2001
Non-coding snoRNA host genes in Drosophila: expression strategies for modification guide snoRNAs
Tycowski K, Steitz J. Non-coding snoRNA host genes in Drosophila: expression strategies for modification guide snoRNAs. European Journal Of Cell Biology 2001, 80: 119-125. PMID: 11302516, DOI: 10.1078/0171-9335-00150.Peer-Reviewed Original ResearchConceptsSnoRNA host genesModification-guide snoRNAsHost genesGuide snoRNAsSplice siteDifferent eukaryotic kingdomsEukaryotic kingdomsPolycistronic unitsD. melanogasterProtein codingTranslational apparatusConserved distanceSnoRNA sequencesTrailer sequencesIntron lariatPrimary transcriptFunctional proteinsNucleotides upstreamExpression strategyExonucleolytic activitySnoRNAsIntronsGenesDebranching activityProtein
1996
A small nucleolar RNA requirement for site-specific ribose methylation of rRNA in Xenopus
Tycowski K, Smith C, Shu M, Steitz J. A small nucleolar RNA requirement for site-specific ribose methylation of rRNA in Xenopus. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 14480-14485. PMID: 8962077, PMCID: PMC26158, DOI: 10.1073/pnas.93.25.14480.Peer-Reviewed Original ResearchConceptsSmall nucleolar RNA (snoRNA) speciesSite-specific ribose methylationXenopus oocyte systemSnoRNA speciesSnoRNA genesRibose methylationVertebrate cellsRNA speciesMultiple homologsSnoRNA stabilityRRNASnoRNAsOocyte systemRNA requirementsXenopusXenopus oocytesFibrillarinMethylationSpeciesOocytesVertebratesHomologCloningGenesTranscriptsA mammalian gene with introns instead of exons generating stable RNA products
Tycowski K, Shu M, Steitz J. A mammalian gene with introns instead of exons generating stable RNA products. Nature 1996, 379: 464-466. PMID: 8559254, DOI: 10.1038/379464a0.Peer-Reviewed Original ResearchConceptsProtein-coding genesRibosomal subunit assemblyRibosomal RNA transcriptionSmall nucleolar RNAsMammalian genesSnoRNA genesEukaryotic cellsProtein codingMature rRNANucleolar RNAsHost genesSubunit assemblyDifferent intronsRNA transcriptionRNA productsExtensive complementarityIntronsGenesSnoRNAsExonsRNARRNATranscriptionPolysomesMaturation1
1995
Mapping of ribosomal protein S3 and internally nested snoRNA U15A gene to human chromosome 11q13.3–q13.5
Polakiewicz R, Munroe D, Sait S, Tycowski K, Nowak N, Shows T, Housman D, Page D. Mapping of ribosomal protein S3 and internally nested snoRNA U15A gene to human chromosome 11q13.3–q13.5. Genomics 1995, 25: 577-580. PMID: 7789996, DOI: 10.1016/0888-7543(95)80063-r.Peer-Reviewed Original ResearchConceptsRibosomal proteinsHuman chromosomesSomatic cell hybrid analysisCell hybrid analysisRibosomal protein S3Small nucleolar RNAsUV-induced DNA damageSTS content mappingMammalian ribosomesProtein S3RNA speciesHuman genomeNucleolar RNAsFirst intronDifferent proteinsDNA damageSitu hybridizationProteinChromosomesHybrid analysisGenesContent mappingIntronsGenomeRibosomes
1994
Requirement for Intron-Encoded U22 Small Nucleolar RNA in 18S Ribosomal RNA Maturation
Tycowski K, Shu M, Steitz J. Requirement for Intron-Encoded U22 Small Nucleolar RNA in 18S Ribosomal RNA Maturation. Science 1994, 266: 1558-1561. PMID: 7985025, DOI: 10.1126/science.7985025.Peer-Reviewed Original ResearchConceptsRibosomal RNASmall RNAsProtein-coding gene transcriptsRibosomal RNA maturationSmall nucleolar RNAsRNA maturationVertebrate cellsCellular functionsNucleolar RNAsHost genesIntron fragmentGene transcriptsRNAXenopus oocytesU22IntronsGenesTranscriptsNucleoliOocytesMaturationTargetingCellsFragmentsDepletion