2018
Immunological differences between primary and metastatic breast cancer
Szekely B, Bossuyt V, Li X, Wali VB, Patwardhan GA, Frederick C, Silber A, Park T, Harigopal M, Pelekanou V, Zhang M, Yan Q, Rimm DL, Bianchini G, Hatzis C, Pusztai L. Immunological differences between primary and metastatic breast cancer. Annals Of Oncology 2018, 29: 2232-2239. PMID: 30203045, DOI: 10.1093/annonc/mdy399.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAntineoplastic Agents, ImmunologicalB7-H1 AntigenBiomarkers, TumorBiopsyBreast NeoplasmsDisease ProgressionDrug Resistance, NeoplasmFemaleGene Expression RegulationHumansImmunologic SurveillanceLymphocyte CountLymphocytes, Tumor-InfiltratingMiddle AgedMutation RateTumor EscapeTumor MicroenvironmentYoung AdultConceptsMetastatic breast cancerBreast cancerTherapeutic targetToll-like receptor pathway genesImmuno-oncology therapeutic targetsBreast cancer evolvesImmune proteasome expressionPD-L1 positivityCorresponding primary tumorsPotential therapeutic targetMHC class IImmune-related genesMetastatic cancer samplesLigand/receptor pairLymphocyte countT helperT-regsPD-L1Immune microenvironmentCytotoxic TPrimary tumorMastoid cellsDisease progressionTherapeutic combinationsMacrophage markers
2017
Immune Gene Expression Is Associated with Genomic Aberrations in Breast Cancer
Safonov A, Jiang T, Bianchini G, Győrffy B, Karn T, Hatzis C, Pusztai L. Immune Gene Expression Is Associated with Genomic Aberrations in Breast Cancer. Cancer Research 2017, 77: 3317-3324. PMID: 28428277, DOI: 10.1158/0008-5472.can-16-3478.Peer-Reviewed Original ResearchMeSH KeywordsBreast NeoplasmsChromosome AberrationsFemaleGene Expression ProfilingGene Expression RegulationHumansLymphocytes, Tumor-InfiltratingTranscriptomeConceptsTumor-infiltrating lymphocytesBreast cancer subtypesImmune infiltrationNeoantigen loadImmune surveillanceLower clonal heterogeneityCancer subtypesHigher immune gene expressionClonal heterogeneityImmune checkpoint inhibitorsMajor breast cancer subtypesFavorable prognostic factorTriple-negative cancersOverall mutation loadImmune gene expressionCheckpoint inhibitorsCancer Genome AtlasPrognostic factorsImmune metagenesBreast cancerCNV loadMutation loadGermline polymorphismsCancerCancer Res
2014
Global gene expression changes induced by prolonged cold ischemic stress and preservation method of breast cancer tissue
Aktas B, Sun H, Yao H, Shi W, Hubbard R, Zhang Y, Jiang T, Ononye SN, Wali VB, Pusztai L, Symmans WF, Hatzis C. Global gene expression changes induced by prolonged cold ischemic stress and preservation method of breast cancer tissue. Molecular Oncology 2014, 8: 717-727. PMID: 24602449, PMCID: PMC4048748, DOI: 10.1016/j.molonc.2014.02.002.Peer-Reviewed Original ResearchConceptsGlobal gene expression changesGlobal gene expressionGene expression changesGenomic signaturesResponse genesGene expressionSensitive transcriptsExpression changesStress response genesCell cycle regulationSignificant transcriptional changesExpression levelsCycle regulationTranscriptional changesIndividual probe setsInduced transcriptsAffected transcriptsProtein processingEnrichment analysis
2007
Gene-expression microarrays provide new prognostic and predictive tests for breast cancer
Gong Y, Symmans WF, Pusztai L. Gene-expression microarrays provide new prognostic and predictive tests for breast cancer. Pharmacogenomics 2007, 8: 1359-1368. PMID: 17979510, DOI: 10.2217/14622416.8.10.1359.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic AgentsBreast NeoplasmsFemaleGene Expression RegulationHumansOligonucleotide Array Sequence AnalysisPharmacogeneticsPredictive Value of TestsPrognosisConceptsBreast cancerSystemic therapySpecific systemic therapySystemic therapy agentsGene expression microarraysBreast cancer researchProbability of responseTherapeutic regimensClinicopathologic variablesNecessary therapyDisease outcomeIndividual patientsAccurate markerClinical decisionIndividual tumorsCancerPredictive indicatorTherapyPredictive testIndividual basisPatientsCancer researchTherapy agentsMolecular differencesRecent progression
2005
Microtubule Associated Protein (MAP)-Tau: A Novel Mediator of Paclitaxel Sensitivity In Vitro and In Vivo
Wagner P, Wang B, Clark E, Lee H, Rouzier R, Pusztai L. Microtubule Associated Protein (MAP)-Tau: A Novel Mediator of Paclitaxel Sensitivity In Vitro and In Vivo. Cell Cycle 2005, 4: 1149-1152. PMID: 16103753, DOI: 10.4161/cc.4.9.2038.Peer-Reviewed Original ResearchMeSH KeywordsAlternative SplicingBreast NeoplasmsCell Line, TumorDown-RegulationDrug Resistance, NeoplasmGene Expression RegulationHumansImmunohistochemistryIn Vitro TechniquesInhibitory Concentration 50Microtubule-Associated ProteinsMicrotubulesModels, BiologicalOligonucleotide Array Sequence AnalysisPaclitaxelRNA, MessengerRNA, Small InterferingTau ProteinsTubulinConceptsPaclitaxel sensitivityHuman breast cancer tissuesBreast cancer tissuesHuman breast cancerRole of tauCell linesRegulation of tauBreast cancerCancer tissuesProtein tauNovel markerLow expressionMicrotubule associated proteinNovel mediatorPaclitaxelTauPhysiological levelsGene expression analysisRecent findingsMediatorsMarkersAssociated proteinsChemotherapyCancerExpression analysis