2024
47. GENE DISCOVERY AND BIOLOGICAL INSIGHTS INTO ANXIETY DISORDERS FROM A MULTI-ANCESTRY GENOME-WIDE ASSOCIATION STUDY OF > 1.2 MILLION PARTICIPANTS
Friligkou E, Løkhammer S, Mendoza B, Shen J, He J, Deiana G, Zanoaga M, Asgel Z, Pilcher A, Di Lascio L, Makharashvili A, Koller D, Tylee D, Pathak G, Polimanti R. 47. GENE DISCOVERY AND BIOLOGICAL INSIGHTS INTO ANXIETY DISORDERS FROM A MULTI-ANCESTRY GENOME-WIDE ASSOCIATION STUDY OF > 1.2 MILLION PARTICIPANTS. European Neuropsychopharmacology 2024, 87: 74-75. DOI: 10.1016/j.euroneuro.2024.08.161.Peer-Reviewed Original ResearchMillion Veteran ProgramPolygenic riskLatent causal variable methodMulti-tissue transcriptome-wide association studyUK Biobank (UKBGenetic correlationsTranscriptome-wide association studyAnxiety disordersGenomic structural equation modelingLD score regressionLocal genetic correlationGWAS meta-analysisProteome-wide analysisGenetics of anxietyAssociated with anxietyMulti-omics informationS-MultiXcanVeteran ProgramLD scoresAncestry-specificTranscriptome-wideAncestral populationsCross-ancestryGene discoveryAssociation studiesGene discovery and biological insights into anxiety disorders from a large-scale multi-ancestry genome-wide association study
Friligkou E, Løkhammer S, Cabrera-Mendoza B, Shen J, He J, Deiana G, Zanoaga M, Asgel Z, Pilcher A, Di Lascio L, Makharashvili A, Koller D, Tylee D, Pathak G, Polimanti R. Gene discovery and biological insights into anxiety disorders from a large-scale multi-ancestry genome-wide association study. Nature Genetics 2024, 56: 2036-2045. PMID: 39294497, DOI: 10.1038/s41588-024-01908-2.Peer-Reviewed Original ResearchGenome-wide association studiesAnxiety disordersAssociation studiesMulti-ancestry genome-wide association studyPathogenesis of anxiety disordersHeritability of anxietyLocal genetic correlationProteome-wide analysisIndividuals of European descentAssociated with anxietyMulti-omics informationWidespread pleiotropyTranscriptome-widePolygenic risk scoresBipolar disorderAncestry-specificGene discoveryContinental groupsLimbic systemEast Asian groupsBiological insightsAnxietyEntorhinal cortexPhysical health domainBrain-specificDistinguishing vulnerability and resilience to posttraumatic stress disorder evaluating traumatic experiences, genetic risk and electronic health records
Løkhammer S, Koller D, Wendt F, Choi K, He J, Friligkou E, Overstreet C, Gelernter J, Hellard S, Polimanti R. Distinguishing vulnerability and resilience to posttraumatic stress disorder evaluating traumatic experiences, genetic risk and electronic health records. Psychiatry Research 2024, 337: 115950. PMID: 38744179, PMCID: PMC11156529, DOI: 10.1016/j.psychres.2024.115950.Peer-Reviewed Original ResearchElectronic health recordsPosttraumatic stress disorderHealth recordsPTSD vulnerabilityUK Biobank (UKBPhenome-wide association studyRisk scorePhenotype risk scoreUs Research ProgramPolygenic risk scoresStress disorderAoU participantsUKB participantsPresence of posttraumatic stress disorderTrauma burdenGenetic riskPosttraumatic stress disorder symptomsAssociation studiesPheWASClinical comorbiditiesComorbid associationsEye conditionsAOUInverse relationshipMultiple phenotypesSex differences in the pleiotropy of hearing difficulty with imaging-derived phenotypes: a brain-wide investigation
He J, Cabrera-Mendoza B, De Angelis F, Pathak G, Koller D, Curhan S, Curhan G, Mecca A, van Dyck C, Polimanti R. Sex differences in the pleiotropy of hearing difficulty with imaging-derived phenotypes: a brain-wide investigation. Brain 2024, 147: 3395-3408. PMID: 38454550, PMCID: PMC11449129, DOI: 10.1093/brain/awae077.Peer-Reviewed Original ResearchImaging-derived phenotypesHearing difficultiesBrain imaging-derived phenotypesSex-combined analysisLatent causal variable analysesMendelian randomization approachGeneralized linear regression analysisLocal genetic correlation analysisMultivariate generalized linear regression analysisGenome-wide association studiesLatent causal variableGenetic correlation analysisGenetic correlationsLocal genetic correlationMendelian randomizationPeripheral auditory systemOlder adultsGWAS dataLinear regression analysisHealth burdenGenomic regionsAssociation studiesPleiotropic regionsSex differencesTranscriptome regulation
2023
Brainwide Mendelian Randomization Study of Anxiety Disorders and Symptoms
Zanoaga M, Friligkou E, He J, Pathak G, Koller D, Cabrera-Mendoza B, Stein M, Polimanti R. Brainwide Mendelian Randomization Study of Anxiety Disorders and Symptoms. Biological Psychiatry 2023, 95: 810-817. PMID: 37967698, PMCID: PMC10978301, DOI: 10.1016/j.biopsych.2023.11.006.Peer-Reviewed Original ResearchImaging-derived phenotypesMiddle cingulate gyrusBrain imaging-derived phenotypesCingulate gyrusBrain structuresMultivariable Mendelian randomization analysesRight anterior superior temporal gyrusGray matter volumeMendelian randomizationAnterior superior temporal gyrusUK BiobankMendelian randomization studyFalse discovery rate correctionSuperior temporal gyrusMultivariable Mendelian randomizationMendelian randomization analysisMillion Veteran ProgramLarge cohortMatter volumeRandomization studySymptom-level analysesTemporal gyrusAnxiety disordersRandomization analysisGyrusStressful Life Events, Unhealthy Eating Behaviors and Obesity among Chinese Government Employees: A Follow-Up Study
Qiu D, He J, Li Y, Ouyang F, Xiao S. Stressful Life Events, Unhealthy Eating Behaviors and Obesity among Chinese Government Employees: A Follow-Up Study. Nutrients 2023, 15: 2637. PMID: 37299600, PMCID: PMC10255864, DOI: 10.3390/nu15112637.Peer-Reviewed Original ResearchConceptsHigher risk of obesityUnhealthy eating behaviorsRisk of obesityFollow-upEating behaviorsStressful life eventsAssociated with obesityIrregular meal timesLife eventsFollow-up studyFollowed-upObesityMeal timesBaselineLife Events ScaleChinese government employeesGovernment employeesChinese workersEvent ScaleReportsTrends in mortality and causes of death among Chinese adolescents aged 10–19 years from 1990 to 2019
Zhu J, Li Y, Zhang C, He J, Niu L. Trends in mortality and causes of death among Chinese adolescents aged 10–19 years from 1990 to 2019. Frontiers In Public Health 2023, 11: 1075858. PMID: 36825144, PMCID: PMC9941149, DOI: 10.3389/fpubh.2023.1075858.Peer-Reviewed Original ResearchConceptsNon-communicable diseasesNon-communicable disease mortality ratesAdolescent HealthRates of non-communicable diseasesGlobal Burden of Disease StudyMortality rateBurden of Disease StudyPromote adolescent healthChinese adolescentsAdolescent mortality ratesAdolescent mortalityGlobal burdenRoad injuriesSelf-harmHealthy ChinaAge disparitiesHigher mortalityDisease StudyMedical practiceCongenital birth defectsSocioeconomic conditionsHealthRate of communicationDisease patternsNutritional diseasesAssociation of Healthy Lifestyles with Non-Alcoholic Fatty Liver Disease: A Prospective Cohort Study in Chinese Government Employees
Ling Z, Zhang C, He J, Ouyang F, Qiu D, Li L, Li Y, Li X, Duan Y, Luo D, Xiao S, Shen M. Association of Healthy Lifestyles with Non-Alcoholic Fatty Liver Disease: A Prospective Cohort Study in Chinese Government Employees. Nutrients 2023, 15: 604. PMID: 36771311, PMCID: PMC9921275, DOI: 10.3390/nu15030604.Peer-Reviewed Original ResearchConceptsHealthy lifestyle factorsLifestyle factorsBody mass indexLow-risk factorsChinese government employeesAssociations of healthy lifestyleCohort studyHealthy lifestyle patternNon-sedentary behaviorIncidence of non-alcoholic fatty liver diseaseNormal body mass indexRisk of non-alcoholic fatty liver diseaseOR of NAFLDNon-alcoholic fatty liver diseaseProspective cohort studyLogistic regression modelsPhysical activityAssociated with non-alcoholic fatty liver diseaseHealthy lifestyleLifestyle patternsHealthy dietMass indexGovernment employeesFatty liver diseaseRegression models
2022
Increased Mortality Trends in Patients With Chronic Non-communicable Diseases and Comorbid Hypertension in the United States, 2000–2019
Ouyang F, Cheng X, Zhou W, He J, Xiao S. Increased Mortality Trends in Patients With Chronic Non-communicable Diseases and Comorbid Hypertension in the United States, 2000–2019. Frontiers In Public Health 2022, 10: 753861. PMID: 35899158, PMCID: PMC9309719, DOI: 10.3389/fpubh.2022.753861.Peer-Reviewed Original ResearchConceptsAverage annual percent changeNon-communicable diseasesAnnual percent changeChronic respiratory diseasesMortality trendsPercent changeCardiovascular diseaseMortality rateCVD mortality ratesIncreasing mortality trendCenters for Disease Control and PreventionConfidence intervalsComorbid hypertensionDisease Control and PreventionDiabetes mellitusControl and PreventionNCD mortalityCVD mortalityUnited StatesMortality dataMinimize disparitiesDemographic subgroupsHypertension-related cardiovascular diseasesIncreased mortality rateRural SouthStressful Life Events and Chronic Fatigue Among Chinese Government Employees: A Population-Based Cohort Study
Qiu D, He J, Li Y, Li R, Ouyang F, Li L, Luo D, Xiao S. Stressful Life Events and Chronic Fatigue Among Chinese Government Employees: A Population-Based Cohort Study. Frontiers In Public Health 2022, 10: 890604. PMID: 35875038, PMCID: PMC9300904, DOI: 10.3389/fpubh.2022.890604.Peer-Reviewed Original ResearchConceptsAssociated with self-reported fatigueSelf-reported fatigueStressful life eventsChinese government employeesNegative stressful life eventsLife Events ScaleLife eventsHealth behavior related factorsPopulation-based cohort studyChronic fatigueAssociated with fatigueBehavior related factorsCumulative life eventsBinary logistic regression analysisParticipants' healthGovernment employeesFollow-upLogistic regression analysisSociodemographic factorsAssociated with lower incidenceProspective associationsEffective interventionsNegative life eventsCohort studyPositive stressful life eventsAssociations of Socioeconomic Status and Healthy Lifestyle With Incidence of Dyslipidemia: A Prospective Chinese Governmental Employee Cohort Study
Li L, Ouyang F, He J, Qiu D, Luo D, Xiao S. Associations of Socioeconomic Status and Healthy Lifestyle With Incidence of Dyslipidemia: A Prospective Chinese Governmental Employee Cohort Study. Frontiers In Public Health 2022, 10: 878126. PMID: 35757615, PMCID: PMC9218108, DOI: 10.3389/fpubh.2022.878126.Peer-Reviewed Original ResearchConceptsIncidence of dyslipidemiaHealthy lifestyleLifestyle scoreSocioeconomic inequalitiesHigher SESLow SESSocial determinants of healthAssociation of socioeconomic statusCumulative incidence of dyslipidemiaPhysician-diagnosed dyslipidemiaHealthy lifestyle behaviorsReduce socioeconomic inequalitiesDeterminants of healthAssociation of SESLipid-lowering drug useParticipants' mean ageLipoprotein cholesterolCox proportional hazards modelsHigh-density lipoprotein cholesterolLifestyle behaviorsPhysical activitySocial determinantsProportional hazards modelUnhealthy lifestylePrimary lifestyleThe Association Between Life Events and Incidence of Hypertension Among Government Employees in China: A Prospective Cohort Study
Ouyang F, He J, Cheng X, Qiu D, Li L, Bangura J, Duan Y, Luo D, Xiao S. The Association Between Life Events and Incidence of Hypertension Among Government Employees in China: A Prospective Cohort Study. Frontiers In Psychology 2022, 13: 822610. PMID: 35707654, PMCID: PMC9190203, DOI: 10.3389/fpsyg.2022.822610.Peer-Reviewed Original ResearchIncidence rate ratiosRisk of hypertensionProspective cohort studyIncreased risk of HTNLife eventsHypertension riskHypertension incidenceNegative life eventsCohort studyPositive life eventsConfidence intervalsHypertension incidence rateIncreased riskRisk factorsPoisson regression modelsWork-related life eventsGlobal public health concernPublic health concernIncidence of hypertensionSociodemographic characteristicsGovernment employeesHypertension diagnosisRate ratiosIncidence ratePrevention strategiesLong working hours, work-related stressors and sleep disturbances among Chinese government employees: A large population-based follow-up study
Qiu D, Li Y, Li R, He J, Ouyang F, Luo D, Xiao S. Long working hours, work-related stressors and sleep disturbances among Chinese government employees: A large population-based follow-up study. Sleep Medicine 2022, 96: 79-86. PMID: 35613538, DOI: 10.1016/j.sleep.2022.05.005.Peer-Reviewed Original ResearchConceptsLong working hoursChinese government employeesGovernment employeesWork stressWorking hoursWork-related stressorsEmployeesChinese workersOvertime workJob dissatisfactionPittsburgh Sleep Quality IndexPath analysisWork dissatisfactionSleep disturbancePopulation-based follow-up studyFollow-upAssociated with poor sleep qualityAntipsychotic-Related Risks of Type 2 Diabetes Mellitus in Enrollees With Schizophrenia in the National Basic Public Health Service Program in Hunan Province, China
Ouyang F, He J, Cheng X, Zhou W, Xiao S, Fang J. Antipsychotic-Related Risks of Type 2 Diabetes Mellitus in Enrollees With Schizophrenia in the National Basic Public Health Service Program in Hunan Province, China. Frontiers In Psychiatry 2022, 13: 754775. PMID: 35280179, PMCID: PMC8909132, DOI: 10.3389/fpsyt.2022.754775.Peer-Reviewed Original ResearchAntipsychotic usePatients’ baseline body mass index.Public Health Service ProgramType 2 diabetes mellitusMental health officersAntipsychotic monotherapyRisk of T2DMSchizophreniaAntipsychoticsProportion of animal productsCumulative person-yearsBaseline fasting plasma glucose levelsHazard ratioClozapineRisperidoneRisk of type 2 diabetes mellitusFasting plasma glucose levelsT2DM riskBaseline body mass indexDiabetes-free patientsPerphenazineHealth service programsDevelopment of type 2 diabetes mellitusChlorpromazineHigher risk of T2DM
2021
Time Trends and Predictions of Suicide Mortality for People Aged 70 Years and Over From 1990 to 2030 Based on the Global Burden of Disease Study 2017
He J, Ouyang F, Qiu D, Li L, Li Y, Xiao S. Time Trends and Predictions of Suicide Mortality for People Aged 70 Years and Over From 1990 to 2030 Based on the Global Burden of Disease Study 2017. Frontiers In Psychiatry 2021, 12: 721343. PMID: 34646174, PMCID: PMC8502866, DOI: 10.3389/fpsyt.2021.721343.Peer-Reviewed Original ResearchSub-Saharan AfricaSuicide mortality ratesSocio-demographic indexElderly mortality rateSuicide mortalitySuicide ratesMortality changesGlobal Burden of Disease StudySouthern Latin AmericaLatin AmericaBurden of Disease StudySub-SaharanWestern EuropeHighest suicide ratesSDGs indicatorsPrevention policiesTrends of suicide mortalityEast AsiaSouth KoreaAfricaCountriesReduce suicide ratesCzech RepublicGlobal burdenPeopleJob Dissatisfaction Mediated the Associations Between Work Stress and Mental Health Problems
Qiu D, Li R, Li Y, He J, Ouyang F, Luo D, Xiao S. Job Dissatisfaction Mediated the Associations Between Work Stress and Mental Health Problems. Frontiers In Psychiatry 2021, 12: 711263. PMID: 34603101, PMCID: PMC8483558, DOI: 10.3389/fpsyt.2021.711263.Peer-Reviewed Original ResearchMental health problemsMental healthJob dissatisfactionAnxiety symptomsWork stressHealth problemsDepressive symptomsPerceived work stressResults of univariate logistic regressionPatient Health Questionnaire-2Generalized Anxiety Disorder-2Assessment of mental healthUnivariate logistic regressionLogistic regressionAssociated with job dissatisfactionSelf-report scalesPath analysisReport anxiety symptomsPsychosocial work environmentPopulation-based studyChinese working adultsPotential mediation effectsMediation modelWork dissatisfactionStress managementInfectious Disease Outbreak and Post-Traumatic Stress Symptoms: A Systematic Review and Meta-Analysis
Qiu D, Li Y, Li L, He J, Ouyang F, Xiao S. Infectious Disease Outbreak and Post-Traumatic Stress Symptoms: A Systematic Review and Meta-Analysis. Frontiers In Psychology 2021, 12: 668784. PMID: 34421723, PMCID: PMC8376538, DOI: 10.3389/fpsyg.2021.668784.Peer-Reviewed Original ResearchPrevalence of post-traumatic stress symptomsPost-traumatic stress symptomsChinese National Knowledge InfrastructurePooled prevalenceInfectious disease outbreaksStress symptomsLong-term prevention strategiesNational Knowledge InfrastructureConsequences of traumatic eventsWeb of ScienceHealth policymakersHealthcare workersGeneral populationSystematic reviewInfectious diseasesSystematic searchKnowledge InfrastructureCochrane LibraryMeta-analysisCases of infectious diseasesSuspected casesTraumatic eventsMortality rateDisease outbreaksTraumaSociodemographic disparity in health-related behaviours and dietary habits among public workers in China: a cross-sectional study
Li L, He J, Ouyang F, Qiu D, Li Y, Luo D, Yu Y, Xiao S. Sociodemographic disparity in health-related behaviours and dietary habits among public workers in China: a cross-sectional study. BMJ Open 2021, 11: e047462. PMID: 34344677, PMCID: PMC8336184, DOI: 10.1136/bmjopen-2020-047462.Peer-Reviewed Original ResearchConceptsHealth-related behaviorsDietary habitsSocioeconomic statusLeisure-time physical inactivityCategories of education levelDairy products patternMultiple unhealthy behavioursTargeted health interventionsHigh-SES groupsAnnual household incomeRates of smokingSecondary outcome measuresYears old peopleGovernment-run institutionsPhysical inactivityShort sleep durationMiddle-aged groupNuts' patternsHigh-SESMultivariate logistic regression analysisUnhealthy behaviorsSociodemographic disparitiesHealth interventionsLogistic regression analysisSociodemographic characteristicsStressful life events and poor sleep quality: a cross-sectional survey in the Chinese governmental employees
Li Y, Qiu D, Hu C, Ouyang F, He J, Zang D, Luo D, Xiao S. Stressful life events and poor sleep quality: a cross-sectional survey in the Chinese governmental employees. Sleep Medicine 2021, 85: 123-130. PMID: 34325381, DOI: 10.1016/j.sleep.2021.06.030.Peer-Reviewed Original ResearchConceptsStressful life eventsAssociated with poor sleep qualityNegative life eventsLife eventsPoor sleep qualitySleep qualityGovernmental employeesCumulative life eventsPositive life eventsSpecific life eventsLikelihood of poor sleep qualityOdds ratioConfidence intervalsAssociated with sleep qualityCross-sectional surveyAssociated with 3 timesLogistic regression modelsEmployeesCross-sectional dataWork stressSpouse's parentsJob dissatisfactionLifestyle changesChronic diseasesCohort studyPrevalence of post-traumatic stress symptoms among people influenced by coronavirus disease 2019 outbreak: A meta-analysis
Qiu D, Li Y, Li L, He J, Ouyang F, Xiao S. Prevalence of post-traumatic stress symptoms among people influenced by coronavirus disease 2019 outbreak: A meta-analysis. European Psychiatry 2021, 64: e30. PMID: 33843547, PMCID: PMC8060540, DOI: 10.1192/j.eurpsy.2021.24.Peer-Reviewed Original ResearchConceptsPost-traumatic stress symptomsPrevalence of post-traumatic stress symptomsPost-traumatic stress disorderStress symptomsSymptoms of post-traumatic stress disorderPooled prevalencePTSD-related symptomsConsequences of traumatic eventsAssociated with higher prevalenceChinese National Knowledge InfrastructureResults of meta-regressionStress disorder