Human iPS cell–derived alveolar epithelium repopulates lung extracellular matrix. Journal Of Clinical Investigation 2013, 123: 4950-4962. PMID: 24135142, PMCID: PMC3809786, DOI: 10.1172/jci68793.Peer-Reviewed Original ResearchMeSH KeywordsAlveolar Epithelial CellsAnimalsBiomarkersCell AdhesionCell DifferentiationCell ProliferationExtracellular MatrixHumansInduced Pluripotent Stem CellsMiceMucin-1Pulmonary AlveoliPulmonary Surfactant-Associated Protein BPulmonary Surfactant-Associated Protein CRatsTissue EngineeringTissue ScaffoldsConceptsAlveolar epithelial type IILung tissueInduced pluripotent stem cellsHuman induced pluripotent stem cellsWnt/β-catenin inhibitorAcellular lung matrixHuman adult lungRespiratory epithelial cellsΒ-catenin inhibitorType I cellsLung tissue engineeringLung extracellular matrixLung matrixAlveolar epitheliumPulmonary epitheliumAlveolar cellsAdult lungCell therapySurfactant protein CMucin 1Protein CEpithelial cellsProgenitor cellsI cellsSurfactant protein B
2011
Decellularized tissue-engineered blood vessel as an arterial conduit
Quint C, Kondo Y, Manson RJ, Lawson JH, Dardik A, Niklason LE. Decellularized tissue-engineered blood vessel as an arterial conduit. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 9214-9219. PMID: 21571635, PMCID: PMC3107282, DOI: 10.1073/pnas.1019506108.Peer-Reviewed Original ResearchConceptsTissue-engineered vesselsBiomimetic perfusion systemArterial tissue engineeringTissue-engineered blood vesselsTissue engineering techniquesEndothelial progenitor cellsTissue engineeringRobust extracellular matrixVein graftsBiological vascular graftPorcine carotid arteriesVascular graftsTissue regenerationIntimal hyperplasiaAutologous endothelial progenitor cellsGraft wallProgenitor cellsControl vein graftsSmooth muscle cellsGraft lumenGraft occlusionArterial conduitsImproved patencyCarotid arteryPorcine smooth muscle cells