2024
BCG vaccination of healthcare workers for protection against COVID-19: 12-month outcomes from an international randomised controlled trial
Messina N, Pittet L, McDonald E, Moore C, Barry S, Bonten M, Byrne A, Campbell J, Croda J, Croda M, Dalcolmo M, de Almeida e Val F, de Oliveira R, dos Santos G, Douglas M, Gardiner K, Gwee A, Jardim B, Kollmann T, Lacerda M, Lucas M, Lynn D, Manning L, Marshall H, O’Connell A, Perrett K, Post J, Prat-Aymerich C, Rocha J, Rodriguez-Baño J, Wadia U, Warris A, Davidson A, Curtis N, Group T. BCG vaccination of healthcare workers for protection against COVID-19: 12-month outcomes from an international randomised controlled trial. Journal Of Infection 2024, 89: 106245. PMID: 39127450, PMCID: PMC11409612, DOI: 10.1016/j.jinf.2024.106245.Peer-Reviewed Original ResearchConceptsBacille Calmette-GuerinBreakthrough COVID-19Healthcare workersSevere COVID-19Risk of severe COVID-19Placebo groupSymptomatic COVID-19BCG-DenmarkRisk of symptomatic COVID-19International randomised controlled trialRandomised controlled trialsBacille Calmette-Guerin vaccineVaccination of healthcare workersHealthcare centresSARS-CoV-2 testingAsymptomatic SARS-CoV-2 infectionRandomised 1:1SARS-CoV-2 infectionCOVID-19MITT populationControlled trialsHealthcareIntradermal doseModified intentionImmunomodulatory effectsEffectiveness of the fourth dose of COVID-19 vaccines against severe COVID-19 among adults 40 years or older in Brazil: a population-based cohort study
Neto F, Hitchings M, Amin A, de França G, Lind M, Torres M, Tsuha D, de Oliveira R, Cummings D, Dean N, Andrews J, Ko A, Croda J, Ranzani O. Effectiveness of the fourth dose of COVID-19 vaccines against severe COVID-19 among adults 40 years or older in Brazil: a population-based cohort study. The Lancet Regional Health - Americas 2024, 34: 100755. PMID: 38737773, PMCID: PMC11087726, DOI: 10.1016/j.lana.2024.100755.Peer-Reviewed Original ResearchSevere COVID-19Cohort ACohort B.Cohort BTwo-doseMRNA vaccinesPrimary outcomeBooster dose effectivenessCOVID-19 outcomesPopulation-based cohort studyDose of COVID-19 vaccinePopulation-based cohortPopulation-based cohort of individualsCOVID-19 vaccine dosesSevere COVID-19 outcomesFollow-upCohort studyMRNA-basedVaccine doseCohort of individualsVaccine effectivenessVaccine combinationsDoseLower hazardCohort
2023
Pan-American Guidelines for the treatment of SARS-CoV-2/COVID-19: a joint evidence-based guideline of the Brazilian Society of Infectious Diseases (SBI) and the Pan-American Association of Infectious Diseases (API)
Barbosa A, Chebabo A, Starling C, Pérez C, Cunha C, de Luna D, Nunes E, Zambrano G, Ferreira J, Croda J, Falavigna M, Gomes-da-Silva M, Thormann M, Cimerman S, Parahiba S, Tanni S, Bernardo W, Rodriguez-Morales A. Pan-American Guidelines for the treatment of SARS-CoV-2/COVID-19: a joint evidence-based guideline of the Brazilian Society of Infectious Diseases (SBI) and the Pan-American Association of Infectious Diseases (API). Annals Of Clinical Microbiology And Antimicrobials 2023, 22: 67. PMID: 37550690, PMCID: PMC10408214, DOI: 10.1186/s12941-023-00623-w.Peer-Reviewed Original ResearchConceptsUse of hydroxychloroquineInfectious diseasesCOVID-19Treatment of outpatientsSARS-CoV-2/COVIDSevere COVID-19Evidence-based guidelinesPan American AssociationGuideline development processLack of benefitEvidence-based medicineAdverse eventsMechanical ventilationClinical manifestationsTherapeutic optionsPharmacological treatmentCOVID-19 episodeInpatient settingAmerican guidelinesGRADE systemSystematic reviewStrong recommendationsProphylaxisOutpatientsDiseaseRandomized Trial of BCG Vaccine to Protect against Covid-19 in Health Care Workers
Pittet L, Messina N, Orsini F, Moore C, Abruzzo V, Barry S, Bonnici R, Bonten M, Campbell J, Croda J, Dalcolmo M, Gardiner K, Gell G, Germano S, Gomes-Silva A, Goodall C, Gwee A, Jamieson T, Jardim B, Kollman T, Lacerda M, Lee K, Lucas M, Lynn D, Manning L, Marshall H, McDonald E, Munns C, Nicholson S, O’Connell A, de Oliveira R, Perlen S, Perrett K, Prat-Aymerich C, Richmond P, Rodriguez-Baño J, dos Santos G, da Silva P, Teo J, Villanueva P, Warris A, Wood N, Davidson A, Curtis N. Randomized Trial of BCG Vaccine to Protect against Covid-19 in Health Care Workers. New England Journal Of Medicine 2023, 388: 1582-1596. PMID: 37099341, PMCID: PMC10497190, DOI: 10.1056/nejmoa2212616.Peer-Reviewed Original ResearchConceptsBacille Calmette-GuerinModified intention-to-treat populationIntention-to-treat populationSevere COVID-19Placebo groupSymptomatic COVID-19Health care workersBCG-DenmarkPlacebo-controlled trialCare workersRisk of severe COVID-19Double-blindSaline placeboRisk of symptomatic COVID-19Severe acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Negative testRandomized trialsRespiratory syndrome coronavirus 2Hazard ratioPrimary outcomeBCG vaccinationTrial definitionSyndrome coronavirus 2Risk difference
2022
Effectiveness of an inactivated Covid-19 vaccine with homologous and heterologous boosters against Omicron in Brazil
Ranzani OT, Hitchings MDT, de Melo RL, de França GVA, Fernandes CFR, Lind ML, Torres MSS, Tsuha DH, David LCS, Said RFC, Almiron M, de Oliveira RD, Cummings DAT, Dean NE, Andrews JR, Ko AI, Croda J. Effectiveness of an inactivated Covid-19 vaccine with homologous and heterologous boosters against Omicron in Brazil. Nature Communications 2022, 13: 5536. PMID: 36202800, PMCID: PMC9537178, DOI: 10.1038/s41467-022-33169-0.Peer-Reviewed Original Research
2021
BCG vaccination to reduce the impact of COVID-19 in healthcare workers: Protocol for a randomised controlled trial (BRACE trial)
Pittet L, Messina N, Gardiner K, Orsini F, Abruzzo V, Bannister S, Bonten M, Campbell J, Croda J, Dalcolmo M, Elia S, Germano S, Goodall C, Gwee A, Jamieson T, Jardim B, Kollmann T, Lacerda M, Lee K, Legge D, Lucas M, Lynn D, McDonald E, Manning L, Munns C, Perrett K, Aymerich C, Richmond P, Shann F, Sudbury E, Villanueva P, Wood N, Lieschke K, Subbarao K, Davidson A, Curtis N, Abreu C, Abruzzo V, Addlem L, Agius S, Barbosa A, Alamrousi A, Santos A, Al-Hindawi Y, Da Silveira S, Cruz L, Anderson J, Anthony C, Pereira A, Almajano F, Arnold A, Arrowsmith B, Azzopardi K, Marti C, Bahaduri T, Bannister S, Barney S, Barrera L, Barriocanal A, Barros D, Barry S, Bartlett A, Muranaka L, Baulman T, Bealing M, Beardsley J, Gutierrez A, Bell J, Benson S, Bennett-Wood V, Bergant N, Barbosa F, Bijllaardt W, Bimboese P, Andrade C, Blake S, Blauwendraat K, Boersma W, Garcia P, Bonnici R, Bonten M, Boon A, Bourke A, Bowes K, Brasil L, Brophy C, Botten R, Buchanan S, Bucholc J, Burns A, Burrell E, Bustos N, Byrne B, Byrne A, Calbo E, Montes J, Camesella B, Campbell J, Cangas A, Carlin J, Roque M, Diogo R, Carvalho E, Casas I, Castro E, Castro R, Catterick H, Escobar R, Chan J, Cheah J, Chern T, Chengodu T, Ciaverella M, Clark S, Espindola M, Cobbledick A, Colaco C, Collopy S, Comella P, Corbett M, Castro G, Costa E, Coya R, Crawford N, Croda J, Cruz A, Curtis N, Cushnahan J, Czajko A, da Silva R, Daitiri B, Dalcolmo M, Dalton K, Dao A, Davidson A, Dawe P, Dawson D, Costa M, De La Cruz K, de Serna A, de Morais Batista F, de Oliveira A, del Rey Morillo R, Desylva M, Dijkstra H, Dixon R, Lopez M, Dominguez J, Doran C, Castellano A, Dos Santos G, Lencina J, Silva D, Douglas M, Dunn R, Dunn A, Dunnill J, Eden G, Edmund H, Eiffler N, Elborough H, Elia S, Elkington O, England M, Ayala W, Esteve M, Evans N, Evans S, Ewe K, Álvarez M, Fahey K, Fairweather J, Faustman D, Silva E, Fernandez M, Fidler G, Filius P, Finn A, Finucane C, Firth S, Fletcher E, Flynn C, Flynn L, Fouracre L, Fowler S, Freitas T, Furtado A, Oliveira M, Santos A, Gonçalves L, Galletta L, Gama L, Gamage D, Ganpat R, García C, Croda M, Gardiner K, Gardiner E, Gell G, Oliveira A, Germano S, Gibbons M, Gibson C, Gifford A, Poderos T, Ginsberg A, Gisolf J, Gladanac B, Glenn P, Godinho V, Santos M, Goikoetxea J, Goldenberg T, Gomes A, Marcos S, Rico C, Goodall C, Gordon V, Greven F, Capella A, Griffith L, Guo C, Campos D, Cuadra M, Gwee A, Hall R, Hall L, Hamilton K, Hannan M, Harbech H, Harding A, Haker N, Harrison R, Hassing R, Rosa T, Haywood Z, Heath C, Henare N, Andrade P, Herrmann S, Hill E, Hilton S, Huijbens D, Hutton H, James J, Jamieson T, Janssen A, Jardim B, Jardim T, Jarvis L, Jenkins N, Jones J, Jones J, Jones K, Jorge L, Vilegas M, Joshi S, Joyce R, Junior J, Kandasamy R, Karunanayake A, Karuppasamy H, Keeble T, Kent J, Kloeg P, Kluytmans J, Knight B, Kollmann T, Korman T, Krastev A, Krieg M, La N, Lacerda M, Lacoma A, Lagunday R, Lalich D, Latkovic E, Latorre I, Leandro P, Lee K, Legge D, Lemmers T, Leurink T, Lieschke K, Lim K, Lockhart G, Bogéa C, Santos K, Marques R, Lucas M, Lynn D, Lynn M, Freitas M, Ma N, Macalister S, Machado C, Ramos M, Machingaifa F, Maia I, Maia B, Malley R, Manning L, Manton S, Carrerero J, Barriocanal A, Alves C, Pereira R, Arruda B, Marins A, Marshall H, Markow A, Martin C, Almeida K, Mather W, Mathers M, Gomes F, Tadokoro M, Mazarakis N, Mazurega K, McAlister S, McAndrews A, McDonald E, McDonald F, McElroy R, McMillan M, McMullan B, McPhate N, Mead L, Meehan A, Meek B, Melo R, Mena G, Mesquita D, Messina N, Mezzetti I, Vieira H, Miller S, Mitchell K, Mitchell M, Mojeed J, Molenaar K, Molina G, Molina B, Montgomery L, Moore C, Moore J, Moorlag S, Morawakage T, Moss J, Moyle W, Mulholland K, Munns C, Nascimento E, Navarrette N, Netea M, Neves J, Newman G, Ngien B, Nguyen J, Nguyen K, Noonan F, Norton W, O’Donnell M, O’Bryan J, O’Connell A, Odoi S, O’Donnell L, Oliveira R, Oliveira M, Oliveira T, Oliveira I, Olivier N, Olivio L, Ong B, Ong J, Ong J, Onysk J, Ooi I, Oppedisano F, Orsini F, Ortika B, Group O, Otsuka A, Overton K, Owens R, Paes R, Palasanthiran P, Jiménez V, Pandine G, Parkin K, Hernandez A, Paternotte N, Paterson D, Souza A, Pelayo L, Pell C, Pelser S, Pereira H, Pereira G, Perez G, Perez C, Porcuna T, Perlen S, Perrett K, Floy A, Pitkin S, Pittet L, Pon R, Calderón I, Post J, Power C, Prado C, Prajitno E, Prat-Aymerich C, Preijers L, Puga M, Queiroz E, Quinn L, Rak A, Figueiredo L, de Arellano E, Ramos P, Oliveira K, Ren J, Reynolds S, Rhodes S, Santos C, Richards C, Richmond P, Richmond H, Souza A, Rocha J, Rodrigues T, Rodrigues L, Rodrigues B, Fernandes I, Rodríguez-Baño J, Roescher N, Rogers S, Rol A, Romme J, Rosell A, Font M, Sallent S, Sacca D, Sampaio V, Sanchez N, Sanchez B, Santos D, Santos T, Sartim A, Sastry A, Sawka A, Schultz N, Seamark C, Seamark D, Septer-Bijleveld E, Serrano R, Shann F, Sharma K, Shave M, Shen L, Sidaway-Lee K, Baena A, Silva R, Silva J, Silva E, Simão M, Singh R, Siqueira M, Chaves M, Sondag T, Sooriyarachchi E, Sousa A, Spry L, Statton S, Steer A, Santos D, Sterling K, Steve L, Stevens L, Stevens N, Stewart C, Stiglmayer L, Stooper L, Studham J, Subbarao K, Sudbury E, Suiker A, Symons L, Taks E, Tan N, Meireles B, Riele M, Oever J, Lima G, Heine R, Angelo J, Thomson H, Toh R, Trindade A, Tripp H, Tristán E, Troeman D, Truelove A, Tsuha D, Uffing M, Val F, Valero O, Valls E, van Ven C, Van Heuvel L, van Veen S, van Waal M, van Leusen J, van Mook L, van Onzenoort H, van Opdorp M, van Rijen M, van Sluis N, Vasconcelos A, Vega N, Velagapudi S, Vennells L, Venton T, Verheij H, Verhoeven P, Ramos C, Silva P, Vidal S, Vieira P, Oliveira M, Ortega R, Villanueva P, Villar R, Vlahos A, Wadia U, Walker M, Wall K, Wallace R, Waring J, Warren R, Warris A, Watts E, Wearing-Smith M, Webber-Rookes D, Wedderburn J, Wee-Hee A, Wesselingh S, Teo J, Whale B, Williams P, Wolters B, Wood N, Xie I, Younes A, Young A, Batista F, Zhou C, Zwart V, Goodchild L. BCG vaccination to reduce the impact of COVID-19 in healthcare workers: Protocol for a randomised controlled trial (BRACE trial). BMJ Open 2021, 11: e052101. PMID: 34711598, PMCID: PMC8557250, DOI: 10.1136/bmjopen-2021-052101.Peer-Reviewed Original ResearchConceptsBCG vaccinationHealthcare workersSARS-CoV-2 infectionCOVID-19Multicentre phase IIISevere COVID-19Episodes of illnessPeer-reviewed open access journalsSARS-CoV-2Respiratory illnessSafety profileClinical detailsWork absenteeismImmune responseBlood samplesVaccinationImmune systemInexpensive interventionSecondary objectiveUnrelated pathogensPhase IIIOff-target effectsImmunological analysisIllnessGovernance approval
2020
Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection
Borba M, Val F, Sampaio V, Alexandre M, Melo G, Brito M, Mourão M, Brito-Sousa J, Baía-da-Silva D, Guerra M, Hajjar L, Pinto R, Balieiro A, Pacheco A, Santos J, Naveca F, Xavier M, Siqueira A, Schwarzbold A, Croda J, Nogueira M, Romero G, Bassat Q, Fontes C, Albuquerque B, Daniel-Ribeiro C, Monteiro W, Lacerda M. Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection. JAMA Network Open 2020, 3: e208857. PMID: 32330277, DOI: 10.1001/jamanetworkopen.2020.8857.Peer-Reviewed Original ResearchConceptsHigh dosage groupSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectionAcute respiratory syndrome coronavirus 2 infectionLow dosage groupSyndrome coronavirus 2 infectionCoronavirus 2 infectionChloroquine diphosphateDay 13COVID-19Phase IIb clinical trialNonsevere COVID-19Secondary end pointsSevere COVID-19High-dose groupSpecific antiviral therapyTertiary care facilityIIb clinical trialCoronavirus disease 2019More heart diseaseParticipants' clinical statusAdjunctive therapyAdult patientsIll patientsPrimary outcomeAntiviral therapy