2017
Long-Chain Polyprenols Promote Spore Wall Formation in Saccharomyces cerevisiae
Hoffmann R, Grabińska K, Guan Z, Sessa WC, Neiman AM. Long-Chain Polyprenols Promote Spore Wall Formation in Saccharomyces cerevisiae. Genetics 2017, 207: 1371-1386. PMID: 28978675, PMCID: PMC5714454, DOI: 10.1534/genetics.117.300322.Peer-Reviewed Original ResearchConceptsLong-chain polyprenolsSpore wallSynthesis of chitinSpore wall layerHaploid genomeCellular processesProtein glycosylationPrenyltransferase activitySporulating cellsWall formationDityrosine layerIsoprenoid lipidsChitin synthaseEndoplasmic reticulumVegetative cellsSRT1Lipid dropletsDividing cellsEssential precursorPrimary enzymeImportant functionsSaccharomycesPolyprenolsDolicholSugar carrier
2009
The YTA7 gene is involved in the regulation of the isoprenoid pathway in the yeast Saccharomyces cerevisiae
Kuranda K, Grabinska K, Berges T, Karst F, Leberre V, Sokol S, François J, Palamarczyk G. The YTA7 gene is involved in the regulation of the isoprenoid pathway in the yeast Saccharomyces cerevisiae. FEMS Yeast Research 2009, 9: 381-390. PMID: 19416104, DOI: 10.1111/j.1567-1364.2009.00485.x.Peer-Reviewed Original ResearchConceptsIsoprenoid pathwayFPP synthaseTwo-hybrid screenMembrane-associated proteinsBiosynthesis of hemeIsoprenoid biosynthesisProtein partnersPresence of lovastatinYeast SaccharomycesN-glycosylationSterol biosynthesisSqualene synthaseCis-prenyltransferaseEndoplasmic reticulumIsoprenoid compoundsZaragozic acidsBiosynthesisCellular levelGenesEnzymatic activityExpression levelsSaccharomycesPathwaySynthaseRegulation
2006
Prenylation of Saccharomyces cerevisiae Chs4p Affects Chitin Synthase III Activity and Chitin Chain Length▿
Grabińska K, Magnelli P, Robbins P. Prenylation of Saccharomyces cerevisiae Chs4p Affects Chitin Synthase III Activity and Chitin Chain Length▿. MSphere 2006, 6: 328-336. PMID: 17142567, PMCID: PMC1797950, DOI: 10.1128/ec.00203-06.Peer-Reviewed Original ResearchConceptsChitin synthase IIIChitin synthase III activityPlasma membrane associationC-terminal endMembrane associationCSIII activityChs4pCatalytic subunitProtein factorsChitin biosynthesisSynthase IIIFarnesyl transferaseYeast cellsPrenylationChitin polymersPrenyl moietyEnzymatic activityChitin contentAttachment sitesAverage chain lengthChs3pSaccharomycesVivoBiosynthesisFTase
2005
Functional relationships between the Saccharomyces cerevisiae cis-prenyltransferases required for dolichol biosynthesis.
Grabińska K, Sosińska G, Orłowski J, Swiezewska E, Berges T, Karst F, Palamarczyk G. Functional relationships between the Saccharomyces cerevisiae cis-prenyltransferases required for dolichol biosynthesis. Acta Biochimica Polonica 2005, 52: 221-32. PMID: 15827619, DOI: 10.18388/abp.2005_3511.Peer-Reviewed Original ResearchConceptsEnzymatic activityCis-prenyltransferase activityLong-chain dolicholsYeast SaccharomycesShorter speciesRER2Dolichol biosynthesisLevels of mRNADiphosphate formationIsoprene unitsSRT1SaccharomycesOverexpressionDolichol contentGenesPreferential synthesisProteinFunctional relationshipMRNADPM1TranscriptionBiosynthesisFarnesylSpecies
2002
The isoprenoid biosynthetic pathway in Saccharomyces cerevisiae is affected in a maf1-1 mutant with altered tRNA synthesis
Kamińska J, Grabińska K, Kwapisz M, Sikora J, Smagowicz W, Palamarczyk G, Żołądek T, Boguta M. The isoprenoid biosynthetic pathway in Saccharomyces cerevisiae is affected in a maf1-1 mutant with altered tRNA synthesis. FEMS Yeast Research 2002, 2: 31-37. DOI: 10.1016/s1567-1356(01)00059-9.Peer-Reviewed Original ResearchIsoprenoid pathwayIsoprenoid biosynthetic pathwayCellular tRNA levelsTRNA synthesisTRNA biosynthesisTRNA levelsSaccharomyces cerevisiaeBiosynthetic pathwayComplex regulationIsopentenyltransferaseProtein levelsMutantsErgosterol contentBiosynthesisPathwayIsopentenylationCerevisiaeSaccharomycesYeastTranscriptsRegulationExpressionDirect effectCellsThe isoprenoid biosynthetic pathway in Saccharomyces cerevisiae is affected in a maf1-1 mutant with altered tRNA synthesis
Kamińska J, Grabińska K, Kwapisz M, Sikora J, Smagowicz W, Palamarczyk G, Żołądek T, Boguta M. The isoprenoid biosynthetic pathway in Saccharomyces cerevisiae is affected in a maf1-1 mutant with altered tRNA synthesis. FEMS Yeast Research 2002, 2: 31-37. PMID: 12702319, DOI: 10.1111/j.1567-1364.2002.tb00066.x.Peer-Reviewed Original ResearchConceptsIsoprenoid pathwayIsoprenoid biosynthetic pathwayCellular tRNA levelsTRNA synthesisTRNA biosynthesisTRNA levelsSaccharomyces cerevisiaeBiosynthetic pathwayComplex regulationIsopentenyltransferaseProtein levelsMutantsErgosterol contentBiosynthesisPathwayIsopentenylationCerevisiaeSaccharomycesYeastTranscriptsRegulationExpressionDirect effectCells