2020
Abnormal Neutrophil Transcriptional Signature May Predict Newly Diagnosed Latent Autoimmune Diabetes in Adults of South China
Xing Y, Lin Q, Tong Y, Zhou W, Huang J, Wang Y, Huang G, Li Y, Xiang Z, Zhou Z, Li T, Xiao Y. Abnormal Neutrophil Transcriptional Signature May Predict Newly Diagnosed Latent Autoimmune Diabetes in Adults of South China. Frontiers In Endocrinology 2020, 11: 581902. PMID: 33391182, PMCID: PMC7775642, DOI: 10.3389/fendo.2020.581902.Peer-Reviewed Original ResearchConceptsSex-matched healthy controlsLADA patientsHealthy controlsDevelopment of LADAPathological processesPeripheral blood neutrophilsCytokine-cytokine receptor interactionReal-time polymerase chain reactionLatent AutoimmuneAdhesion molecule signalingAutoimmune diabetesFunction deteriorationNeutrophil numbersPeripheral neutrophilsBlood neutrophilsPolymerase chain reactionPathological alterationsCell differentiationLeukocyte degranulationMyeloid cell differentiationGenomes (KEGG) pathway enrichmentPatientsPresent study resultsNeutrophilsTranscriptional levelAbnormal Peripheral Neutrophil Transcriptome in Newly Diagnosed Type 2 Diabetes Patients
Lin Q, Zhou W, Wang Y, Huang J, Hui X, Zhou Z, Xiao Y. Abnormal Peripheral Neutrophil Transcriptome in Newly Diagnosed Type 2 Diabetes Patients. Journal Of Diabetes Research 2020, 2020: 9519072. PMID: 32377527, PMCID: PMC7195634, DOI: 10.1155/2020/9519072.Peer-Reviewed Original ResearchConceptsType 2 diabetes patientsGene OntologyType 2 diabetesComprehensive transcriptome analysisKEGG pathway enrichment analysisCytokine receptor interaction pathwayMyeloid leukocyte activationPathway enrichment analysisReceptor interaction pathwayQPCR of genesGene expression analysisDiabetes patientsHealthy controlsUpregulated DEGsTranscriptome analysisTranscriptome levelGO analysisKEGG pathwaysRNA sequencingCell adhesion moleculeExpression analysisEnrichment analysisInteraction pathwayMolecular mechanismsDEGs
2018
Distinct neutrophil counts and functions in newly diagnosed type 1 diabetes, latent autoimmune diabetes in adults, and type 2 diabetes
Huang J, Xiao Y, Zheng P, Zhou W, Wang Y, Huang G, Xu A, Zhou Z. Distinct neutrophil counts and functions in newly diagnosed type 1 diabetes, latent autoimmune diabetes in adults, and type 2 diabetes. Diabetes/Metabolism Research And Reviews 2018, 35: e3064. PMID: 30123986, DOI: 10.1002/dmrr.3064.Peer-Reviewed Original ResearchConceptsNeutrophil countType 1 diabetesT1D patientsNeutrophil numbersPhagocytosis rateTitres of autoantibodiesΒ-cell antigensΒ-cell autoimmunityChemokine receptor expressionType 2 diabetesMigration of neutrophilsLADA patientsPositive autoantibodiesAutoimmune diabetesChemokine levelsCD62L expressionT2D patientsClinical parametersNeutrophil migrationHealthy controlsReceptor expressionAnimal modelsDiabetesPatientsDifferent subtypes
2016
Neutrophils in type 1 diabetes
Huang J, Xiao Y, Xu A, Zhou Z. Neutrophils in type 1 diabetes. Journal Of Diabetes Investigation 2016, 7: 652-663. PMID: 27181374, PMCID: PMC5009125, DOI: 10.1111/jdi.12469.Peer-Reviewed Original ResearchConceptsType 1 diabetesImmune cellsDiabetogenic T cell responseAutoimmune type 1 diabetesType 1 diabetes pathogenesisType 1 diabetes developmentΒ-cellsInsulin-producing pancreatic β-cellsProgression of insulitisT cell responsesFirst immune cellsNon-immune cellsImmune cell typesPancreatic β-cellsDendritic cellsDiabetes developmentAutoimmune diseasesDegranulation productsDiabetes pathogenesisExtracellular trapsT cellsDiabetesCell responsesNeutrophilsIslet cells