2009
Leptospirosis pulmonary haemorrhage syndrome is associated with linear deposition of immunoglobulin and complement on the alveolar surface
Croda J, Neto A, Brasil R, Pagliari C, Nicodemo A, Duarte M. Leptospirosis pulmonary haemorrhage syndrome is associated with linear deposition of immunoglobulin and complement on the alveolar surface. Clinical Microbiology And Infection 2009, 16: 593-599. PMID: 19778300, DOI: 10.1111/j.1469-0691.2009.02916.x.Peer-Reviewed Original ResearchConceptsLeptospirosis pulmonary hemorrhage syndromePulmonary hemorrhage syndromeLPHS patientsPulmonary hemorrhageAlveolar surfaceLinear depositionUnique histological patternLife-threatening syndromeImmunoglobulin depositsTreatment regimensPathological featuresPresent studyHistological patternLung specimensLung tissueSevere diseaseAlveolar septaHuman leptospirosisLinear stainingSyndromeZoonotic infectionGranular stainingHemorrhageHeterogeneous stainingPatients
2001
Leptospiral Proteins Recognized during the Humoral Immune Response to Leptospirosis in Humans
Guerreiro H, Croda J, Flannery B, Mazel M, Matsunaga J, Reis M, Levett P, Ko A, Haake D. Leptospiral Proteins Recognized during the Humoral Immune Response to Leptospirosis in Humans. Infection And Immunity 2001, 69: 4958-4968. PMID: 11447174, PMCID: PMC98588, DOI: 10.1128/iai.69.8.4958-4968.2001.Peer-Reviewed Original ResearchConceptsHumoral immune responseImmune responseNatural infectionLeptospiral proteinsInfection-associated antigenConvalescent-phase seraPositive reactionConvalescent phaseHumoral responseHealthy individualsHuman leptospirosisControl individualsVaccine designImmunodominant antigensQuantitative immunoblot analysisTwo-dimensional immunoblotsProtein antigensPathogenic leptospiral strainsGenus LeptospiraInfectionAntigenLeptospirosisSerumImmunodominant proteinsPatients