1996
Matrix-Assisted Laser Desorption Ionization Mass Spectrometry as a Complement to Internal Protein Sequencing
Williams K, Samandar S, Stone K, Saylor M, Rush J. Matrix-Assisted Laser Desorption Ionization Mass Spectrometry as a Complement to Internal Protein Sequencing. Springer Protocols Handbooks 1996, 541-555. DOI: 10.1007/978-1-60327-259-9_91.Peer-Reviewed Original ResearchLaser desorption ionization mass spectrometryDesorption ionization mass spectrometryIonization mass spectrometryMass spectrometryMatrix-Assisted Laser Desorption Ionization Mass SpectrometryInternal protein sequencingBiological moleculesMALDI-MSSimple instrumentationSpectrometryBiochemical laboratoryMass analysis methodProtein sequencingMoleculesHigh throughput
1982
Comparative Peptide Mapping by HPLC: Identification of Single Amino Acid Substitutions in Temperature Sensitive Mutants
Williams K, L’Italien J, Guggenheimer R, Sillerud L, Spicer E, Chase J, Konigsberg W. Comparative Peptide Mapping by HPLC: Identification of Single Amino Acid Substitutions in Temperature Sensitive Mutants. Experimental Biology And Medicine 1982, 499-507. DOI: 10.1007/978-1-4612-5832-2_44.Peer-Reviewed Original ResearchPeptide mappingChemical modificationCovalent proteinComparative peptide mappingAmino acid analysisProtein structureParticular amino acid replacementsPrimary structureLac repressor moleculesHuman hemoglobinHPLCAcid analysisSubstitutionStructurePowerful approachSingle amino acid substitutionCrosslinkingMoleculesAmino acid substitutionsSubtitutionAcid substitutionsMutant proteins