2024
A single arm phase 2 clinical trial of YIV-906 with neoadjuvant concurrent chemo-radiation therapy in patients with locally advanced rectal cancer
Verma N, Johung K, Kortmansky J, Zaheer W, Lacy J, Cecchini M, Stein S, Cheng Y, Lam W, Liu S, Reddy V, Hochster H, Higgins S. A single arm phase 2 clinical trial of YIV-906 with neoadjuvant concurrent chemo-radiation therapy in patients with locally advanced rectal cancer. Journal Of Gastrointestinal Oncology 2024, 15: 1050-1059. PMID: 38989411, PMCID: PMC11231844, DOI: 10.21037/jgo-24-23.Peer-Reviewed Original Research
2017
Pilot trial of KD018 with neo-adjuvant concurrent chemo-radiation therapy in patients with locally advanced rectal cancer.
Kann B, Johung K, Cheng Y, Lam W, Liu S, Decker R, Higgins S. Pilot trial of KD018 with neo-adjuvant concurrent chemo-radiation therapy in patients with locally advanced rectal cancer. Journal Of Clinical Oncology 2017, 35: e15162-e15162. DOI: 10.1200/jco.2017.35.15_suppl.e15162.Peer-Reviewed Original ResearchGI toxicityRectal cancerClinical studiesGrade 3Day 1Clinical stage T3-T4Concurrent chemo-radiation therapyPilot phase I trialPathologic partial responseStandardized pharmaceutical productsAdvanced rectal cancerPhase I trialStage T3-T4Favorable toxicity profileChemo-radiation therapyFirst clinical studyFirst clinical trialTraditional Chinese medicineAbdominal RTGI ailmentsN0-N2Po bidAccrual goalCTCAE v4.0Gastrointestinal toxicity