2024
23. GENOME-WIDE ASSOCIATION STUDIES OF BINGE-EATING BEHAVIOUR AND ANOREXIA NERVOSA YIELD INSIGHTS INTO THE UNIQUE AND SHARED BIOLOGY OF EATING DISORDER PHENOTYPES
Huckins L, Termorshuizen J, Davies H, Lee S, Johnson J, Munn-Chernoff M, Thornton L, Källberg J, Bulik C, Breen G, Coleman J. 23. GENOME-WIDE ASSOCIATION STUDIES OF BINGE-EATING BEHAVIOUR AND ANOREXIA NERVOSA YIELD INSIGHTS INTO THE UNIQUE AND SHARED BIOLOGY OF EATING DISORDER PHENOTYPES. European Neuropsychopharmacology 2024, 87: 60. DOI: 10.1016/j.euroneuro.2024.08.137.Peer-Reviewed Original ResearchGenome-wide association studiesIdentification of novel lociGenome-wide association study meta-analysisGenetic correlationsEating Disorders Working GroupBinge-eating behaviorNovel lociGenome-wideGenomic lociAssociation studiesLociGenetic componentEating disorder phenotypesPhenotypeEarly onset obesityBE phenotypeSevere early onset obesityDisorder phenotypesTrans-diagnosticAN subtypesAN-BPAN-RAN-R.Eating disordersBinge-eating/purgingDissecting the biology of feeding and eating disorders
Huckins L, Brennand K, Bulik C. Dissecting the biology of feeding and eating disorders. Trends In Molecular Medicine 2024, 30: 380-391. PMID: 38431502, DOI: 10.1016/j.molmed.2024.01.009.Peer-Reviewed Original ResearchGenome-wide association studiesVariants to genesGenes to pathwaysSignificant lociFunctional genomicsAssociation studiesGenetic relationshipsIntestinal microbiotaGenetic researchGenomeGenetic correlationsGenesMetabolic contributorsAnorexia nervosaEating disordersPathwayBiologyMetabolic outcomesRisk factorsLociMicrobiotaPhenomicsLethal illnessTraitsFeeding
2022
Using phenotype risk scores to enhance gene discovery for generalized anxiety disorder and posttraumatic stress disorder
Wendt FR, Pathak GA, Deak JD, De Angelis F, Koller D, Cabrera-Mendoza B, Lebovitch DS, Levey DF, Stein MB, Kranzler HR, Koenen KC, Gelernter J, Huckins LM, Polimanti R. Using phenotype risk scores to enhance gene discovery for generalized anxiety disorder and posttraumatic stress disorder. Molecular Psychiatry 2022, 27: 2206-2215. PMID: 35181757, PMCID: PMC9133008, DOI: 10.1038/s41380-022-01469-y.Peer-Reviewed Original Research
2021
Examining Sex-Differentiated Genetic Effects Across Neuropsychiatric and Behavioral Traits
Martin J, Khramtsova E, Goleva S, Blokland G, Traglia M, Walters R, Hübel C, Coleman J, Breen G, Børglum A, Demontis D, Grove J, Werge T, Bralten J, Bulik C, Lee P, Mathews C, Peterson R, Winham S, Wray N, Edenberg H, Guo W, Yao Y, Neale B, Faraone S, Petryshen T, Weiss L, Duncan L, Goldstein J, Smoller J, Stranger B, Davis L, Consortium S, Alda M, Bortolato M, Burton C, Byrne E, Carey C, Erdman L, Huckins L, Mattheisen M, Robinson E, Stahl E. Examining Sex-Differentiated Genetic Effects Across Neuropsychiatric and Behavioral Traits. Biological Psychiatry 2021, 89: 1127-1137. PMID: 33648717, PMCID: PMC8163257, DOI: 10.1016/j.biopsych.2020.12.024.Peer-Reviewed Original ResearchConceptsSex-differential effectsSex differencesGenetic architectureBehavioral traitsSingle nucleotide polymorphism (SNP)-based heritabilityGenetic correlationsGenome-wide association summary statisticsSNP-based heritabilityMultiple gene setsOrigins of sex differencesAssociation summary statisticsIdentified 4 genesGene-based approachRisk-taking behaviorIdentified genesGene setsWell-powered studiesBehavioral phenotypesBiological functionsGenetic contributionBetween-sexGenetic effectsTrait pairsGenetic correlation estimatesNeuron-related
2019
Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa
Watson H, Yilmaz Z, Thornton L, Hübel C, Coleman J, Gaspar H, Bryois J, Hinney A, Leppä V, Mattheisen M, Medland S, Ripke S, Yao S, Giusti-Rodríguez P, Hanscombe K, Purves K, Adan R, Alfredsson L, Ando T, Andreassen O, Baker J, Berrettini W, Boehm I, Boni C, Perica V, Buehren K, Burghardt R, Cassina M, Cichon S, Clementi M, Cone R, Courtet P, Crow S, Crowley J, Danner U, Davis O, de Zwaan M, Dedoussis G, Degortes D, DeSocio J, Dick D, Dikeos D, Dina C, Dmitrzak-Weglarz M, Docampo E, Duncan L, Egberts K, Ehrlich S, Escaramís G, Esko T, Estivill X, Farmer A, Favaro A, Fernández-Aranda F, Fichter M, Fischer K, Föcker M, Foretova L, Forstner A, Forzan M, Franklin C, Gallinger S, Giegling I, Giuranna J, Gonidakis F, Gorwood P, Mayora M, Guillaume S, Guo Y, Hakonarson H, Hatzikotoulas K, Hauser J, Hebebrand J, Helder S, Herms S, Herpertz-Dahlmann B, Herzog W, Huckins L, Hudson J, Imgart H, Inoko H, Janout V, Jiménez-Murcia S, Julià A, Kalsi G, Kaminská D, Kaprio J, Karhunen L, Karwautz A, Kas M, Kennedy J, Keski-Rahkonen A, Kiezebrink K, Kim Y, Klareskog L, Klump K, Knudsen G, La Via M, Le Hellard S, Levitan R, Li D, Lilenfeld L, Lin B, Lissowska J, Luykx J, Magistretti P, Maj M, Mannik K, Marsal S, Marshall C, Mattingsdal M, McDevitt S, McGuffin P, Metspalu A, Meulenbelt I, Micali N, Mitchell K, Monteleone A, Monteleone P, Munn-Chernoff M, Nacmias B, Navratilova M, Ntalla I, O’Toole J, Ophoff R, Padyukov L, Palotie A, Pantel J, Papezova H, Pinto D, Rabionet R, Raevuori A, Ramoz N, Reichborn-Kjennerud T, Ricca V, Ripatti S, Ritschel F, Roberts M, Rotondo A, Rujescu D, Rybakowski F, Santonastaso P, Scherag A, Scherer S, Schmidt U, Schork N, Schosser A, Seitz J, Slachtova L, Slagboom P, Slof-Op ‘t Landt M, Slopien A, Sorbi S, Świątkowska B, Szatkiewicz J, Tachmazidou I, Tenconi E, Tortorella A, Tozzi F, Treasure J, Tsitsika A, Tyszkiewicz-Nwafor M, Tziouvas K, van Elburg A, van Furth E, Wagner G, Walton E, Widen E, Zeggini E, Zerwas S, Zipfel S, Bergen A, Boden J, Brandt H, Crawford S, Halmi K, Horwood L, Johnson C, Kaplan A, Kaye W, Mitchell J, Olsen C, Pearson J, Pedersen N, Strober M, Werge T, Whiteman D, Woodside D, Stuber G, Gordon S, Grove J, Henders A, Juréus A, Kirk K, Larsen J, Parker R, Petersen L, Jordan J, Kennedy M, Montgomery G, Wade T, Birgegård A, Lichtenstein P, Norring C, Landén M, Martin N, Mortensen P, Sullivan P, Breen G, Bulik C. Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa. Nature Genetics 2019, 51: 1207-1214. PMID: 31308545, PMCID: PMC6779477, DOI: 10.1038/s41588-019-0439-2.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesAssociation studiesTwin-based heritability estimatesEating Disorders Working GroupPsychiatric Genomics ConsortiumAnorexia nervosaBody-mass indexSignificant lociGenetic architectureRisk lociGenetics InitiativeGenomics ConsortiumLow body-mass indexMetabo-psychiatric disorderGenetic correlationsMetabolic componentsLociCases of anorexia nervosaPhysical activityAnthropometric traitsPsychiatric disordersHeritability estimatesAnorexia Nervosa Genetics InitiativeNervosaImprove outcomesAssociations Between Attention-Deficit/Hyperactivity Disorder and Various Eating Disorders: A Swedish Nationwide Population Study Using Multiple Genetically Informative Approaches
Yao S, Kuja-Halkola R, Martin J, Lu Y, Lichtenstein P, Norring C, Birgegård A, Yilmaz Z, Hübel C, Watson H, Baker J, Almqvist C, Consortium E, Adan R, Ando T, Baker J, Bergen A, Berrettini W, Birgegård A, Boni C, Perica V, Brandt H, Burghardt R, Cassina M, Cesta C, Clementi M, Coleman J, Cone R, Courtet P, Crawford S, Crow S, Crowley J, Danner U, Davis O, de Zwaan M, Dedoussis G, Degortes D, DeSocio J, Dick D, Dikeos D, Dmitrzak-Weglarz M, Docampo E, Egberts K, Ehrlich S, Escaramís G, Esko T, Estivill X, Favaro A, Fernández-Aranda F, Fichter M, Finan C, Fischer K, Föcker M, Foretova L, Forzan M, Franklin C, Gaspar H, Gonidakis F, Gorwood P, Gratacos M, Guillaume S, Guo Y, Hakonarson H, Halmi K, Hatzikotoulas K, Hauser J, Hebebrand J, Helder S, Hendriks J, Herpertz-Dahlmann B, Herzog W, Hilliard C, Hinney A, Huckins L, Hudson J, Huemer J, Imgart H, Inoko H, Jiménez-Murcia S, Johnson C, Jordan J, Juréus A, Kalsi G, Kaminska D, Kaplan A, Kaprio J, Karhunen L, Karwautz A, Kas M, Kaye W, Kennedy J, Kennedy M, Keski-Rahkonen A, Kiezebrink K, Kim Y, Klump K, Knudsen G, Koeleman B, Koubek D, La Via M, Landén M, Levitan R, Li D, Lichtenstein P, Lilenfeld L, Lissowska J, Magistretti P, Maj M, Mannik K, Martin N, McDevitt S, McGuffin P, Merl E, Metspalu A, Meulenbelt I, Micali N, Mitchell J, Mitchell K, Monteleone P, Monteleone A, Mortensen P, Munn-Chernoff M, Nacmias B, Nilsson I, Norring C, Ntalla I, O’Toole J, Pantel J, Papezova H, Parker R, Rabionet R, Raevuori A, Rajewski A, Ramoz N, Rayner N, Reichborn-Kjennerud T, Ricca V, Ripke S, Ritschel F, Roberts M, Rotondo A, Rybakowski F, Santonastaso P, Scherag A, Schmidt U, Schork N, Schosser A, Seitz J, Slachtova L, Slagboom P, Landt M, Slopien A, Smith T, Sorbi S, Strengman E, Strober M, Sullivan P, Szatkiewicz J, Szeszenia-Dabrowska N, Tachmazidou I, Tenconi E, Thornton L, Tortorella A, Tozzi F, Treasure J, Tsitsika A, Tziouvas K, van Elburg A, van Furth E, Wade T, Wagner G, Walton E, Watson H, Woodside D, Yao S, Yilmaz Z, Zeggini E, Zerwas S, Zipfel S, Alfredsson L, Andreassen O, Aschauer H, Barrett J, Bencko V, Carlberg L, Cichon S, Cohen-Woods S, Dina C, Ding B, Espeseth T, Floyd J, Gallinger S, Gambaro G, Giegling I, Herms S, Janout V, Julià A, Klareskog L, Le Hellard S, Leboyer M, Lundervold A, Marsal S, Mattingsdal M, Navratilova M, Ophoff R, Palotie A, Pinto D, Ripatti S, Rujescu D, Scherer S, Scott L, Sladek R, Soranzo N, Southam L, Steen V, Wichmann H, Widen E, Breen G, Bulik C, Thornton L, Magnusson P, Bulik C, Larsson H. Associations Between Attention-Deficit/Hyperactivity Disorder and Various Eating Disorders: A Swedish Nationwide Population Study Using Multiple Genetically Informative Approaches. Biological Psychiatry 2019, 86: 577-586. PMID: 31301758, PMCID: PMC6776821, DOI: 10.1016/j.biopsych.2019.04.036.Peer-Reviewed Original ResearchConceptsPolygenic risk scoresAttention-deficit/hyperactivity disorder polygenic risk scoresAttention-deficit/hyperactivity disorderQuantitative genetic modelRisk scoreGenetic associationGenetic correlationsEating disordersRegister-based informationAnorexia nervosaPopulation-based sampleGenetic modelsDegree of relatednessGenetically informed approachesAttention-deficit/hyperactivityNationwide population studyMaternal half-sistersCorrelates of attention-deficit/hyperactivity disorderFull-sistersAttention-deficit/hyperactivity disorder symptomsFamilial coaggregationNationwide populationGenetically informative designsShared etiologySubscales Drive63 TRANSCRIPTOMIC IMPUTATION ANALYSIS IN ANOREXIA NERVOSA IDENTIFIES BOTH METABOLIC AND PSYCHIATRIC AETIOLOGIES
Huckins L, Dobbyn A, Thornton L, Group of the PGC E, Devlin B, Sieberts S, Cox N, Im H, Breen G, Sklar P, Bulik C, Stahl E. 63 TRANSCRIPTOMIC IMPUTATION ANALYSIS IN ANOREXIA NERVOSA IDENTIFIES BOTH METABOLIC AND PSYCHIATRIC AETIOLOGIES. European Neuropsychopharmacology 2019, 29: s818. DOI: 10.1016/j.euroneuro.2017.08.064.Peer-Reviewed Original ResearchGene-tissue associationsTranscriptome imputationCommonMind ConsortiumGene expression prediction modelsGenome-wide significant lociTissue-specific gene expressionExpression prediction modelsMetabolic tissuesCaudate basal gangliaSignificant lociGenotype dataCharacterization of AnGene associationsReference panelGene expressionAetiology of ANMetabolic phenotypeMolecular pathwaysGenetic correlationsAssociation TestPsychiatric disordersAN riskMetabolic systemsImputation analysisBackground Anorexia nervosa