2024
Insights into SARS-CoV-2 Surveillance among Prison Populations in Mato Grosso do Sul, Brazil, in 2022
da Silva L, Alcantara L, Fonseca V, Frias D, Zardin M, de Castro Lichs G, Esposito A, Xavier J, Fritsch H, Lima M, de Oliveira C, de Arruda L, de Mello Almeida Maziero L, Barretos E, Oshiro P, Menezes E, de Freitas Cardoso L, Lemos E, Lourenço J, de Albuquerque C, do Carmo Said R, Rosewell A, Demarchi L, Croda J, Giovanetti M, Gonçalves C. Insights into SARS-CoV-2 Surveillance among Prison Populations in Mato Grosso do Sul, Brazil, in 2022. Viruses 2024, 16: 1143. PMID: 39066305, PMCID: PMC11281713, DOI: 10.3390/v16071143.Peer-Reviewed Original ResearchConceptsNext-generation sequencingPrison populationIncarcerated populationsOvercrowded cellsGenome sequenceGenomic characteristicsPrisonGenomic surveillanceEnclosed populationMato GrossoAverage coverageIsolation protocolSARS-CoV-2RT-qPCR testSARS-CoV-2 surveillanceRT-qPCRSequenceFrequent transferEpidemiological monitoringLimited healthcare accessGenomeCellsOmicron variantSeroprevalence of Treponema pallidum infection among high-risk populations from Brazil
Queiroz J, Barbosa M, Perez E, da Silva B, de Souza G, Gonçalves C, Croda J, Simionatto S. Seroprevalence of Treponema pallidum infection among high-risk populations from Brazil. Acta Tropica 2024, 256: 107255. PMID: 38761835, DOI: 10.1016/j.actatropica.2024.107255.Peer-Reviewed Original ResearchConceptsSexually transmitted infectionsHigh-risk groupCases of syphilisFactors associated with syphilisPregnant womenHistory of sexually transmitted infectionsPublic health strategiesHealthy populationSignificant public health concernPrevent future complicationsHigh risk of infectionHigh-risk populationPublic health concernHealth strategiesParticipant demographicsCross-sectional oneRisk of infectionVulnerable populationsFuture complicationsPLHIVTreatment outcomesHealth concernHigh riskSyphilisInfectionEffect of BCG vaccination against Mycobacterium tuberculosis infection in adult Brazilian health-care workers: a nested clinical trial
dos Santos P, Messina N, de Oliveira R, da Silva P, Puga M, Dalcolmo M, dos Santos G, de Lacerda M, Jardim B, de Almeida e Val F, Curtis N, Andrews J, Croda J. Effect of BCG vaccination against Mycobacterium tuberculosis infection in adult Brazilian health-care workers: a nested clinical trial. The Lancet Infectious Diseases 2024, 24: 594-601. PMID: 38423021, PMCID: PMC11111441, DOI: 10.1016/s1473-3099(23)00818-6.Peer-Reviewed Original ResearchConceptsQuantiFERON-TB GoldPlacebo groupEffect of BCG vaccinationBCG vaccinationBCG groupBCG-DenmarkHealth-care workersNegative baseline resultsMonths of treatmentMycobacterium tuberculosis infectionAdult pulmonary tuberculosisQuantiFERON-TBMedian ageRandomised controlled trialsPulmonary tuberculosisNo significant differenceEfficacy outcomesTuberculosis infectionClinical trialsControlled trialsEffect of vaccinationTreatment drugsTuberculosis preventionSubstudySignificant difference
2020
Primary Prophylaxis to Prevent Tuberculosis Infection in Prison Inmates: A Randomized, Double-Blind, Placebo-Controlled Trial.
Dias de Oliveira R, da Silva Santos A, Reis C, de Cássia Leite A, Correia Sacchi F, de Araujo R, Dos Santos P, Rolla V, Martinez L, Andrews J, Croda J. Primary Prophylaxis to Prevent Tuberculosis Infection in Prison Inmates: A Randomized, Double-Blind, Placebo-Controlled Trial. American Journal Of Tropical Medicine And Hygiene 2020, 103: 1466-1472. PMID: 32876010, PMCID: PMC7543866, DOI: 10.4269/ajtmh.20-0110.Peer-Reviewed Original ResearchConceptsQFT conversionTB infectionSecondary outcomesPlacebo-controlled trialQuantiFERON-TB GoldFuture clinical trialsPrimary prophylaxisMiddle-income countriesPrimary outcomeTuberculosis infectionIntervention armTuberculosis incidenceControl armTrial protocolClinical trialsElevated riskInterim analysisLatent infectionCutoff pointInfectionTrialsHigher cutoffSustained conversionInternational unitsLower ratesGestational outcomes in women infected by Zika virus during pregnancy in Mato Grosso do Sul, Brazil: A cross-sectional study
Sousa I, Souza C, Barbosa M, Croda J, Gonçalves C, Bernardes S, Marchioro S. Gestational outcomes in women infected by Zika virus during pregnancy in Mato Grosso do Sul, Brazil: A cross-sectional study. International Journal Of Infectious Diseases 2020, 98: 359-365. PMID: 32619757, DOI: 10.1016/j.ijid.2020.06.084.Peer-Reviewed Original ResearchConceptsCongenital Zika syndromeZIKV infectionCross-sectional studyGestational outcomesZika virusNormal-appearing infantMain clinical findingsCase fatality rateMother-infant pairsMothers of infantsQRT-PCRZika syndromeClinical caveatsClinical findingsClinical parametersFirst trimesterCongenital alterationsLive birthsLaboratory confirmationCongenital abnormalitiesFatality rateEpidemic burstsInfectionPregnancyInfants
2019
Investigation of Preanalytical Variables Impacting Pathogen Cell-Free DNA in Blood and Urine
Murugesan K, Hogan C, Palmer Z, Reeve B, Theron G, Andama A, Somoskovi A, Steadman A, Madan D, Andrews J, Croda J, Sahoo M, Cattamanchi A, Pinsky B, Banaei N. Investigation of Preanalytical Variables Impacting Pathogen Cell-Free DNA in Blood and Urine. Journal Of Clinical Microbiology 2019, 57: 10.1128/jcm.00782-19. PMID: 31511335, PMCID: PMC6813001, DOI: 10.1128/jcm.00782-19.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusCell-free DNABlood collection tubesUrine samplesLower medianPCR cycle thresholdCollection tubesEDTA blood samplesTB patientsTuberculosis patientsUrine volumeHealthy donorsBlood samplesAttractive biomarkerEDTA tubesPatient samplesBloodWhole urineThawed plasmaUrineUrine preservativeCycle thresholdMedianPatientsPreanalytical factorsHigh level of exposure to hepatitis B virus infection in a vulnerable population of a low endemic area: A challenge for vaccination coverage
Weis-Torres S, Fitts S, Cardoso W, Higa Junior M, Lima L, Bandeira L, Castro V, Carneiro F, Iglecias L, Cesar G, Tanaka T, Puga M, Rezende G, Croda J, Lago B, Motta-Castro A. High level of exposure to hepatitis B virus infection in a vulnerable population of a low endemic area: A challenge for vaccination coverage. International Journal Of Infectious Diseases 2019, 90: 46-52. PMID: 31589921, DOI: 10.1016/j.ijid.2019.09.029.Peer-Reviewed Original ResearchConceptsLow endemic areasHBV infectionHBV exposureEndemic areasHepatitis B virus infectionHIV serological markersB virus infectionHistory of surgeryHBV transmissionHBV vaccinationHBV vaccineHepatitis BChronic carriersSerological markersVaccination coverageHomosexual contactVirus infectionPrevalence ratesSusceptible adultsAge 18InfectionVulnerable populationsDisadvantaged populationsVaccinationMolecular featuresGenetic Diversity and Molecular Epidemiology of Mycobacterium tuberculosis in Roraima State, Brazil.
Tatara M, Perdigão J, Viveiros M, Kritski A, Silva K, Sacchi F, de Lima C, Dos Santos P, Diniz J, Almeida Silva P, Gomes P, Gomes M, Cunha E, Lapa E Silva J, Portugal I, Croda J, Andrade M. Genetic Diversity and Molecular Epidemiology of Mycobacterium tuberculosis in Roraima State, Brazil. American Journal Of Tropical Medicine And Hygiene 2019, 101: 774-779. PMID: 31392954, PMCID: PMC6779181, DOI: 10.4269/ajtmh.19-0324.Peer-Reviewed Original ResearchConceptsPopulation-based prospective studyDrug resistanceMolecular epidemiologyResistance profilesRepetitive units-variable numberMTB/RIFDrug susceptibility testDrug resistance profilesTransmission of MtbPublic health policyPhenotypic resistance profilesIsoniazid monoTB preventionProspective studyNew strain typesTB epidemiologyPrimary resistanceHigh prevalenceMTB isolatesProportion methodHealth policyMycobacterium tuberculosisSusceptibility testsTuberculosisVulnerable populationsHigh Prevalence of Syphilis and Inadequate Prenatal Care in Brazilian Pregnant Women: A Cross-Sectional Study.
Benedetti K, Ribeiro A, Queiroz J, Melo A, Batista R, Delgado F, da Silva K, Croda J, Simionatto S. High Prevalence of Syphilis and Inadequate Prenatal Care in Brazilian Pregnant Women: A Cross-Sectional Study. American Journal Of Tropical Medicine And Hygiene 2019, 101: 761-766. PMID: 31407659, PMCID: PMC6779194, DOI: 10.4269/ajtmh.18-0912.Peer-Reviewed Original ResearchConceptsPregnant womenHigh prevalenceVenereal Disease Research Laboratory testDisease Research Laboratory testSeroprevalence of syphilisUnlinked anonymous testingAntenatal care servicesInadequate prenatal careRisk factor questionnaireBrazilian pregnant womenBehavioral risk factorsCross-sectional studyPresence of antibodiesTime of deliveryData of newbornsHistory of abortionAntenatal careAnonymous testingThird trimesterFirst trimesterPrenatal careSectional studyClinical managementMedical recordsRisk factors
2018
Assessment of Validity of a Blood-Based 3-Gene Signature Score for Progression and Diagnosis of Tuberculosis, Disease Severity, and Treatment Response
Warsinske H, Rao A, Moreira F, Santos P, Liu A, Scott M, Malherbe S, Ronacher K, Walzl G, Winter J, Sweeney T, Croda J, Andrews J, Khatri P. Assessment of Validity of a Blood-Based 3-Gene Signature Score for Progression and Diagnosis of Tuberculosis, Disease Severity, and Treatment Response. JAMA Network Open 2018, 1: e183779. PMID: 30646264, PMCID: PMC6324428, DOI: 10.1001/jamanetworkopen.2018.3779.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAntitubercular AgentsBrazilChildCohort StudiesDisease ProgressionFemaleGenes, BacterialGenetic MarkersHumansLatent TuberculosisMaleMiddle AgedMolecular TypingMycobacterium tuberculosisReal-Time Polymerase Chain ReactionReproducibility of ResultsRNA, BacterialSeverity of Illness IndexTuberculosisYoung AdultConceptsTB scoreAdolescent cohort studyNegative predictive valueTreatment responseTB diseaseCohort studyTuberculosis infectionTriage testPositron emission tomography-computed tomography scanPredictive valueLatent M tuberculosis infectionLatent Mycobacterium tuberculosis infectionPrimary health care clinicsHigh negative predictive valueCulture-positive adultsM tuberculosis infectionWhole bloodMycobacterium tuberculosis infectionEnd of treatmentHealth care clinicsCase-control studyIndependent prospective cohortsDiagnosis of tuberculosisSlower treatment responseCase-control cohortSuicide in Brazilian indigenous communities: clustering of cases in children and adolescents by household
Lazzarini TA, Gonçalves CCM, Benites WM, da Silva L, Tsuha DH, Ko AI, Rohrbaugh R, Andrews JR, Croda J. Suicide in Brazilian indigenous communities: clustering of cases in children and adolescents by household. Revista De Saúde Pública 2018, 52: 56. PMID: 29791676, PMCID: PMC5958965, DOI: 10.11606/s1518-8787.2018052000541.Peer-Reviewed Original ResearchConceptsHealth interventionsSuicide ratesHousehold clustersRetrospective cohort studyBroader public health interventionsConclusions High ratesPublic health interventionsMental health interventionsHigh rateCohort studyHigh suicide ratesLower socioeconomic indicatorsAdult suicideAdolescent malesOverall suicide ratesChildrenSuicideGreater proportionChild suicideInterventionSocioeconomic indicatorsAdolescentsIndigenous individualsSuicide clusteringTreatment Outcomes of Brazilian Inmates with Treponema pallidum and Human Immunodeficiency Virus Infection: A Prospective Cohort Study.
Bet G, Souza G, Croda J, Correa M, de Sales R, Santos R, Viebrantz Enne Sgarbi R, Yassuda R, Coimbra Motta-Castro A, Pompílio M, Simionatto S. Treatment Outcomes of Brazilian Inmates with Treponema pallidum and Human Immunodeficiency Virus Infection: A Prospective Cohort Study. American Journal Of Tropical Medicine And Hygiene 2018, 98: 1603-1608. PMID: 29737273, PMCID: PMC6086195, DOI: 10.4269/ajtmh.17-0592.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusHIV-1 viral loadProspective cohort studyPoor treatment outcomesTreatment outcomesCohort studyHIV infectionViral loadHuman immunodeficiency virus (HIV) infectionImmunodeficiency virus infectionCopies/mLMedical record dataPublic health programsSyphilis treatmentImmunodeficiency virusAcquired syphilisRisk factorsSerological testingVirus infectionBlood samplesMultivariate analysisHealth programsNew casesInfectionTreponema pallidum
2017
Increase in Tuberculosis Cases among Prisoners, Brazil, 2009–2014 - Volume 23, Number 3—March 2017 - Emerging Infectious Diseases journal - CDC
Bourdillon PM, Gonçalves CC, Pelissari DM, Arakaki-Sanchez D, Ko AI, Croda J, Andrews JR. Increase in Tuberculosis Cases among Prisoners, Brazil, 2009–2014 - Volume 23, Number 3—March 2017 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2017, 23: 496-499. PMID: 28221118, PMCID: PMC5382752, DOI: 10.3201/eid2303.161006.Peer-Reviewed Original ResearchResistência às drogas antituberculose na fronteira do Brasil com Paraguai e Bolívia
Marques M, Cunha E, do Socorro Nantua Evangelista M, Basta P, Marques A, Croda J, de Andrade S. Resistência às drogas antituberculose na fronteira do Brasil com Paraguai e Bolívia. BULL PAN AM HEALTH ORGAN 2017, 41: 1. PMID: 28444009, PMCID: PMC6645181, DOI: 10.26633/rpsp.2017.9.Peer-Reviewed Original ResearchConceptsObserved treatmentDrug resistanceAssociated risk factorsPulmonary tuberculosis casesHistory of alcoholismCases of PTBCombination of drugsPatterns of resistanceRespiratory symptomsPTB casesTuberculosis casesDevelopment of resistanceRisk factorsEpidemiological studiesSingle drugHealth actionsSusceptibility testingMultidrug resistanceDiabetesSusceptibility testsAlcoholismPatientsDrugsTreatmentPresence/absenceSeroprevalence of Chikungunya Virus in a Rural Community in Brazil
Cunha R, Trinta K, Montalbano C, Sucupira M, de Lima M, Marques E, Romanholi I, Croda J. Seroprevalence of Chikungunya Virus in a Rural Community in Brazil. PLOS Neglected Tropical Diseases 2017, 11: e0005319. PMID: 28107342, PMCID: PMC5287455, DOI: 10.1371/journal.pntd.0005319.Peer-Reviewed Original ResearchConceptsCases of chikungunyaCHIKV infectionChikungunya virusCHIKV IgMSymptomatic CHIKV infectionIgM-specific antibodiesFeira de SantanaIgG-specific antibodiesEpidemiological surveillance systemBrazilian Epidemiological Surveillance SystemCHIKV IgGModerate seroprevalenceSeropositive patientsJoint painIgG antibodiesCHIKV transmissionFirst serosurveySeroprevalenceInfectionMagnitude of transmissionAntibodiesPatientsFirst caseSerosurveyIgMPrevalence and Incidence of HCV Infection among Prisoners in Central Brazil
Puga M, Bandeira L, Pompilio M, Croda J, de Rezende G, Dorisbor L, Tanaka T, Cesar G, Teles S, Simionatto S, Novais A, Nepomuceno B, Castro L, do Lago B, Motta-Castro A. Prevalence and Incidence of HCV Infection among Prisoners in Central Brazil. PLOS ONE 2017, 12: e0169195. PMID: 28060860, PMCID: PMC5218405, DOI: 10.1371/journal.pone.0169195.Peer-Reviewed Original ResearchConceptsHCV infectionCohort studyHCV RNASectional studyInjecting-drug useNew HCV infectionsHCV risk behaviorsCross-sectional studyHCV exposureHepatitis CHIV positivityEffective intervention strategiesAssociated FactorsClinical evaluationIndependent associationOverall prevalenceRisk factorsIncidence rateBlood samplesDrug useNew casesRisk behaviorsInfectionHigh frequency ratePrevalence
2016
Impact of mass-screening on tuberculosis incidence in a prospective cohort of Brazilian prisoners
Paião DS, Lemos EF, Carbone AD, Sgarbi RV, Junior AL, da Silva FM, Brandão LM, dos Santos LS, Martins VS, Simionatto S, Motta-Castro AR, Pompílio MA, Urrego J, Ko AI, Andrews JR, Croda J. Impact of mass-screening on tuberculosis incidence in a prospective cohort of Brazilian prisoners. BMC Infectious Diseases 2016, 16: 533. PMID: 27716170, PMCID: PMC5048439, DOI: 10.1186/s12879-016-1868-5.Peer-Reviewed Original ResearchConceptsTuberculin skin testingActive tuberculosisRisk factorsSubsequent diseaseProspective cohort studyEarly case detectionHigh transmission settingsHigh-risk populationPotential risk factorsProportional hazards modelSubsequent disease riskMass screening interventionTST conversionCohort studyProspective cohortHIV testingTuberculosis infectionScreening interventionsSkin testingTB notificationsTuberculosis incidenceSubsequent riskCase detectionSputum samplesActive screeningFactors associated with anti-TB drug-induced hepatotoxicity and genetic polymorphisms in indigenous and non-indigenous populations in Brazil
Heinrich M, Zembrzuski V, Ota M, Sacchi F, Teixeira R, Acero P, Cunha G, Souza-Santos R, Croda J, Basta P. Factors associated with anti-TB drug-induced hepatotoxicity and genetic polymorphisms in indigenous and non-indigenous populations in Brazil. Tuberculosis 2016, 101: 15-24. PMID: 27865386, DOI: 10.1016/j.tube.2016.07.006.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAntitubercular AgentsArylamine N-AcetyltransferaseBrazilChemical and Drug Induced Liver InjuryChildChild, PreschoolCross-Sectional StudiesCytochrome P-450 CYP2E1FemaleGenetic Predisposition to DiseaseGenotypeGlutathione TransferaseHumansIncidenceInfantLongitudinal StudiesMaleMiddle AgedPolymorphism, Single NucleotideTuberculosis, PulmonaryYoung AdultConceptsIncidence of hepatotoxicityAdverse drug reactionsIndigenous patientsAnti-TB drug-induced hepatotoxicityNon-conditional logistic regressionClinical-epidemiological factorsClinical-epidemiological variablesNon-Indigenous patientsGenetic polymorphismsRisk of hepatotoxicityDrug-induced hepatotoxicityPolymorphisms of CYP2E1Anti-tuberculosis drugsAcetylation profileTB patientsSerum levelsDrug reactionsGSTM1 polymorphismOdds ratioLiver enzymesNon-Indigenous populationsTherapeutic schemesPharmacogenetic analysisBetter outcomesPatients
2015
A Cross-Sectional Survey of HIV Testing and Prevalence in Twelve Brazilian Correctional Facilities
Sgarbi RV, da Silva Santos Carbone A, Paião DS, Lemos EF, Simionatto S, Puga MA, Motta-Castro AR, Pompilio MA, Urrego J, Ko AI, Andrews JR, Croda J. A Cross-Sectional Survey of HIV Testing and Prevalence in Twelve Brazilian Correctional Facilities. PLOS ONE 2015, 10: e0139487. PMID: 26466312, PMCID: PMC4605759, DOI: 10.1371/journal.pone.0139487.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAnti-Retroviral AgentsBrazilCross-Sectional StudiesFemaleHealth Services AccessibilityHIV InfectionsHumansMaleMass ScreeningMiddle AgedMultivariate AnalysisOdds RatioPrevalencePrisonersPrisonsSurveys and QuestionnairesSyphilisVulnerable PopulationsYoung AdultConceptsHIV testingHIV careMental illnessMultivariable logistic regression modelPrevious HIV testingHIV testing ratesMajority of HIVHIV testing practicesTreatment of HIVHigh HIV prevalencePopulation-based samplePercent of participantsLogistic regression modelsAntiretroviral therapyHIV diagnosisPrevious surgeryHIV infectionHIV statusMultivariable analysisHIV prevalenceSyphilis testingClinical careGeneral populationHIVTesting ratesRisk Factors for Death from Visceral Leishmaniasis in an Urban Area of Brazil
Druzian A, de Souza A, de Campos D, Croda J, Higa M, Dorval M, Pompilio M, de Oliveira P, Paniago A. Risk Factors for Death from Visceral Leishmaniasis in an Urban Area of Brazil. PLOS Neglected Tropical Diseases 2015, 9: e0003982. PMID: 26274916, PMCID: PMC4537269, DOI: 10.1371/journal.pntd.0003982.Peer-Reviewed Original ResearchConceptsHIV/AIDSVisceral leishmaniasisRisk factorsAdult patientsMortality rateUrban endemic areaProspective cohort studySecondary bacterial infectionHigh mortality rateEndemic urban areaCohort studyEpidemiological profileMean ageUniversity HospitalEndemic areasMultivariate analysisPatientsBacterial infectionsAIDSDeathSignificant increaseHigh rateLeishmaniasisEdemaRelapse