Upgrading and upstaging at radical prostatectomy in the post–prostate-specific antigen screening era: an effect of delayed diagnosis or a shift in patient selection?
Edmund L, Rotker KL, Lakis NS, Brito JM, Lepe M, Lombardo KA, Renzulli JF, Matoso A. Upgrading and upstaging at radical prostatectomy in the post–prostate-specific antigen screening era: an effect of delayed diagnosis or a shift in patient selection? Human Pathology 2016, 59: 87-93. PMID: 27720731, DOI: 10.1016/j.humpath.2016.09.017.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiopsy, NeedleCytoreduction Surgical ProceduresDelayed DiagnosisEarly Detection of CancerHumansKallikreinsMaleMiddle AgedNeoplasm GradingNeoplasm StagingPatient SelectionPredictive Value of TestsProstate-Specific AntigenProstatectomyProstatic NeoplasmsTime FactorsWatchful WaitingConceptsGroup 2Group 1Group 3Needle biopsyActive surveillanceProstate-specific antigen (PSA) screeningPathologic stage pT3Radical prostatectomy findingsLow-risk diseaseGleason score 4High-risk diseaseGleason score 8Prostate needle biopsyProstate cancer managementProstatectomy findingsCytoreductive surgeryStage pT3Screening eraMore patientsPatient selectionAntigen screeningScore 8Radical prostatectomyGleason 6Cancer management