2019
End points for sickle cell disease clinical trials: renal and cardiopulmonary, cure, and low-resource settings
Farrell A, Panepinto J, Desai A, Kassim A, Lebensburger J, Walters M, Bauer D, Blaylark R, DiMichele D, Gladwin M, Green N, Hassell K, Kato G, Klings E, Kohn D, Krishnamurti L, Little J, Makani J, Malik P, McGann P, Minniti C, Morris C, Odame I, Oneal P, Setse R, Sharma P, Shenoy S. End points for sickle cell disease clinical trials: renal and cardiopulmonary, cure, and low-resource settings. Blood Advances 2019, 3: 4002-4020. PMID: 31809537, PMCID: PMC6963248, DOI: 10.1182/bloodadvances.2019000883.Peer-Reviewed Original ResearchConceptsLow-resource settingsEnd pointClinical trial end pointsTrial end pointsPatient-reported outcomesSickle cell disease clinical trialsPanel of cliniciansSickle cell diseaseMeasurement of cureClinical trialsNovel therapiesCell diseaseConsensus recommendationsGlobal burdenUS FoodBiomarker panelDrug AdministrationAvailable evidenceAmerican SocietyCureRelevant findingsLiterature reviewPainPatientsTherapy
2013
Comprehensive integrated care for patients with sickle cell disease in a remote aboriginal tribal population in southern India
Nimgaonkar V, Krishnamurti L, Prabhakar H, Menon N. Comprehensive integrated care for patients with sickle cell disease in a remote aboriginal tribal population in southern India. Pediatric Blood & Cancer 2013, 61: 702-705. PMID: 24347362, DOI: 10.1002/pbc.24723.Peer-Reviewed Original ResearchConceptsSickle cell diseaseClinic visitsCare indicatorsCell diseaseHealthcare maintenanceHigh-quality comprehensive careComprehensive clinic visitComprehensive integrated careMedian spleen sizeAcute chest syndromeEpisodes/yearSudden unexplained deathHealthcare deliveryLow-resource settingsQuality comprehensive careChest syndromePenicillin prophylaxisPneumococcal immunizationPuerperal sepsisMesenteric infarctionMedian ageSCD careSevere anemiaActive patientsMedical recordsLong Term Safety and Efficacy Of Low Fixed Dose Hydroxyurea In Pediatric Patients With Sickle Cell Anemia: A Single Center Study From Central India
Jain D, Krishnamurti L, Sarathi V, Desai S, Gokhale A. Long Term Safety and Efficacy Of Low Fixed Dose Hydroxyurea In Pediatric Patients With Sickle Cell Anemia: A Single Center Study From Central India. Blood 2013, 122: 1000. DOI: 10.1182/blood.v122.21.1000.1000.Peer-Reviewed Original ResearchAcute chest syndromeSickle cell anemiaLong-term safetyChest syndromeLow-resource settingsPediatric patientsSevere anemiaHigh HbF levelsSCA patientsTerm safetyCell anemiaLong-term observational followSingle tertiary care centerResource settingsAvascular bone necrosisEvidence of neutropeniaHbF levelsSingle-center studyTertiary care centerAmelioration of diseaseMean corpuscular hemoglobin concentrationHIV/AIDSCorpuscular hemoglobin concentrationSequestration crisisMean hemoglobin