2022
Associated comorbidities, healthcare utilization & mortality in hospitalized patients with haemophilia in the United States: Contemporary nationally representative estimates
Day J, Takemoto C, Sharathkumar A, Makhani S, Gupta A, Bitner S, Josephson C, Bloch E, Tobian A, Krishnamurti L, Goel R. Associated comorbidities, healthcare utilization & mortality in hospitalized patients with haemophilia in the United States: Contemporary nationally representative estimates. Haemophilia 2022, 28: 532-541. PMID: 35412659, PMCID: PMC9540439, DOI: 10.1111/hae.14557.Peer-Reviewed Original ResearchConceptsNationwide Inpatient SampleHealthcare utilizationPrevalence of comorbiditiesAge-related comorbiditiesCentral line infectionsInpatient discharge databaseOverall mortality rateCatheter-related infectionsHealthcare utilization patternsMedian hospital chargesICD-10 codesRepresentative estimatesCause admissionsCause hospitalizationAdult PWHAssociated comorbidityCommon comorbiditiesHospitalized patientsMedian ageContemporary cohortHospital burdenHospital chargesDischarge databaseInpatient SampleLine infections
2018
Platelet transfusion practices in immune thrombocytopenia related hospitalizations
Goel R, Chopra S, Tobian A, Ness P, Frank S, Cushing M, Vasovic L, Kaicker S, Takemoto C, Josephson C, Nellis M, Bussel J, Krishnamurti L. Platelet transfusion practices in immune thrombocytopenia related hospitalizations. Transfusion 2018, 59: 169-176. PMID: 30520045, DOI: 10.1111/trf.15069.Peer-Reviewed Original ResearchConceptsPlatelet transfusion practicesImmune thrombocytopeniaPlatelet transfusionsNational Inpatient SampleAdmission diagnosisTransfusion practiceCurrent guidelinesHigher mean total hospital chargesMean total hospital chargesSmall bed size hospitalsMultivariable logistic regression analysisPayer inpatient databasePrimary admission diagnosisSurgery/procedureTotal hospital chargesMajor operative proceduresLogistic regression analysisNon-teaching hospitalsInvasive surgical proceduresHospital mortalityMultivariable adjustmentITP patientsClinical outcomesRelated hospitalizationsHospital charges
2015
Platelet transfusions in platelet consumptive disorders are associated with arterial thrombosis and in-hospital mortality
Goel R, Ness P, Takemoto C, Krishnamurti L, King K, Tobian A. Platelet transfusions in platelet consumptive disorders are associated with arterial thrombosis and in-hospital mortality. Blood 2015, 125: 1470-1476. PMID: 25588677, PMCID: PMC4342358, DOI: 10.1182/blood-2014-10-605493.Peer-Reviewed Original ResearchConceptsImmune thrombocytopenic purpuraThrombotic thrombocytopenic purpuraAcute myocardial infarctionPlatelet transfusionsArterial thrombosisVenous thrombosisHigher oddsHospital mortalityThrombocytopenic purpuraGender-adjusted odds ratioPlatelet transfusion practicesNationwide Inpatient SampleConsumptive disordersHIT patientsTransfusion practiceInpatient SampleMyocardial infarctionClinical severityOdds ratioTransfusionThrombosisPrimary mediatorMortalityLittle dataPurpura
2014
Impact of individualized pain plan on the emergency management of children with sickle cell disease
Krishnamurti L, Smith‐Packard B, Gupta A, Campbell M, Gunawardena S, Saladino R. Impact of individualized pain plan on the emergency management of children with sickle cell disease. Pediatric Blood & Cancer 2014, 61: 1747-1753. PMID: 24962217, DOI: 10.1002/pbc.25024.Peer-Reviewed Original ResearchConceptsVaso-occlusive crisisSickle cell diseaseIndividualized pain plansPain management planEmergency departmentPain managementPain planPatient satisfactionCell diseaseRate of hospitalizationWong-Baker scaleRate of admissionHealth Information DatabaseBaker scalePain scoresED visitsReadmission ratesChildren's HospitalED managementAvoidable hospitalizationsPatient responsePatientsComparable hospitalsHospitalHigh levels
2013
Comprehensive integrated care for patients with sickle cell disease in a remote aboriginal tribal population in southern India
Nimgaonkar V, Krishnamurti L, Prabhakar H, Menon N. Comprehensive integrated care for patients with sickle cell disease in a remote aboriginal tribal population in southern India. Pediatric Blood & Cancer 2013, 61: 702-705. PMID: 24347362, DOI: 10.1002/pbc.24723.Peer-Reviewed Original ResearchConceptsSickle cell diseaseClinic visitsCare indicatorsCell diseaseHealthcare maintenanceHigh-quality comprehensive careComprehensive clinic visitComprehensive integrated careMedian spleen sizeAcute chest syndromeEpisodes/yearSudden unexplained deathHealthcare deliveryLow-resource settingsQuality comprehensive careChest syndromePenicillin prophylaxisPneumococcal immunizationPuerperal sepsisMesenteric infarctionMedian ageSCD careSevere anemiaActive patientsMedical records
2012
Mortality, health care utilization and associated diagnoses in hospitalized patients with haemophilia in the United States: first reported nationwide estimates
GOEL R, KRISHNAMURTI L. Mortality, health care utilization and associated diagnoses in hospitalized patients with haemophilia in the United States: first reported nationwide estimates. Haemophilia 2012, 18: 688-692. PMID: 22500777, DOI: 10.1111/j.1365-2516.2012.02774.x.Peer-Reviewed Original ResearchConceptsNational Inpatient SampleCentral line infectionsHospital mortalityHospital dischargeLine infectionsHemophilia AMean hospital chargesCause of hospitalizationHealth care utilizationGeneral male populationDiagnosis of hemophiliaAge-related illnessesStratified probability sampleHepatitis CRespiratory failureHeart failureIntraventricular hemorrhageMedian ageAge of mortalityCare utilizationHospital chargesIntracranial hemorrhageNeonatal periodPediatric deathsHepatic coma
2011
Hospitalization for pain in patients with sickle cell disease treated with sildenafil for elevated TRV and low exercise capacity
Machado R, Barst R, Yovetich N, Hassell K, Kato G, Gordeuk V, Gibbs J, Little J, Schraufnagel D, Krishnamurti L, Girgis R, Morris C, Rosenzweig E, Badesch D, Lanzkron S, Onyekwere O, Castro O, Sachdev V, Waclawiw M, Woolson R, Goldsmith J, Gladwin M. Hospitalization for pain in patients with sickle cell disease treated with sildenafil for elevated TRV and low exercise capacity. Blood 2011, 118: 855-864. PMID: 21527519, PMCID: PMC3148167, DOI: 10.1182/blood-2010-09-306167.Peer-Reviewed Original ResearchConceptsTricuspid regurgitation velocitySickle cell diseaseLower exercise capacityExercise capacityCell diseaseN-terminal pro-brain natriuretic peptideElevated tricuspid regurgitation velocityPro-brain natriuretic peptideSerious adverse eventsPulmonary arterial hypertensionSildenafil trialArterial hypertensionAdverse eventsWalk distanceDoppler echocardiographySCD patientsHospitalization ratesNatriuretic peptidePatientsSildenafilPredominant causePainHospitalizationTreatment effectsDisease