2024
Assessment of the BNT162B2 COVID-19 vaccine immune response in Brazilian indigenous adolescents
de Oliveira L, de Morais I, Marchioro S, de Almeida G, de Almeida de Souza G, da Silva Ferreira T, Rossoni R, de Oliveira Barbosa D, Navarini V, Croda J, Torres A, Simionatto S. Assessment of the BNT162B2 COVID-19 vaccine immune response in Brazilian indigenous adolescents. Vaccine 2024, 43: 126494. PMID: 39571350, DOI: 10.1016/j.vaccine.2024.126494.Peer-Reviewed Original ResearchCD8+ T cellsBNT162b2 vaccineT cellsB lymphocytesIncreased levels of B lymphocytesImmune responseCell subpopulationsLevels of B lymphocytesSARS-CoV-2-specific immune responsesMemory B cellsNon-classical monocytesIndigenous adolescentsStatistically significant increaseNK cellsVaccinated adolescentsB cellsNo significant changesBooster doseCohort studyBNT162b2Vaccination scheduleLimited healthcare resourcesImmunogenic responseDemographic dataCOVID-19 vaccineSeroprevalence of Zika virus in pregnant women in Brazil: a cohort study in the macroregion of Dourados - Mato Grosso do Sul
Dan C, Brito G, Croda J, Koishi A, Santos C, Benedetti K, Marchioro S, Simionatto S. Seroprevalence of Zika virus in pregnant women in Brazil: a cohort study in the macroregion of Dourados - Mato Grosso do Sul. Revista Eletrônica Acervo Saúde 2024, 24: e17324. DOI: 10.25248/reas.e17324.2024.Peer-Reviewed Original ResearchPregnant womenSeroprevalence of Zika virusInter-atrial communicationMaternal ZIKV infectionZika virusZIKV vaccinesInter-atrialPremature childbirthHigh feverZIKV infectionCohort studyNeurological alterationsTertiary hospitalImage analysis systemEthics CommitteeSerological diagnosisWomenResearch Ethics CommitteeQuantification of antibodiesZIKVAntibodiesSeroprevalenceVirusMyalgiaOstealgiaEffectiveness of the fourth dose of COVID-19 vaccines against severe COVID-19 among adults 40 years or older in Brazil: a population-based cohort study
Neto F, Hitchings M, Amin A, de França G, Lind M, Torres M, Tsuha D, de Oliveira R, Cummings D, Dean N, Andrews J, Ko A, Croda J, Ranzani O. Effectiveness of the fourth dose of COVID-19 vaccines against severe COVID-19 among adults 40 years or older in Brazil: a population-based cohort study. The Lancet Regional Health - Americas 2024, 34: 100755. PMID: 38737773, PMCID: PMC11087726, DOI: 10.1016/j.lana.2024.100755.Peer-Reviewed Original ResearchSevere COVID-19Cohort ACohort B.Cohort BTwo-doseMRNA vaccinesPrimary outcomeBooster dose effectivenessCOVID-19 outcomesPopulation-based cohort studyDose of COVID-19 vaccinePopulation-based cohortPopulation-based cohort of individualsCOVID-19 vaccine dosesSevere COVID-19 outcomesFollow-upCohort studyMRNA-basedVaccine doseCohort of individualsVaccine effectivenessVaccine combinationsDoseLower hazardCohortFactors influencing adverse events following COVID-19 vaccination
Villanueva P, McDonald E, Croda J, Croda M, Dalcolmo M, dos Santos G, Jardim B, Lacerda M, Lynn D, Marshall H, Oliveira R, Rocha J, Sawka A, Val F, Pittet L, Messina N, Curtis N. Factors influencing adverse events following COVID-19 vaccination. Human Vaccines & Immunotherapeutics 2024, 20: 2323853. PMID: 38445666, PMCID: PMC10936640, DOI: 10.1080/21645515.2024.2323853.Peer-Reviewed Original ResearchConceptsVaccine typesSystemic reactionsIncidence of AEFIAdverse eventsVaccine doseIncidence of adverse eventsCovid-19 specific vaccineCOVID-19 vaccineNested cohort studyIgG antibody responsesRisk of AEFICOVID-19 vaccine typesChAdOx1 recipientsBNT162b2 recipientsCohort studyPfizer-BioNTechCoronaVac vaccineAntibody responseChAdOx1Oxford-AstraZenecaCoronaVacBNT162b2Local reactionsDoseDevelopment of COVID-19 vaccines
2023
Multicenter study of the natural history and therapeutic responses of patients with chikungunya, focusing on acute and chronic musculoskeletal manifestations – a study protocol from the clinical and applied research in Chikungunya (REPLICK network)
da Silva Duarte G, Jones A, de Goes Cavalcanti L, de Melo Rêgo M, Ribeiro G, Boyton R, Pereira D, Croda J, Costa F, Duarte A, Consolaro M, Stabeli R, Negrão F, Proenca-Modena J, Villalobos-Salcedo J, da Rocha Castelar Pinheiro G, de Barros Albuquerque A, de Almeida Barreto F, Moreira J, Ferrari I, Évora P, da Silva V, Lacerda M, Altmann D, Siqueira A. Multicenter study of the natural history and therapeutic responses of patients with chikungunya, focusing on acute and chronic musculoskeletal manifestations – a study protocol from the clinical and applied research in Chikungunya (REPLICK network). BMC Infectious Diseases 2023, 23: 499. PMID: 37507666, PMCID: PMC10386654, DOI: 10.1186/s12879-023-08292-y.Peer-Reviewed Original ResearchConceptsMusculoskeletal manifestationsStudy protocolTherapeutic responseChronic diseasesNatural historyDestructive disease courseMulticenter cohort studyLong-term sequelaeAssociated risk factorsClinical report formsClinical trial designQuality of lifeAliquots of bloodCohort studyCHIKV infectionDisease courseChronic painSymptomatic infectionBlood testsHigh morbidityMulticenter studyMusculoskeletal symptomsTherapeutic guidelinesClinical spectrumPatient cohortDelay in the diagnosis and treatment of tuberculosis in prisons in Mato Grosso do Sul, Brazil
Ribeiro C, da Silva Santos A, Tshua D, de Oliveira R, Lemos E, Bourdillon P, Laranjeira A, Gonçalves C, Andrews J, Ko A, Croda J. Delay in the diagnosis and treatment of tuberculosis in prisons in Mato Grosso do Sul, Brazil. Revista Da Sociedade Brasileira De Medicina Tropical 2023, 56: e0015-2023. PMID: 37493729, PMCID: PMC10367220, DOI: 10.1590/0037-8682-0015-2023.Peer-Reviewed Original ResearchConceptsSymptom onsetFirst symptomsLargest male prisonPrison medical recordsTB case dataRetrospective cohort studyPulmonary TB casesYear of diagnosisStart of treatmentTreatment of TBTreatment of tuberculosisNumber of symptomsAverage timePercentage of cureProvider delayTB casesCohort studyTreatment initiationHIV statusSmoking statusTuberculosis casesTB transmissionFirst consultationPatient delayMedical records
2022
Infant BCG vaccination and risk of pulmonary and extrapulmonary tuberculosis throughout the life course: a systematic review and individual participant data meta-analysis
Martinez L, Cords O, Liu Q, Acuna-Villaorduna C, Bonnet M, Fox G, Carvalho A, Chan P, Croda J, Hill P, Lopez-Varela E, Donkor S, Fielding K, Graham S, Espinal M, Kampmann B, Reingold A, Huerga H, Villalba J, Grandjean L, Sotgiu G, Egere U, Singh S, Zhu L, Lienhardt C, Denholm J, Seddon J, Whalen C, García-Basteiro A, Triasih R, Chen C, Singh J, Huang L, Sharma S, Hannoun D, Del Corral H, Mandalakas A, Malone L, Ling D, Kritski A, Stein C, Vashishtha R, Boulahbal F, Fang C, Boom W, Netto E, Lemos A, Hesseling A, Kay A, Jones-López E, Horsburgh C, Lange C, Andrews J. Infant BCG vaccination and risk of pulmonary and extrapulmonary tuberculosis throughout the life course: a systematic review and individual participant data meta-analysis. The Lancet Global Health 2022, 10: e1307-e1316. PMID: 35961354, PMCID: PMC10406427, DOI: 10.1016/s2214-109x(22)00283-2.Peer-Reviewed Original ResearchConceptsInfant BCG vaccinationBCG vaccinationExtrapulmonary tuberculosisCohort studyIndividual participant dataPulmonary tuberculosisParticipant dataSystematic reviewIndividual-level participant dataPositive tuberculin skin testMultivariable logistic regression analysisTuberculin skin testTuberculosis infection statusParticipant-level dataLogistic regression analysisAge-specific impactStudy-level random effectWeb of ScienceIncident tuberculosisPrevious tuberculosisTuberculosis developmentSecondary outcomesTuberculosis contactsPrimary outcomeSkin testHuman T-Lymphotropic Virus-1/2 Infection in Central Brazil Prisons: A Multicenter Study
Bandeira L, Puga M, Croda J, Pompílio M, Amianti C, de Rezende G, Motta-Castro A. Human T-Lymphotropic Virus-1/2 Infection in Central Brazil Prisons: A Multicenter Study. Frontiers In Microbiology 2022, 12: 740245. PMID: 35126323, PMCID: PMC8815966, DOI: 10.3389/fmicb.2021.740245.Peer-Reviewed Original ResearchHTLV infectionCross-sectional studyEnzyme-linked immunosorbent assayHTLV-1New casesHuman T-lymphotropic virus (HTLV) infectionAnti-HTLV antibodiesHTLV proviral DNAProspective cohort studyWestern blot methodHarm reduction measuresBrazilian general populationHTLV transmissionCohort studyMulticenter studySerological evidenceVirus infectionPrevalence ratesHigh riskGeneral populationPreventive interventionsHTLV-2Risk behaviorsInfectionProviral DNA
2020
Prevalence, incidence and associated factors for HBV infection among male and female prisoners in Central Brazil: A multicenter study
Rezende G, Lago B, Puga M, Bandeira L, Pompilio M, Castro V, Tanaka T, Cesar G, Oliveira S, Yassuda R, Simionatto S, Weis S, Basílio S, Croda J, Motta-Castro A. Prevalence, incidence and associated factors for HBV infection among male and female prisoners in Central Brazil: A multicenter study. International Journal Of Infectious Diseases 2020, 96: 298-307. PMID: 32315810, DOI: 10.1016/j.ijid.2020.04.019.Peer-Reviewed Original ResearchConceptsHBV exposureHepatitis B virus infectionHCV/HBVIncidence of HBVHBV serological markersB virus infectionCross-sectional studyGenotypes/subtypesHBV infectionCohort studySerological markersHBV isolatesMulticenter studyHigh prevalenceLower incidenceVirus infectionHigh riskHBVNew casesBlood collectionFemale prisonersInfectionIncidencePreventive measuresPrevalence
2018
119. Prospective Validation of a 3-Gene Signature for Tuberculosis Diagnosis, Predicting Progression and Evaluating Treatment Response
Warsinske H, Rao A, Moreira F, Dos Santos P, Liu A, Scott M, Malherbe S, Ronacher K, Walzl G, Winter J, Sweeney T, Croda J, Andrews J, Khatri P. 119. Prospective Validation of a 3-Gene Signature for Tuberculosis Diagnosis, Predicting Progression and Evaluating Treatment Response. Open Forum Infectious Diseases 2018, 5: s5-s5. PMCID: PMC6253029, DOI: 10.1093/ofid/ofy209.010.Peer-Reviewed Original ResearchNegative predictive valueTB scoreWorld Health OrganizationActive tuberculosisATB patientsCohort studyTriage testTreatment responseHigh negative predictive valueProspective cohort studyCase-control trialEnd of treatmentIndependent prospective cohortsAdolescent cohort studySputum positivityActive diseaseProspective cohortTreatment initiationSputum testDisease onsetProspective validationPET-CTPredicting ProgressionTuberculosis diagnosisPredictive valueAssessment of Validity of a Blood-Based 3-Gene Signature Score for Progression and Diagnosis of Tuberculosis, Disease Severity, and Treatment Response
Warsinske H, Rao A, Moreira F, Santos P, Liu A, Scott M, Malherbe S, Ronacher K, Walzl G, Winter J, Sweeney T, Croda J, Andrews J, Khatri P. Assessment of Validity of a Blood-Based 3-Gene Signature Score for Progression and Diagnosis of Tuberculosis, Disease Severity, and Treatment Response. JAMA Network Open 2018, 1: e183779. PMID: 30646264, PMCID: PMC6324428, DOI: 10.1001/jamanetworkopen.2018.3779.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAntitubercular AgentsBrazilChildCohort StudiesDisease ProgressionFemaleGenes, BacterialGenetic MarkersHumansLatent TuberculosisMaleMiddle AgedMolecular TypingMycobacterium tuberculosisReal-Time Polymerase Chain ReactionReproducibility of ResultsRNA, BacterialSeverity of Illness IndexTuberculosisYoung AdultConceptsTB scoreAdolescent cohort studyNegative predictive valueTreatment responseTB diseaseCohort studyTuberculosis infectionTriage testPositron emission tomography-computed tomography scanPredictive valueLatent M tuberculosis infectionLatent Mycobacterium tuberculosis infectionPrimary health care clinicsHigh negative predictive valueCulture-positive adultsM tuberculosis infectionWhole bloodMycobacterium tuberculosis infectionEnd of treatmentHealth care clinicsCase-control studyIndependent prospective cohortsDiagnosis of tuberculosisSlower treatment responseCase-control cohortSuicide in Brazilian indigenous communities: clustering of cases in children and adolescents by household
Lazzarini TA, Gonçalves CCM, Benites WM, da Silva L, Tsuha DH, Ko AI, Rohrbaugh R, Andrews JR, Croda J. Suicide in Brazilian indigenous communities: clustering of cases in children and adolescents by household. Revista De Saúde Pública 2018, 52: 56. PMID: 29791676, PMCID: PMC5958965, DOI: 10.11606/s1518-8787.2018052000541.Peer-Reviewed Original ResearchConceptsHealth interventionsSuicide ratesHousehold clustersRetrospective cohort studyBroader public health interventionsConclusions High ratesPublic health interventionsMental health interventionsHigh rateCohort studyHigh suicide ratesLower socioeconomic indicatorsAdult suicideAdolescent malesOverall suicide ratesChildrenSuicideGreater proportionChild suicideInterventionSocioeconomic indicatorsAdolescentsIndigenous individualsSuicide clusteringTreatment Outcomes of Brazilian Inmates with Treponema pallidum and Human Immunodeficiency Virus Infection: A Prospective Cohort Study.
Bet G, Souza G, Croda J, Correa M, de Sales R, Santos R, Viebrantz Enne Sgarbi R, Yassuda R, Coimbra Motta-Castro A, Pompílio M, Simionatto S. Treatment Outcomes of Brazilian Inmates with Treponema pallidum and Human Immunodeficiency Virus Infection: A Prospective Cohort Study. American Journal Of Tropical Medicine And Hygiene 2018, 98: 1603-1608. PMID: 29737273, PMCID: PMC6086195, DOI: 10.4269/ajtmh.17-0592.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusHIV-1 viral loadProspective cohort studyPoor treatment outcomesTreatment outcomesCohort studyHIV infectionViral loadHuman immunodeficiency virus (HIV) infectionImmunodeficiency virus infectionCopies/mLMedical record dataPublic health programsSyphilis treatmentImmunodeficiency virusAcquired syphilisRisk factorsSerological testingVirus infectionBlood samplesMultivariate analysisHealth programsNew casesInfectionTreponema pallidum
2017
Prevalence and Incidence of HCV Infection among Prisoners in Central Brazil
Puga M, Bandeira L, Pompilio M, Croda J, de Rezende G, Dorisbor L, Tanaka T, Cesar G, Teles S, Simionatto S, Novais A, Nepomuceno B, Castro L, do Lago B, Motta-Castro A. Prevalence and Incidence of HCV Infection among Prisoners in Central Brazil. PLOS ONE 2017, 12: e0169195. PMID: 28060860, PMCID: PMC5218405, DOI: 10.1371/journal.pone.0169195.Peer-Reviewed Original ResearchConceptsHCV infectionCohort studyHCV RNASectional studyInjecting-drug useNew HCV infectionsHCV risk behaviorsCross-sectional studyHCV exposureHepatitis CHIV positivityEffective intervention strategiesAssociated FactorsClinical evaluationIndependent associationOverall prevalenceRisk factorsIncidence rateBlood samplesDrug useNew casesRisk behaviorsInfectionHigh frequency ratePrevalence
2016
Impact of mass-screening on tuberculosis incidence in a prospective cohort of Brazilian prisoners
Paião DS, Lemos EF, Carbone AD, Sgarbi RV, Junior AL, da Silva FM, Brandão LM, dos Santos LS, Martins VS, Simionatto S, Motta-Castro AR, Pompílio MA, Urrego J, Ko AI, Andrews JR, Croda J. Impact of mass-screening on tuberculosis incidence in a prospective cohort of Brazilian prisoners. BMC Infectious Diseases 2016, 16: 533. PMID: 27716170, PMCID: PMC5048439, DOI: 10.1186/s12879-016-1868-5.Peer-Reviewed Original ResearchConceptsTuberculin skin testingActive tuberculosisRisk factorsSubsequent diseaseProspective cohort studyEarly case detectionHigh transmission settingsHigh-risk populationPotential risk factorsProportional hazards modelSubsequent disease riskMass screening interventionTST conversionCohort studyProspective cohortHIV testingTuberculosis infectionScreening interventionsSkin testingTB notificationsTuberculosis incidenceSubsequent riskCase detectionSputum samplesActive screening
2015
Risk Factors for Death from Visceral Leishmaniasis in an Urban Area of Brazil
Druzian A, de Souza A, de Campos D, Croda J, Higa M, Dorval M, Pompilio M, de Oliveira P, Paniago A. Risk Factors for Death from Visceral Leishmaniasis in an Urban Area of Brazil. PLOS Neglected Tropical Diseases 2015, 9: e0003982. PMID: 26274916, PMCID: PMC4537269, DOI: 10.1371/journal.pntd.0003982.Peer-Reviewed Original ResearchConceptsHIV/AIDSVisceral leishmaniasisRisk factorsAdult patientsMortality rateUrban endemic areaProspective cohort studySecondary bacterial infectionHigh mortality rateEndemic urban areaCohort studyEpidemiological profileMean ageUniversity HospitalEndemic areasMultivariate analysisPatientsBacterial infectionsAIDSDeathSignificant increaseHigh rateLeishmaniasisEdemaRelapse
2012
Tuberculosis control in a highly endemic indigenous community in Brazil
Croda M, Trajber Z, da Costa Lima R, Croda J. Tuberculosis control in a highly endemic indigenous community in Brazil. Transactions Of The Royal Society Of Tropical Medicine And Hygiene 2012, 106: 223-229. PMID: 22365154, DOI: 10.1016/j.trstmh.2012.01.005.Peer-Reviewed Original ResearchConceptsTB treatmentNon-Indigenous populationsTB patientsTB case fatality rateImplementation of DOTSRetrospective cohort studyCase fatality rateNumber of patientsHIV-positive statusTimes higher mortalityHigh rateCohort studyTB controlCase fatalityDOTS implementationHIV prevalenceTuberculosis controlFatality rateHigh mortalityMultivariate analysisPatientsYoung adultsMortalityPriority groupsIndigenous populations
2009
Benefit of antiretroviral therapy on survival of human immunodeficiency virus-infected patients admitted to an intensive care unit
Croda J, Croda M, Neves A, dos Santos S. Benefit of antiretroviral therapy on survival of human immunodeficiency virus-infected patients admitted to an intensive care unit. Critical Care Medicine 2009, 37: 1605-1611. PMID: 19325488, PMCID: PMC4143892, DOI: 10.1097/ccm.0b013e31819da8c7.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-Retroviral AgentsAntiretroviral Therapy, Highly ActiveBrazilCohort StudiesConfidence IntervalsCritical CareCritical IllnessDose-Response Relationship, DrugDrug Administration ScheduleFemaleFollow-Up StudiesHIV InfectionsHospital MortalityHumansIntensive Care UnitsLogistic ModelsMaleMiddle AgedMultivariate AnalysisOdds RatioProportional Hazards ModelsRetrospective StudiesRisk AssessmentSurvival AnalysisConceptsIntensive care unitAntiretroviral therapyICU admissionCare unitChronic Health Evaluation II scoreHuman immunodeficiency virus-infected patientsCD4 T-cell countUse of ARTTertiary care teaching hospitalMultivariate logistic regression analysisCox proportional hazards modelAcute illness severityRetrospective cohort studyT-cell countsVirus-infected patientsDay of admissionHuman immunodeficiency virusCause of admissionProportional hazards modelPotential confounding factorsLogistic regression analysisAcute PhysiologyICU mortalityII scoreCohort study