Abnormal Neutrophil Transcriptional Signature May Predict Newly Diagnosed Latent Autoimmune Diabetes in Adults of South China
Xing Y, Lin Q, Tong Y, Zhou W, Huang J, Wang Y, Huang G, Li Y, Xiang Z, Zhou Z, Li T, Xiao Y. Abnormal Neutrophil Transcriptional Signature May Predict Newly Diagnosed Latent Autoimmune Diabetes in Adults of South China. Frontiers In Endocrinology 2020, 11: 581902. PMID: 33391182, PMCID: PMC7775642, DOI: 10.3389/fendo.2020.581902.Peer-Reviewed Original ResearchConceptsSex-matched healthy controlsLADA patientsHealthy controlsDevelopment of LADAPathological processesPeripheral blood neutrophilsCytokine-cytokine receptor interactionReal-time polymerase chain reactionLatent AutoimmuneAdhesion molecule signalingAutoimmune diabetesFunction deteriorationNeutrophil numbersPeripheral neutrophilsBlood neutrophilsPolymerase chain reactionPathological alterationsCell differentiationLeukocyte degranulationMyeloid cell differentiationGenomes (KEGG) pathway enrichmentPatientsPresent study resultsNeutrophilsTranscriptional levelAltered Systemic and Intestinal IgA Immune Responses in Individuals With Type 1 Diabetes
Huang J, Huang G, Li X, Hu F, Xie Z, Xiao Y, Luo S, Chao C, Guo K, Wong FS, Zhou Z, Wen L. Altered Systemic and Intestinal IgA Immune Responses in Individuals With Type 1 Diabetes. The Journal Of Clinical Endocrinology & Metabolism 2020, 105: dgaa590. PMID: 32860693, PMCID: PMC7549925, DOI: 10.1210/clinem/dgaa590.Peer-Reviewed Original ResearchConceptsIgA-bound bacteriaType 1 diabetesHealthy control individualsIgA immune responseControl individualsIgA immunityAutoantibody titersIgA concentrationsImmune responseType 1 diabetes patientsΒ-cell autoimmunityLonger disease durationSerum IgA concentrationNovel therapeutic targetEnzyme-linked immunosorbentDisease durationIgA levelsDiabetes patientsDiabetes displayGut homeostasisBlood samplesOral cavityTherapeutic targetDiabetesHost immunity