2024
Exposome-Wide Ranking to Uncover Environmental Chemicals Associated with Dyslipidemia: A Panel Study in Healthy Older Chinese Adults from the BAPE Study.
Ding E, Deng F, Fang J, Liu J, Yan W, Yao Q, Miao K, Wang Y, Sun P, Li C, Liu Y, Dong H, Dong L, Zhang X, Lu Y, Lin X, Ding C, Li T, Shi Y, Cai Y, Liu X, Godri Pollitt K, Ji J, Tong S, Tang S, Shi X. Exposome-Wide Ranking to Uncover Environmental Chemicals Associated with Dyslipidemia: A Panel Study in Healthy Older Chinese Adults from the BAPE Study. Environmental Health Perspectives 2024, 132: 97005. PMID: 39240788, PMCID: PMC11379127, DOI: 10.1289/ehp13864.Peer-Reviewed Original ResearchConceptsDyslipidemia markersCardiovascular diseaseMulti-omicsMarkers of dyslipidemiaExamination of cytokinesMeasurement of cytokinesSerum lipidomeSystemic inflammationMulti-omics profilingCardiac functionDyslipidemiaPrimary preventionClinical measuresSerumChinese adultsBlood transcriptomeImpact spectraCytokinesExposome-wide association studyInflammationMarkersBiomolecular pathwaysAssociationHealthy older adultsElectrocardiogramAssociation between Personal Abiotic Airborne Exposures and Body Composition Changes among Healthy Adults (60–69 Years Old): A Combined Exposome-Wide and Lipidome Mediation Approach from the China BAPE Study
Sun P, Guo X, Ding E, Li C, Ren H, Xu Y, Qian J, Deng F, Shi W, Dong H, Lin E, Guo P, Fang J, Zhang Q, Zhao W, Tong S, Lu X, Pollitt K, Shi X, Tang S. Association between Personal Abiotic Airborne Exposures and Body Composition Changes among Healthy Adults (60–69 Years Old): A Combined Exposome-Wide and Lipidome Mediation Approach from the China BAPE Study. Environmental Health Perspectives 2024, 132: 077005. PMID: 39028628, PMCID: PMC11259245, DOI: 10.1289/ehp13865.Peer-Reviewed Original ResearchConceptsFat mass indicatorsHealthy older adultsBayesian kernel machine regressionVisceral fat areaOlder adultsPercent body fatBody compositionBody fat massExposome-wide association studyPrevention of chronic diseasesAir pollution exposureBody composition indicatorsMediation analysisInBody 770 deviceHealthy adultsAssociated with increased body fat massBody composition changesKernel machine regressionBayesian kernel machine regression modelsChronic diseasesPollution exposureBody fatAssociation studiesAdverse health effectsFat areaHigh-Resolution Mass Spectrometry for Human Exposomics: Expanding Chemical Space Coverage
Lai Y, Koelmel J, Walker D, Price E, Papazian S, Manz K, Castilla-Fernández D, Bowden J, Nikiforov V, David A, Bessonneau V, Amer B, Seethapathy S, Hu X, Lin E, Jbebli A, McNeil B, Barupal D, Cerasa M, Xie H, Kalia V, Nandakumar R, Singh R, Tian Z, Gao P, Zhao Y, Froment J, Rostkowski P, Dubey S, Coufalíková K, Seličová H, Hecht H, Liu S, Udhani H, Restituito S, Tchou-Wong K, Lu K, Martin J, Warth B, Pollitt K, Klánová J, Fiehn O, Metz T, Pennell K, Jones D, Miller G. High-Resolution Mass Spectrometry for Human Exposomics: Expanding Chemical Space Coverage. Environmental Science And Technology 2024, 58: 12784-12822. PMID: 38984754, PMCID: PMC11271014, DOI: 10.1021/acs.est.4c01156.Peer-Reviewed Original ResearchHigh-resolution mass spectrometryChemical spaceCoverage of chemical spaceMass spectrometryAccurate mass measurementsChemical space coverageNon-target approachHuman exposomeAnalytical workflowMass measurementsDisease outcomeGenetic driversSpectrometryHarmonized workflowMulti-omics integrationRetrospective validationCare providersChemistsMetabolomicsSpace coverageBiomoleculesHypothesis-drivenDiseasePersonal exposure to airborne organic pollutants and lung function changes among healthy older adults
Guo X, Ren H, Sun P, Ding E, Fang J, Fang K, Ma X, Li C, Li C, Xu Y, Cao K, Lin E, Guo P, Pollitt K, Tong S, Tang S, Shi X. Personal exposure to airborne organic pollutants and lung function changes among healthy older adults. Environmental Research 2024, 258: 119411. PMID: 38876423, DOI: 10.1016/j.envres.2024.119411.Peer-Reviewed Original ResearchPolyMatch: Novel Libraries, Algorithms, and Visualizations for Discovering Polymers and Chemical Series
Koelmel J, Stelben P, Oranzi N, Kummer M, Godri D, Qi J, Rennie E, Lin E, Weil D, Pollitt K. PolyMatch: Novel Libraries, Algorithms, and Visualizations for Discovering Polymers and Chemical Series. Journal Of The American Society For Mass Spectrometry 2024, 35: 413-420. PMID: 38301121, DOI: 10.1021/jasms.3c00313.Peer-Reviewed Original ResearchAccurate mass matchingChemical moietiesQ-TOF instrumentMS/MS libraryPolymer databaseSeries polymersEsterified speciesLC-HRMS/MSHomologous seriesMass matchingFunctional groupsRepeat unitsAdvancement of materials sciencePolyethylene glycolContaining fragmentsMaterials scienceMoietyDegree of unsaturationPolymerPhysicochemical propertiesChemical speciesFragment coverageHTML linksIterative exclusionMolecular levelHousehold air pollution and risk of pulmonary tuberculosis in HIV-Infected adults
Katoto P, Bihehe D, Brand A, Mushi R, Kusinza A, Alwood B, van Zyl-Smit R, Tamuzi J, Sam-Agudu N, Yotebieng M, Metcalfe J, Theron G, Godri Pollitt K, Lesosky M, Vanoirbeek J, Mortimer K, Nawrot T, Nemery B, Nachega J. Household air pollution and risk of pulmonary tuberculosis in HIV-Infected adults. Environmental Health 2024, 23: 6. PMID: 38233832, PMCID: PMC10792790, DOI: 10.1186/s12940-023-01044-0.Peer-Reviewed Original ResearchConceptsRisk of pulmonary tuberculosisPulmonary tuberculosisHousehold air pollutionHIV infectionTB-HIV coinfectionHIV-infected adultsAssociated with increased riskCase-control studyMultivariate logistic regressionHAP exposureDose-dependentlyPersonal CO exposuresPersonal carbon monoxidePTB riskLowest quintileCo-exposureHighest quintileBackgroundIn low-Logistic regressionRandom sub-sampleEffective interventionsHIVTuberculosisAir pollutionEastern Democratic Republic of CongoAssessment of wood smoke induced pulmonary toxicity in normal- and chronic bronchitis-like bronchial and alveolar lung mucosa models at air–liquid interface
Upadhyay S, Rahman M, Rinaldi S, Koelmel J, Lin E, Mahesh P, Beckers J, Johanson G, Pollitt K, Palmberg L, Irmler M, Ganguly K. Assessment of wood smoke induced pulmonary toxicity in normal- and chronic bronchitis-like bronchial and alveolar lung mucosa models at air–liquid interface. Respiratory Research 2024, 25: 49. PMID: 38245732, PMCID: PMC10799428, DOI: 10.1186/s12931-024-02686-5.Peer-Reviewed Original ResearchConceptsWood smokeBiomass fuel burningHuman primary bronchial epithelial cellsSecretion levels of proinflammatory cytokinesLevels of proinflammatory cytokinesPrimary bronchial epithelial cellsTumor necrosis factor-aAir-liquid interfacePrimary ciliary dyskinesiaHousehold air pollutionHighest increased riskBackgroundChronic obstructive pulmonary diseaseBronchial epithelial cellsChronic respiratory disordersPassive samplingToxicological end pointsAssociated with COPDExposed to WSObstructive pulmonary diseaseTobacco smoke exposureAir pollutionWS exposureExposure induced changesPulmonary toxicityAcute phase response
2023
Perfluorooctanesulfonic Acid and Perfluorooctanoic Acid Promote Migration of Three-Dimensional Colorectal Cancer Spheroids
Zheng J, Sun B, Berardi D, Lu L, Yan H, Zheng S, Aladelokun O, Xie Y, Cai Y, Pollitt K, Khan S, Johnson C. Perfluorooctanesulfonic Acid and Perfluorooctanoic Acid Promote Migration of Three-Dimensional Colorectal Cancer Spheroids. Environmental Science And Technology 2023, 57: 21016-21028. PMID: 38064429, DOI: 10.1021/acs.est.3c04844.Peer-Reviewed Original ResearchConceptsColorectal cancerFatty acid β-oxidationCell linesSW48 cell linesSynthesis of proteinsProgression of CRCMigration phenotypeCRC cell linesEpithelial-mesenchymal transitionThree-dimensional spheroidsMetabolic pathwaysN-cadherinΒ-oxidationMechanism of actionNovel insightsE-cadherinBiological techniquesPromotes MigrationColorectal cancer spheroidsMigration assaysMetabolic profilingKRAS G12APerfluorooctanoic acidPersistent environmental contaminantsMetabolic profileProceedings from a special symposium and panel session on the aerosol science of infectious diseases: what we learned and what we still need to know
Taylor J, Ratnesar-Shumate S, Pollitt K, Huffman J. Proceedings from a special symposium and panel session on the aerosol science of infectious diseases: what we learned and what we still need to know. Aerosol Science And Technology 2023, 57: 1175-1177. DOI: 10.1080/02786826.2023.2273707.Peer-Reviewed Original ResearchExpanding Per- and Polyfluoroalkyl Substances Coverage in Nontargeted Analysis Using Data-Independent Analysis and IonDecon
Koelmel J, Kummer M, Chevallier O, Hindle R, Hunt K, Camacho C, Abril N, Gill E, Beecher C, Garrett T, Yost R, Townsend T, Klein C, Rennie E, Bowden J, Pollitt K. Expanding Per- and Polyfluoroalkyl Substances Coverage in Nontargeted Analysis Using Data-Independent Analysis and IonDecon. Journal Of The American Society For Mass Spectrometry 2023, 34: 2525-2537. PMID: 37751518, DOI: 10.1021/jasms.3c00244.Peer-Reviewed Original ResearchDaily Summer Temperatures and Hospitalization for Acute Cardiovascular Events: Impact of Outdoor PM2.5 Oxidative Potential on Observed Associations Across Canada
Weichenthal S, Lavigne E, You H, Pollitt K, Shin T, Kulka R, Stieb D, Hatzopoulou M, Evans G, Burnett R. Daily Summer Temperatures and Hospitalization for Acute Cardiovascular Events: Impact of Outdoor PM2.5 Oxidative Potential on Observed Associations Across Canada. Epidemiology 2023, 34: 897-905. PMID: 37732880, DOI: 10.1097/ede.0000000000001651.Peer-Reviewed Original ResearchConceptsIschaemic heart disease eventsHeart disease eventsAcute cardiovascular eventsCardiovascular eventsDisease eventsOdds ratioPotential time-varying confoundersAcute cardiovascular effectsFine particulate air pollutionCase-crossover studyOutdoor fine particulate air pollutionHealth impactsCardiovascular health impactsParticulate air pollutionCardiovascular effectsHighest tertileTime-varying confoundersOlder subjectsHospitalizationObserved associationsOxidative stressOxidative potentialPM2.5 oxidative potentialMonthsAssociationPer- and polyfluoroalkyl substances (PFAS) and thyroid hormone measurements in dried blood spots and neonatal characteristics: a pilot study
Rosen Vollmar A, Lin E, Nason S, Santiago K, Johnson C, Ma X, Godri Pollitt K, Deziel N. Per- and polyfluoroalkyl substances (PFAS) and thyroid hormone measurements in dried blood spots and neonatal characteristics: a pilot study. Journal Of Exposure Science & Environmental Epidemiology 2023, 33: 737-747. PMID: 37730931, PMCID: PMC10541328, DOI: 10.1038/s41370-023-00603-4.Peer-Reviewed Original ResearchConceptsThyroid hormone concentrationsNeonatal characteristicsThyroid hormone measurementsHormone concentrationsThyroid hormonesBlood spotsPilot studyNewborn DBSHormone measurementsPopulation-based studyThyroid hormone levelsEnvironmental risk factorsPFAS concentrationsNewborn screening testNon-parametric WilcoxonThyroid diseaseRisk factorsHormone levelsKruskal-Wallis testPFAS exposureThyroid hormone dataScreening testNeonatal DBSEnvironmental exposuresPerformance liquid chromatography-mass spectrometryPer- and polyfluoroalkyl substances and sleep health in U.S. adults, NHANES 2005–2014
Guo P, Jin Z, Bellia G, Luo J, Inoue K, Pollitt K, Deziel N, Liew Z. Per- and polyfluoroalkyl substances and sleep health in U.S. adults, NHANES 2005–2014. Environmental Research 2023, 237: 117092. PMID: 37683785, DOI: 10.1016/j.envres.2023.117092.Peer-Reviewed Original ResearchSleep disordersSleep outcomesU.S. adultsNHANES 2005Inverse associationSleep durationSerum polyfluoroalkyl substancesCentral nervous systemSerum concentration dataDaily sleep durationExposure tertilesOxidative inflammatory responseQuartile increaseBias analysisInflammatory responseExcessive sleepUncontrolled confoundingNervous systemSleep healthPFAS exposureHealth measuresQuantitative bias analysisLogistic regressionConsistent associationDisordersCOVID-19 and the environment: the pandemic and beyond
Bell M, Pollitt K, Deziel N. COVID-19 and the environment: the pandemic and beyond. Environmental Research Letters 2023, 18: 092001. DOI: 10.1088/1748-9326/acedc8.Peer-Reviewed Original ResearchNon-targeted analysis (NTA) and suspect screening analysis (SSA): a review of examining the chemical exposome
Manz K, Feerick A, Braun J, Feng Y, Hall A, Koelmel J, Manzano C, Newton S, Pennell K, Place B, Godri Pollitt K, Prasse C, Young J. Non-targeted analysis (NTA) and suspect screening analysis (SSA): a review of examining the chemical exposome. Journal Of Exposure Science & Environmental Epidemiology 2023, 33: 524-536. PMID: 37380877, PMCID: PMC10403360, DOI: 10.1038/s41370-023-00574-6.Peer-Reviewed Original ResearchConceptsHigh-resolution mass spectrometryNon-targeted analysisExposure mediaChemical spaceSoils/sedimentsMass spectrometryPolyfluoroalkyl substancesSemi-volatile organic compoundsChemical exposomePolyaromatic hydrocarbonsLiquid chromatographyEnvironmental mediaOrganic compoundsGC-HRMSHuman exposureLC-HRMSAnalytical platformConsumer productsChemical exposureSedimentsPesticidesEnvironmental chemicalsChemicalsExposure sourcesSpectrometryWithin-city spatial variations in long-term average outdoor oxidant gas concentrations and cardiovascular mortality: Effect modification by oxidative potential in the Canadian Census Health and Environment Cohort
Ripley S, Gao D, Pollitt K, Lakey P, Shiraiwa M, Hatzopoulou M, Weichenthal S. Within-city spatial variations in long-term average outdoor oxidant gas concentrations and cardiovascular mortality: Effect modification by oxidative potential in the Canadian Census Health and Environment Cohort. Environmental Epidemiology 2023, 7: e257. PMID: 37545813, PMCID: PMC10403014, DOI: 10.1097/ee9.0000000000000257.Peer-Reviewed Original ResearchCanadian Census HealthCardiovascular mortalityReactive oxygen species concentrationParticulate air pollutionEnvironment CohortMeasures of PMRetrospective cohort studyFine particulate air pollutionRelevant confounding factorsProportional hazards modelOutdoor fine particulate air pollutionPopulation health impactHealth impactsCardiovascular health impactsOutdoor air pollutionCardiovascular deathCohort studyOxidant gasesEffect modificationHazards modelConfounding factorsMortalityOxidative stressHealth effectsOxidative potentialAssessment of children's personal and land use regression model-estimated exposure to NO2 in Springfield, Massachusetts
Gao D, Esenther S, Minet L, De Jesus A, Hudson S, Leaderer B, Hatzopoulou M, Godri Pollitt K. Assessment of children's personal and land use regression model-estimated exposure to NO2 in Springfield, Massachusetts. The Science Of The Total Environment 2023, 892: 164681. PMID: 37302586, DOI: 10.1016/j.scitotenv.2023.164681.Peer-Reviewed Original ResearchAdequacy of stationary measurements as proxies for residential personal exposure to gaseous and particle air pollutants
González Serrano V, Lin E, Godri Pollitt K, Licina D. Adequacy of stationary measurements as proxies for residential personal exposure to gaseous and particle air pollutants. Environmental Research 2023, 231: 116197. PMID: 37224948, DOI: 10.1016/j.envres.2023.116197.Peer-Reviewed Original ResearchConceptsVolatile organic compoundsOrganic compoundsTotal volatile organic compoundsPassive samplersSingle COCompoundsCOPollutantsCarbon dioxideStationary samplesEnvironmental monitorsReal-time sensorsSVOCsParticlesHigh concentrationsPersonal exposure monitorsAirborne pollutantsInhalation exposure assessmentAir quality monitoringDioxideAir pollutantsParticle number concentrationConcentrationSamplerParticle pollutantsNovel perfluoroalkyl substances (PFAS) discovered in whole blood using automated non-targeted analysis of dried blood spots
Koelmel J, Lin E, Parry E, Stelben P, Rennie E, Godri Pollitt K. Novel perfluoroalkyl substances (PFAS) discovered in whole blood using automated non-targeted analysis of dried blood spots. The Science Of The Total Environment 2023, 883: 163579. PMID: 37100129, PMCID: PMC10247435, DOI: 10.1016/j.scitotenv.2023.163579.Peer-Reviewed Original ResearchConceptsBlood spotsNovel perfluoroalkyl substancesHuman bloodVenous blood drawBlood spot cardsBlood spot samplesPerfluoroalkyl substancesPrenatal exposureBlood drawEnvironmental epidemiology studiesEpidemiology studiesFalse negative rateBloodLow false negative rateInvasive collection techniquesWhole bloodVulnerable populationsLiquid chromatography-high resolution tandem mass spectrometryUnderstanding of exposureSpot samplesSpot cardsHigh-resolution tandem mass spectrometryExposurePerfluoroalkyl ether carboxylic acidsScreeningTrace analysis of per- and polyfluorinated alkyl substances (PFAS) in dried blood spots – Demonstration of reproducibility and comparability to venous blood samples
Lin E, Nason S, Zhong A, Fortner J, Godri Pollitt K. Trace analysis of per- and polyfluorinated alkyl substances (PFAS) in dried blood spots – Demonstration of reproducibility and comparability to venous blood samples. The Science Of The Total Environment 2023, 883: 163530. PMID: 37094673, PMCID: PMC10248884, DOI: 10.1016/j.scitotenv.2023.163530.Peer-Reviewed Original ResearchConceptsPolyfluoroalkyl substancesLiquid chromatography-high resolution mass spectrometryResolution mass spectrometryWater-repellent propertiesVenous blood samplesBlood samplesTrace levelsTrace analysisMass spectrometryWhole blood samplesChemical analysisAlkyl substancesHealthy adultsMan-made chemicalsAdverse health outcomesAnalytical methodBlank correctionHousehold productsHealth outcomesPFAS exposureInvasive methodBlood collectionBlood spotsCritical windowEnvironmental exposures