2023
Secondary Neoplasms After Hematopoietic Cell Transplant for Sickle Cell Disease
Eapen M, Brazauskas R, Williams D, Walters M, St Martin A, Jacobs B, Antin J, Bona K, Chaudhury S, Coleman-Cowger V, DiFronzo N, Esrick E, Field J, Fitzhugh C, Kanter J, Kapoor N, Kohn D, Krishnamurti L, London W, Pulsipher M, Talib S, Thompson A, Waller E, Wun T, Horowitz M. Secondary Neoplasms After Hematopoietic Cell Transplant for Sickle Cell Disease. Journal Of Clinical Oncology 2023, 41: 2227-2237. PMID: 36623245, PMCID: PMC10448940, DOI: 10.1200/jco.22.01203.Peer-Reviewed Original ResearchConceptsLow-intensity regimensSickle cell diseaseSecondary neoplasmsRisk factorsCell diseaseLeukemia/myelodysplastic syndromeMixed donor chimerismReduced-intensity regimensFull donor chimerismHematopoietic cell transplantTotal body irradiationLow-dose radiationGray regression modelsMyeloid mutationsPrior inflammationCell transplantMyelodysplastic syndromeTolerance inductionIntense regimensPlausible etiologyHigh riskRegimensSolid tumorsNeoplasmsMyeloid malignancies
2007
Unrelated cord blood transplantation in children with sickle cell disease: Review of four‐center experience
Adamkiewicz T, Szabolcs P, Haight A, Baker K, Staba S, Kedar A, Chiang K, Krishnamurti L, Boyer M, Kurtzberg J, Wagner J, Wingard J, Yeager A. Unrelated cord blood transplantation in children with sickle cell disease: Review of four‐center experience. Pediatric Transplantation 2007, 11: 641-644. PMID: 17663687, DOI: 10.1111/j.1399-3046.2007.00725.x.Peer-Reviewed Original ResearchConceptsUnrelated cord blood transplantationReduced-intensity regimensPrimary graft failureCord blood transplantationStable mixed chimerismSickle cell diseaseBlood transplantationGraft failureMyeloablative regimensMixed chimerismGrade IIICell diseaseViral infectionGVHDUCBTRegimensPatientsEngraftmentInfectionChildrenTransplantationStrokeChimerismEngraftDisease
2005
Unrelated Cord Blood Transplantation (UCBT) in Children with Sickle Cell Disease (SCD): US Centers Experience.
Adamkiewicz T, Haight A, Mazur M, Baker K, Szabolcs P, Kedar A, Chiang K, Krishnamurti L, Wagner J, Wingard J, Yeager A. Unrelated Cord Blood Transplantation (UCBT) in Children with Sickle Cell Disease (SCD): US Centers Experience. Blood 2005, 106: 2044. DOI: 10.1182/blood.v106.11.2044.2044.Peer-Reviewed Original ResearchUnrelated cord blood transplantationAnti-thymocyte globulinSickle cell diseaseHigh-risk sickle cell diseaseReduced-intensity regimensMycophenolate mofetilYo maleDonor engraftmentAutologous reconstitutionDonor originReduced-intensity preparative regimenUnrelated cord blood unitsAcute grade IIIConventional myeloablative regimensExtensive chronic GVHDGrade 1 mucositisGrade III mucositisGrade IV GVHDMyeloablative preparative regimensParainfluenza 3 infectionSevere acute GVHDSustained donor engraftmentTotal lymphoid irradiationTransfusion-induced alloimmunizationElevated liver enzymes