2024
Antecedent and persistent symptoms in COVID-19 and other respiratory illnesses: Insights from prospectively collected data in the BRACE trial
ald E, Pittet L, Barry S, Bonten M, Campbell J, Croda J, Croda M, Dalcolmo M, Davidson A, de Almeida e Val F, dos Santos G, Gardiner K, Gell G, Gwee A, Krastev A, Lacerda M, Lucas M, Lynn D, Manning L, McPhate N, Perrett K, Post J, Prat-Aymerich C, Quinn L, Richmond P, Wood N, Messina N, Curtis N, Group T. Antecedent and persistent symptoms in COVID-19 and other respiratory illnesses: Insights from prospectively collected data in the BRACE trial. Journal Of Infection 2024, 89: 106267. PMID: 39245151, PMCID: PMC11489119, DOI: 10.1016/j.jinf.2024.106267.Peer-Reviewed Original ResearchConceptsBraced trialsChronic respiratory diseasesHealthcare workersPre-existing symptomsRisk of PaCMulticentre randomised controlled trialNon-COVID-19Non-COVID-19 respiratory illnessesRandomised controlled trialsRespiratory illnessNon-COVID-19 illnessesSymptom patternsLonger-lasting symptomsProportion of COVID-19 casesRespiratory diseaseIllness episodesWHO definitionCOVID-19Compare symptomsControlled trialsRespiratory illness episodesSymptom dataPersistence of symptomsIllnessIncreased riskBCG vaccination of healthcare workers for protection against COVID-19: 12-month outcomes from an international randomised controlled trial
Messina N, Pittet L, McDonald E, Moore C, Barry S, Bonten M, Byrne A, Campbell J, Croda J, Croda M, Dalcolmo M, de Almeida e Val F, de Oliveira R, dos Santos G, Douglas M, Gardiner K, Gwee A, Jardim B, Kollmann T, Lacerda M, Lucas M, Lynn D, Manning L, Marshall H, O’Connell A, Perrett K, Post J, Prat-Aymerich C, Rocha J, Rodriguez-Baño J, Wadia U, Warris A, Davidson A, Curtis N, Group T. BCG vaccination of healthcare workers for protection against COVID-19: 12-month outcomes from an international randomised controlled trial. Journal Of Infection 2024, 89: 106245. PMID: 39127450, PMCID: PMC11409612, DOI: 10.1016/j.jinf.2024.106245.Peer-Reviewed Original ResearchConceptsBacille Calmette-GuerinBreakthrough COVID-19Healthcare workersSevere COVID-19Risk of severe COVID-19Placebo groupSymptomatic COVID-19BCG-DenmarkRisk of symptomatic COVID-19International randomised controlled trialRandomised controlled trialsBacille Calmette-Guerin vaccineVaccination of healthcare workersHealthcare centresSARS-CoV-2 testingAsymptomatic SARS-CoV-2 infectionRandomised 1:1SARS-CoV-2 infectionCOVID-19MITT populationControlled trialsHealthcareIntradermal doseModified intentionImmunomodulatory effectsInsights into SARS-CoV-2 Surveillance among Prison Populations in Mato Grosso do Sul, Brazil, in 2022
da Silva L, Alcantara L, Fonseca V, Frias D, Zardin M, de Castro Lichs G, Esposito A, Xavier J, Fritsch H, Lima M, de Oliveira C, de Arruda L, de Mello Almeida Maziero L, Barretos E, Oshiro P, Menezes E, de Freitas Cardoso L, Lemos E, Lourenço J, de Albuquerque C, do Carmo Said R, Rosewell A, Demarchi L, Croda J, Giovanetti M, Gonçalves C. Insights into SARS-CoV-2 Surveillance among Prison Populations in Mato Grosso do Sul, Brazil, in 2022. Viruses 2024, 16: 1143. PMID: 39066305, PMCID: PMC11281713, DOI: 10.3390/v16071143.Peer-Reviewed Original ResearchConceptsNext-generation sequencingPrison populationIncarcerated populationsOvercrowded cellsGenome sequenceGenomic characteristicsPrisonGenomic surveillanceEnclosed populationMato GrossoAverage coverageIsolation protocolSARS-CoV-2RT-qPCR testSARS-CoV-2 surveillanceRT-qPCRSequenceFrequent transferEpidemiological monitoringLimited healthcare accessGenomeCellsOmicron variantSeroprevalence of Treponema pallidum infection among high-risk populations from Brazil
Queiroz J, Barbosa M, Perez E, da Silva B, de Souza G, Gonçalves C, Croda J, Simionatto S. Seroprevalence of Treponema pallidum infection among high-risk populations from Brazil. Acta Tropica 2024, 256: 107255. PMID: 38761835, DOI: 10.1016/j.actatropica.2024.107255.Peer-Reviewed Original ResearchConceptsSexually transmitted infectionsHigh-risk groupCases of syphilisFactors associated with syphilisPregnant womenHistory of sexually transmitted infectionsPublic health strategiesHealthy populationSignificant public health concernPrevent future complicationsHigh risk of infectionHigh-risk populationPublic health concernHealth strategiesParticipant demographicsCross-sectional oneRisk of infectionVulnerable populationsFuture complicationsPLHIVTreatment outcomesHealth concernHigh riskSyphilisInfectionFactors influencing adverse events following COVID-19 vaccination
Villanueva P, McDonald E, Croda J, Croda M, Dalcolmo M, dos Santos G, Jardim B, Lacerda M, Lynn D, Marshall H, Oliveira R, Rocha J, Sawka A, Val F, Pittet L, Messina N, Curtis N. Factors influencing adverse events following COVID-19 vaccination. Human Vaccines & Immunotherapeutics 2024, 20: 2323853. PMID: 38445666, PMCID: PMC10936640, DOI: 10.1080/21645515.2024.2323853.Peer-Reviewed Original ResearchConceptsVaccine typesSystemic reactionsIncidence of AEFIAdverse eventsVaccine doseIncidence of adverse eventsCovid-19 specific vaccineCOVID-19 vaccineNested cohort studyIgG antibody responsesRisk of AEFICOVID-19 vaccine typesChAdOx1 recipientsBNT162b2 recipientsCohort studyPfizer-BioNTechCoronaVac vaccineAntibody responseChAdOx1Oxford-AstraZenecaCoronaVacBNT162b2Local reactionsDoseDevelopment of COVID-19 vaccinesEffect of BCG vaccination against Mycobacterium tuberculosis infection in adult Brazilian health-care workers: a nested clinical trial
dos Santos P, Messina N, de Oliveira R, da Silva P, Puga M, Dalcolmo M, dos Santos G, de Lacerda M, Jardim B, de Almeida e Val F, Curtis N, Andrews J, Croda J. Effect of BCG vaccination against Mycobacterium tuberculosis infection in adult Brazilian health-care workers: a nested clinical trial. The Lancet Infectious Diseases 2024, 24: 594-601. PMID: 38423021, PMCID: PMC11111441, DOI: 10.1016/s1473-3099(23)00818-6.Peer-Reviewed Original ResearchConceptsQuantiFERON-TB GoldPlacebo groupEffect of BCG vaccinationBCG vaccinationBCG groupBCG-DenmarkHealth-care workersNegative baseline resultsMonths of treatmentMycobacterium tuberculosis infectionAdult pulmonary tuberculosisQuantiFERON-TBMedian ageRandomised controlled trialsPulmonary tuberculosisNo significant differenceEfficacy outcomesTuberculosis infectionClinical trialsControlled trialsEffect of vaccinationTreatment drugsTuberculosis preventionSubstudySignificant difference
2023
Genomic characterization of SARS-CoV-2 from an indigenous reserve in Mato Grosso do Sul, Brazil
de Oliveira L, de Rezende I, Navarini V, Marchioro S, Torres A, Croda J, Croda M, Gonçalves C, Xavier J, de Castro E, Lima M, Iani F, Adelino T, Aburjaile F, Demarchi L, Taira D, Zardin M, Fonseca V, Giovanetti M, Andrews J, Alcantara L, Simionatto S. Genomic characterization of SARS-CoV-2 from an indigenous reserve in Mato Grosso do Sul, Brazil. Frontiers In Public Health 2023, 11: 1195779. PMID: 37965526, PMCID: PMC10641392, DOI: 10.3389/fpubh.2023.1195779.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 lineagesIntroduction eventsCharacterization of SARS-CoV-2Nanopore sequencing platformSARS-CoV-2 positive samplesMultiple SARS-CoV-2 variantsMultiple introduction eventsPhylogenetic reconstructionPhylogenetic dataGenome sequenceSequencing platformsGenomic characterizationSARS-CoV-2Genomic surveillanceSARS-CoV-2 variantsLineagesMato GrossoMortality rateViral dynamicsIndigenous populationCo-circulationPrevalence of malesMidwestern BrazilPositive samplesIndigenous mobilization
2022
HTLV infection in Brazil’s second-largest indigenous reserve
Amianti C, Bandeira L, Cesar G, Weis-Torres S, Tanaka T, Machado I, Gonçalves C, Simionatto S, Schnaufer E, Freitas F, Vallinoto A, Croda J, Motta-Castro A. HTLV infection in Brazil’s second-largest indigenous reserve. Scientific Reports 2022, 12: 16701. PMID: 36202887, PMCID: PMC9537150, DOI: 10.1038/s41598-022-21086-7.Peer-Reviewed Original ResearchConceptsHTLV infectionHTLV-1HTLV-2HTLV-1-associated myelopathyAdult T-cell leukemia/lymphomaHuman T-lymphotropic virus 1T-cell leukemia/lymphomaChronic inflammatory neurological diseaseHTLV-1 prevalenceInflammatory neurological diseasesHTLV-2 infectionAggressive malignant diseaseLeukemia/lymphomaEnzyme-linked immunosorbentMedian agePregnant populationMalignant diseaseBlood donorsStudy populationDrug usersNeurological diseasesCosmopolitan subtypeWestern blotSerum samplesDisease
2021
Anti-inflammatory properties of ethanolic extract from Vatairea macrocarpa leaves
Santos E, Silva-Filho S, Santos Radai J, Arena A, Fraga T, Lima Cardoso C, Croda J, Leite Kassuya C. Anti-inflammatory properties of ethanolic extract from Vatairea macrocarpa leaves. Journal Of Ethnopharmacology 2021, 278: 114308. PMID: 34102271, DOI: 10.1016/j.jep.2021.114308.Peer-Reviewed Original ResearchConceptsAnti-inflammatory propertiesMethylthiazolyldiphenyl-tetrazolium bromideComplete Freund's adjuvantAnti-inflammatory featuresEthanolic extractLong-term treatmentBacillus Calmette-GuerinInflammatory evaluationInflammatory parametersConventional medicationsDaily administrationNeutrophil activityPersistent inflammationRheumatic diseasesFreund's adjuvantInflammatory aspectsPleurisy modelTraditional folk medicineSwiss miceCalmette-GuerinInflammatory diseasesC57BL6 miceVivo modelExperimental modelAdverse effectsRisk Factors for Death Among 120,804 Hospitalized Patients with Confirmed COVID-19 in São Paulo, Brazil
da Silva P, de Oliveira S, Escalante J, Almiron M, Tsuha D, Sato H, Menezes P, de Paula R, D’Agostini T, Croda J. Risk Factors for Death Among 120,804 Hospitalized Patients with Confirmed COVID-19 in São Paulo, Brazil. American Journal Of Tropical Medicine And Hygiene 2021, 105: 88-92. PMID: 34061773, PMCID: PMC8274770, DOI: 10.4269/ajtmh.20-1598.Peer-Reviewed Original ResearchConceptsCOVID-19Confirmed COVID-19Characteristics of patientsChronic lung diseaseIntensive care unitChronic cardiovascular diseaseChronic neurological diseaseMore comorbiditiesClinical characteristicsDiabetes mellitusMedian ageCare unitLung diseaseRisk factorsCardiovascular diseaseHigh riskSevere casesElderly individualsPatientsNeurological diseasesSurvival analysisCoronavirus diseaseDiseaseSão PauloDeathEpidemiological study in Brazilian women highlights that syphilis remains a public health problem
dos Santos Barbosa M, de Lima L, Ribeiro S, Croda J, de Sá Queiroz J, Ortolani L, Negrão F, Souza E, da Silva K, de Souza R, Simionatto S. Epidemiological study in Brazilian women highlights that syphilis remains a public health problem. Revista Do Instituto De Medicina Tropical De São Paulo 2021, 63: e4. PMID: 33533807, PMCID: PMC7845940, DOI: 10.1590/s1678-9946202163004.Peer-Reviewed Original ResearchConceptsT. pallidum infectionSexual partnersPrimary health care unitsContinuous surveillance studiesGlobal public health concernHistory of STICross-sectional studyHigher prevalence ratioPublic health problemMultiple sexual partnersPopulation-based sampleHealth care unitsPublic health concernCommitment of patientsCare unitMultivariable analysisNeonatal deathPrevalence ratiosSyphilis testingSyphilis screeningReproductive ageRisk factorsBlood samplesEpidemiological studiesSurveillance study
2020
Increased incarceration rates drive growing tuberculosis burden in prisons and jeopardize overall tuberculosis control in Paraguay
Sequera V, Aguirre S, Estigarribia G, Cellamare M, Croda J, Andrews J, Martinez L, García-Basteiro A. Increased incarceration rates drive growing tuberculosis burden in prisons and jeopardize overall tuberculosis control in Paraguay. Scientific Reports 2020, 10: 21247. PMID: 33277515, PMCID: PMC7718226, DOI: 10.1038/s41598-020-77504-1.Peer-Reviewed Original ResearchConceptsTB casesPopulation attributable fractionAttributable fractionAnnual TB notification ratesNational TB Control ProgrammeOverall population attributable riskIncarcerated populationsTB control programsCharacteristics of tuberculosisPopulation attributable riskTB notification ratesTB control measuresTrend of tuberculosisPercentage of casesSame age groupIncarcerated casesTB burdenTB controlTuberculosis burdenCase RegistryTuberculosis controlTB epidemicAttributable riskNotification ratesRelative riskReinfection of COVID‐19 after 3 months with a distinct and more aggressive clinical presentation: Case report
de Araujo Torres D, do Carmo Bueno Ribeiro L, de Freitas Linhares Riello A, Horovitz D, Pinto L, Croda J. Reinfection of COVID‐19 after 3 months with a distinct and more aggressive clinical presentation: Case report. Journal Of Medical Virology 2020, 93: 1857-1859. PMID: 33112002, DOI: 10.1002/jmv.26637.Peer-Reviewed Original ResearchBlutaparon portulacoides ethanolic extract reduced IL-1β and inflammatory parameters induced by the Mycobacterium complex and carrageenan in mice
Kassuya R, Radai J, Macorini L, Nunes V, Salvador M, Leite P, Oliveira R, Croda J, Arena A, Kassuya C. Blutaparon portulacoides ethanolic extract reduced IL-1β and inflammatory parameters induced by the Mycobacterium complex and carrageenan in mice. Inflammopharmacology 2020, 29: 439-450. PMID: 32910315, DOI: 10.1007/s10787-020-00752-0.Peer-Reviewed Original ResearchMeSH KeywordsAmaranthaceaeAnimalsAnti-Inflammatory AgentsAntitubercular AgentsCarrageenanDisease Models, AnimalDose-Response Relationship, DrugEdemaFemaleInflammationInterleukin-1betaMaleMiceMice, Inbred C57BLMicrobial Sensitivity TestsMycobacterium tuberculosisPlant ExtractsPleurisyRatsRats, WistarConceptsSwiss miceIL-1β levelsC57BL-6 miceEthanolic extractInflammation/infectionSafe new drugsM. tuberculosis growthMechanical hyperalgesiaInflammatory parametersOral treatmentIL-1βPleurisy modelMinimum inhibitory concentrationPharmacoeconomic perspectiveC57BL6 miceComplete adjuvantSubcutaneous injectionOral administrationWistar ratsMiceMycobacterium tuberculosisNew drugsHealth benefitsTuberculosis growthInhibitory concentrationGestational outcomes in women infected by Zika virus during pregnancy in Mato Grosso do Sul, Brazil: A cross-sectional study
Sousa I, Souza C, Barbosa M, Croda J, Gonçalves C, Bernardes S, Marchioro S. Gestational outcomes in women infected by Zika virus during pregnancy in Mato Grosso do Sul, Brazil: A cross-sectional study. International Journal Of Infectious Diseases 2020, 98: 359-365. PMID: 32619757, DOI: 10.1016/j.ijid.2020.06.084.Peer-Reviewed Original ResearchConceptsCongenital Zika syndromeZIKV infectionCross-sectional studyGestational outcomesZika virusNormal-appearing infantMain clinical findingsCase fatality rateMother-infant pairsMothers of infantsQRT-PCRZika syndromeClinical caveatsClinical findingsClinical parametersFirst trimesterCongenital alterationsLive birthsLaboratory confirmationCongenital abnormalitiesFatality rateEpidemic burstsInfectionPregnancyInfantsPrevalence, incidence and associated factors for HBV infection among male and female prisoners in Central Brazil: A multicenter study
Rezende G, Lago B, Puga M, Bandeira L, Pompilio M, Castro V, Tanaka T, Cesar G, Oliveira S, Yassuda R, Simionatto S, Weis S, Basílio S, Croda J, Motta-Castro A. Prevalence, incidence and associated factors for HBV infection among male and female prisoners in Central Brazil: A multicenter study. International Journal Of Infectious Diseases 2020, 96: 298-307. PMID: 32315810, DOI: 10.1016/j.ijid.2020.04.019.Peer-Reviewed Original ResearchConceptsHBV exposureHepatitis B virus infectionHCV/HBVIncidence of HBVHBV serological markersB virus infectionCross-sectional studyGenotypes/subtypesHBV infectionCohort studySerological markersHBV isolatesMulticenter studyHigh prevalenceLower incidenceVirus infectionHigh riskHBVNew casesBlood collectionFemale prisonersInfectionIncidencePreventive measuresPrevalenceEffect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection
Borba M, Val F, Sampaio V, Alexandre M, Melo G, Brito M, Mourão M, Brito-Sousa J, Baía-da-Silva D, Guerra M, Hajjar L, Pinto R, Balieiro A, Pacheco A, Santos J, Naveca F, Xavier M, Siqueira A, Schwarzbold A, Croda J, Nogueira M, Romero G, Bassat Q, Fontes C, Albuquerque B, Daniel-Ribeiro C, Monteiro W, Lacerda M. Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection. JAMA Network Open 2020, 3: e208857. PMID: 32330277, DOI: 10.1001/jamanetworkopen.2020.8857.Peer-Reviewed Original ResearchConceptsHigh dosage groupSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectionAcute respiratory syndrome coronavirus 2 infectionLow dosage groupSyndrome coronavirus 2 infectionCoronavirus 2 infectionChloroquine diphosphateDay 13COVID-19Phase IIb clinical trialNonsevere COVID-19Secondary end pointsSevere COVID-19High-dose groupSpecific antiviral therapyTertiary care facilityIIb clinical trialCoronavirus disease 2019More heart diseaseParticipants' clinical statusAdjunctive therapyAdult patientsIll patientsPrimary outcomeAntiviral therapyGenomic and Epidemiological Surveillance of Zika Virus in the Amazon Region
Giovanetti M, Faria N, Lourenço J, de Jesus J, Xavier J, Claro I, Kraemer M, Fonseca V, Dellicour S, Thézé J, da Silva Salles F, Gräf T, Silveira P, do Nascimento V, de Souza V, de Melo Iani F, Castilho-Martins E, Cruz L, Wallau G, Fabri A, Levy F, Quick J, de Azevedo V, Aguiar R, de Oliveira T, de Menezes C, da Costa Castilho M, Terra T, da Silva M, de Filippis A, de Abreu A, Oliveira W, Croda J, de Albuquerque C, Nunes M, Sabino E, Loman N, Naveca F, Pybus O, Alcantara L. Genomic and Epidemiological Surveillance of Zika Virus in the Amazon Region. Cell Reports 2020, 30: 2275-2283.e7. PMID: 32075736, DOI: 10.1016/j.celrep.2020.01.085.Peer-Reviewed Original ResearchNeurosyphilis in Brazilian newborns: a health problem that could be avoided
da Costa Ribeiro A, de Sá Dan C, da Silva Santos A, Croda J, Simionatto S. Neurosyphilis in Brazilian newborns: a health problem that could be avoided. Revista Do Instituto De Medicina Tropical De São Paulo 2020, 62: e82. PMID: 33174978, PMCID: PMC7653815, DOI: 10.1590/s1678-9946202062082.Peer-Reviewed Original ResearchConceptsPregnant womenCongenital syphilisBrazilian newbornsHealth problemsLong bone radiographyPregnant Brazilian womenCerebrospinal fluid analysisLength of hospitalizationLow birth weightCase-control studyNon-treponemal testsCases of newbornsCases of neurosyphilisPublic health problemCentral nervous systemRisk of transmissionNeurosyphilis treatmentClinical complicationsPrenatal careBirth weightBone radiographyLate diagnosisPrenatal coverageNeurosyphilisNervous system
2019
Investigation of Preanalytical Variables Impacting Pathogen Cell-Free DNA in Blood and Urine
Murugesan K, Hogan C, Palmer Z, Reeve B, Theron G, Andama A, Somoskovi A, Steadman A, Madan D, Andrews J, Croda J, Sahoo M, Cattamanchi A, Pinsky B, Banaei N. Investigation of Preanalytical Variables Impacting Pathogen Cell-Free DNA in Blood and Urine. Journal Of Clinical Microbiology 2019, 57: 10.1128/jcm.00782-19. PMID: 31511335, PMCID: PMC6813001, DOI: 10.1128/jcm.00782-19.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusCell-free DNABlood collection tubesUrine samplesLower medianPCR cycle thresholdCollection tubesEDTA blood samplesTB patientsTuberculosis patientsUrine volumeHealthy donorsBlood samplesAttractive biomarkerEDTA tubesPatient samplesBloodWhole urineThawed plasmaUrineUrine preservativeCycle thresholdMedianPatientsPreanalytical factors