2025
Unsupervised Dimensionality Reduction Techniques for the Assessment of ASD Biomarkers.
Jacokes Z, Adoremos I, Hussain A, Newman B, Pelphrey K, Van Horn J. Unsupervised Dimensionality Reduction Techniques for the Assessment of ASD Biomarkers. Biocomputing 2025, 30: 614-630. PMID: 39670400.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderNeural basisDevelopmental disabilitiesCognitive traitsDiagnostic disparitiesSpectrum disorderNeuroimaging techniquesASD biomarkersSex differencesSocial functioningASD researchEffects of gene expressionNeuronal microstructureTailored interventionsBiological influencesGenetic interactionsGene expressionPhenotypic heterogeneityAutismCognitionPrincipal component analysis
2024
Early‐ and Late‐Stage Auditory Processing of Speech Versus Non‐Speech Sounds in Children With Autism Spectrum Disorder: An ERP and Oscillatory Activity Study
Edgar E, McGuire K, Pelphrey K, Ventola P, van Noordt S, Crowley M. Early‐ and Late‐Stage Auditory Processing of Speech Versus Non‐Speech Sounds in Children With Autism Spectrum Disorder: An ERP and Oscillatory Activity Study. Developmental Psychobiology 2024, 66: e22552. PMID: 39508446, DOI: 10.1002/dev.22552.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderNon-speech soundsSpeech soundsTD childrenSpectrum disorderCortical activityResponses to speech soundsProcessing stagesSensitivity to speechAtypical auditory processingTheta phase coherenceAuditory speech processingP3a amplitudeAuditory speechIntra-individual variabilityDevelopment of cortical networksASD childrenCortical networksSpeech processingAuditory processingElectroencephalography sessionLanguage processingCortical responsesAutismSpeechThe relationship between gamma-band neural oscillations and language skills in youth with Autism Spectrum Disorder and their first-degree relatives
Arutiunian V, Santhosh M, Neuhaus E, Borland H, Tompkins C, Bernier R, Bookheimer S, Dapretto M, Gupta A, Jack A, Jeste S, McPartland J, Naples A, Van Horn J, Pelphrey K, Webb S. The relationship between gamma-band neural oscillations and language skills in youth with Autism Spectrum Disorder and their first-degree relatives. Molecular Autism 2024, 15: 19. PMID: 38711098, PMCID: PMC11075235, DOI: 10.1186/s13229-024-00598-1.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAutism Spectrum DisorderChildElectroencephalographyFamilyFemaleGamma RhythmHumansLanguageMaleSiblingsConceptsAutism spectrum disorderElevated gamma powerLow language skillsGamma powerResponses to speech stimuliLanguage skillsLanguage functionFirst-degree relativesSpectrum disorderClinical Evaluation of Language FundamentalsCo-occurring language impairmentSpeech stimuliCortical gamma-band oscillationsHigh gamma powerSex-balanced sampleGamma-band oscillationsSample of participantsNonverbal IQLanguage impairmentASD participantsTD controlsNeural profilesAutism phenotypeTD groupLanguage FundamentalsConduction velocity, G-ratio, and extracellular water as microstructural characteristics of autism spectrum disorder
Newman B, Jacokes Z, Venkadesh S, Webb S, Kleinhans N, McPartland J, Druzgal T, Pelphrey K, Van Horn J, Consortium F. Conduction velocity, G-ratio, and extracellular water as microstructural characteristics of autism spectrum disorder. PLOS ONE 2024, 19: e0301964. PMID: 38630783, PMCID: PMC11023574, DOI: 10.1371/journal.pone.0301964.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAutism Spectrum DisorderBrainCerebral CortexDiffusion Magnetic Resonance ImagingHumansMagnetic Resonance ImagingWhite MatterConceptsAutism spectrum disorderSocial Communication QuestionnaireSpectrum disorderCharacteristics of autism spectrum disorderAssociated with higher scoresEtiology of autism spectrum disorderMagnetic resonance imagingNeurotypical participantsWhite matter skeletonCommunication QuestionnaireBehavioral functionsFunctional connectivityT1w/T2w ratioNeuronal differencesStructural connectivityAdolescent participantsHigher scoresConduction velocityCortexExtracellular waterDisordersResonance imagingDiffusion MRI techniques