2024
Signatures of transmission in within-host Mycobacterium tuberculosis complex variation: a retrospective genomic epidemiology study
Walter K, Cohen T, Mathema B, Colijn C, Sobkowiak B, Comas I, Goig G, Croda J, Andrews J. Signatures of transmission in within-host Mycobacterium tuberculosis complex variation: a retrospective genomic epidemiology study. The Lancet Microbe 2024, 100936. PMID: 39615498, DOI: 10.1016/j.lanmic.2024.06.003.Peer-Reviewed Original ResearchWithin-host variationMycobacterium tuberculosis complexTransmission inferenceSequence dataMinority variantsGenome Epidemiology StudyMTBC diversityWhole-genome sequencing dataPairs of isolatesAvailable sequence dataPublicly available sequencing dataRetrospective population-based studyPopulation-based studyIdentical genomesPPE genesGenetic differencesWalker etCulture isolatesTuberculosis complexHousehold transmission studyIsolatesEpidemiological linkageReceiver operating characteristicEpidemiological studiesCulture of sputumAssessment of the BNT162B2 COVID-19 vaccine immune response in Brazilian indigenous adolescents
de Oliveira L, de Morais I, Marchioro S, de Almeida G, de Almeida de Souza G, da Silva Ferreira T, Rossoni R, de Oliveira Barbosa D, Navarini V, Croda J, Torres A, Simionatto S. Assessment of the BNT162B2 COVID-19 vaccine immune response in Brazilian indigenous adolescents. Vaccine 2024, 43: 126494. PMID: 39571350, DOI: 10.1016/j.vaccine.2024.126494.Peer-Reviewed Original ResearchCD8+ T cellsBNT162b2 vaccineT cellsB lymphocytesIncreased levels of B lymphocytesImmune responseCell subpopulationsLevels of B lymphocytesSARS-CoV-2-specific immune responsesMemory B cellsNon-classical monocytesIndigenous adolescentsStatistically significant increaseNK cellsVaccinated adolescentsB cellsNo significant changesBooster doseCohort studyBNT162b2Vaccination scheduleLimited healthcare resourcesImmunogenic responseDemographic dataCOVID-19 vaccineA case report on symptomatic disease caused by serotype 4 vaccine virus following tetravalent anti-dengue vaccination
Oliveira R, Santos A, Gonçalves C, Giovanetti M, Alcantara L, Demarchi L, Lichs G, Ilis T, Hiane S, Abbud A, Sacchi C, Naveca F, Santos D, Marques E, Lucena Junior W, Croda J. A case report on symptomatic disease caused by serotype 4 vaccine virus following tetravalent anti-dengue vaccination. Travel Medicine And Infectious Disease 2024, 62: 102782. PMID: 39461453, DOI: 10.1016/j.tmaid.2024.102782.Peer-Reviewed Original ResearchMass incarceration as a driver of the tuberculosis epidemic in Latin America and projected effects of policy alternatives: a mathematical modelling study
Liu Y, Mabene Y, Camelo S, Rueda Z, Pelissari D, Johansen F, Huaman M, Avalos-Cruz T, Alarcón V, Ladutke L, Bergman M, Cohen T, Goldhaber-Fiebert J, Croda J, Andrews J. Mass incarceration as a driver of the tuberculosis epidemic in Latin America and projected effects of policy alternatives: a mathematical modelling study. The Lancet Public Health 2024, 9: e841-e851. PMID: 39419058, PMCID: PMC11602220, DOI: 10.1016/s2468-2667(24)00192-0.Peer-Reviewed Original ResearchConceptsLatin AmericaIncarceration policiesIncarcerated populationsEffects of policy alternativesDuration of incarcerationMinistry of JusticePrison admissionsIncarceration ratesMass incarcerationIncarcerationPolicy alternativesInternational health agenciesEl SalvadorHistorical riseTuberculosis incidenceLatinPrisonAge structureHealth agenciesCounterfactual scenariosCountriesPolicyHealth crisisNational Tuberculosis ProgrammeTuberculosis epidemicThe greatest Dengue epidemic in Brazil: Surveillance, Prevention, and Control
Gurgel-Gonçalves R, de Oliveira W, Croda J. The greatest Dengue epidemic in Brazil: Surveillance, Prevention, and Control. Revista Da Sociedade Brasileira De Medicina Tropical 2024, 57: e00203-2024. PMID: 39319953, PMCID: PMC11415067, DOI: 10.1590/0037-8682-0113-2024.Peer-Reviewed Original ResearchConceptsHealth education initiativesPhase 3 clinical trialsPublic health systemMinistry of HealthIndoor residual sprayingSterile insect techniqueHealth servicesHealth systemTakeda vaccineCommunity mobilizationMultisectoral approachDengue epidemicsDengue casesEducational initiativesDengue mortalityResidual sprayingMosquito controlHome cleaningInsect techniqueAedes aegyptiPotential mosquito breeding sitesHealthVaccination coverageDengue virusVaccineAntecedent and persistent symptoms in COVID-19 and other respiratory illnesses: Insights from prospectively collected data in the BRACE trial
ald E, Pittet L, Barry S, Bonten M, Campbell J, Croda J, Croda M, Dalcolmo M, Davidson A, de Almeida e Val F, dos Santos G, Gardiner K, Gell G, Gwee A, Krastev A, Lacerda M, Lucas M, Lynn D, Manning L, McPhate N, Perrett K, Post J, Prat-Aymerich C, Quinn L, Richmond P, Wood N, Messina N, Curtis N, Group T. Antecedent and persistent symptoms in COVID-19 and other respiratory illnesses: Insights from prospectively collected data in the BRACE trial. Journal Of Infection 2024, 89: 106267. PMID: 39245151, PMCID: PMC11489119, DOI: 10.1016/j.jinf.2024.106267.Peer-Reviewed Original ResearchConceptsBraced trialsChronic respiratory diseasesHealthcare workersPre-existing symptomsRisk of PaCMulticentre randomised controlled trialNon-COVID-19Non-COVID-19 respiratory illnessesRandomised controlled trialsRespiratory illnessNon-COVID-19 illnessesSymptom patternsLonger-lasting symptomsProportion of COVID-19 casesRespiratory diseaseIllness episodesWHO definitionCOVID-19Compare symptomsControlled trialsRespiratory illness episodesSymptom dataPersistence of symptomsIllnessIncreased riskSeverity-dependent test-seeking behaviors and test-negative designs: impact on estimated vaccine effectiveness and utility of analytic and design choices
Amin A, Hitchings M, Ranzani O, Andrews J, Cummings D, Ko A, Croda J, Dean N. Severity-dependent test-seeking behaviors and test-negative designs: impact on estimated vaccine effectiveness and utility of analytic and design choices. American Journal Of Epidemiology 2024, kwae303. PMID: 39191656, DOI: 10.1093/aje/kwae303.Peer-Reviewed Original ResearchBCG vaccination of healthcare workers for protection against COVID-19: 12-month outcomes from an international randomised controlled trial
Messina N, Pittet L, McDonald E, Moore C, Barry S, Bonten M, Byrne A, Campbell J, Croda J, Croda M, Dalcolmo M, de Almeida e Val F, de Oliveira R, dos Santos G, Douglas M, Gardiner K, Gwee A, Jardim B, Kollmann T, Lacerda M, Lucas M, Lynn D, Manning L, Marshall H, O’Connell A, Perrett K, Post J, Prat-Aymerich C, Rocha J, Rodriguez-Baño J, Wadia U, Warris A, Davidson A, Curtis N, Group T. BCG vaccination of healthcare workers for protection against COVID-19: 12-month outcomes from an international randomised controlled trial. Journal Of Infection 2024, 89: 106245. PMID: 39127450, PMCID: PMC11409612, DOI: 10.1016/j.jinf.2024.106245.Peer-Reviewed Original ResearchConceptsBacille Calmette-GuerinBreakthrough COVID-19Healthcare workersSevere COVID-19Risk of severe COVID-19Placebo groupSymptomatic COVID-19BCG-DenmarkRisk of symptomatic COVID-19International randomised controlled trialRandomised controlled trialsBacille Calmette-Guerin vaccineVaccination of healthcare workersHealthcare centresSARS-CoV-2 testingAsymptomatic SARS-CoV-2 infectionRandomised 1:1SARS-CoV-2 infectionCOVID-19MITT populationControlled trialsHealthcareIntradermal doseModified intentionImmunomodulatory effectsInsights into SARS-CoV-2 Surveillance among Prison Populations in Mato Grosso do Sul, Brazil, in 2022
da Silva L, Alcantara L, Fonseca V, Frias D, Zardin M, de Castro Lichs G, Esposito A, Xavier J, Fritsch H, Lima M, de Oliveira C, de Arruda L, de Mello Almeida Maziero L, Barretos E, Oshiro P, Menezes E, de Freitas Cardoso L, Lemos E, Lourenço J, de Albuquerque C, do Carmo Said R, Rosewell A, Demarchi L, Croda J, Giovanetti M, Gonçalves C. Insights into SARS-CoV-2 Surveillance among Prison Populations in Mato Grosso do Sul, Brazil, in 2022. Viruses 2024, 16: 1143. PMID: 39066305, PMCID: PMC11281713, DOI: 10.3390/v16071143.Peer-Reviewed Original ResearchConceptsNext-generation sequencingPrison populationIncarcerated populationsOvercrowded cellsGenome sequenceGenomic characteristicsPrisonGenomic surveillanceEnclosed populationMato GrossoAverage coverageIsolation protocolSARS-CoV-2RT-qPCR testSARS-CoV-2 surveillanceRT-qPCRSequenceFrequent transferEpidemiological monitoringLimited healthcare accessGenomeCellsOmicron variantSeroprevalence of Zika virus in pregnant women in Brazil: a cohort study in the macroregion of Dourados - Mato Grosso do Sul
Dan C, Brito G, Croda J, Koishi A, Santos C, Benedetti K, Marchioro S, Simionatto S. Seroprevalence of Zika virus in pregnant women in Brazil: a cohort study in the macroregion of Dourados - Mato Grosso do Sul. Revista Eletrônica Acervo Saúde 2024, 24: e17324. DOI: 10.25248/reas.e17324.2024.Peer-Reviewed Original ResearchPregnant womenSeroprevalence of Zika virusInter-atrial communicationMaternal ZIKV infectionZika virusZIKV vaccinesInter-atrialPremature childbirthHigh feverZIKV infectionCohort studyNeurological alterationsTertiary hospitalImage analysis systemEthics CommitteeSerological diagnosisWomenResearch Ethics CommitteeQuantification of antibodiesZIKVAntibodiesSeroprevalenceVirusMyalgiaOstealgiaAccelerated Bacille Calmette-Guérin reactions: More than meets the eye
Villanueva P, Crawford N, Croda M, Croda J, Dalcolmo M, Jardim B, de Almeida Pinto Jardim T, Marshall H, Prat-Aymerich C, Sawka A, Sharma K, Troeman D, Warris A, Wood N, Messina N, Pittet L, Curtis N. Accelerated Bacille Calmette-Guérin reactions: More than meets the eye. Heliyon 2024, 10: e32510. PMID: 39027494, PMCID: PMC11255489, DOI: 10.1016/j.heliyon.2024.e32510.Peer-Reviewed Original ResearchInterferon-gamma release assayBacille Calmette-GuerinTB prevalence settingInjection site reactionsBCG reactionBCG vaccinationSite reactionsTB infectionLow TB prevalence countriesHistory of BCG vaccinationLocal injection site reactionsBacille Calmette-Guerin vaccineTB prevalence countriesInternational randomised trialLatent TB infectionDays of vaccinationSafety surveillance dataActive tuberculosisAdverse eventsBCG vaccineesMycobacterial exposureRelease assayClinical significanceTB symptomsFemale sexSeroprevalence of Treponema pallidum infection among high-risk populations from Brazil
Queiroz J, Barbosa M, Perez E, da Silva B, de Souza G, Gonçalves C, Croda J, Simionatto S. Seroprevalence of Treponema pallidum infection among high-risk populations from Brazil. Acta Tropica 2024, 256: 107255. PMID: 38761835, DOI: 10.1016/j.actatropica.2024.107255.Peer-Reviewed Original ResearchConceptsSexually transmitted infectionsHigh-risk groupCases of syphilisFactors associated with syphilisPregnant womenHistory of sexually transmitted infectionsPublic health strategiesHealthy populationSignificant public health concernPrevent future complicationsHigh risk of infectionHigh-risk populationPublic health concernHealth strategiesParticipant demographicsCross-sectional oneRisk of infectionVulnerable populationsFuture complicationsPLHIVTreatment outcomesHealth concernHigh riskSyphilisInfectionBacille Calmette-Guérin vaccination to prevent febrile and respiratory illness in adults (BRACE): secondary outcomes of a randomised controlled phase 3 trial
Pittet L, Messina N, McDonald E, Orsini F, Barry S, Bonten M, Campbell J, Croda J, Croda M, Dalcolmo M, Gardiner K, Gwee A, Jardim B, Lacerda M, Lucas M, Lynn D, Manning L, Perrett K, Post J, Prat-Aymerich C, Richmond P, Rocha J, Rodriguez-Baño J, Warris A, Wood N, Davidson A, Curtis N, Curtis N, Davidson A, Gardiner K, Gwee A, Jamieson T, Messina N, Morawakage T, Perlen S, Perrett K, Pittet L, Sastry A, Teo J, Orsini F, Lee K, Moore C, Vidmar S, Pittet L, Ali R, Dunn R, Edler P, Gell G, Goodall C, Hall R, Krastev A, La N, McDonald E, McPhate N, Nguyen T, Ren J, Stevens L, Messina N, Alamrousi A, Bonnici R, Dang T, Germano S, Hua J, McElroy R, Razmovska M, Reddiex S, Wang X, Anderson J, Azzopardi K, Bennett-Wood V, Czajko A, Mazarakis N, McCafferty C, Oppedisano F, Ortika B, Pell C, Spry L, Toh R, Velagapudi S, Vlahos A, Wee-Hee A, Ramos P, De La Cruz K, Gamage D, Karunanayake A, Mezzetti I, Ong B, Singh R, Sooriyarachchi E, Nicholson S, Cain N, Brizuela R, Huang H, Abruzzo V, Bealing M, Bimboese P, Bowes K, Burrell E, Chan J, Cushnahan J, Elborough H, Elkington O, Fahey K, Fernandez M, Flynn C, Fowler S, Andrit M, Gladanac B, Hammond C, Ma N, Macalister S, Milojevic E, Mojeed J, Nguyen J, O'Donnell L, Olivier N, Ooi I, Reynolds S, Shen L, Sherry B, Spotswood J, Wedderburn J, Younes A, Legge D, Bell J, Cheah J, Cobbledick A, Lim K, Elia S, Addlem L, Bourke A, Brophy C, Henare N, Jenkins N, Machingaifa F, Miller S, Mitchell K, Pitkin S, Wall K, Villanueva P, Crawford N, Pittet L, Norton W, Tan N, Chengodu T, Dawson D, Gordon V, Korman T, O'Bryan J, Abruzzo V, Agius S, Bannister S, Bucholc J, Burns A, Camesella B, Carlin J, Ciaverella M, Curtis M, Firth S, Guo C, Hannan M, Hill E, Joshi S, Lieschke K, Mathers M, Odoi S, Rak A, Richards C, Steve L, Stewart C, Sudbury E, Thomson H, Watts E, Williams F, Young A, Glenn P, Kaynes A, De Floy A, Buchanan S, Sondag T, Xie I, Edmund H, Byrne B, Keeble T, Ngien B, Noonan F, Wearing-Smith M, Clarke A, Davies P, Eastwood O, Ellinghaus A, Ghieh R, Hilton Z, Jennings E, Kakkos A, Liang I, Nicol K, O'Callaghan S, Osman H, Rajaram G, Ratcliffe S, Rayner V, Salmon A, Scheppokat A, Stevens A, Street R, Toogood N, Wood N, Bahaduri T, Baulman T, Byrne J, Carter C, Corbett M, Dao A, Desylva M, Dunn A, Gardiner E, Joyce R, Kandasamy R, Munns C, Pelayo L, Sharma K, Sterling K, Uren C, Colaco C, Douglas M, Hamilton K, Bartlett A, McMullan B, Palasanthiran P, Williams P, Beardsley J, Bergant N, Lagunday R, Overton K, Post J, Al-Hindawi Y, Barney S, Byrne A, Mead L, Plit M, Lynn D, Benson S, Blake S, Botten R, Chern T, Eden G, Griffith L, James J, Lynn M, Markow A, Sacca D, Stevens N, Wesselingh S, Doran C, Barry S, Sawka A, Evans S, Goodchild L, Heath C, Krieg M, Marshall H, McMillan M, Walker M, Richmond P, Amenyogbe N, Anthony C, Arnold A, Arrowsmith B, Ben-Othman R, Clark S, Dunnill J, Eiffler N, Ewe K, Finucane C, Flynn L, Gibson C, Hartnell L, Hollams E, Hutton H, Jarvis L, Jones J, Jones J, Jones K, Kent J, Kollmann T, Lalich D, Lee W, Lim R, McAlister S, McDonald F, Meehan A, Minhaj A, Montgomery L, O'Donnell M, Ong J, Ong J, Parkin K, Perez G, Power C, Rezazadeh S, Richmond H, Rogers S, Schultz N, Shave M, Skut P, Stiglmayer L, Truelove A, Wadia U, Wallace R, Waring J, England M, Latkovic E, Manning L, Herrmann S, Lucas M, Lacerda M, Andrade P, Barbosa F, Barros D, Brasil L, Capella A, Castro R, Costa E, de Souza D, Dias M, Dias J, Ferreira K, Figueiredo P, Freitas T, Furtado A, Gama L, Godinho V, Gouy C, Hinojosa D, Jardim B, Jardim T, Junior J, Lima A, Maia B, Marins A, Mazurega K, Medeiros T, Melo R, Moraes M, Nascimento E, Neves J, Oliveira M, Oliveira T, Oliveira I, Otsuka A, Paes R, Pereira H, Pereira G, Prado C, Queiroz E, Rodrigues L, Rodrigues B, Sampaio V, Santos A, Santos D, Santos T, Santos E, Sartim A, Silva A, Silva J, Silva E, Simão M, Soares C, Sousa A, Trindade A, Val F, Vasconcelos A, Vasconcelos H, Croda J, Abreu C, Almeida K, de Andrade C, Angelo J, de Araújo Arcanjo G, Arruda B, Ayala W, Barbosa A, Batista F, de Morais Batista F, de Jesus Costa M, Croda M, da Cruz L, Diogo R, Escobar R, Fernandes I, Figueiredo L, Gonçalves L, Lahdo S, dos Santos Lencina J, de Lima G, MEIRELES B, Moreira D, Muranaka L, de Oliveira A, de Oliveira K, de Oliveira M, de Oliveira R, dos Reis Pereira A, Puga M, Ramos C, da Rosa T, dos Santos K, dos Santos C, dos Santos D, Santos K, da Silva P, da Silva P, dos Santos Silva D, da Silva P, da Rosa Soares B, Sperotto M, Tadokoro M, Tsuha D, Vieira H, Dalcolmo M, da Paixão C, Castro G, Collopy S, da Costa Silva R, da Silveira S, Da-Cruz A, de Carvalho A, de Cássia Batista R, De Freitas M, de Oliveira Ferreira A, de Souza A, Doblas P, dos Santos A, dos Santos V, dos Santos Gomes D, Fortunato A, Gomes-Silva A, Gonçalves M, Meireless P, da Costa Carvalho E, do Couto Motta F, de Mendonça L, dos Santos Pandine G, Pereira R, Maia I, da Rocha J, Romano J, dos Santos G, da Silva E, de Siqueira M, Soares Á, Bonten M, Arroyo S, Besten H, Boon A, Brakke K, Janssen A, Koopmans M, Lemmens T, Leurink T, Prat-Aymerich C, Septer-Bijleveld E, Stadhouders K, Troeman D, van der Waal M, van Opdorp M, van Sluis N, Wolters B, Kluytmans J, Romme J, van den Bijllaardt W, van Mook L, van Rijen M, Filius P, Gisolf J, Greven F, Huijbens D, Hassing R, Pon R, Preijers L, van Leusen J, Verheij H, Boersma W, Brans E, Kloeg P, Molenaar-Groot K, Nguyen N, Paternotte N, Rol A, Stooper L, Dijkstra H, Eggenhuizen E, Huijs L, Moorlag S, Netea M, Pranger E, Taks E, Oever J, Heine R, Blauwendraat K, Meek B, Erkaya I, Harbech H, Roescher N, Peeters R, Riele M, Zhou C, Calbo E, Marti C, Palomares E, Porcuna T, Barriocanal A, Barriocanal A, Casas I, Dominguez J, Esteve M, Lacoma A, Latorre I, Molina G, Molina B, Rosell A, Vidal S, Barrera L, Bustos N, Calderón I, Campos D, Carretero J, Castellano A, Compagnone R, de Arellano E, de la Serna A, del Toro Lopez M, Espindola M, Gutierrez A, Hernandez A, Jiménez V, Moreno E, Navarrete N, Paño T, Rodríguez-Baño J, Tristán E, Villegas M, Garces A, Amo E, Guerrero R, Goikoetxea J, Jorge L, Perez C, Álvarez M, Cuadra M, de las Revillas Almajano F, Garcia P, Poderos T, Rico C, Sanchez B, Valero O, Vega N, Campbell J, Barnes A, Catterick H, Cranston T, Dawe P, Fletcher E, Fouracre L, Gifford A, Gow N, Kirkwood J, Martin C, McAnew A, Mitchell M, Newman G, O'Connell A, Onysk J, Quinn L, Rhodes S, Stone S, Symons L, Tripp H, Watkins D, Whale B, Harding A, Lockhart G, Sidaway-Lee K, Campbell J, Hilton S, Manton S, Webber-Rookes D, Winder R, Moore J, Bateman F, Gibbons M, Knight B, Moss J, Statton S, Studham J, Hall L, Moyle W, Venton T. Bacille Calmette-Guérin vaccination to prevent febrile and respiratory illness in adults (BRACE): secondary outcomes of a randomised controlled phase 3 trial. EClinicalMedicine 2024, 72: 102616. PMID: 38774675, PMCID: PMC11106519, DOI: 10.1016/j.eclinm.2024.102616.Peer-Reviewed Original ResearchBacille Calmette-Guerin vaccineBacille Calmette-GuerinRandomised controlled phase 3 trialControlled phase 3 trialPhase 3 trialIntention-to-treatRespiratory illnessBCG-DenmarkControl groupHealthcare workersDecreased all-cause mortalityRisk of severe diseasePresence of co-morbidityAssociated with protectionAll-cause mortalityEpisodes of illnessRespiratory infectionsIncreased riskHealthcare centresSecondary outcomesCo-morbiditySevere diseaseOff-target effectsSevere episodesVaccineEffectiveness of the fourth dose of COVID-19 vaccines against severe COVID-19 among adults 40 years or older in Brazil: a population-based cohort study
Neto F, Hitchings M, Amin A, de França G, Lind M, Torres M, Tsuha D, de Oliveira R, Cummings D, Dean N, Andrews J, Ko A, Croda J, Ranzani O. Effectiveness of the fourth dose of COVID-19 vaccines against severe COVID-19 among adults 40 years or older in Brazil: a population-based cohort study. The Lancet Regional Health - Americas 2024, 34: 100755. PMID: 38737773, PMCID: PMC11087726, DOI: 10.1016/j.lana.2024.100755.Peer-Reviewed Original ResearchSevere COVID-19Cohort ACohort B.Cohort BTwo-doseMRNA vaccinesPrimary outcomeBooster dose effectivenessCOVID-19 outcomesPopulation-based cohort studyDose of COVID-19 vaccinePopulation-based cohortPopulation-based cohort of individualsCOVID-19 vaccine dosesSevere COVID-19 outcomesFollow-upCohort studyMRNA-basedVaccine doseCohort of individualsVaccine effectivenessVaccine combinationsDoseLower hazardCohortFactors influencing adverse events following COVID-19 vaccination
Villanueva P, McDonald E, Croda J, Croda M, Dalcolmo M, dos Santos G, Jardim B, Lacerda M, Lynn D, Marshall H, Oliveira R, Rocha J, Sawka A, Val F, Pittet L, Messina N, Curtis N. Factors influencing adverse events following COVID-19 vaccination. Human Vaccines & Immunotherapeutics 2024, 20: 2323853. PMID: 38445666, PMCID: PMC10936640, DOI: 10.1080/21645515.2024.2323853.Peer-Reviewed Original ResearchConceptsVaccine typesSystemic reactionsIncidence of AEFIAdverse eventsVaccine doseIncidence of adverse eventsCovid-19 specific vaccineCOVID-19 vaccineNested cohort studyIgG antibody responsesRisk of AEFICOVID-19 vaccine typesChAdOx1 recipientsBNT162b2 recipientsCohort studyPfizer-BioNTechCoronaVac vaccineAntibody responseChAdOx1Oxford-AstraZenecaCoronaVacBNT162b2Local reactionsDoseDevelopment of COVID-19 vaccinesEffect of BCG vaccination against Mycobacterium tuberculosis infection in adult Brazilian health-care workers: a nested clinical trial
dos Santos P, Messina N, de Oliveira R, da Silva P, Puga M, Dalcolmo M, dos Santos G, de Lacerda M, Jardim B, de Almeida e Val F, Curtis N, Andrews J, Croda J. Effect of BCG vaccination against Mycobacterium tuberculosis infection in adult Brazilian health-care workers: a nested clinical trial. The Lancet Infectious Diseases 2024, 24: 594-601. PMID: 38423021, PMCID: PMC11111441, DOI: 10.1016/s1473-3099(23)00818-6.Peer-Reviewed Original ResearchConceptsQuantiFERON-TB GoldPlacebo groupEffect of BCG vaccinationBCG vaccinationBCG groupBCG-DenmarkHealth-care workersNegative baseline resultsMonths of treatmentMycobacterium tuberculosis infectionAdult pulmonary tuberculosisQuantiFERON-TBMedian ageRandomised controlled trialsPulmonary tuberculosisNo significant differenceEfficacy outcomesTuberculosis infectionClinical trialsControlled trialsEffect of vaccinationTreatment drugsTuberculosis preventionSubstudySignificant differenceIncarceration and TB: the epidemic beyond prison walls
Sequera G, Aguirre S, Estigarribia G, Walter K, Horna-Campos O, Liu Y, Andrews J, Croda J, Garcia-Basteiro A. Incarceration and TB: the epidemic beyond prison walls. BMJ Global Health 2024, 9: e014722. PMID: 38382977, PMCID: PMC10882329, DOI: 10.1136/bmjgh-2023-014722.Peer-Reviewed Original ResearchSerial Mass Screening for Tuberculosis Among Incarcerated Persons in Brazil
de Araujo R, Martinez L, da Silva Santos A, Lemos E, de Oliveira R, Croda M, Silva D, Lemes I, Cunha E, Gonçalves T, dos Santos P, da Silva B, Gonçalves C, Andrews J, Croda J. Serial Mass Screening for Tuberculosis Among Incarcerated Persons in Brazil. Clinical Infectious Diseases 2024, 78: 1669-1676. PMID: 38324908, PMCID: PMC11175667, DOI: 10.1093/cid/ciae055.Peer-Reviewed Original ResearchScreening roundsIncarcerated personsMass screeningIndividual prisonersIncarcerated peoplePrison populationBrazilian prisonsCases of pulmonary tuberculosisHigh-risk populationPrisonHealth QuestionnaireChest X-rayImprove case detectionPrevalence of tuberculosisRate of tuberculosisTB screeningMedian scoreHyperendemic settingsPulmonary tuberculosisXpert MTB/RIFTB scoreTuberculosis casesTuberculosis burdenCase detectionTuberculosisExcess tuberculosis risk during and following incarceration in Paraguay: a retrospective cohort study
Sequera G, Estigarribia-Sanabria G, Aguirre S, Piñanez C, Martinez L, Lopez-Olarte R, Andrews J, Walter K, Croda J, Garcia-Basteiro A. Excess tuberculosis risk during and following incarceration in Paraguay: a retrospective cohort study. The Lancet Regional Health - Americas 2024, 31: 100668. PMID: 38500958, PMCID: PMC10945421, DOI: 10.1016/j.lana.2023.100668.Peer-Reviewed Original ResearchPeople deprived of libertyMonths of incarcerationDuration of incarcerationRisk factors associated with TBPrison environmentIncarcerated individualsInstitution-level factorsIncarcerationPrisonTB control measuresFactors associated with TBHealth of peopleRisk of TBNational censusTB notification ratesLibertyRate of TBRisk of tuberculosisRetrospective cohort studyIncreased risk of tuberculosisTB programsAlarming riskParaguayPeopleCox regression modelsThe impact of sputum quality on Xpert positivity in active case-finding for TB
Oliveira da Silva B, Salindri A, Gonçalves T, Cunha E, da Silva Santos A, dos Santos P, Lemes I, Silva D, da Silva Oliveira V, Croda J, de Oliveira R, Andrews J. The impact of sputum quality on Xpert positivity in active case-finding for TB. The International Journal Of Tuberculosis And Lung Disease 2024, 28: 29-36. PMID: 38178289, DOI: 10.5588/ijtld.23.0244.Peer-Reviewed Original ResearchConceptsSputum qualityXpert-positiveCase findingChest X-rayLog-binomial regressionCross-sectional analysisMass screening programmeActive case findingCurrent smokingParticipant characteristicsScreening programmeSymptom screeningStandardised questionnaireSpot sputum samplesBlood-stained sputumAbnormal chest radiographBinomial regressionCAD4TBSputum appearanceMucopurulent sputumXpert testingSputum samplesClinical characteristicsSalivary specimensChest radiographs